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OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity

International Journal of Ophthalmology(English edition) 2024年第2期17卷 289-296页

作者： Hong-Xia Gong Bin Wu Shi-Yong Xie Wei Zhang Song chen Tianjin Key Lab of Ophthalmology and Visual Science Department of Ophthalmology for Integrated Traditional Chinese and Western MedicineTianjin Eye HospitalTianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300010China Eye Hospital Affiliated to Nankai University Tianjin 300020China

AIM:To observe the retinal and choroidal circulations in patients with non-arteritic permanent central retinal artery occlusion(NA-CRAO)via optical coherence tomography angiography(OCTA)and analyze their correlation with visual ***:Sixty-two eyes with clinically confirmed acute NA-CRAO were included in the study and divided into:A type(mild n=29),B type(moderate n=27)and C type(severe n=6)based on the degree of visual loss,retinal edema,and arterial blood flow delay in fundus fluorescence angiography(FFA).Contralateral healthy eyes were used as the control ***-corrected visual acuity(BCVA),slit lamp microscopy,indirect ophthalmoscopy,fundus color photography,OCTA,and FFA were ***’s correlation analysis was used to determine the correlations between retinal and choroidal vessels and visual ***:There were no statistically significant differences in age,gender,and intraocular pressure among the three types and the control group(P>0.05).Vessel density in deep capillary plexus(VD-DCP)significantly decreased(P<0.05)in all three types of NA-CRAO patients compared to the control *** density in superficial vascular plexus(VD-SVP)significantly decreased(P<0.05)in type A patients and choriocapillaris flow area significantly decreased(P<0.05)in type B and type C patients compared to the control group;while outer retinal flow areas significantly increased in the type A(P<0.05)and decreased in type C patients(P<0.05).The retinal thickness significantly increased in type C group(P<0.05).The VD-SVP at fovea in the type A was significantly lower than both of type B and *** VD-SVP at nasal parafovea in type A and B was significantly lower than type C(P<0.05).The logMAR BCVA of type A was significantly better than that of type B and C groups(P<0.05).Spearman’s correlation analysis showed that the logMAR BCVA was positively correlated with VD-SVP at fovea(r=0.679,P=0.031)and nasal parafovea(r=0.826,P=0.013).CONCLUSION:OCTA is valua

关键词： non-arteritic central retinal artery occlusion fundus fluorescence angiography optical coherence tomography angiography retinal vessel density visual acuity

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PointSmile: point self-supervised learning via curriculum mutual information

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Science China(Information Sciences) 2024年第11期67卷 121-135页

作者： Xin LI Mingqiang WEI Songcan chen School of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Shenzhen Research Institute Nanjing University of Aeronautics and Astronautics

Self-supervised learning is attracting significant attention from researchers in the point cloud processing field. However, due to the natural sparsity and irregularity of point clouds, effectively extracting discriminative and transferable features for efficient training on downstream tasks remains an unsolved challenge. Consequently, we propose PointSmile, a reconstruction-free self-supervised learning paradigm by maximizing curriculum mutual information(CMI) across the replicas of point cloud objects. From the perspective of how-and-what-to-learn, PointSmile is designed to imitate human curriculum learning, i.e.,starting with easier topics in a curriculum and gradually progressing to learning more complex topics in the curriculum. To solve “how-to-learn”, we introduce curriculum data augmentation(CDA) of point *** encourages PointSmile to follow a learning path that starts from learning easy data samples and progresses to learning hard data samples, such that the latent space can be dynamically affected to create better embeddings. To solve “what-to-learn”, we propose maximizing both feature-and class-wise CMI to better extract discriminative features of point clouds. Unlike most existing methods, PointSmile does not require a pretext task or cross-modal data to yield rich latent representations; additionally, it can be easily transferred to various backbones. We demonstrate the effectiveness and robustness of PointSmile in downstream tasks such as object classification and segmentation. The study results show that PointSmile outperforms existing self-supervised methods and compares favorably with popular fully supervised methods on various standard architectures. The code is available at https://***/theaalee/PointSmile.

关键词： PointSmile self-supervised learning curriculum mutual information point cloud representation learning

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The exploration and practice of low-altitude airspace flight service and traffic management in China

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Green Energy and Intelligent Transportation 2024年第2期3卷 1-8页

作者： Xiangmin Guan Hongxia Shi Dongsong Xu Binhua Zhang Jian Wei Jun chen CAAC Key Laboratory of General Aviation Operation Department of General AviationCivil Aviation Management Institute of ChinaBeijing 100102China Research Institute of Civil Aviation Regulations and Standardization China Academy of Civil Aviation Science and TechnologyBeijing 100028China Department of Technology Platform Phoenix Wings Technology(Shen zhen)Co.LtdShenZhen 518054China Shenzhen Highgreat Innovation Technology Development Co. Ltd dShenzhen 518000China School of Engineering and Materials Science Queen Mary University of LondonLondonE14NSUK

Due to the inherent nature of being highly digitalized,networked and intelligent,Unmanned Aerial System(UAS)operations pose a huge challenge to traditional aviation regulation and technical *** to keep safe,efficient and integrated operation for different Airspace users has become a pressing issue faced by civil aviation around the *** paper focuses on the main operational scenarios and characteristics of unmanned aviation development in *** operational characteristics and associated challenges due to diverse low-altitude users are analyzed,including operation concepts,UAS traffic management,technological test and verification,and *** light on the practices in Europe and the United States,this paper summarizes China's practices and progress in low-altitude operations management,and analyzes future technological development needs and trends,as well as feasible implementation pathways and measures based on actual needs.

关键词： UAS Low-altitude airspace UAS traffic management Exploration and practice

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Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors

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Science China Mathematics 2024年

作者： Masataka Iwai chen Jiang Haidong Liu Department of Mathematics Graduate School of Science Osaka University Shanghai Center for Mathematical Sciences & School of Mathematical Sciences Fudan University Department of mathematics Sun Yat-sen University

In this paper,we study Miyaoka-type inequalities on Chern classes of terminal projective 3-folds with nef anti-canonical *** X be a terminal projective 3-fold such that-KXis *** show that if c1（X）·c2（X）≠0,then c1（X）·c2（X）≥1/252;if further X is not rationally connected,then c1（X）·c2（X）≥4/5 and this inequality is *** order to prove this,we give a partial classification of such varieties along with many *** also study the nonvanishing of c1（X）dimX-2·c2（X） for terminal weak Fano varieties and prove a Miyaoka-Kawamata-type inequality.

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Bhlhe40 protects cochlear hair cell-like HEI-OC1 cells against H_(2)O_(2) ‑triggered oxidative injury

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BIOCELL 2024年第6期48卷 991-999页

作者： LITING WEN XIAOXIA ZENG PEIXIONG chen DAPENG ZHAO YANGYANG LI XIANHAI ZENG Department of Otorhinolaryngology Longgang Otorhinolaryngology Hospital and Shenzhen Key Laboratory of OtorhinolaryngologyShenzhen Institute of OtorhinolaryngologyShenzhenChina

Background:Cochlear hair cell injury is a common pathological feature of hearing *** basic helix-loop-helix family,member e40(Bhlhe40),a gene belonging to the basic helix-loop-helix(bHLH)family,exhibits strong transcriptional repression ***:Oxidative damage,in House Ear Institute-Organ of Corti 1(HEI-OC1)cells,was caused using hydrogen peroxide(H2O2).The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 *** assays including cell counting kit-8(CCK-8),terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay(TUNEL),ﬂow cytometry,immunoﬂuorescence,and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability,apoptosis,oxidative stress levels,mitochondrial membrane potential and cellular ***,a dual-luciferase reporter assay was performed to conﬁrm the targeting of the histone deacetylases 2(Hdac2)by ***:The results revealed that Bhlhe40 was downregulated in H_(2)O_(2)-treated HEI-OC1 cells,but its overexpression improved cell viability and mitigated H_(2)O_(2)-induced oxidative injury in HEI-OC1 cells with increase of superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GPx)activities and decrease of reactive oxygen species(ROS)***,overexpression of Bhlhe40 suppressed H_(2)O_(2)-triggered cell senescence,as evidenced by the fact that the upregulation of P53,P21,and P16 in HEI-OC1 cells treated with H2O2 were all alleviated by Bhlhe40 *** we further veriﬁed that overexpression of Bhlhe40 could inhibit the expression of Hdac2,which may be related to the repression of Hdac2 ***:This study suggests that Bhlhe40 plays a protective role against senescence and oxidative damage in cochlear hair cells exposed to H2O2.

关键词： Bhlhe40 Oxidative injury Cochlear hair cell Histone deacetylases 2

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Amitriptyline inhibits NLRP3 inflammasome activation via the ASM/CE pathway in a cell model of NAFLD

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BIOCELL 2024年第5期48卷 759-769页

作者： QIN LIU CHUNYAN NIU QIANG ZHANG SHIQIN SUN YUE chen YONGQIANG SHI Shengli Clinical Medical College Fujian Medical UniversityFuzhou350001China Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing211200China Department of Gastroenterology Yancheng Third People’s Hospital(The Yancheng School of Clinical Medicine of Nanjing Medical University)Yancheng224000China Administrative Department of Teaching and Scientific Research Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing211200China

Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(ASM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome identified as pivotal players in lipid disorders and *** study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models,aiming to understand the impact of amitriptyline(Ami),an ASM inhibitor,on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 ***:HepG2 and HL-7702 cells were exposed to free fatty acids(FFAs)to establish the NAFLD *** cells were divided into 5 groups:control group,model group,Ami group,tumor necrosis factoralpha(TNF-α)group,and Ami+TNF-α*** lipid droplets were visualized using Oil Red O staining,and Western blot analysis quantified ASM,NLRP3,and caspase 1 protein *** linked immunosorbent assay(ELISA)was measured CE and ASM levels,while qRT-PCR assessed mRNA *** apoptotic rate was evaluated by flow cytometry(FCM).Results:Following FFAs incubation,significant increases in ASM and CE levels were observed in HepG2 and HL-7702 cells,accompanied by elevated expression of NLRP3,and caspase 1,and IL-1β.TNF-αtreatment further amplified these *** demonstrated a reduction in lipid deposition,suppressed ASM/CE pathway activation,downregulated NLRP3 and caspase 1 expression,and improved ***,MCC950,a selective inhibitor of the NLRP3,mitigated NLRP3,caspase 1,and IL-1βexpression,alleviating lipid deposition and apoptosis in the NAFLD cell ***:The ASM/CE-NLRP3 pathway in NAFLD cells promotes hepatocyte steatosis,inflammation,and cell *** emerges as a promising therapeutic agent by inhibiting the ASM/CE-NLRP3 pathway,underscoring its potential as a key target for NAFLD treatment.

关键词： Nonalcoholic fatty liver disease Hepatocyte Amitriptyline ASM/CE pathway NLRP3 Nonalcoholic steatohepatitis

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急性冠脉综合征患者发生肺部感染的危险因素及其风险预测模型的评估价值

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中华医院感染学杂志 2024年第17期34卷 2613-2616页

作者：曹静杨红红刘琛衡水市人民医院心内科河北衡水053000

目的探究急性冠脉综合征(ACS)患者发生肺部感染的危险因素,并构建风险预测模型。方法选择2021年05月-2023年03月衡水市人民医院诊治的ACS患者554例作为研究对象,依据患者是否合并肺部感染分为感染组68例、未感染组486,多因素Logistic回... 详细信息

目的探究急性冠脉综合征(ACS)患者发生肺部感染的危险因素,并构建风险预测模型。方法选择2021年05月-2023年03月衡水市人民医院诊治的ACS患者554例作为研究对象,依据患者是否合并肺部感染分为感染组68例、未感染组486,多因素Logistic回归分析患者发生肺部感染的危险因素,并构建肺部感染风险预测模型,收集肺部感染患者痰液标本进行病原菌培养,分析病原学分布特征。结果多因素Logistic回归分析表明,有吸烟史、合并慢性阻塞性肺疾病、血红蛋白<90 g/L、左室射血分数≤0.4、侵入性操作、心功能Killip分级Ⅲ~Ⅳ级是患者发生肺部感染的危险因素(P<0.05);根据筛选的危险因素构建的风险预测模型,经受试者工作特征(ROC)曲线分析显示,该模型预测肺部感染的曲线下面积(AUC)值为0.855(95%CI:0.737~0.974),诊断效能较好;68例感染患者痰液标本共分离76株病原菌,其中56株(73.68%)革兰阴性菌,15株(19.74%)革兰阳性菌,5株真菌(6.58%)。结论ACS患者发生肺部感染的危险因素较多,构建的风险预测模型具有良好的预测价值,导致感染的病原菌以革兰阴性菌为主。

关键词：急性冠脉综合征肺部感染危险因素病原菌预测模型受试者工作特征

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Frequency-Bessel multi-mode surface wave tomography utilizing microseisms excited by energetic typhoons

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Science China Earth Sciences 2024年第11期67卷 3436-3447页

作者： Xuping FENG Yingjie XIA Xiaofei chen Department of Earth and Space Sciences Southern University of Science and Technology College of Geophysics Chengdu University of Technology Shenzhen Key Laboratory of Deep Offshore Oil and Gas Exploration Technology Southern University of Science and Technology Guangdong Province Key Laboratory of Geophysical High-resolution Imaging Technology Southern University of Science and Technology Institute of Risk Analysis Prediction and Management Southern University of Science and Technology

The recently developed Frequency-Bessel（F-J） transform array technique has significantly advanced multi-mode surface wave tomography, providing precise constraints on shear wave velocity（VS） models of the crust and uppermost *** technique has primarily focused on extracting inter-station surface waves from ambient noise cross-correlation. Energetic typhoons generate abundant surface wave signals, prompting growing interest in utilizing these signals to investigate subsurface structures. This study explores the feasibility and application of using microseisms excited by strong typhoons for F-J transform surface wave tomography. By analyzing microseisms recorded by a broadband seismic array in Mongolia during energetic typhoons, we observed multi-mode surface waves with high signal-to-noise ratios. Our analysis revealed that the sources of these waves closely correspond to typhoon tracks, confirming that they were primarily excited by typhoons. We successfully extracted multi-mode dispersion curves for imaging the VSstructure beneath the array using the F-J transform. Additionally, we derived multi-mode dispersion curves from a two-year noise dataset recorded by the same array, which were also used to invert for the VSstructure. Comparison of VSmodels derived from typhoon-induced microseisms and the two-year noise dataset showed negligible differences within the depth range of 0–140 km. Our findings demonstrate the potential value of microseisms generated by energetic typhoons in precisely probing the VSstructure of the crust and uppermost mantle.

关键词： Multi-mode surface wave tomography Typhoon-excited microseisms Frequency-Bessel transform Ambient noise cross-correlation Crustal and uppermost mantle structure

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Highly Stable sp^(2) Carbon-Conjugated Porous Organic Cages

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CCS Chemistry 2024年第1期6卷 149-156页

作者： Fenglei Qiu Xun chen Wenjing Wang Kongzhao Su Daqiang Yuan State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002 College of Chemistry Fuzhou UniversityFuzhouFujian 350116 University of the Chinese Academy of Sciences Beijing 100049

The high-yield synthesis of ultrastable porous organic cages(POCs)by facile methods is highly desirable but *** by highly stable sp^(2) carbon-conjugated(C=C)covalent organic frameworks,we used rational design and synthesized the first family of sp^(2) carbon-linked POCs(sp^(2)c-POCs)with triangular prism shapes by a one-step Knoevenagel reaction that is a high yield[2+3]condensation *** stability of sp^(2)c-POC was demonstrated under strenuous conditions involving for example concentrated HCl or saturated NaOH ***^(2)c-POC was used as a robust adsorbent for efficient separation of CO_(2)/CH_(4) or CO_(2)/N_(2) *** view of their facile synthesis and unique properties,we expect widespread use of these sp^(2) C=C linkages in the development of POC materials.

关键词： porous organic cages Knoevenagel condensation sp^(2)C=C linkage exceptional chemical stability gas adsorption and separation properties

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen Xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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