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Nomogram to predict severe retinopathy of prematurity in Southeast China

International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-Yong Li Hong-Wu He Ka-Lu Jin Ling-Xia Zhang Yang Zhou Zhi-Min Zhu chen-chen jiang Hai-Jian Wu Sui-Lian Zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;P<0.001],multiple births(OR,1.885;95%CI,1.013-3.506;P=0.045),and non-invasive ventilation(OR,0.288;95%CI,0.146-0.570;P<0.001)were identified as predictive factors for the prediction of severe ROP,by univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)for the nomogram,32.9(95%CI,15.3-50.5)for WINROP model,70.2(95%CI,55.8-84.6)for Digirop-Birth *** external validation group,AUC of the nomogram was also higher than that of WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation

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Blockchain-based immunization against kleptographic attacks

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Science China(Information Sciences) 2024年第7期67卷 172-183页

作者： Changsong jiang Chunxiang XU Jie chen Kefei chen School of Computer Science and Engineering University of Electronic Science and Technology of China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Department of Mathematics Hangzhou Normal University

Adversarial implementations of cryptographic primitives called kleptographic attacks cause the leakage of secret information. Subliminal channel attacks are one of the kleptographic attacks. In such attacks, backdoors are embedded in implementations of randomized algorithms to elaborately control randomness generation, such that the secrets will be leaked from biased outputs. To thwart subliminal channel attacks, double-splitting is a feasible solution, which splits the randomness generator of a randomized algorithm into two independent generators. In this paper, we instantiate double-splitting to propose a secure randomness generation algorithm dubbed SRG using two physically independent generators: ordinary and public randomness generators. Based on public blockchains, we construct the public randomness generator,which can be verified publicly. Hashes of a sufficient number of consecutive blocks that are newly confirmed on a blockchain are used to produce public randomness. In SRG, outputs from the two generators are taken as inputs of an immunization function. SRG accomplishes immunization against subliminal channel ***, we discuss the application strategies of SRG for symmetric and public-key encryption.

关键词： kleptographic attacks subliminal channel blockchain immunization randomized algorithm

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Controllable chemical redox reactions to couple microbial degradation for organic contaminated sites remediation:A review

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Journal of Environmental Sciences 2024年第5期139卷 428-445页

作者： Bin chen jiang Xu Lizhong Zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Zhejiang UniversityHangzhou 310058China Zhejiang Agriculture&Forest University Lin'an 311300China

Global environmental concern over organic contaminated sites has been progressively conspicuous during the process of urbanization and industrial *** traditional physical or chemical remediation technologies may significantly destroy the soil structure and function,coupling moderate chemical degradation with microbial remediation becomes a potential way for the green,economic,and efficient remediation of contaminated ***,this work systematically elucidates why and how to couple chemical technology with microbial remediation,mainly focused on the controllable redox reactions of organic *** rational design of materials structure,selective generation of reactive oxygen species,and estimation of degradation pathway are described for chemical ***,current progress on efficient and selective reductions of organic contaminants(i.e.,dechlorination,defluorination,-NO_(2) reduction)is *** with the microbial remediation of contaminated sites,several consideration factors of how to couple chemical and microbial remediation are proposed based on both fundamental and practical points of *** review will advance the understanding and development of chemical-microbial coupled remediation for organic contaminated sites.

关键词： Soil remediation Groundwater remediation Rational design Reactive species Environmental nanotechnology

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An extended numerical model of the first exothermic peak for three dimensional printed cement-based materials

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 80-88页

作者： Wei jiang Wenqian LI Xi chen School of Materials Science and Engineering Tongji UniversityShanghai 200092China School of Civil Engineering Tongji UniversityShanghai 200092China

The first exothermic peak of cement-based material occurs a few minutes after mixing,and the properties of three dimensional(3D)printed concrete,such as setting time,are very sensitive to *** this background,based on the classical Park cement exothermic model of hydration,we propose and construct a numerical model of the first exothermic peak,taking into account the proportions of C_(3)S,C_(3)A and quicklime in *** calculated parameters are calibrated by means of relevant published exothermic test *** is found that this developed model offers a good simulation of the first exothermic peak of hydration for C_(3)S and C_(3)A proportions from 0 to 100% of cement clinker and reflects the effect of quicklime content at 8%-10%.The unique value of this research is provision of an important computational tool for applications that are sensitive to the first exothermic peak of hydration,such as 3D printing.

关键词： 3D printed cement-based materials cement hydration the first exothermic peak liquid quick-setting agent numerical model

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Particle Distribution Informed by Chain Rigidity in Diblock Copolymer Melts: The Effect of Entropy

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Chinese Journal of Polymer Science 2024年第3期42卷 388-399,I0009页

作者： Yuguo chen Shuanhu Qi Ying jiang School of Chemistry Beihang UniversityBeijing 100191China

We study the effect of chain rigidity on tailoring the nanoparticle locations for neutral and selective particles embedded in the lamellar morphology formed by semiflexible diblock copolymer chains using self-consistent field calculations. The nanoparticles are modeled through a cavity function, and the semiflexible chains are represented by the continuous Kratsky-Porod chain model. In general situation, the nanoparticles prefer to stay at the interface in order to reduce the interface areas and thus the system free energy. However, the particle distribution at the domain center is subtle, and the underlying physics is intrinsically different depending on the polymer flexibility. In the case of flexible chains, the entropy just contributes a constant shift to the free energy when the nanoparticles move around the domain center indicating that the local metastable state if appears at the domain center is wholly attributed to the local minimum in the enthalpy. If the polymers are rigid, the variation of the particle distribution at the domain center has a close relation with the polymer rigidity and nanoparticle size. In the case of strongly rigid polymers with small nanoparticles, a nearly uniform particle distribution at the domain center is observed, while in other cases, a local enhancement of particle distribution there is found. In contrast to the case of flexible chains, further analysis reveals the crucial role of entropy in controlling the shape of particle distributions at the phase domain. Specifically, the local metastable state appears in the domain center is determined by the large entropy there which arises from the weak coupling of bond orientations that allows the polymer chains to be relatively relaxed. When the particle becomes selective, its distribution in the phase domain exhibits a shift almost uniformly rather than changes its profile, and the underlying physics still holds. In all, our study establishes a strong coupling between the chain rigi

关键词： Semiflexible diblock copolymer Nanoparticle distribution Self-consistent field theory Entropic effect

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AFM probe for measuring~10^(−5)ultra-low friction coefficient:Design and application

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Friction 2024年第1期12卷 64-73页

作者： Yushan chen Liang jiang Linmao QIAN Tribology Research Institute State Key Laboratory of Traction PowerSouthwest Jiaotong UniversityChengdu 610031China

Superlubricity provides a novel approach to addressing friction and wear issues in mechanical ***,little is known regarding improving the atomic force microscope(AFM)friction coefficient measurement ***,this study established the theoretical formula for the AFM friction coefficient measurement and deduced the measurement ***,the formula was applied to the AFM probe with a rectangular cross-section *** measurement resolution is associated with the dimensional properties of the AFM probe,the mechanical properties of the cantilever material,the properties of the position-sensitive detector(PSD),and probably the anti-vibration performance of the *** is feasible to make the cantilever as short as possible and the tip as high as possible to improve the measurement *** AFM probe for measuring an ultra-low friction coefficient was designed and *** cantilever’s length,width,and thickness are 50,35,and 0.6μm,*** tip height is 23μ*** measurement resolution can reach 7.1×10^(−6) under the maximum normal ***,the AFM probe was applied to measure the superlubricity between graphene *** friction coefficient is 0.00139 under 853.08 *** work provides a promising method for measuring a~10^(−5) friction coefficient of superlubricity.

关键词： atomic force microscope(AFM) superlubricity friction coefficientμ probe

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Signalling pathways in autism spectrum disorder:mechanisms and therapeutic implications

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2863-2898页

作者： chen-chen jiang Li-Shan Lin Sen Long Xiao-Yan Ke Kohji Fukunaga Ying-Mei Lu Feng Han International Joint Laboratory for Drug Target of Critical Illnesses Key Laboratory of Cardiovascular&Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjing 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Department of Pharmacy Hangzhou Seventh People’s HospitalMental Health Center Zhejiang University School of MedicineHangzhou 310013China Child Mental Health Research Center Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China Department of CNS Drug Innovation Graduate School of Pharmaceutical SciencesTohoku UniversitySendai 980-8578Japan Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing 210029China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002China

Autism spectrum disorder(ASD)is a prevalent and complex neurodevelopmental disorder which has strong genetic *** the rapidly rising incidence of autism,little is known about its aetiology,risk factors,and disease *** are currently neither validated biomarkers for diagnostic screening nor specific medication for *** the last two decades,there have been remarkable advances in genetics,with hundreds of genes identified and validated as being associated with a high risk for *** convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of *** have been devoted to exploring the behavioural functions,key pathological mechanisms and potential treatments of ***,as we highlight in this review,emerging evidence shows that signal transduction molecular events are involved in pathological processes such as transcription,translation,synaptic transmission,epigenetics and immunoinflammatory *** involvement has important implications for the discovery of precise molecular targets for ***,we review recent insights into the mechanisms and clinical implications of signal transduction in autism from molecular,cellular,neural circuit,and neurobehavioural ***,the challenges and future perspectives are discussed with regard to novel strategies predicated on the biological features of autism.

关键词： mechanisms spectrum behaviour

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Co/CoO heterojunction rich in oxygen vacancies introduced by O2 plasma embedded in mesoporous walls of carbon nanoboxes covered with carbon nanotubes for rechargeable zinc-air battery

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Carbon Energy 2024年第7期6卷 14-25页

作者： Leijun Ye Weiheng chen Zhong-Jie jiang Zhongqing jiang Key Laboratory of Optical Field Manipulation of Zhejiang Province Department of PhysicsZhejiang Sci-Tech UniversityHangzhouChina Department of Mechanical Engineering Ningbo University of TechnologyNingboChina Guangzhou Key Laboratory for Surface Chemistry of Energy Materials Guangdong Engineering and Technology Research Center for Surface Chemistry of Energy MaterialsCollege of Environment and EnergySouth China University of TechnologyGuangzhouChina

Herein,Co/CoO heterojunction nanoparticles(NPs)rich in oxygen vacancies embedded in mesoporous walls of nitrogen-doped hollow carbon nanoboxes coupled with nitrogen-doped carbon nanotubes(P-Co/CoOV@NHCNB@NCNT)are well designed through zeolite-imidazole framework(ZIF-67)carbonization,chemical vapor deposition,and O_(2) plasma *** a result,the threedimensional NHCNBs coupled with NCNTs and unique heterojunction with rich oxygen vacancies reduce the charge transport resistance and accelerate the catalytic reaction rate of the P-Co/CoOV@NHCNB@NCNT,and they display exceedingly good electrocatalytic performance for oxygen reduction reaction(ORR,halfwave potential[EORR,1/2=0.855 V *** hydrogen electrode])and oxygen evolution reaction(OER,overpotential(η_(OER,10)=377mV@10mA cm^(−2)),which exceeds that of the commercial Pt/C+RuO_(2) and most of the formerly reported ***,both the aqueous and flexible foldable all-solid-state rechargeable zinc-air batteries(ZABs)assembled with the P-Co/CoOV@NHCNB@NCNT catalyst reveal a large maximum power density and outstanding long-term cycling ***-principles density functional theory calculations show that the formation of heterojunctions and oxygen vacancies enhances conductivity,reduces reaction energy barriers,and accelerates reaction kinetics *** work opens up a new avenue for the facile construction of highly active,structurally stable,and cost-effective bifunctional catalysts for ZABs.

关键词： heterojunction oxygen evolution/reduction reaction oxygen vacancies rechargeable zinc–air battery three‐dimensional nitrogen‐doped hollow carbon nanoboxes

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A Reverse Path Planning Approach for Enhanced Performance of Multi-Degree-of-Freedom Industrial Manipulators

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1357-1379页

作者： Zhiwei Lin Hui Wang Tianding chen Yingtao jiang Jianmei jiang Yingpin chen Key Laboratory of Light Field Manipulation and System Integration Applications in Fujian Province School of Physics and Information EngineeringMinnan Normal UniversityZhangzhou363000China Department of Electrical and Computer Engineering University of NevadaLas Vegas89154USA College of Material Engineering Fujian Agriculture and Forestry UniversityFuzhou350000China

In the domain of autonomous industrial manipulators,precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance,such as handling,heat sealing,and *** Multi-Degree-of-Freedom(MDOF)manipulators offer kinematic redundancy,aiding in the derivation of optimal inverse kinematic solutions to meet position and posture requisites,their path planning entails intricate multiobjective optimization,encompassing path,posture,and joint motion *** satisfactory results in practical scenarios remains *** response,this study introduces a novel Reverse Path Planning(RPP)methodology tailored for industrial *** approach commences by conceptualizing the manipulator’s end-effector as an agent within a reinforcement learning(RL)framework,wherein the state space,action set,and reward function are precisely defined to expedite the search for an initial collision-free *** enhance convergence speed,the Q-learning algorithm in RL is augmented with ***,we formulate the cylindrical bounding box of the manipulator based on its Denavit-Hartenberg(DH)parameters and propose a swift collision detection ***,the motion performance of the end-effector is refined through a bidirectional search,and joint weighting coefficients are introduced to mitigate motion in high-power *** efficacy of the proposed RPP methodology is rigorously examined through extensive simulations conducted on a six-degree-of-freedom(6-DOF)manipulator encountering two distinct obstacle configurations and target *** results substantiate that the RPP method adeptly orchestrates the computation of the shortest collision-free path while adhering to specific posture constraints at the target ***,itminimizes both posture angle deviations and joint motion,showcasing its prowess in enhancing the operational performance of MDOF industrial manipulators.

关键词： Reverse path planning Dyna-Q bidirectional search posture angle joint motion

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Numerical and experimental investigation into the evolution of the shock wave when a muzzle jet impacts a constrained moving body

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Defence Technology（防务技术） 2024年第3期33卷 317-326页

作者： Zijie Li Hao Wang Changshun chen Kun jiang School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210016China

The gun-track launch system is a new special launch device that connects the track outside the *** it is constrained by the track,the characteristics of development of the muzzle jet differ from those of the traditional muzzle ***,it changes from freely developing to doing so in a constrained manner,where this results in an asymmetric direction of flow as well as spatio-temporal coupling-induced interference between various shock waves and the formation of *** this background,the authors of this article formulate and consider the development and characteristics of evolution of the muzzle jet as it impacts a constrained moving *** designed simulations to test the gun-track launch system,and established a numerical model based on the dynamic grid method to explore the development and characteristics of propagation of disturbances when the muzzle jet impacted a constrained moving *** also considered models without a constrained track for the sake of *** results showed that the muzzle jet assumed a circumferential asymmetric shape,and tended to develop in the area above the *** the test platform was close to the ground,the muzzle jet was subjected to reflections from it that enhanced the development and evolution of various forms of shock waves and vortices in the muzzle jet to exacerbate its rate of distortion and asymmetric *** in turn led to significant differences in the changes in pressure at symmetric points that would otherwise have been *** results of a comparative analysis showed that the constrained track could hinder the influence of reflections from the ground on the muzzle jet to some extent,and could reduce the velocity of the shock waves inducing the motion of the muzzle as well as the Mach number of the moving *** work here provides a theoretical basis and the requisite technical support for applications of the gun-track launch *** also sheds light on the

关键词： Shock wave/vortex interference Muzzle jet Constrained boundary Dynamic grid

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