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Identification of NR3C2 as a functional diagnostic and prognostic biomarker and potential therapeutic target in non‐small cell lung cancer

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Cancer Innovation 2024年第4期3卷 67-86页

作者： Yuan‐yuan Sun Hai‐cheng gao Peng Guo Na Sun Chan Peng Zhi‐hua cheng Jing Gu Jin‐yi Liu Fei Han Department of Clinical Pharmacy Jilin University School of Pharmaceutical SciencesChangchunChina Institute of Toxicology College of Preventive MedicineArmy Medical UniversityChongqingChina Department of Hepatobiliary Surgery Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina College of Pharmaceutical Sciences Southwest UniversityChongqingChina Vascular Surgery Department General Surgery CenterFirst Hospital of Jilin UniversityChangchunChina Department of Toxicology School of Public HealthChongqing Medical UniversityChongqingChina Laboratory of Reproductive Biology Chongqing Medical UniversityChongqingChina

Background:Non‐small cell lung cancer(NSCLC),including the lung squamous cell carcinoma(LUSC)and lung adenocarcinoma(LUAD)subtypes,is a malignant tumor type with a poor 5‐year survival *** identification of new powerful diagnostic biomarkers,prognostic biomarkers,and potential therapeutic targets in NSCLC is urgently ***:The UCSC Xena,UALCAN,and GEO databases were used to screen and analyze differentially expressed genes,regulatory modes,and genetic/epigenetic alterations in *** UCSC Xena database,GEO database,tissue microarray,and immunohistochemistry staining analyses were used to evaluate the diagnostic and prognostic ***‐of‐function assays were performed to examine the *** ESTIMATE,TIMER,Linked Omics,STRING,and DAVID algorithms were used to analyze potential molecular ***:NR3C2 was identified as a potentially important molecule in ***3C2 is expressed at low levels in NSCLC,LUAD,and LUSC tissues,which is significantly related to the clinical indexes of these *** operating characteristic curve analysis suggests that the altered NR3C2 expression patterns have diagnostic value in NSCLC,LUAD,and especially LUSC *** NR3C2 expression levels can help predict poor prognosis in NSCLC and LUAD patients but not in LUSC *** results have been confirmed both with database analysis and real‐world clinical samples on a tissue *** number variation contributes to low NR3C2 expression levels in NSCLC and LUAD,while promoter DNA methylation is involved in its downregulation in *** NR3C2 promoter methylation sites have high sensitivity and specificity for LUSC diagnosis with clinical application ***3C2 may be a key participant in NSCLC development and progression and is closely associated with the tumor microenvironment and immune cell ***3C2 co‐expressed genes are involved in many cancer‐related signaling pathways,further supporting a potentially si

关键词： diagnosis and prognosis expression regulation function immune cell infiltration non‐small cell lung cancer NR3C2 therapeutic target tumor microenvironment

Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism

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World Journal of Hepatology 2024年第2期16卷 264-278页

作者： Hao Ouyang Hui Miao Zhen Li Duan Wu Si-cheng gao Yao-Yao Dai Xiao-Di gao Hai-Sheng Chai Wei-Ye Hu Jun-Feng Zhu Department of Liver Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 201203China

BACKGROUND Liver fibrosis is a formidable global medical challenge,with no effective clinical treatment currently *** granule(YHG)is a proprietary Chinese medicine comprising Scutellariae Radix and Lonicerae Japonicae *** is frequently used for upper respiratory tract infections,pharyngitis,as well as acute and chronic *** To investigate the potential of YHG in alleviating carbon tetrachloride(CCl4)-induced liver fibrosis in *** To induce a hepatic fibrosis model in mice,this study involved intraperitoneal injections of 2 mL/kg of CCl4 twice a week for 4 ***,liver fibrosis mice in the low dose of YHG(0.4 g/kg)and high dose of YHG(0.8 g/kg)groups were orally administered YHG once a day for 4 *** alanine/aspartate aminotransferase(ALT/AST)activity and liver hydroxyproline content were *** red and Masson's trichrome staining assay were *** polymerase chain reaction,western-blot and enzyme-linked immunosorbent assay were *** glutathione content,superoxide dismutase activity level,reactive oxygen species and protein carbonylation amount were *** The administration of YHG ameliorated hepatocellular injury in CCl4-treated mice,as reflected by decreased serum ALT/AST activity and improved liver histological *** also attenuated liver fibrosis,evident through reduced liver hydroxyproline content,improvements in Sirius red and Masson's trichrome staining,and lowered serum hyaluronic acid ***,YHG hindered the activation of hepatic stellate cells(HSCs)and ameliorated oxidative stress injury and inflammation in liver from CCl4-treated *** prompted the nuclear accumulation of nuclear factor erythroid 2-related factor 2(Nrf2)and upregulated the expression of Nrf2-dependent downstream antioxidant *** addition,YHG promoted mitochondrial biogenesis in liver from CCl4-treated mice,as demonstrated by increased liver adenosine triphosphate content,

关键词： Yinhuang granule Liver fibrosis Hepatic stellate cells Oxidative injury Nuclear factor erythroid 2-related factor 2 Inflammation

加工流畅性、期望和认知目标如何塑造审美判断?——基于多模型整合的视角

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心理科学进展 2024年第11期32卷 1872-1881页

作者：高程刘昌南京师范大学心理学院南京210097

审美愉悦的加工流畅性理论认为刺激加工的容易程度会引发积极情绪,从而促进对刺激的积极评价。在近20年的概念发展和实证研究中,该模型逐渐面临理论和经验的双重挑战。结合预测加工框架和认知动机模型有望对早期流畅性理论进行补充和完... 详细信息

审美愉悦的加工流畅性理论认为刺激加工的容易程度会引发积极情绪,从而促进对刺激的积极评价。在近20年的概念发展和实证研究中,该模型逐渐面临理论和经验的双重挑战。结合预测加工框架和认知动机模型有望对早期流畅性理论进行补充和完善,形成多模型整合的审美判断流畅性解释框架。它强调了四个因素在影响审美判断方面的作用:对刺激的期望、对流畅性本身的期望、与特定信念相关的定向目标以及与流畅性和确定性相关的非定向目标。四个因素共同决定了加工流畅性如何介入审美判断,以及会对审美判断产生哪些具体影响。该框架为更好地解释审美判断过程中矛盾而复杂的流畅性效应提供了理论支持,并为该领域未来的实证研究指明了方向。

关键词：审美判断加工流畅性期望预测加工认知目标

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基于长短期记忆网络与轻梯度提升机的航空发动机大修期内剩余寿命预测

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航空发动机 2024年第3期50卷 87-92页

作者：杨硕高成沈阳工业大学化工过程自动化学院辽宁辽阳111003

针对航空发动机大修期内由性能主导的剩余使用寿命预测中复杂设备具有状态变量多、非线性特征严重的特点以及单一模型面临特征提取不充分、预测精度不足等问题,提出一种长短期记忆网络(LSTM)与轻梯度提升机(LightGBM)的组合新模型方法... 详细信息

针对航空发动机大修期内由性能主导的剩余使用寿命预测中复杂设备具有状态变量多、非线性特征严重的特点以及单一模型面临特征提取不充分、预测精度不足等问题,提出一种长短期记忆网络(LSTM)与轻梯度提升机(LightGBM)的组合新模型方法进行大修期内剩余使用寿命(RUL)预测。通过LSTM对原始数据进行特征提取,将LSTM的输出门中特征提取后的数据作为LightGBM模型的输入进行RUL预测。利用NASA提供的发动机实测数据集进行了仿真试验,实现了对单个发动机的RUL预测,并与其他6种模型预测结果进行对比,对其预测剩余使用寿命的有效性进行验证。结果表明:LSTM和LightGBM组合模型比其他模型的预测误差显著减小,其4组数据集均方根误差仅为12.45、20.23、12.58、21.75。

关键词：剩余寿命预测组合模型轻梯度提升机长短期记忆网络航空发动机

17-4PH不锈钢表面仿生梯度硬度高强层组织与性能

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复合材料学报 2024年第3期41卷 1480-1486页

作者：姚建洮高成李俊强刘晓刚西安石油大学材料科学与工程学院西安710065 陕西省机械研究院咸阳712000

本文拟在17-4PH不锈钢表面制备高硬度耐磨层,为缓解高硬度堆焊层与基体间的开裂问题,提出制备仿生梯度硬度表面堆焊结构。采用手工电弧焊在17-4PH不锈钢表面制备仿生梯度硬度高强层,选用D322焊条和D707焊条分别做过渡层和高强层在17-4P... 详细信息

本文拟在17-4PH不锈钢表面制备高硬度耐磨层,为缓解高硬度堆焊层与基体间的开裂问题,提出制备仿生梯度硬度表面堆焊结构。采用手工电弧焊在17-4PH不锈钢表面制备仿生梯度硬度高强层,选用D322焊条和D707焊条分别做过渡层和高强层在17-4PH不锈钢表面进行仿生梯度硬度高强层的制备,采用光学显微镜、维氏硬度计、X射线衍射仪、冲击试验机对高强层的微观组织、显微硬度等性能进行了表征。结果表明:在17-4PH不锈钢表面所制备的仿生梯度硬度高强层组织均匀,界面冶金结合良好;仿生梯度硬度高强层组织主要为马氏体、奥氏体、WC及碳化物;仿生梯度硬度高强层相结构主要由Fe-Cr、WC、γ-Fe组成,平均硬度为HV_(0.5)726.5,较基板有明显的提高;17-4PH不锈钢表面仿生梯度硬度高强层平均冲击吸收功为12.90 J,其冲击吸收功降低的主要原因是由于各层之间的性能不同所导致。

关键词： 17-4PH不锈钢仿生结构梯度硬度高强层过渡层显微组织

短线预制悬拼连续梁施工误差实桥试验及安装线形分析

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中国公路学报 2024年第8期37卷 170-178页

作者：刘红平邢江陈浩程高周浩刘江长安大学工程设计研究院长安大学公路学院中铁第一勘察设计院集团有限公司

短线法节段预制悬拼连续梁安装线形偏差源于节段制造尺寸、质量、安装时机、温度、接缝宽度、预应力等施工误差，设置接缝垫片来纠偏安装线形易产生接缝不密实、渗水、预应力损失、整体刚度削弱等问题，但目前尚无其他有效纠偏方式。为... 详细信息

短线法节段预制悬拼连续梁安装线形偏差源于节段制造尺寸、质量、安装时机、温度、接缝宽度、预应力等施工误差，设置接缝垫片来纠偏安装线形易产生接缝不密实、渗水、预应力损失、整体刚度削弱等问题，但目前尚无其他有效纠偏方式。为探明短线法节段梁施工偏差及其对大跨连续梁悬拼安装线形的影响规律，依托某短线法节段预制拼装大跨连续梁桥，基于三维点云数据进行节段的虚拟拼装及线形控制，开展梁段质量、温度、胶接缝宽度等实桥测试和悬拼线形监测，分析施工偏差变化特征并基于有限元模型揭示主梁安装线形受施工偏差的影响规律，提出安装线形纠偏策略与方法。实桥试验及有限元分析结果表明：短线法预制连续梁节段质量偏差介于-6%～6%,而悬臂梁边中跨总质量偏差约4.5 t,仅为单个节段质量的1/10。以连续梁最大悬臂状态恒载产生最大挠度为基准值，可得到因节段制作尺寸、温度、胶接缝宽、存梁时间、节段质量及预应力等施工误差产生的下挠值分别为259.2%、108.9%、81.8%、20.5%、9.0%和7.5%。节段制造尺寸是引起安装线形偏差的关键，间接影响节段质量、胶接缝宽度，首节段尺寸偏差对安装线形的影响最大。节段制作尺寸若不及时纠偏，可产生最大83 mm的高程偏差。提出的节段预制逆作法和安装线形“两级纠偏”方法为大跨变截面连续梁安装线形控制提供参考。

关键词：桥梁工程悬臂拼装实桥试验短线法节段预制施工误差安装线形

Nomogram based on multimodal magnetic resonance combined with B7-H3mRNA for preoperative lymph node prediction in esophagus cancer

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World Journal of Clinical Oncology 2024年第3期15卷 419-433页

作者： Yan-Han Xu Peng Lu Ming-cheng gao Rui Wang Yang-Yang Li Rong-Qi Guo Wei-Song Zhang Jian-Xiang Song School of Clinical Sciences Graduate School of Nantong UniversityYancheng 226019Jiangsu ProvinceChina Department of Thoracic Surgery Yancheng Third People's HospitalThe Affiliated Hospital 6 of Nantong UniversityYancheng 224000Jiangsu ProvinceChina Department of Imaging Yancheng Third People's HospitalThe Affiliated Hospital 6 of Nantong UniversityYancheng 224000Jiangsu ProvinceChina

Accurate preoperative prediction of lymph node metastasis(LNM)in esophageal cancer(EC)patients is of crucial clinical significance for treatment planning and *** To develop a clinical radiomics nomogram that can predict the preoperative lymph node(LN)status in EC *** A total of 32 EC patients confirmed by clinical pathology(who underwent surgical treatment)were ***-time fluorescent quantitative reverse transcription-polymerase chain reaction was used to detect the expression of B7-H3 mRNA in EC tissue obtained during preoperative gastroscopy,and its correlation with LNM was *** features were extracted from multi-modal magnetic resonance imaging of EC using Pyradiomics in *** extraction,data dimensionality reduction,and feature selection were performed using XGBoost model and leave-one-out *** logistic regression analysis was used to establish the prediction model,which included radiomics features,LN status from computed tomography(CT)reports,and B7-H3 mRNA expression,represented by a radiomics *** operating characteristic area under the curve(AUC)and decision curve analysis(DCA)were used to evaluate the predictive performance and clinical application value of the *** The relative expression of B7-H3 mRNA in EC patients with LNM was higher than in those without metastasis,and the difference was statistically significant(P<0.05).The AUC value in the receiver operating characteristic(ROC)curve was 0.718(95%CI:0.528-0.907),with a sensitivity of 0.733 and specificity of 0.706,indicating good diagnostic *** individualized clinical prediction nomogram included radiomics features,LN status from CT reports,and B7-H3 mRNA *** ROC curve demonstrated good diagnostic value,with an AUC value of 0.765(95%CI:0.598-0.931),sensitivity of 0.800,and specificity of *** indicated the practical value of the radiomics nomogram in clinical ***

关键词： Esophageal cancer Radiomics B7-H3mRNA Multimodal magnetic resonance imaging Lymph node metastasis Nomogram

基于CAFPC教学模式的社会性科学议题单元教学设计——新型甜味剂的使用

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化学教育（中英文） 2024年第1期45卷 74-81页

作者：张雯渝高成陈骜西华师范大学化学化工学院四川南充637009

在科学课堂中开展社会性科学议题教学能够增进学生科学思维的发展,促进学生科学态度与社会责任的形成,加深学生对科学观念的理解。构建由“直面情境、问题剖析、议题聚焦、实践应用、模型建构”5阶段组成的CAFPC教学模式用于SSI单元教学... 详细信息

在科学课堂中开展社会性科学议题教学能够增进学生科学思维的发展,促进学生科学态度与社会责任的形成,加深学生对科学观念的理解。构建由“直面情境、问题剖析、议题聚焦、实践应用、模型建构”5阶段组成的CAFPC教学模式用于SSI单元教学,具有较强的可操作性、实用性及适切性。以“新型甜味剂的使用”社会性科学议题为例,将其蕴含于“无糖饮料”系列情境贯穿于整个教学过程,应用CAFPC教学模式进行SSI教学,以期推动SSI教学在科学课堂的真正落实。

关键词： CAFPC教学模式教学设计 SSI 新型甜味剂

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面向复杂多任务的异构无人机集群分组调配

系统工程与电子技术 2024年第3期46卷 972-981页

作者：高程都延丽步雨浓刘燕斌王宇飞南京航空航天大学航天学院江苏南京211106 北京机电工程研究所北京100854

针对复杂多任务下的异构无人机(unmanned aerial vehicle,UAV)集群分组调配问题,提出一种基于改进K均值和延迟接受(deferred-acceptance,DA)算法的先聚类后匹配方法。在任务聚类分组环节,通过离群点检测和固定初始聚类中心的方法来提高K... 详细信息

针对复杂多任务下的异构无人机(unmanned aerial vehicle,UAV)集群分组调配问题,提出一种基于改进K均值和延迟接受(deferred-acceptance,DA)算法的先聚类后匹配方法。在任务聚类分组环节,通过离群点检测和固定初始聚类中心的方法来提高K-means聚类的精度,并设计余量裕度下的分组均衡性调整策略,在最优性的前提下提高分组的均衡性。在集群匹配分组环节,改进了DA算法,通过任务倾向的偏好列表快速生成预中选方案,并设计两阶段冲突消除来保证匹配的稳定性和收敛性。仿真实验表明,所提方法能够快速有效地解决复杂多任务下的UAV集群分组调配问题,具备良好的最优性和时效性。

关键词：异构无人机集群分组调配聚类延迟接受算法稳定匹配