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An update on chemotherapy of colorectal liver metastases

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World Journal of Gastroenterology 2012年第1期18卷 25-33页

作者： chen-chen wang Jin Li Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Surgical resection of liver metastases of colorectal cancer greatly improves the clinical outcome of patients with advanced disease. Developments in chemotherapeutic agents and strategies bring hope of a cure to patients with initially unresectable colorectal liver metastases (CLM). Perioperative chemotherapy signif icantly improves the survival time of patients who receive curative-intent hepatectomy. Even for unresectable CLM, recent studies demonstrated that active preoperative chemotherapy could achieve shrinkage of liver metastasis and thus render some for resection. Furthermore, an increase in tumor resection rate and prolonged survival time among patients with CLM has been observed following the application of monoclonal antibodies in recent years. However, the value of chemotherapy via hepatic arterial infusion is still unclear. More trials should be conducted in patients with CLM in order to improve survival.

关键词： Chemotherapy Colorectal cancer Liver metastases Resection rate Targeted agents

Circulating microRNAs in cardiovascular diseases： from biomarkers to therapeutic targets

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Frontiers of Medicine 2014年第4期8卷 404-418页

作者： Fengwang chen chen Daowen wang Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

microRNAs （miRNAs） are a class of conserved, short, non-coding RNAs that have important and potent capacities to regulate gene expression at the posttranscriptional level. In the past several years, the aberrant expressions of miRNAs in the cardiovascular system have been widely reported, and the crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascular diseases have been gradually recognized. Recently, it was discovered that miRNAs are presented in peripheral circulation abundantly and stably. This has raised the possibility of using circulating miRNAs as biomarkers for diseases. Furthermore, some studies demonstrated that circulating miRNAs may serve as novel extracellular communicators of cell-ceU communication. These discoveries not only reveal the functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeutic strategies. In this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic targets to clearly understand the roles of circulating miRNAs in cardiovascular system.

关键词： microRNA cardiovascular disease biomarkers therapeutic target

Study on heavy metal concentrations in river sediments through the total amount evaluation method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第5期12卷 399-404页

作者： chen-chen wang Zhi-guang NIU Yan LI Jie SUN Fang wang School of Environment Science and Technology Tianjin University Tianjin 300072 China Yangtze River Waterway Bureau Encamped in the Binhai Office Tianjin 300072 China Tianjin Urban Construction Design Institute Co. Ltd Tianjin 300072 China

A quantitative method to evaluate the amounts of heavy metals in river sediments is established. Using the BT Drainage River in North China as a study object, six representative cross sections were selected for measurement of heavy metal indicators in sediments, and then the main contamination indicators were determined by performing a potential ecological risk assessment. Using a section of this river as an example, the total amounts of the main pollution indicators and those of their harmful forms are estimated by the Surfer software, which simulates the pollution status within the downstream sediments of the outfall at this section. The calculation results could provide a theoretical guideline and data support for pollution treatment of the BT Drainage River.

关键词： Total amount evaluation Heavy metal pollution River sediments Surfer software

Corrosion resistance of benzotriazole passivated Cu-Zn-Alshape memory alloy in artificial Ringer's solution

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Rare Metals 2005年第3期24卷 252-256页

作者： LIANG chenghao chen Bangyi chen Wan wang Hua State Key laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian 116012 China

The corrosion resistance of the Cu-Zn-Al shape memory alloy passivated by benzotriazole was investigated by salt spraying test and electrochemical methods in artificial Ringer＇s solution. The results showed that after benzotriazole passivation, the corrosion resistance of the Cu-Zn-Al shape memory alloy was improved evidently. The anodic polarization current density of the passivated alloy decreased, the mass loss reduced, the anodic passivation accelerated, the anodic active dissolution was inhibited effectively, and the surface tarnishing was reswained. Infrared reflection spectrum test showed that Cu（Ⅰ）-benzotriazole or Cu（Ⅱ）-benzotriazole complex layer was formed on the surface of the Cu-Zn-Al shape memory alloy after passivation. This layer appeared plane, well adhesion, and presented homogeneous golden metallic luster. The corrosion resistance of the Cu-Zn-Al shape memory alloy passivated by benzotriazole is improved for the formation of an electrochemical stable baffle layer on passivated surface. This layer separates the metal substrate from the outside corrosion medium effectively and retards the corrosion process of dezincification.

关键词： surface modification corrosion resistance electrochemical method Cu-Zn-Al shape memory alloy benzotriazole passivation

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibi- tion of transforming growth factor 13-induced Smad signaling

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Frontiers of Medicine 2014年第4期8卷 445-455页

作者： Wei Gong＊ Mengwen Yan Junxiong chen Sandip Chaugai chen chen Daowen wang Department of Internal Medicine and Gene Therapy Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 （PDE5） inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis. We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction （TAC）. Oral sildenafil, a PDE5 inhibitor, was administered in the therapy group. In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiac fibroblast activation （proliferation and transformation to myofibroblasts）. Sildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β0 （TGF-β1） production and phosphorylation of Smad2/3. In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation, proliferation and collagen synthesis. Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein （CREB） and reduced CREB-binding protein 1 （CBP1） recruitment to Smad transcriptional complexes. PDE5 inhibition prevents cardiac fibrosis by reducing CBP1 recruitment to Smad transcriptional complexes through CREB activation in cardiac fibroblasts.

关键词： PDE5 cardiac fibrosis TGF-β CREB

Synthesis and Characterization of a New Symmetric Dinucleating Ligand and Its Dizinc(Ⅱ)Complex with Alkoxo and Carboxylate Bridges

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1127-1131页

作者： WU Ai-Zhi ZHU chen-chen wang Tao School of Chinese Materia Medica GuangzhouUniversity of Chinese Medicine Guangzhou 510006 China

A novel dinuclear zinc（II） complex [Zn2L（μ-OAc）]（PF6）2（CH3OH） has been synthesized from a new symmetrical compartmental ligand HL in which the pendant arms, bearing pyridyl groups, are bridged by 1,3-diaminopropan-2-ol. X-ray crystal structure shows that the two zinc atoms reside within the adjacent ligand compartments and are bridged by the endogenous alkoxo-O from ligand and one exogenous carboxylate from acetate with a syn-syn mode. The coordination geometry of two zinc atoms is a distorted trigonal bipyramid with the pyridyl-N atoms and bridging alkoxo-O atom providing the equatorial donor set. Such coordination geometry observed in this complex is similar to that found in the dinuclear unit ofphospholipase C.

关键词： symmetric dinucleating ligand zinc crystal structure

Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang wang Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

Influence of matrix physical properties on flow characteristics in dual network model

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Petroleum Science 2023年第4期20卷 2244-2252页

作者： chen-chen wang Yong-Fei Yang Deng-Lin Han Miao-Miao Su Rong-Rong Hu Cooperative Innovation Center of Unconventional Oil and Gas Yangtze UniversityWuhan430100HubeiChina Laboratory of Reservoir Microstructure Evolution and Digital Characterization Yangtze UniversityWuhan430100HubeiChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences Yangtze UniversityWuhan430100HubeiChina College of Resources and Environment Yangtze UniversityWuhan430100HubeiChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina

The tight oil formation develops with microfractures and matrix pores,it is important to study the influence of matrix physical properties on flow *** first,the representative fracture and matrix samples are selected respectively in the dual media,the fracture and matrix digital rocks are constructed with micro-CT scanning at different resolutions,and the corresponding fracture and matrix pore networks are extracted,***,the modified integration method is proposed to build the dual network model containing both fracture and matrix pore-throat elements,while the geometric-topological structure equivalent matrix pores are generated to fill in the skeleton domain of fracture network,the constructed dual network could describe the geometric-topological structure characteristics of fracture and matrix pore-throat *** last,by adjusting the matrix pore density and the matrix filling domain factor,a series of dual network models are obtained to analyze the influence of matrix physical properties on flow characteristics in *** can be seen that the matrix system contributes more to the porosity of the dual media and less to the *** the decrease in matrix pore density,the porosity/permeability contributions of matrix system to dual media keep decreasing,but the decrease is not significant,the oil-water co-flow zone decreases and the irreducible water saturation increases,and the saturation interval dominated by the fluid flow in the fracture keeps *** the decrease in matrix filling domain factor,the porosity/permeability contributions of matrix system to dual media decreases,the oil-water co-flow zone increases and the irreducible water saturation decreases,and the saturation interval dominated by the fluid flow in the fracture keeps *** results can be used to explain the dual-media flow pattern under different matrix types and different fracture control volumes during tight oil production

关键词： Network integration Dual media Flow characteristics Matrix pore density Matrix filling domain

A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation