检索结果-南通市图书馆

Agricultural Sciences in China 2006年第6期5卷 456-461页

作者： chen yi wu chun-yan shui jian-guo wang jia-yu Institute of Environmental Resources ＆ Soil Fertilizer Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R.China

The observations of 25-yr long-term experiment in Zhejiang paddy soils showed that the soil organic matter could increase continuously with applying organic manure, and the increase in rate enhanced along with the application rates of organic manure. By mathematical modeling, the soil organic matter increased by 22 kg when 1 t of fresh FYM was applied. The CO2 emission resulting from the mineralization of soil organic matter increased with the increase in the application rate of the organic manure as well as the increase in the root residues. It is expected that the CO2 emission will be at 10.04-21.61 t ha-1 yr-1 when 16.5-49.5 t ha-1 yr-1 of fresh FYM is applied. The soil organic carbon from mineralization and release of applied organic carbon (fresh FYM and root residues) will affect the CO2 concentration in the atmosphere. So, the higher the application rate of organic manure, the more is the fixed organic carbon. The CO2 fixation will be at 1.885-3.463 t ha-1 yr-1 when 16.5-49.5 t ha-1 yr-1 of fresh FYM is applied. Thus, the CO2 fixation will increase by 46.7 kg by applying 1 t fresh FYM. To apply organic manure continuously in rice fields may reduce the contribution to the increase of CO2 concentration in the atmosphere.

关键词： paddy soil organic manure carbon cycle carbon dioxide global climatic changes

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng wang Li-Tao yang Qian yue Ke-Jun Kang yuan-Jing Li Hai-Peng An C.Greeshma jian-Ping Chang yun-Huan chen jian-Ping cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju guo Xu-yuan guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-chen Huang Hai-Tao jia Xi jiang S.Karmakar Hao-Bin Li jian-Min Li Jin Li Qian-yun Li Ren-Ming-Jie Li Xue-Qian Li yu-Lan Li yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin jia-Xuan Liu Shu-Kui Liu yan-Dong Liu yu Liu yuan-yuan Liu Zhong-Zhi Liu Hao Ma yu-Cai Mao Qi-yuan Nie Jin-Hua Ning Hui Pan Ning-chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-jian Tang Wei-You Tang yang Tian Guang-Fu wang Li wang Qing wang yu-Feng wang yun-Xiang wang Henry-Tsz-King Wong Shi-Yong wu yu-cheng wu Hao-yang Xing Rui Xu yin Xu Tao Xue yu-Lu yan Nan yi chun-Xu yu Hai-Jun yu jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang shui-Hong Zhou Wei-Hong jiang yan jiang Jing-wu Sun Qin-Tai yang Xue-Zhong Li Ya-Nan Sun Li Shi Min wang Xi-cheng Song Fu-Quan chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong chen chun-Guang Shan Guang-Ke wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu yu Xu Xiao Cai Wei Huang Ru-Xin Zhang yu-Lin Zhao guo-Dong yu Guang-Gang Shi Mei-Ping Lu yang Shen yu-Tong Zhao jia-Hong Pei Shao-Bing Xie Long-Gang yu Ye-Hai Liu Shao-Wei Gu yu-cheng yang Lei cheng jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai yijian Cai yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang guofu Cao jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti yimin Che yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen guoming chen Hua-Xing chen Huirun chen Jinhui chen Ji-yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen ying chen yukai chen Zelin chen Zilin chen Gang chen Boping chen chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

长期施用有机肥对水稻土CO2释放与固定的影响

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中国农业科学 2005年第12期38卷 2468-2473页

作者：陈义吴春艳水建国王家玉浙江省农业科学院环境资源与土壤肥料研究所浙江省农业科学院环境资源与土壤肥料研究所杭州310021

在浙江省黄岩水稻土上开展的26年长期施肥定位试验表明,长期施用有机肥可以促使土壤有机质持续增长,增长幅度随有机肥用量增加而增加。通过数学模拟,估算出每年施用猪厩肥16.5～49.5t·ha-1相应释放CO210.04～21.61t·ha-1·a-1。每年... 详细信息

在浙江省黄岩水稻土上开展的26年长期施肥定位试验表明,长期施用有机肥可以促使土壤有机质持续增长,增长幅度随有机肥用量增加而增加。通过数学模拟,估算出每年施用猪厩肥16.5～49.5t·ha-1相应释放CO210.04～21.61t·ha-1·a-1。每年施入鲜猪厩肥16.5～49.5t·ha-1则相应固定CO21.885～3.463t·ha-1·a-1。为此,通过长期施用有机肥对削弱土壤碳释放对大气CO2浓度升高的影响是可行的。

关键词：水稻土有机肥碳循环二氧化碳全球气候变化

Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

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World Journal of Gastroenterology 2022年第31期28卷 4417-4430页

作者： Zi-Xuan Shen Dan-Dan wu Jie Xia Xian-Bo wang Xin Zheng yan Huang Bei-Ling Li Zhong-Ji Meng yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu jia Shang Hua-Dong yan yu-Bao Zheng Wen-yi Gu yan Zhang jian-yi Wei Wen-Ting Tan yi-Xin Hou Qun Zhang yan Xiong Cong-Cong Zou Jun chen Ze-Bing Huang Xiu-Hua jiang Sen Luo yuan-yuan chen Na Gao chun-yan Liu Wei yuan Xue Mei Jing Li Tao Li Xin-yi Zhou guo-Hong Deng Jin-Jun chen Xiong Ma Hai Li Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of HealthShanghai Jiao Tong UniversityShanghai 200001China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 430418Hubei ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China Tianjin Institute of Hepatology Nankai University Second People’s HospitalTianjin 300102China Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054XinjiangChina Department of Infectious Diseases Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases Hwamei HospitalThe Second Hospital of NingboUniversity of Chinese Academy of SciencesNingbo 315153Zhejiang ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 5

BACKGROUND Autoimmune liver disease(AILD)has been considered a relatively uncommon disease in China,epidemiological data for AILD in patients with cirrhosis and acute decompensation(AD)is *** To investigate the prevalence,outcome and risk factors for AILD in cirrhotic patients complicated with AD in *** We collected data from patients with cirrhosis and AD from two prospective,multicenter cohorts in hepatitis B virus endemic *** were regularly followed up at the end of 28-d,90-d and 365-d,or until death or liver transplantation(LT).The primary outcome in this study was 90-d LTfree ***-on-chronic liver failure(ACLF)was assessed on admission and during 28-d hospitalization,according to the diagnostic criteria of the European Association for the Study of the Liver(EASL).Risk factors for death were analyzed with logistic regression *** In patients with cirrhosis and AD,the overall prevalence of AILD was 9.3%(242/2597).Prevalence of ACLF was significantly lower in AILD cases(14%)than those with all etiology groups with cirrhosis and AD(22.8%)(P<0.001).Among 242 enrolled AILD patients,the prevalence rates of primary biliary cirrhosis(PBC),autoimmune hepatitis(AIH)and PBC-AIH overlap syndrome(PBC/AIH)were 50.8%,28.5%and 12.0%,*** ACLF patients,the proportions of PBC,AIH and PBC/AIH were 41.2%,29.4% and 20.6%.28-d and 90-d mortality were 43.8% and 80.0% in AILD-related *** etiology of AILD had no significant impact on 28-d,90-d or 365-d LTfree mortality in patients with cirrhosis and AD in both univariate and multivariate *** bilirubin(TB),hepatic encephalopathy(HE)and blood urea nitrogen(BUN)were independent risk factors for 90-d LT-free mortality in multivariate *** development of ACLF during hospitalization only independently correlated to TB and international normalized *** AILD was not rare in hospitalized patients with cirrhosis and AD in China,among which PBC was the m

关键词： Prevalence Autoimmune liver disease Cirrhosis and acute decompensation Mortality Acuteon-chronic liver failure

Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China,2017

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Infectious Diseases of Poverty 2020年第3期9卷 65-73页

作者： Rui-Hua Kang Shu-jia Liang yan-Ling Ma Shu Liang Lin Xiao Xin-Hui Zhang Hong-yan Lu Xiao-Qin Xu shui-Bin Luo Xiao-Guang Sun Lin chen jian-Mei He guo-Hui wu Ling-Jie Liao Hui Xing yi-Ming Shao yu-Hua Ruan State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases155 Changbai RoadChangping DistrictBeijingPR China Guangxi Center for Disease Control and Prevention NanningGuangxiChina yunnan Center for Disease Control and Prevention KunmingYunnanChina Sichuan Center for Disease Control and Prevention ChengduSichuanChina Liangshan Center for Disease Control and Prevention Liangshan prefectureSichuanChina Guizhou Center for Disease Control and Prevention GuiyangGuizhouChina Beijing Center for Disease Control and Prevention BeijingChina jiangsu Center for Disease Control and Prevention NanjingJiangsuChina Neijiang Center for Disease Control and Prevention NeijiangSichuanChina Shandong Center for Disease Control and Prevention JinanShandongChina Shenzhen Center for Disease Control and Prevention ShenzhenGuangdongChina Hunan Center for Disease Control and Prevention ChangshaHunanChina Chongqing Center for Disease Control and Prevention ChongqingChina

Background:After the scale-up of antiretroviral therapy(ART)for HIV infected people,increasing numbers of patients have pretreatment drug resistance(PDR).In this study,the prevalence of PDR was evaluated in adults initiating antiretroviral therapy in ***:Blood samples were obtained from 1943 patients who initiated antiretroviral therapy(ART)in 2017 from 13 provinces or cities in *** sequences were used to analyze drug resistance and construct transmission *** regression model was used to estimate the potential factors associated with ***:In total,1711 eligible patients(76.0%male;87.8%aged≥25 years)were included,of which 117(6.8%)had *** highest rates of PDR were 12.2%in Liangshan Prefecture of Sichuan and 9.3 and 8.9%in Dehong and Lincang Prefecture of yunnan.A multivariate logistic regression analysis revealed that PDR was significantly higher among intravenous drug users(adjusted Odds Ratio(aOR)=2.64,95%CI:1.57–4.44)and individuals from Liangshan,Dehong,and Lincang(aOR=2.04,95%CI:1.26–3.30).In total,754 sequences were used to generate 164 transmission *** transmission networks had two or three sequences containing the same mutations,two networks contained subjects from Liangshan,and one network contained subjects from ***:Overall,the PDR prevalence was moderate,with a particularly high prevalence in areas with severe HIV *** results indicate the importance of continuous PDR monitoring in patients initiating antiretroviral therapy.

关键词： HIV Pretreatment drug resistance Transmission network Antiretroviral therapy

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li Wei Dong yu-Qi Liu yang wu Da-Xuan Tang Fu-chun Zhang Meng Qiu Qi Hua Jing-yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun jiang Bo Cui jiang-Bin chen yang-Gan wang Hai-Rong wang Qin yu Jing He yi-Lin Mao Xiao-Fang Bin yue Deng yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-ying Zhang Hai-ying Dai Ze-Hua Li ying Xiao You-Zhi Hu Xiao-yu Huang Kun Xing Xin jiang Chao-Feng Liu Jing An Feng-chun Li Tao Tao Jin-Fa jiang ying yang Yao-Rong Dong Lei Zhang Guang Fu ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun ying-Qiang Zhao Jie Li yun Xia Jun Liu Fan Liu Wen-Jin He ying Li jian-Cong Tan yang Lin Ya-Bin Zhou jian-Fei yang guo-Qing Ma Hui-Jun chen He-Ping Liu Zong-wu Liu jian-Xiong Liu Xiao-jia Luo Xiao-Hong Bin Ya-Nan yu Hai-Xia Dang Bing Li Fei Teng wang-Min Qiao Xiao-Long Zhu Bing-Wei chen Qi-Guang chen chun-Ti Shen Yong-yan wang yun-Dai chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu yue Huang Guang-cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei jia Fang-Jun Lu Xiang Ma Lian Tao Wei Zhang Li chen Li-Ming Song Ti-Pei Li yu-Peng Xu Xue-Lei Cao Yong chen Cong-Zhan Liu Ce Cai Zhi Chang Gang chen Tian-Xiang chen yi-Bao chen yu-Peng chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong yuan-yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-yu Ge yu-Dong Gu Ju Guan cheng-cheng guo Da-Wei Han jia Huo Lu-Hua jiang Wei-chun jiang Jing Jin Yong-Jie Jin Ling-Da Kong Bing Li cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li Xu-Fang Li yang-guo Li Zheng-Wei Li Xiao-Hua Liang Jing-yuan Liao Bai-Sheng Liu guo-Qing Liu Hong-Wei Liu Xiao-Jing Liu yi-Nong Liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng yi Nang jian-yin Nie Ge Ou Na Sai Ren-cheng Shang Xin-ying Song Liang Sun ying Tan You-Li Tuo chen wang guo-Feng wang Juan wang Ling-Jun wang Weng-Shuai wang yu-Sa wang Xiang-yang Wen Bai-yang wu Bo-Bing wu Mei wu Shuo Xiao Shao-Lin Xiong He Xu jia-Wei yang Sheng yang yan-Ji yang yi-Jung yang Qi-Bin yi Qian-Qing yin yuan You Ai-Mei Zhang cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang yi Zhang yi-Fei Zhang Yong-Jie Zhang yuan-Hang Zhang yue Zhang Zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou yu-Xuan Zhu Ren-Lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of China

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第4期34卷 469-475页

作者： jian-qiang Cai Shou-wang Cai Wen-ming Cong Min-shan chen Ping chen Xiao-ping chen yan-ling chen yi-fa chen Chao-liu Dai Qiang Huang Zhi-yong Huang Bo jiang Bin jiang Ke-wei jiang Bo Li Zong-fangLi Li-jian Liang Bin Liu Hui-chun Liu Lian-xin Liu Qing-guang Liu Rong Liu ying-bin Liu jian-guo Lu Shi-chun Lu yi Lu yi-lei Mao Bin Mei Jun Niu Bao-gang Peng Xiao Qin yu-dong Qiu Guang-yi wang Yao-don wangg Zhi-ming wang Ren-hua Wan Ya-fu wu Bao-cai Xing Feng Xia Ge-liang Xu jia-mei yang Xiao-fang yu Yong Zeng Yong-yi Zeng Bi-xiang Zhang Bin-hao Zhang Qi-yu Zhang shui-jun Zhang Wan-guang Zhang Yong-jie Zhang Zhi-wei Zhang Dong Zhou Wei-ping Zhou Cancer Institute and Hospital Chinese Academy of Medical Sciences Chinese PLA General Hospital Eastern Hepatobiliary Surgery Hospital of Second Military Medical University Sun Yat-sen University Cancer Center Daping Hospital of Third Military Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Fujian Medical University Union Hospital Shengjing Hospital of China Medical University Anhui Provincial Hospital Hunan Provincial People’s Hospital Taihe Hospital Affiliated to Hubei University of Medicine Peking University People’s Hospital West China Hospital Sichuan University The Second Affiliated Hospital of Xi’an jiao Tong University The First Affiliated Hospital Sun Yat-sen University First Affiliated Hospital of Kunming Medical University The First Affiliated Hospital of Bengbu Medical College The First Affiliated Hospital of Harbin Medical University The First Affiliated Hospital of Xi’an jiao Tong University Xinhua Hospital Affiliated to Shanghai jiao Tong University School of Medicine Tangdu Hospital of Fourth Military Medical University Peking Union Medical College Hospital Qilu Hospital of Shandong University The First Affiliated Hospital of Guangxi Medical University Nanjing Drum Tower Hospital The First Affiliated Hospital of Jilin University Fujian Provincial Hospital Xiangya Hospital of Central South University The First Affiliated Hospital of Nanchang University Beijing Cancer Hospital Southwest Hospital of Third Military Medical University Shenzhen People’s Hospital The First Affiliated Hospital of Fujian Medical University The First Affiliated Hospital of Wenzhou Medical University The First Affiliated Hospital of Zhengzhou University Fujian Provincial Cancer Hospital

Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma （ICC） and extrahepatic cholangiocarcinoma （ECC）. ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct.

关键词： A Consensus from Surgical Specialists of China Diagnosis and Treatment of Cholangiocarcinoma