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Chinese Journal of Chemical Engineering 2024年第4期68卷 263-275页

作者： Kejin Li Jiahui Liu Dajian Li xiaolan chen Chunhui Zhou Research Group for Advanced Materials&Sustainable Catalysis(AMSC) State Key Laboratory Breeding Base of Green Chemistry-Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310032China Qing Yang Institute for Industrial Minerals Qingyang 242804China Engineering Research Center of Non-metallic Minerals of Zhejiang Province Zhejiang Institute of Geology and Mineral ResourcesHangzhou 310007China

Microreactors are increasingly used for green and safe chemical processes owing to their benefits of superior mass and heat transfer,increased yield,safety,and simplicity of ***,immobilizing catalysts in microreactors remains *** this investigation,a technique for creating Cu_(2)O/montmorillonite catalyst coating,using electrostatic attraction for layer-by-layer self-assembly,was *** montmorillonite film's morphology and thickness could be efficiently regulated by adjusting the degree of exfoliation and surface charge of montmorillonite,alongside layer-by-layer coating *** Cu_(2)O nanoparticles were immobilized using the flow deposition *** resulting Cu_(2)O@montmorillonite-film-coated capillary microreactor successfully transformed glycerol into *** conversion of glycerol and product selectivity could be controlled by adjusting the molar ratio of reactants,temperature,residence time,and Cu_(2)O *** maximum glycerol conversion observed was 47.6%,with a 27%selectivity toward *** study presents a technique for immobilizing montmorillonite-based catalyst coatings in capillary tubing,which can serve as a foundation for the future application of microreactors in glycerol conversion.

关键词： Microreactor Coating Montmorillonite Glycerol Cu_(2)O

Metal-Free Electrochemical Trifluoromethylation of Imidazole-Fused Heterocycles with Trifluoromethyl Thianthrenium Triflate

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Chinese Journal of Chemistry 2024年第15期42卷 1679-1685页

作者： Chang Ge Lipeng Qiao Yuyang Zhang Kai Sun jangzhen An Mei Peng xiaolan chen Lingbo Qu Bing Yu College of Chemistry Zhengzhou UniversityZhengzhouHenan 450001China National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass Nanjing Forestry UniversityNanjingJiangsu210037China School of Pharmacy Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

A novel and eco-friendly electrochemical activation of trifluoromethyl thianthrenium triflate(TT-CF_(3)^(+)OTf^(-))for trifluoromethylation of imidazole-fused heteroaromatic compounds was *** method involves the direct electrolysis of TT-CF_(3)^(+)OTf^(-)without the requirement of external oxidants or catalysts,aligning with the principles of green chemistry.A wide range of imidazole-fused heteroaromatic compounds including imidazo[1,2-a]pyridines and benzo[d]imidazo[2,1-b]thiazoles have been successfully trifluoromethylated using this technique,exhibiting excellent compatibility with various functional groups and a broad substrate ***,the method's applicability for one-pot sequential reactions enables the reduction of waste and resource consumption by eliminating the need for intermediate purification steps.

关键词： Trifluoromethylation Electrochemical Metal-free Imidazole-fused heterocycles Thianthrenium

Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

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Nano Research 2024年第1期17卷 270-281页

作者： Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo xiaolan chen State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen UniversityXiamen 361102China The High Educational Key Laboratory for Biomedical Engineering&Key Laboratory of Fire Retardant Materials of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

Lactic acid(LA)plays a major role in the occurrence,development,and spread of *** by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor *** detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic ***,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic *** importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in *** together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor ***,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward.

关键词： lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

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吃的隐喻——近代中英海外游记中的食物再现

中国比较文学 2024年第3期 221-235页

作者：陈晓兰上海大学文学院

旅行者不只运用视觉凝视异国,也通过味觉品尝异国。18世纪末英国访华使团的使华记述、19世纪后期清朝使臣的出使欧美记,对于中餐、西餐以及中西食物之道和待客之道的再现,为窥视近代中西相遇中的饮食问题和文化差异提供了独特的维度。... 详细信息

旅行者不只运用视觉凝视异国,也通过味觉品尝异国。18世纪末英国访华使团的使华记述、19世纪后期清朝使臣的出使欧美记,对于中餐、西餐以及中西食物之道和待客之道的再现,为窥视近代中西相遇中的饮食问题和文化差异提供了独特的维度。这些异域游记记录了来自东西两大帝国的使者们带着既定的知识武装和消化系统走向对方,初遇异国食物时的生理、心理反应,对于异国饮食之道和待客之道的复杂感受,对于食物的生产、分配、消费制度和文化习俗的评价,反映了早期中西相遇中巨大的文化差异和难以调和的分歧,折射出不平等的国际关系在餐桌上的体现。

关键词：吃的隐喻食物再现英使访华记晚清出使记

A Clinical Observation Report on Prenatal Management and Postnatal Treatment of Congenital Granular Cell Epulis

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Maternal-Fetal Medicine 2024年第2期6卷 102-105页

作者： Feng Qin Xiaochuan Xu Yong Yang Qiong Li Ting Huang Xiaoyan chen xiaolan chen Yamin Liu Gongli chen Department of Gynecology and Obstetrics Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 401147China Department of Pathology Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 401147China

Introduction Congenital granular cell epulis(CGCE)is a rare,benign tumor that manifests on the mucosal surface of the alveolar ridge in *** was initially described by Neumann in 1871 and has been referred to by various names such as congenital epulis,congenital epulis of the newborn,and congenital granular cell tumor.1 Documentation on larger tumors is limited and reported diameters vary.2 Diagnosis necessitates histological examination and immunohistochemical staining,typically revealing negative immunoreactivity for S-100 and cluster of differentiation 68(CD68).3,4 This article presents a case of CGCE with weakly positive S-100 and CD68 staining,alongside a relatively large ***,it conducts a literature review on diverse aspects,encompassing multidisciplinary prenatal diagnosis,antenatal management,choice of delivery mode during childbirth,and postnatal treatment,with the objective of augmenting clinicians’comprehension of the *** study adhered to the guidelines of the Declaration of Helsinki and obtained informed consent from the patient and approval from the medical ethics committee of Chongqing Health Center for Women and Children.

关键词： Congenital epulis Fetal Immunohistochemical Prenatal management Postnatal treatment

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2215-2230页

作者： Wei Zhu Zhiming Zhang Jinzhang chen xiaolan chen Lei Huang Xiaoyong Zhang Xuan Huang Na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang Guosheng Yuan Mengya Zang Qi Li Xiaotao Jiang Yajing He Sha Wu Yukai He Yongyin Li Jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was established,and TCR-T armed with the novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phenotype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： hepatocellular TCR utilize

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酒店官网和OTA渠道博弈研究

中国管理科学 2024年第1期32卷 242-250页

作者：郭强陈小兰赵新元海南大学旅游学院海南海口570228 澳门科技大学博雅学院中国澳门特别行政区999078

酒店对在线旅游代理商(online travel agent,OTA)的话语权主要表现为佣金议价权和客房定价权。以酒店聚焦官网运营战略来重掌对OTA的话语权为背景,针对官网和OTA渠道博弈问题,以常被忽视的成本因素为决策变量构建一对一博弈模型,讨论了... 详细信息

酒店对在线旅游代理商(online travel agent,OTA)的话语权主要表现为佣金议价权和客房定价权。以酒店聚焦官网运营战略来重掌对OTA的话语权为背景,针对官网和OTA渠道博弈问题,以常被忽视的成本因素为决策变量构建一对一博弈模型,讨论了单渠道官网模式、双渠道净价模式、双渠道佣金模式三种模式下酒店收益最优的实现条件。研究发现:首先,酒店实现收益最优不一定要与OTA合作,一定条件下酒店采用单渠道官网模式就能够实现最优。其次,酒店决定与OTA合作时,运用双渠道净价模式能够实现利润最大化,其实现条件可分为两种情况。最后,酒店在双渠道净价模式下实现收益最优时,仅能满足OTA参与约束,无法实现激励相容。

关键词：双渠道供应链佣金模式净价模式 OTA 营销努力

基于病床工作效率法和床位产出效率的床位优化配置研究

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中国医院 2024年第10期28卷 101-104页

作者：陈晓兰张雅婷湖南省人民医院(湖南师范大学附属第一医院) 湖南省长沙市410000

目的:从病床工作效率以及产出效率对某医院2023年内外科情况做整体评估,为医院床位管理及相关医疗资源配置提供依据,使医院的医疗资源利用最大化。方法:提取样本医院2023年临床科室医疗质量统计报表中相关指标数据,运用病床工作效率指... 详细信息

目的:从病床工作效率以及产出效率对某医院2023年内外科情况做整体评估,为医院床位管理及相关医疗资源配置提供依据,使医院的医疗资源利用最大化。方法:提取样本医院2023年临床科室医疗质量统计报表中相关指标数据,运用病床工作效率指标计算各科室平均开放床位数95%的置信区间;从床位产出角度将床位有效RW值计算床位产出效率,兼顾工作效率与产出效率;为了方便统计,以病区为单位进行统计。结果:默认床位有效或者产出有效均可,所以被统计的88个临床科室中,27个科室床位设置合理,14个科室需要增加床位,46个科室需要适量减少床位。结论:新医改背景下,特别是随着DRG/DIP的支付体系逐步完善,床作为医院重要的投入资源之一,它的效率与产出发挥着重要的作用,医院应结合各专业临床特点动态调整床位,发展优势学科,加强双向转诊,床位资源共享,从而更有效地利用病床资源,创造良好的社会效益和经济效益。

关键词：床位工作效率床位产出效率床位有效率

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铁观音中降解β-胡萝卜素菌株的筛选及其陈香提升应用

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食品与发酵工业 2024年第6期50卷 122-129页

作者：杨小雪彭政蒋心怡陈成聪蔡宗敏陈晓兰张娟江南大学工业生物技术教育部重点实验室江苏无锡214122 江南大学未来食品科学中心江苏无锡214122 福建安溪铁观音集团股份有限公司福建泉州362441

陈香型铁观音具有独特陈香风味,但其自然陈化周期漫长,提高铁观音的陈香品质并缩短陈化周期具有重要的经济和文化价值。从铁观音中筛选获得3株具有β-胡萝卜素降解能力的菌株并鉴定为Aspergillus niger(HA)、Bacillus velezensis(Hb)、S... 详细信息

陈香型铁观音具有独特陈香风味,但其自然陈化周期漫长,提高铁观音的陈香品质并缩短陈化周期具有重要的经济和文化价值。从铁观音中筛选获得3株具有β-胡萝卜素降解能力的菌株并鉴定为Aspergillus niger(HA)、Bacillus velezensis(Hb)、Saccharopolyspora gregorii(Hc),它们的降解率分别为94.54%、72.97%、61.26%。将菌株投入茶叶进行强化发酵,并测定发酵结束后茶叶的挥发性物质含量和感官品评得分。结果表明,HA和Hb发酵茶样含量提升幅度最大的是酮类化合物,分别提升了128.12%和109.38%;Hc发酵茶样醛类化合物提升幅度最大为61.11%,发酵茶样中的类胡萝卜素降解产物总量也分别提升了1.6、1.4、1.3倍。发酵茶样总体评价均高于对照,同时HA发酵茶样的甜香得分提高,Hb发酵茶样的果香得分提高,Hc发酵茶样的甜香和陈香得分提高。该研究筛选出一株降解β-胡萝卜素的Saccharopolyspora gregorii,成功在短期内实现了铁观音陈香品质的提升。

关键词：铁观音陈香 β-胡萝卜素强化发酵挥发性化合物感官品评

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医学专业英语教学模式的探究

中国继续医学教育 2024年第10期16卷 148-152页

作者：陈小兰潘磊王勇首都医科大学附属北京世纪坛医院呼吸与危重症医学科北京100038

随着我国医学国际化程度越来越高,对医学生的英语水平尤其是专业英语要求也是与日俱增。文章将阐述教师在医学专业英语教学中的感受。涉及医学专业英语现状,教师在医学专业英语教学中的作用,学生在医学专业英语教学中的角色,国内医学专... 详细信息

随着我国医学国际化程度越来越高,对医学生的英语水平尤其是专业英语要求也是与日俱增。文章将阐述教师在医学专业英语教学中的感受。涉及医学专业英语现状,教师在医学专业英语教学中的作用,学生在医学专业英语教学中的角色,国内医学专业英语教学模式进行探讨。打破传统的以教师为中心的教学方式,采用各种新型的教学方式如混合式教学(线下+线上)、以问题为导向的教学、基于案例的学习法、情景教学、跨学科的合作交流等模式进行医学专业英语的教学改革。学生获得知识的同时,授课老师也能从中吸取经验,取长补短。培养具有国际化视野、同时具备科研能力和临床实践能力的医学拔尖创新人才。在“新医科”建设这个大的背景下,以大学医学英语教学为模板,推动教学改革和创新,构建科学的、有医学特色的专业英语教学模式。

关键词：医学专业英语教学改革混合式教学多媒体情景教学