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Expression analysis of ETS1 gene in peripheral blood mononuclear cells with systemic lupus erythematosus by real-time reverse transcription PCR

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Chinese Medical Journal 2010年第16期123卷 2287-2288页

作者： Li Yun Sun Liang-dan Lu Wen-sheng Hu Wen-long Gao Jin-ping cheng Yi-lin Yu Ze-ying Yao Sha He Cai-feng Liu Jian-lan Cui Yong Yang Sen Anhui Med Univ Inst Dermatol Affiliated Hosp 1 Hefei 230032 Anhui Peoples R China Minist Educ Key Lab Dermatol Hefei 230032 Anhui Peoples R China

To the editor： Systemic lupus erythematosus （SLE） is a prototypic autoimmune disease with complex genetic inheritance.l In recent years, genome-wide association studies （GWAS） had further provided novel insights ... 详细信息

关键词： PCR reverse transcription real-time systemic lupus erythematosus mononuclear cells peripheral blood ETS1 susceptibility genes association studies autoimmune disease different provided multiple complex SLE novel

高效毛细管电泳紫外检测器光路的特殊性及其优化

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高等学校化学学报 1998年第3期19卷 379-381页

作者：许旭吴如金林炳承中国科学院大连化学物理研究所中国药科大学

紫外检测器用于高效毛细管电泳（ＨＰＣＥ）的主要难题在光路中，ＨＰＣＥ中熔融石英毛细管（内径通常在５０μｍ左右）直接放在光路中，一方面光程短，另一方面，光在透镜及毛细管界面上的折射与反射使光程常比毛细管内径短，甚至可能... 详细信息

紫外检测器用于高效毛细管电泳（ＨＰＣＥ）的主要难题在光路中，ＨＰＣＥ中熔融石英毛细管（内径通常在５０μｍ左右）直接放在光路中，一方面光程短，另一方面，光在透镜及毛细管界面上的折射与反射使光程常比毛细管内径短，甚至可能绕过毛细管内腔［１，２］．本文编制...

关键词：高效毛细管电泳紫外检测器光路灵敏度 HPCE

LPs控制算法在SCARA机器人控制中的应用研究

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机床与液压 2020年第24期48卷 260-264页

作者：毕馨文程艳明毕霖柳成北华大学吉林吉林132021 长春理工大学吉林长春130012

在传统鲁棒控制方法中,设计控制法则时候需要不确定边界,而往往提出的边界通常会增加控制信号的幅值并且对系统造成伤害。针对此问题提出了一种勒让德多项式(LPS,Legendre polynomials)控制法则,每个关节的集总不确定性被估计,而不确定... 详细信息

在传统鲁棒控制方法中,设计控制法则时候需要不确定边界,而往往提出的边界通常会增加控制信号的幅值并且对系统造成伤害。针对此问题提出了一种勒让德多项式(LPS,Legendre polynomials)控制法则,每个关节的集总不确定性被估计,而不确定边界通过勒让德多项式进行计算。与传统鲁棒控制器相比,所提出的控制器简单、计算量小并且需要的反馈少,消除了必须预先知道外部干扰和参数不确定性上限的条件,通过一个SCARA机器人机械手对本文提出的控制法则进行仿真,仿真结果验证了所提控制方法的有效性。

关键词：不确定边界鲁棒控制 LPs控制法则

微波快速合成—烧结制备ZrNiSn半赫斯勒热电合金

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稀有金属材料与工程 2016年第6期45卷 1565-1570页

作者：雷鹰李雨徐林程诚王蒙万润东安徽工业大学安徽马鞍山243002 华中科技大学材料成形与模具技术国家重点实验室湖北武汉430074 昆明理工大学云南昆明650504

开展了ZrNiSn热电块体材料的微波快速合成-烧结研究,并对样品的物相组成、电性能、热性能、微观结构和综合热电性能进行了测试和表征分析。相组成分析表明,采用微波固相合成在4~5 min内即获得了单一相纯度很高的ZrNiSn合金,但存在少量杂... 详细信息

开展了ZrNiSn热电块体材料的微波快速合成-烧结研究,并对样品的物相组成、电性能、热性能、微观结构和综合热电性能进行了测试和表征分析。相组成分析表明,采用微波固相合成在4~5 min内即获得了单一相纯度很高的ZrNiSn合金,但存在少量杂质Sn;合成样品经30 min微波烧结后,部分Sn因二次反应而消除。电性能分析表明,电阻率较高为13.7~16.9μ?·m,从而对功率因子产生较大影响,功率因子最高为1683μW·m^(-1)·K^(-2)。热性能分析表明,ZrNiSn样品的热导率随着温度升高而降低,热导率最大为4.288 W·m^(-1)·K^(-1),晶格热导率仅为2.86~3.96 W·m^(-1)·K^(-1),热性能良好。微观结构分析表明,微波烧结抑制了ZrNiSn晶粒长大,ZrNiSn基体晶内和晶界分布有大量纳米晶粒,绝大部分属于晶内析出,且分布较均匀,少部分分布在晶界。综合热电性能ZT值随测试温度的增加显著上升,在573~673 K获得最大值0.25。

关键词：微波加热 ZrNiSn半赫斯勒合金固相合成烧结热电性能

ADC值在内皮抑素对小鼠结肠癌疗效评价中的应用价值

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中国医学影像技术 2009年第6期25卷 963-965页

作者：韩明程鑫张仕状王滨曲林涛潍坊医学院基础医学教学部山东潍坊261053 潍坊医学院附属医院影像中心山东潍坊261031 潍坊医学院附属莱阳中心医院影像中心山东烟台265200

目的探讨ADC值在内皮抑素(ES)对小鼠结肠癌皮下移植瘤疗效评价中的应用价值。方法建立小鼠结肠癌皮下移植瘤模型,1周后筛选成瘤均匀的16只小鼠随机分成ES组和生理盐水(NS)组,分别给予ES6mg/(kg·d)和0.9%生理盐水各0.2ml,14d后行MMMRI检... 详细信息

目的探讨ADC值在内皮抑素(ES)对小鼠结肠癌皮下移植瘤疗效评价中的应用价值。方法建立小鼠结肠癌皮下移植瘤模型,1周后筛选成瘤均匀的16只小鼠随机分成ES组和生理盐水(NS)组,分别给予ES6mg/(kg·d)和0.9%生理盐水各0.2ml,14d后行MMMRI检查,测量肿瘤的表观弥散系数(ADC)值,并与病理特征相对照。结果b=800s/mm2时DWI图像质量可,肿瘤显示清晰,结合T2WI像可明确肿瘤位置;NS组与ES组的ADC值分别为(0.87±0.21)×10-3mm/s和(1.64±0.34)×10-3mm/s,差异有统计学意义(t=5.412,P<0.001);病理表现与影像学表现一致,ES组肿瘤内部坏死较多。结论采用DWI图像可以观察肿瘤内部的病理变化,通过测量肿瘤的ADC值可以有效地评价ES的疗效。

关键词：结肠肿瘤磁共振成像内皮抑素皮下移植瘤小鼠

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流域不透水面遥感提取及尺度依赖性研究

自然灾害学报 2015年第1期24卷 61-65页

作者：张新程熙李万庆路明林超中国科学院遥感与数字地球研究所遥感科学国家重点实验室北京100101 成都理工大学地球物理学院四川成都610059 河北工程大学河北邯郸056038 水利部海委漳河上游管理局河北邯郸056006

流域不透水面能直接影响非点源污染的转移模式,降低受纳水体质量,对生态环境造成巨大压力,是流域生态水文模型的一个重要参数。针对流域不透水面遥感信息提取及尺度依赖性问题,从像元、亚像元两个尺度进行了研究,论述了流域初始分类与... 详细信息

流域不透水面能直接影响非点源污染的转移模式,降低受纳水体质量,对生态环境造成巨大压力,是流域生态水文模型的一个重要参数。针对流域不透水面遥感信息提取及尺度依赖性问题,从像元、亚像元两个尺度进行了研究,论述了流域初始分类与样本获取、局部不透水面信息提取和亚像元级不透水面覆盖率计算的技术方法。以福建省九龙江流域为例,对2010年不透水面空间格局进行了提取,其总体精度达到82.81%,验证了本文研究成果的实用性。

关键词：流域不透水面遥感信息提取九龙江流域

A gain-of-function mutation of the MATE family transporter DTX6 confers paraquat resistance in Arabidopsis

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Molecular Plant 2021年第12期14卷 2126-2133页

作者： Jin-Qiu Xia Tahmina Nazish Ayesha Javaid Mohsin Ali Qian-Qian Liu Liang Wang Zheng-Yi Zhang Zi-Sheng Zhang Yi-Jie Huang Jie Wu Zhi-Sen Yang lin-Feng Sun Yu-xing Chen cheng-Bin Xiang School of Life Sciences Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleMOE Key Laboratory for Membraneless Organelles and Cellular DynamicsUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China

Paraquat is one of the most widely used nonselective herbicides and has elicited the emergence of para-quat-resistant ***,the molecular mechanisms of paraquat resistance are not completely *** we report the Arabidopsis gain-of-function mutant pqt15-D with significantly enhanced resistance to paraquat and the corresponding gene PQT15,which encodes the Multidrug and Toxic Extru-sion(MATE)transporter DTX6.A point mutation at+932 bp in DTX6 causes a G311E amino acid substitution,enhancing the paraquat resistance ofpqt15-D,and overexpression of DTX6/PQT15 in the wild-type plants also results in strong paraquat ***,heterologous expression of DTX6 and DTX6-D in Es-cherichia coil significantly enhances bacterial resistance to ***,overexpression of DTX6-D enables Arabidopsis plants to tolerate 4 mM paraquat,a near-commercial application ***6/PQT15 is localized in the plasma membrane and endomembrane,and functions as a paraquat efflux transporter as demonstrated by paraquat efflux assays with isolated protoplasts and bacterial *** together,our results demonstrate that DTX6/PQT15 is an efflux transporter that confers paraquat resis-tance by exporting paraquat out of the *** findings reveal a molecular mechanism of paraquat resistance in higher plants and provide a promising candidate gene for engineering paraquat-resistant crops.

关键词： paraquat paraquat resistance DTX/MATE transporter subfamily AtDTX6/PQT15

Preparation and Photoconductivity of Fe-Phthalocyanine Derivation and C_(60) Composite Films

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Journal of Shanghai University(English Edition) 2001年第2期5卷 156-159页

作者： CHEN Jian ming, ZHANG Jian cheng, SHEN Yue, LIU Xiu hong, YANG lin hong School of Material Science and Engineering, Shanghai University, Shanghai, 200072, China School of Material Science and Engineering Shanghai University Shanghai China

Fe (III) 2,9,16,23 tertracarboxy phthalocyanine (Fe (III) taPc) was synthesized, and bonded to polystyrene (PS) with covalence by Friedel Crafts reaction to form a new polymer (Fe (III) taPc PS) (polymer (II)). UV VIS and Infrared spectra indicated that Fe (III) taPc was successfully bonded to PS. A photoreceptor device of sandwich structure consisting of alternate layers of polymer (II) and fullerene (C 60 ) was prepared. The experiment results show that the photoconductivity of the photoreceptor is higher than that of the single layer film of polymer (II) or C 60 , because of the charge transfer effect between the layers.

关键词： phthalocyanine polystyrene C 60 photoconductivity composite films

Effect of sustained intensive therapy with disease modifying anti-rheumatic drugs in rheumatoid arthritis:a 5-year real-world consecutive study

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Chinese Medical Journal 2020年第12期133卷 1397-1403页

作者： Yue-Ming Cai Ru Li Hua Ye Jing He Xiao-lin Sun Jia-Yang Jin Jia-Jia Liu Yu-Zhou Gan Xu-Jie You Jing Xu Lian-Jie Shi Gong cheng Qing-Wen Wang Zhan-Guo Li Department of Rheumatology and Immunology Peking University People’s HospitalBeijing 100044China Department of Rheumatology and Immunology Peking University Shenzhen HospitalShenzhenGuangdong 518035China Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135) Beijing 100044China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100044China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China

Background:Intensive therapy with disease modifying anti-rheumatic drugs(DMARDs)has been reported to improve the outcomes of rheumatoid arthritis(RA).However,real-world study on the effect of intensive therapy on RA sustained remission is still *** study aimed to investigate the outcome of sustained intensive DMARD therapy(SUIT)for RA in a real-world 5-year consecutive ***:Based on a consecutive cohort of 610 out-patients with RA,remission of RA was assessed in 541 patients from 2012 to 2017,by dividing into SUIT,non-SUIT,and intermittent SUIT(Int-SUIT)*** in the disease activity scores were evaluated by 28-joint disease activity score based on erythrocyte sedimentation rate(DAS28-ESR),28-joint disease activity score based on C-reactive protein(DAS28-CRP),and clinical deep remission criteria(CliDR).Cumulative remission rates between different groups were compared using Kaplan-Meier curves and predictive factors of sustained remission were identified by univariate and multivariate logistic regression ***:The remission rates of the SUIT group decreased from 12.0%(65/541)to 5.6%(20/359)based on DAS28-ESR,from 14.0%(76/541)to 7.2%(26/359)based on DAS28-CRP,and from 8.5%(46/541)to 3.1%(11/359)based on CliDR,respectively,with a gradually decreasing trend during the 5 *** SUIT regimen led to a significantly higher cumulative remission rate than non-SUIT regimen based on DAS28-ESR(39.7%vs.19.5%,P=0.001),DAS28-CRP(42.0%vs.19.6%,P=0.001),and CliDR(24.5%vs.8.7%,P=0.001).The cumulative remission rates of patients treated with SUIT regimen were significantly higher than those treated with Int-SUIT regimen based on DAS28-ESR(39.7%vs.25.7%,P=0.043)and CliDR(24.5%vs.14.2%,P=0.047),but there was no significant difference between the two groups based on DAS28-CRP(42.0%vs.27.4%,P=0.066).Multivariate logistic regression analysis showed that the use of SUIT regimen was an independent favorable predictor according to different remission d

关键词： Rheumatoid arthritis Remission Sustained intensive therapy Cohort study