Circulating microRNAs in cardiovascular diseases： from biomarkers to therapeutic targets

作     者：FengWang Chen Chen Daowen Wang 

作者机构：Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2014年第8卷第4期

页      面：404-418页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 081803[工学-地质工程] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0818[工学-地质资源与地质工程] 

基　　金：supported by grant from the National Natural Science Foundation of China 国家教育部高等学校博士学科点专项科研基金 Project from Hubei Province 

主　　题：microRNA cardiovascular disease biomarkers therapeutic target 

摘      要：microRNAs （miRNAs） are a class of conserved, short, non-coding RNAs that have important and potent capacities to regulate gene expression at the posttranscriptional level. In the past several years, the aberrant expressions of miRNAs in the cardiovascular system have been widely reported, and the crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascular diseases have been gradually recognized. Recently, it was discovered that miRNAs are presented in peripheral circulation abundantly and stably. This has raised the possibility of using circulating miRNAs as biomarkers for diseases. Furthermore, some studies demonstrated that circulating miRNAs may serve as novel extracellular communicators of cell-ceU communication. These discoveries not only reveal the functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeutic strategies. In this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic targets to clearly understand the roles of circulating miRNAs in cardiovascular system.