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New method in synthesizing an optical active intermediate for (R,R)-formoterol

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Chinese Chemical Letters 2008年第3期19卷 279-280页

作者： Wei Fan Lei chen Li hai yong Wu Key Laboratory of Drug Targeting Education Ministry West China School of Pharmacy Sichuan University Chengdu 610041 China

（R）-1-（4-Methoxyphenyl）propan-2-amine 2a, an optical active intermediate for （R,R）-formoterol, was synthesized from Dalanine in 65% overall yield by using a simple route, which contained protecting amino group, ... 详细信息

关键词： (R)-1-(4-Methoxyphenyl)propan-2-amine Formoterol Intermediate Synthesis

A New Interface Anisotropic Potential of Zinc-Blende Semiconductor Interface Induced by Lattice Mismatch

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Chinese Physics Letters 1999年第1期16卷 56-58页

作者： chen yong-hai WANG Zhan-guo YANG Zhi-yu Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 Department of Physics the Hong Kong University of Science and TechnologyKowloonHong Kong

A new interface anisotropic potential,which is proportional to the lattice mismatch of interfaces and has no fitting parameter,has been deduced for(001)zinc-blende semiconductor *** comparison with other interface models is given for GaAs/AlAs and GaAs/InAs *** strong influence of the interface anisotropic potential on the inplane optical anisotropy of GaAs/AlGaAs low dimensional structures is demonstrated theoretically within the envelope function approximation.

关键词： interface Lattice Zinc

Chinese Medicine for Idiopathic Parkinson's Disease:A Meta Analysis of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2017年第1期23卷 55-61页

作者： WEI Wei chen hai-yong FAN Wen YE Shui-fen XU Yi-hui CAI Jing College of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122China 477 Hospital of Chinese People's Liberation Army XiangyangHubei Province 441000China School of Chinese Medicine the University of Hong KongHong Kong SARChina Xiamen haicang Hospital XiamenFujian Province 361026China Longyan First Hospital Affiliated to Fujian Medical University LongyanFujian Province 364000China Second People's Hospital Fujian University of Traditional Chinese MedicineFuzhou 350003China

Objective：To evaluate the efficacy of Chinese medicine（CM）adjunct to conventional medications for idiopathic Parkinson’s disease（PD）.Methods：Electronic English and Chinese databases including Pub Med,Cochrane Library,Web of Science,Chinese Medical Current Contents,China National Knowledge Infrastructure,China Science and Technology Journal Database,Wanfang Med Database,and Traditional Chinese Medical Database System were used for key words searching in a highly sensitive search *** extracted data was analyzed by the Review Manager ***：Twelve trials involving 869 participants were included in the *** PD Rating Scale（UPDRS）Ⅰ,Ⅱ,Ⅲ,Ⅳscores and UPDRSⅠ–Ⅳtotal scores were used to be the primary outcomes,Parkinson Disease Question-39（PDQ-39）and Scores of Chinese Medical Symptoms were the secondary *** adjunct therapy had greater improvement in UPDRSⅠ[2 trials;standardized mean difference（SMD）–0.40,95%confidence interval（CI）–0.71 to–0.09;Z=2.49（P=0.01）],Ⅱ[5 trials;SMD–0.47,95%CI–0.69 to–0.25;Z=4.20（P〈0.01）],Ⅲ[5 trials;SMD-0.35,95%CI–0.57 to–0.13;Z=3.16（P=0.002）],Ⅳscores[3 trials;SMD-0.32,95%CI–0.60 to–0.03;Z=2.17（P=0.03）],UPDRSⅠ–Ⅳtotal scores[7 trials;SMD-0.36,95%CI–0.53 to–0.20;Z=4.24（P〈0.05）].PDQ-39 and Chinese medical symptoms compared to the conventional medication ***：CM adjunct therapy has potential therapeutic benefits by decreasing UPDRS scores and reducing adverse effect.

关键词： Parkinson's disease Chinese medicine meta analysis randomized controlled trials

Effect of Essential Oil on Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Pilot Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2019年第2期25卷 91-95页

作者： YING Jian ZHOU Min-jie chen hai-yong chen Lei ZHANG Wei JI Jun YU Chao ZHANG Zhang-jin Department of Urology and Andrology Longhua HospitalShanghai University of Traditional Chinese Medicine Shanghai Qigong Research Institute Shanghai University of Traditional Chinese Medicine Department of Vascular Surgery Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese Medicine School of Chinese Medicine the University of Hong Kong Department of Chinese Medicine the University of Hong Kong-Shenzhen Hospital

Objective: To evaluate the efficacy and safety of essential oil treatment for type Ⅲ chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS). Methods: A randomized controlled trial was conducted from December 2014 to October 2015. Seventy type Ⅲ CP/CPPS patients were assigned to the essential oil group(35 cases) or almond placebo oil control group(35 cases) by a random number table. The oil was smeared by self-massage on the suprapubic and sacral region once a day for 4 weeks. The National Institutes of Health Chronic Prostatitis Syndrome Index(NIH-CPSI) and expressed prostatic secretions(EPS) were examined. The primary outcome was NIH-CPSI pain domain. The secondary outcomes included other NIH-CPSI domains and laboratory examinations of EPS. Adverse events were also observed. Results: Sixty-six subjects completed the full 4-week treatment. There was no significant difference between almond oil control and essential oil groups in terms of the total score of NIH-CPSI, pain, quality of life and urination domain scores of NIH-CPSI and EPS examinations(P>0.05). In the essential oil group, pain between rectum and testicles(perineum) in the domain of pain or discomfort was significantly reduced at week 2 and week 4 compared with almond oil control group(P<0.01). No serious adverse events occurred. Conclusion: The essential oil may reduce the pain or discomfort in the perineum region in patients with CP/CPPS.

关键词： essential oil chronic prostatitis/chronic pelvic pain syndrome randomized controlled trial

Review of Surface Plasmon Resonance and Localized Surface Plasmon Resonance Sensor

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Photonic Sensors 2012年第1期2卷 37-49页

作者： yong chen hai MING Department of Optics & Optical Engineering Anhui Key Laboratory of Optoelectronic Science and Technology University of Science and Technology of China Hefei Anhui 230026 China

An overview of recent researches of surface plasmon resonance （SPR） sensing technology in Laboratory of Science and Technology of Micro-Nano Optics （LMNO）, University of Science and Technology of China, is presented. Some novel SPR sensors, such as sensors based on metallic grating, metal-insulator-metal （MIM） nanoring and optical fiber, are designed or fabricated and tested. The sensor based on localized surface plasmon resonance （LSPR） of metallic nanoparticles is also be summarized. Because of the coupling of propagating surface plasmons and localized surface plasmons, the localized electromagnetic field is extremely enhanced, which is applied to surface-enhanced Raman scattering （SERS） and fluorenscence enhancement. Future prospects of SPR and/or LSPR sensing developments and applications are atso discussed.

关键词： Surface plasmons resonance localized surface plasmon resonance sensor electromagnetic-fieldenhancement high sensitivity

Photorefractive Effect of a Liquid Crystal Cell with a ZnO Nanorod Doped in Only One PVA Layer

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Chinese Physics Letters 2011年第9期28卷 198-200页

作者： GUO Yu-Bing chen yong-hai XIANG Ying QU Sheng-Chun WANG Zhan-Guo Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesPO Box 912Beijing 100083 School of Information Engineering Guangdong University of TechnologyGuangzhou 510006

We observe obviously different diffraction efficiencies with forward and reverse dc voltages in a forced-light-scattering(FLS)experiment for a cell with ZnO nanorod doped in only one poly(vinyl alcohol)(PVA)*** a dc voltage with a positive pole on the ZnO nanorod doped side is applied,the excited charge carriers primarily move along the transverse direction,which results in a higher diffraction ***,when the dc voltage with a negative pole on the ZnO nanorod doped side is applied,the excited charge carriers primarily move along the longitudinal direction,which leads to a lower diffraction efficiency.A largest diffraction efficiency of about 9%is achieved in the ZnO nanorod doped liquid crystal cell.

关键词： scattering Photorefractive Crystal

Increased expression of insulin-like growth factor-binding protein-3 is implicated in erectile dysfunction in two-kidney one-clip hypertensive rats after propranolol treatment

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Asian Journal of Andrology 2011年第6期13卷 851-855页

作者： Zhang-Yan Zhou Zhong-Hua Yang Xing-Huan Wang Hong Cao Dong chen yong-Zhi Wang hai-Hong Zhou Mou Peng Quan-Liang Liu Shao-Ping Wan Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China

This study aimed to investigate the role of insulin-like growth factor-binding protein-3 （IGFBP-3） in erectUe dysfunction （ED） in two-kidney one-clip （2K-1C） hypertensive rats treated with the β-blocking agent propranolol. Adult male Wistar rats were randomly divided into three groups： a normal control group, a hypertensive control group and a propranolol treatment group （n=9）. After 4 weeks of propranolol treatment, intracavemous pressure （ICP） responses to electrical stimulation of the cavernous nerves were evaluated. The expression of IGFBP-3 and insulin-like growth factor-1 （IGF-1） mRNA and protein in the rat cavernous tissue were detected by quantitative real-time PCR and Western blot, respectively. The concentration of cyclic guanosine monophosphate （cGMP） in the cavernous tissue was determined by enzyme-linked immunosorbent assay （ELISA）. Cavernosal pressure in response to cavernous nerve stimulation was decreased 4 weeks after propranolol treatment （P〈0.01, compared to the hypertensive control group）. IGFBP-3 mRNA and protein expression was increased in the propranolol treatment group compared to the hypertensive control group （P〈O.01）, whereas IGF-1 expression was decreased in the propranolol treatment group compared to the hypertensive control group （P〈0.01）. In addition, cavernous cGMP concentration was decreased in the prepranolol treatment group compared to the hypertensive control group （P〈0.01）. Taken together, these results suggest that the upregulation of IGFBP-3 may play a role in the development of ED in hypertensive rats.

关键词： erectile dysfunction insulin-like growth factor-binding protein-3 propranolol two-kidney one-clip hypertension

基于LMI的参数随机变化系统的概率密度函数控制

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自动化学报 2007年第11期33卷 1216-1220页

作者：陈海永王宏中国科学院自动化研究所东北大学自动化研究中心

针对模型参数在有界区域内随机变化的系统,基于平方根B样条模型,提出了输出概率密度函数(Probability density function,PDF)跟踪控制策略.目标是控制系统输出的概率密度函数跟踪给定的概率密度函数.通过B样条逼近建立了输出PDF和权值... 详细信息

针对模型参数在有界区域内随机变化的系统,基于平方根B样条模型,提出了输出概率密度函数(Probability density function,PDF)跟踪控制策略.目标是控制系统输出的概率密度函数跟踪给定的概率密度函数.通过B样条逼近建立了输出PDF和权值之间的对应关系,把PDF的跟踪转化为权值的跟踪,同时系统转化为MIMO系统,从而权值向量的跟踪就转化为MIMO系统的跟踪问题,接着给出了系统输出概率密度函数跟踪给定概率密度函数的控制器存在的充分条件,通过求解线性矩阵不等式完成状态反馈和输出反馈跟踪控制器的设计,得到了系统具有Hinfinity范数界Gamma鲁棒镇定的结果.仿真结果表明本文提出的控制算法是有效的.

关键词：概率密度函数控制平方根B样条随机控制跟踪控制

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基于效益函数与优先级的网格服务质量保证

计算机工程 2009年第12期35卷 70-72,75页

作者：陈海勇李男解放军信息工程大学信息工程学院计算机科学与技术系郑州450002

将资源预约请求作为网格调度对象是提高网格整体服务质量的有效手段。针对传统预约方式成功率低的问题,提出将效益函数与优先级引入资源预约,采用可连续预约的方法,在减少预约双方交互负担的同时,有效提高资源预约成功率。通过模拟与比... 详细信息

将资源预约请求作为网格调度对象是提高网格整体服务质量的有效手段。针对传统预约方式成功率低的问题,提出将效益函数与优先级引入资源预约,采用可连续预约的方法,在减少预约双方交互负担的同时,有效提高资源预约成功率。通过模拟与比较,表明该算法在应对大量预约请求时均有较好的性能。

关键词：网格服务质量资源预约效益函数调度