New method in synthesizing an optical active intermediate for (R,R)-formoterol

作     者：Wei Fan Lei Chen Li Hai Yong Wu 

作者机构：Key Laboratory of Drug Targeting Education Ministry West China School of Pharmacy Sichuan University Chengdu 610041 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第3期

页      面：279-280页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：National Natural Science Foundation of China NSFC: 29972013 

主　　题：(R)-1-(4-Methoxyphenyl)propan-2-amine Formoterol Intermediate Synthesis 

摘      要：（R）-1-（4-Methoxyphenyl）propan-2-amine 2a, an optical active intermediate for （R,R）-formoterol, was synthesized from Dalanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.