OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity
作者机构：Tianjin Key Lab of Ophthalmology and Visual Science Department of Ophthalmology for Integrated Traditional Chinese and Western Medicine Tianjin Eye Hospital Tianjin 300020 China Clinical College of Ophthalmology Tianjin Medical University Tianjin 300010 China Eye Hospital Affiliated to Nankai University Tianjin 300020 China
出 版 物：《International Journal of Ophthalmology》
年 卷 期：2024年第17卷第2期
主 题：non-arteritic central retinal artery occlusion fundus fluorescence angiography optical coherence tomography angiography retinal vessel density visual acuity
摘 要：AIM To observe the retinal and choroidal circulations in patients with non-arteritic permanent central retinal artery occlusion (NA-CRAO) via optical coherence tomography angiography (OCTA) and analyze their correlation with visual acuity. METHODS Sixty-two eyes with clinically confirmed acute NA-CRAO were included in the study and divided into: A type (mild n =29), B type (moderate n =27) and C type (severe n =6) based on the degree of visual loss, retinal edema, and arterial blood flow delay in fundus fluorescence angiography (FFA). Contralateral healthy eyes were used as the control group. Best-corrected visual acuity (BCVA), slit lamp microscopy, indirect ophthalmoscopy, fundus color photography, OCTA, and FFA were performed. Spearman s correlation analysis was used to determine the correlations between retinal and choroidal vessels and visual acuity. RESULTS There were no statistically significant differences in age, gender, and intraocular pressure among the three types and the control group ( P 0.05). Vessel density in deep capillary plexus (VD-DCP) significantly decreased ( P 0.05) in all three types of NA-CRAO patients compared to the control group. Vessel density in superficial vascular plexus (VD-SVP) significantly decreased ( P 0.05) in type A patients and choriocapillaris flow area significantly decreased ( P 0.05) in type B and type C patients compared to the control group; while outer retinal flow areas significantly increased in the type A ( P 0.05) and decreased in type C patients ( P 0.05). The retinal thickness significantly increased in type C group ( P 0.05). The VD-SVP at fovea in the type A was significantly lower than both of type B and C. The VD-SVP at nasal parafovea in type A and B was significantly lower than type C ( P 0.05). The logMAR BCVA of type A was significantly better than that of type B and C groups ( P 0.05). Spearman s correlation analysis showed that the logMAR BCVA was positively correlated with VD-SVP at fovea ( r