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Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function

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Cellular & Molecular Immunology 2017年第11期14卷 935-947页

作者： chen-Yuan Chiang chen-chen lee Chia-Kwung Fan Huei-Mei Huang Bor-Luen Chiang Yueh-Lun lee Division of Pulmonary Medicine Department of Internal MedicineWan Fang HospitalTaipei Medical UniversityTaipei 11031TaiwanChina Department of Internal Medicine School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina Department of Microbiology and Immunology School of MedicineCollege of MedicineChina Medical UniversityTaichung 40402TaiwanChina Department of Parasitology School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipei 10048TaiwanChina Department of Microbiology and Immunology School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina

Osthole,an active component of Chinese herbal medicines,reportedly possesses various pharmacological properties and has potential therapeutic *** study explored the anti-allergic effects of osthole in asthmatic mice and investigated the immunomodulatory actions of osthole on dendritic cells(DCs)and T ***,we show that oral administration of osthole to BALB/c mice after ovalbumin(OVA)sensitization ameliorated all of the cardinal features of T helper 2(Th2)-mediated allergic asthma;namely,the production of OVA-specific immunoglobulin E,airway hyperresponsiveness,airway inflammation and the production of Th2-type cytokines including interleukin(IL)-4,IL-5 and ***,IL-10 production was not inhibited and was even enhanced by osthole *** observed a significant increase in the percentages of IL-10-producing DCs and forkhead box P3-positive regulatory T(Treg)cells in osthole-treated asthmatic ***,in vitro analyses revealed that osthole-treated bone-marrow-derived DCs had a partial maturation phenotype,secreting large amounts of IL-10 and low levels of proinflammatory cytokines,such as IL-12,IL-6 and tumor necrosis factor-α,and displaying reduced levels of MHC class II surface *** DCs displayed immunosuppressive capacity by directly inhibiting effector T-cell responses or inducing Treg *** addition,osthole directly inhibited the activated CD4+T-cell proliferation and Th1/Th2-type cytokine production in this ***,these results suggest that DCs and T cells are potential target cells responsible for the action of osthole against allergic asthma.

关键词： asthma dendritic cell osthole T cell

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Notch ligand-expressing adenovirus infection enhances the efficacy of dendritic cell-based immunotherapy for allergic asthma in mice

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Cellular & Molecular Immunology 2019年第8期16卷 730-732页

作者： Chu-Lun Lin chen-chen lee Chia-Kwung Fan Yueh-Lun lee Department of Microbiology and Immunology School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031 TaiwanChina Department of Microbiology and Immunology School of MedicineChina Medical UniversityTaichung 40402 TaiwanChina Department of Molecular Parasitology and Tropical Medicine School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031 TaiwanChina

According to the World Health Organization,the prevalence of asthma is rising worldwide,and asthma causes 250,000 deaths annually.1 Allergic asthma is a type of chronic airway inflammation caused by dysregulated T helper type 2(Th2)-type immune *** with allergic asthma are characterized by elevated serum immunoglobulin E(IgE)antibody levels,mucus production,and pulmonary inflammation as well as airway hyperresponsiveness(AHR).2 Current therapeutic methods for asthma include inhaled corticosteroids andβ2 agonists to relieve asthma syndromes,but these treatments do not change the chronic disease course in *** patients need high doses of inhaled corticosteroids or require long-term daily treatment with oral steroids.3 Therefore,efforts should be targeted towards developing innovative therapeutic strategies to improve patient quality of life and reduce unwanted *** of the advances in the development of future therapies is the use of genetically modified dendritic cells(DCs)to decrease pathological Th2-mediated responses and maintain a disease-modifying effect long *** activation is crucial for inducing T cell immunity as well as determining T cell differentiation.4 Importantly,DCs can be cultured in vitro,and large amounts of generated clinical-grade DCs have become ***,DCs has been shown to be permissive of adenoviral(Ad)vector infection in vitro,and Ad vectors are a promising gene delivery platform for a variety of therapeutic and vaccine applications.5 In this regard,overexpressing immunoregulatory proteins in Ad-modified DCs would be an effective way to suppress Th2 cell immunity and establish an antiallergic response.

关键词： asthma allergic immunity

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Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma

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Cellular & Molecular Immunology 2010年第5期7卷 375-380页

作者： Kuan-Hua Chu chen-chen lee Shao-Chi Hsin Bao-Chang Cai Jin-Hong Wang Bor-Luen Chiang Graduate Institute of Immunology National Taiwan UniversityTaipeiTaiwan School of Medicine China Medical UniversityTaichungTaiwan Nanjing University of Traditional Chinese Medicine NanjingChina Department of Pediatrics National Taiwan University HospitalTaipeiTaiwan

Asthma is one of the most common chronic airway inflammatory *** clinical hallmarks of asthma include elevated serum levels of immunoglobulin E(IgE),eosinophilic inflammation and airway hyper-responsiveness(AHR).Arsenic trioxide(As2O3)is considered a carcinogen;however,it has also been used to treat diseases,such as syphilis,in traditional Chinese and Western ***,As2O3 is used as one of the standard therapies for acute promyelocytic leukemia(APL).Previous studies have indicated that As2O3 can induce apoptosis in ***,the effect of As2O3 on asthma has not been *** used ovalbumin(OVA)-immunized mice as a model for asthma and treated mice with As2O3 at doses of 2.5 and 5 mg/*** mice were then monitored for OVA-specific IgE production,airway inflammatory cell infiltration and *** found that administration of As2O3 in OVA-immunized mice abrogated airway eosinophil recruitment by downregulating eotaxin expression but did not alter serum IgE or IL-5 levels in bronchoalveolar lavage fluid(BALF).Furthermore,the development of AHR and cellular infiltration into the airway were reduced by treating mice with *** vitro data suggested that low concentrations of As2O3 could induce only a small degree of apoptosis in primary pulmonary cells but could significantly inhibit the secretion of eotaxin by these *** results indicate that the administration of As2O3 to OVA-immunized mice can suppress lung allergic inflammatory ***2O3 might therefore have therapeutic potential in treating allergic airway inflammatory diseases.

关键词： arsenic trioxide asthma eosinophils

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun lee Dan Cao Younghye Moon chen chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Recent progress in the study of transition in the hypersonic boundary layer

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National Science Review 2019年第1期6卷 155-170页

作者： Cunbiao lee Shiyi chen State Key Laboratory for Turbulence and Complex Systems Advanced Aero Engine Collaborative Innovation Center Peking University

Turbulence is a universal form of fluid motion. It is the key issue in fluid mechanics. Very recently, it has become a bottleneck in some key engineering research of national importance, such as aeronautics,astronautics and navigation. Developed turbulence and the onset of turbulence, i.e. transition, are two interrelated parts of turbulence. The hypersonic boundary-layer transition is a strategic focus in the fluid mechanics community. This article reviews recent developments in the study of the hypersonic boundary-layer transition, research facilities and experimental techniques. The hypersonic quiet wind tunnel is introduced as a necessary device to obtain real flight data in near space. Near-wall measurement techniques, such as temperature-sensitive paint, near-wall particle image velocimetry and Rayleigh-scattering visualization, are shown. The most important issues in the recent development of the transition in the hypersonic boundary layer are addressed. The instability and nonlinear interaction of different instability modes are discussed. The recent contributions from China, especially at Peking University, are also introduced.

关键词： hypersonic boundary layer transition quiet wind tunnel

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Research Progress in Lithium-Excess Disordered Rock-Salt Oxides Cathode

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Energy & Environmental Materials 2022年第4期5卷 1139-1154页

作者： Manxi Wang Xiaochuan chen Hurong Yao Ganggang Lin Jinhyuk lee Yuming chen Qinghua chen College of Environmental Science and Engineering and College of Physics and Energy Fujian Normal UniversityFuzhou 350000China School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China State Grid Fujian EHV Company Fuzhou 350000China Department of Mining and Materials Engineering McGill UniversityMontrealQC H3A 0C5Canada

The increasing demand for new energy sources has promoted the improvement of the energy storage capacity of lithium-ion batteries(LIBs)that urged the development of higher energy density cathode *** enhancement of the classical cathode in the last 30 years has reached a bottleneck,and then the discovery of the lithium-excess disordered materials has greatly expanded the research space of the cathode *** with the conventional layered oxides,the lithium-excess disordered rock-salt oxides(LEDRXs)with a more stable structure has higher extractable Li^(+)content,even though the inactive high-valent transition metals(TMs)were needed to compensate for the excess Li,which would reduce the total TM redox *** addition,oxygen redox provides additional electron capacity for the materials,which also causes O loss and results in the subsequent poor cycle ***,a series of studies about LEDRXs and their targeted modification measures are summarized,including the prospect of the materials,in order to provide ideas for the design of highperformance ***,the new discoveries and outlook on future research directions of LEDRX cathode materials for LIBs with higher energy density are given.

关键词： disordered rock-salt oxides lithium-excess lithium-ion batteries

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Advanced Feature Fusion Algorithm Based on Multiple Convolutional Neural Network for Scene Recognition

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Computer Modeling in Engineering & Sciences 2020年第2期122卷 505-523页

作者： Lei chen Kanghu Bo Feifei lee Qiu chen School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China. Algorithm Department UnisocShanghai201203China. Major of Electrical Engineering and Electronics Graduate School of EngineeringKogakuin UniversitySinjuku-kuTokyo163-8677Japan.

Scene recognition is a popular open problem in the computer vision *** lots of methods proposed in recent years,Convolutional Neural Network(CNN)based approaches achieve the best performance in scene *** propose in this paper an advanced feature fusion algorithm using Multiple Convolutional Neural Network(Multi-CNN)for scene *** existing works that usually use individual convolutional neural network,a fusion of multiple different convolutional neural networks is applied for scene ***,we split training images in two directions and apply to three deep CNN model,and then extract features from the last full-connected(FC)layer and probabilistic layer on each ***,feature vectors are fused with different fusion strategies in groups forwarded into SoftMax *** proposed algorithm is evaluated on three scene datasets for scene *** experimental results demonstrate the effectiveness of proposed algorithm compared with other state-of-art approaches.

关键词： Scene recognition deep feature fusion multiple convolutional neural network.

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Fundamental Understanding and Optimization Strategies for Dual‑Ion Batteries:A Review

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Nano-Micro Letters 2023年第8期15卷 205-224页

作者： Chong chen Chun‑Sing lee Yongbing Tang Advanced Energy Storage Technology Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Center of Super‑Diamond and Advanced Film(COSDAF) City University of Hong KongKowloon 999077Hong KongSARPeople’s Republic of China

There has been increasing demand for high-energy density and longcycle life rechargeable batteries to satisfy the ever-growing requirements for nextgeneration energy storage *** all available candidates,dual-ion batteries(DIBs)have drawn tremendous attention in the past few years from both academic and industrial battery communities because of their fascinating advantages of high working voltage,excellent safety,and environmental ***,the dynamic imbalance between the electrodes and the mismatch of traditional electrolyte systems remain *** fully employ the advantages of DIBs,the overall optimization of anode materials,cathode materials,and compatible electrolyte systems is urgently ***,we review the development history and the reaction mechanisms involved in ***,the optimization strategies toward DIB materials and electrolytes are *** addition,their energy-related applications are also ***,the research challenges and possible development directions of DIBs are outlined.

关键词： Dual-ion batteries Reaction mechanisms Optimization strategies Energy storage

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Influence of viscosity on chondrogenic differentiation of mesenchymal stem cells during 3D culture in viscous gelatin solution-embedded hydrogels

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Journal of Materials Science & Technology 2021年第4期63卷 1-8页

作者： Kyubae lee Yazhou chen Xiaomeng Li Naoki Kawazoe Yingnan Yang Guoping chen Research Center for Functional Materials National Institute for Materials Science1-1 NamikiTsukubaIbaraki305-0044Japan Department of Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of Tsukuba1-1-1 TennodaiTsukubaIbaraki305-8577Japan School of Mechanics and Engineering Science Zhengzhou UniversityZhengzhou450001China Graduate School of Life and Environmental Science University of Tsukuba1-1-1 TennodaiTsukubaIbaraki305-8571Japan

Differentiation of human bone marrow-derived mesenchymal stem cells(hMSCs)is regulated by a variety of cues of their surrounding *** particular,mechanical properties of cell culture matrices have been recently disclosed to play a pivotal role in stem cell ***,it remains elusive how viscosity affects the chondrogenic differentiation of hMSCs during three-dimensional(3 D)*** this study,a 3 D culture system that was established by embedding viscous gelatin solution in chemically cross-linked gelatin hydrogels was used for 3 D culture of hMSCs in gelatin solutions with different *** influence of solution viscosity on chondrogenic differentiation of hMSCs was *** gelatin solutions promoted cell proliferation in the order of low,middle and high viscosity while elastic hydrogels restricted cell *** viscosity gelatin solution led to increased production of the cartilaginous *** the synergistic stimulation of chondrogenic induction factors,high viscosity was beneficial for the chondrogenic differentiation of *** results suggested the role of viscosity should be considered as one of the dominant mechanical cues affecting stem cell differentiation.

关键词： viscosity culture stimulation

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Current Progress on the Geological Record of Microbialites and Microbial Carbonates

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Acta Geologica Sinica(English Edition) 2014年第1期88卷 260-275页

作者： chen Jitao lee Jeong-Hyun Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences School of Earth and Environmental Sciences Seoul National University

This paper reviews the current progress and problems in the study of microbialites and microbial carbonates. Microbialites and microbial carbonates, formed during growth of microbes by their calcification and binding of detrital sediment, have recently become one of the most popular geological topics. They occur throughout the entire geological history, and bear important theoretical and economic significances due to their complex structures and formative processes. Microbialites are in place benthic microbial buildups, whereas microbial carbonates can be classified into two categories： stabilized microbial carbonates（i.e., carbonate microbialites, such as stromatolites and thrombolites） and mobilized microbial carbonates（i.e., microbial carbonate grains, such as oncoids and microbial lumps）. Various texture, structures, and morphologies of microbialites and microbial carbonates hamper the systematic description and classification. Moreover, complex calcification pathways and diagenetic modifications further obscure the origin of some microbialites and microbial carbonates. Recent findings of abundant sponge spicules in previously identified ＂microbialites＂ challenge the traditional views about the origins of these ＂microbialites＂ and their implications to reef evolution. Microbialites and microbial carbonates did not always flourish in the aftermath of extinction events, which, together with other evidences, suggests that they are affected not only by metazoans but also by other geological factors. Their growth, development, and demise are also closely related to sea-level changes, due to their dependence on water depth, clarity, nutrient, and sunlight. Detailed studies on microbialites and microbial carbonates throughout geological history would certainly help understand causes and effects of major geological events as well as the coevolution of life and environment.

关键词： microbialite microbial carbonate reef calcification calcimicrobe

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