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Effect of Coagulation and Diffusion on Nanoparticle Distribution in a Fully Developed Turbulent Boundary Layer

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Chinese Physics Letters 2012年第5期29卷 157-160页

作者： liN Jian-zhong chen zhong-li Department of Mechanics Zhejiang UniversityHangzhou 310027 Institute of Fluid Mechanics China Jiliang UniversityHangzhou 310018

Nanoparticle distributions in a fully developed turbulent boundary layer are simulated numerically using the moment *** effects of Schmidt number and Damk(o)hler number on the nanoparticle distribution are *** is found that the particle number concentration and total particle mass increase from the wall to the *** difference of particle number concentration and total particle mass near the wall and near the outside becomes smaller with the increasing Schmidt number *** particle diameter and geometric standard deviation increase from the wall to the outside at a fixed Damk(o)hler number Da,and grow with the increase of Da at the same lateral position.

关键词： particle outside Boundary

Properties of the Collision Efficiency of Nanoparticles in Brownian Coagulation

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Chinese Physics Letters 2011年第1期28卷 130-133页

作者： WANG Yu-Ming liN Jian-zhong chen zhong-li Institute of Fluid Mechanics China Jiliang University Hangzhou 310018 Department of Mechanics Zhejiang University Hangzhou 310027

The collision efficiency of nanoparticles with diameters from 100nm to 750nm in the Brownian coagulation is studied by building and solving＂ numerically the equations of particle collision in the presence of the van der Waals force, the elastic deformation force, the Stokes resistance, the lubrication force and the electrostatic force. The results show that the collision efficiency decreases overall with the increasing- particle diameter. It is found that there exists an abrupt increase in the collision efficiency when the particle diameter is equals to 550nm. Finally a new expression for the collision efficiency is presented.

关键词： Condensed matter: structural, mechanical & thermal Nanoscale science and low-D systems

Special Topic:Point-of-Care Testing(POCT)and In Vitro Diagnostics(IVDs)

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Journal of Analysis and Testing 2019年第1期3卷 1-2页

作者： chen-zhong li Nanobioengineering/Bioelectronics Lab The Department of Biomedical EngineeringFlorida International University10555 West Flagler StreetMiamiFL 33174USA

In last two decades,substantial efforts have been made to develop in vitro diagnostic(IVD)*** distinct features,including:rapid results,reduced patient discomfort,simplicity,cost-effectiveness,enablement of early diagnosing and accessibility in remote areas,make these technologies attractive to the medical *** tests are generally performed on biological samples such as blood,sweat,urine or tissue,in a controlled environment outside a living organism,with the goal of obtaining a diagnosis from the assays.

关键词： POCT diagnosis urine IVD

Nanotechnology Powered CRISPR-Cas Systems for Point of Care Diagnosis and Therapeutic

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Research 2023年第3期2022卷 155-156页

作者： chen-zhong li Tony Y.Hu Center for Cellular and Molecular Diagnostics Department of Biochemistry and Molecular BiologyTulane University School of Medicine1324Tulane Ave.New OrleansLA70112US

Inspired by the successful application of Cas9 gene editing for“genome surgery,”we are looking back at what has been accomplished in the ten years of CRISPR *** effort is now focused on how to utilize the unique functions of CRISPR-Cas systems for molecular diagnostics and the next generation of therapeutic ***-Cas systems have two major advantages for gene editing that render them attractive for these new applications,specifically the ability to easily control their target recognition specificity and to couple this specificity to a targeted or secondary cleavage ***,despite the great potential of CRISPR/Cas for both gene editing and diagnosis,its medical applications have yet to be fully realized due factors that limit their delivery or utility for point-of-care(POC)*** this editorial note,we discuss how nanotechnology can address challenges associated with new CRISPR applications and what nanotechnology-specific advances are needed to circumvent remaining barriers that limit the development or use of new CRISPR/CAS-based genome editing and diagnostic approaches.

关键词： limit specificity utilize

Sweat-Based in Vitro Diagnostics(IVD):From Sample Collection to Point-of-Care Testing(POCT)

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Journal of Analysis and Testing 2019年第1期3卷 80-88页

作者： Mehenur Sarwar Pablo Rodriguez chen-zhong li Nanobioengineering/Bioelectronics Laboratory and Department of Biomedical EngineeringFlorida International UniversityMiami 33174USA

Sweat-based diagnostics offer an exciting avenue to noninvasively monitor analytes which had previously only been avail-able through painful blood *** is enriched with physiologically valuable information,and recent proteomic studies have identified numerous critical analytes which have highly correlated levels in blood,interstitial fluid and ***-ever,usage of sweat for health monitoring has not been studied extensively due to the substantial challenge of assembling a composite clinic-ready *** advances in soft electronics have made this goal realizable,as these devices can perform electronic or optical monitoring on a flexible substrate using small volumes of *** this field is still in its infancy,this review examines the physiological composition of sweat,various improvements in material science that improve sensor design,existing FDA approvals,methods of extracting sweat and comparisons to blood-based ***,this review assesses the critical challenges which must be overcome for this type of technology to make it out of research laboratories and into continuous clinical *** believe that once properly harnessed,sweat-based diagnostics can provide patients a painless monitoring tool which can be customized to track a wide variety of medical conditions from the comfort of a patient’s own home.

关键词： Wearable sensors Sweat tests In vitro diagnostics Biomarkers POCTs Sweat collection

Smart-phone,paper-based fluorescent sensor for ultra-low inorganic phosphate detection in environmental samples

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Microsystems & Nanoengineering 2019年第1期5卷 164-173页

作者： Mehenur Sarwar Jared Leichner Ghinwa MNaja chen-zhong li Nanobioengineering/Bioelectronics Laboratory Department of Biomedical EngineeringFlorida International University10555 West Flagler StreetMiamiFL 33174USA Everglades Foundation 18001 Old Culter RoadPalmetto BayFL 33157USA

A major goal of environmental agencies today is to conduct point-of-collection monitoring of excess inorganic phosphate(Pi)in environmental water samples for tracking aquatic“dead zones”caused by algae ***,there are no existing commercial devices which have been miniaturized and are suitable for the point-of-need-testing(“PONT”)that is required to fully map a large region,such as the Florida *** solve this challenge,a reflection-mode fluorescence-sensing apparatus was developed,leveraging an environmentally sensitive fluorophore(MDCC)bound to a bacterial phosphate-binding protein to generate a fluorescent optical signal proportional to the concentration of(Pi)*** combined end-to-end integrated sensor system had a response time of only 4 s,with minimal effects of common interfering agents and a linear range spanning from 1.1 to 64 *** support easeof-use during PONT,the platform incorporated disposable wax-printed paper strip sample pads and a smartphone camera detection *** the EPA threshold is currently 30 ppb to prevent eutrophication,this system serves as a rapid test of whether a region is compliant.

关键词： Smart system apparatus

A novel-green adsorbent based on betaine-modified magnetic nanoparticles for removal of methyl blue

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Science Bulletin 2017年第5期62卷 319-325页

作者： Haowei Wang Shangning Jia Haojiang Wang Bo li Wen liu Ningbo li Jie Qiao chen-zhong li College of Basic Medicine Shanxi Medical University Department of Biomedical Engineering Florida International University

A potential adsorbent based on betaine-modified magnetic iron oxide nanoparticles(BMNPs) was successfully synthesized by facile method, characterized and applied for methyl blue(MB) removal from aqueous solution. The characterization results of FTIR, transmission electron microscopy(TEM), X-ray diffraction(XRD) and vibrating sample magnetometer(VSM) showed that the prepared nanoparticles could be well dispersed in water and exhibited excellent superparamagnetism. These properties imply the potential to recycle BMNPs from wastewater through magnetic field. In the adsorption process, the effects of main experimental parameters such as p H of MB solution, initial concentration of MB, contact time, and adsorption capacity for MB were studied and optimized. These results demonstrated that large amounts of quaternary ammonium groups existing on the surface of BMNPs could promote absorption of MB via electrostatic forces. Additionally, the adsorption kinetics of MB was found to follow a pseudosecond-order kinetic model and the adsorption equilibrium data fitted very closely to the Langmuir adsorption isotherm model. The maximum adsorption capacity for MB was calculated to be 136 mg g 1at room temperature. Moreover, the BMNPs showed good reusability with 73.33% MB adsorption in the5 th cycle.

关键词： Iron oxide nanoparticles Betaine Adsorption Methyl blue

A label-free colorimetric assay for detection of c-Myc mRNA based on peptide nucleic acid and silver nanoparticles

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Science Bulletin 2016年第4期61卷 276-281页

作者： Xia li Juan Song Bao-li chen Bing Wang Rui li Hui-Min Jiang Ji-Feng liu chen-zhong li Department of Chemistry Liaocheng UniversityLiaocheng 252059 China Key Laboratory of Food Nutrition and Safety Ministry ofEducation Tianjin University of Science and TechnologyTianjin 300457 China Nanobioengineering/Bioelectronics Laboratory Department ofBiomedical Engineering Florida International UniversityMiami FL 33174 USA

A label-free colorimetric protocol based on peptide nucleic acid/silver nanoparticles(PNA/Ag NPs) has been initially proposed for specific recognition of m *** use of the controlled silver nanoparticles aggregation/dispersion by PNA/PNA–RNA complex, proto-oncogene c-Myc m RNA detection can be achieved. Moreover, the PNA/Ag NPs platform can undergo color change in response to target c-Myc m RNA with single-base-mismatch sensitivity, which could further help in visually identify single nucleotide differences in target genes.

关键词： Colorimetric · c-Myc mRNA · Peptidenucleic acid · Silver nanoparticles

Microfluidic Electrochemical Devices for Biosensing

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Journal of Analysis and Testing 2019年第1期3卷 3-18页

作者： Noel Nesakumar Srinivasan Kesavan chen-zhong li Subbiah Alwarappan Electrodics and Electrocatalysis Division CSIR-Central Electrochemical Research InstituteKaraikudiTamil Nadu 630003India Nanobiosensors Laboratory Department of Biomedical EngineeringFlorida International UniversityMiamiFLUSA

The integration of the electrochemical detection system together with microfluidic technology is an attractive choice for the construction of miniaturized components in a single *** networks fabricated on conductive substrates prevent environmental contaminants and require only a tiny(μL or nL)sample for *** coupled electrochemical detection system is particularly advantageous compared to traditional electrochemical sensing systems due to its flexibility,rapid analysis,low fabrication costs,ease of implementation and *** these electrochemical sensing platforms,biochemical assays that require complex pre-processing of biological samples can be conducted on a *** this review,a comprehensive overview of the basic concepts of microfluidics and its recent applications in the design of miniaturized electrochemical sensors for biosensing applications are presented.

关键词： Microfluidics Electrochemical sensor Electrode Microchannel Fabrication