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Epidemiology of hepatitis B virus infection among young adults in Taiwan,China after public vaccination program

Chinese Medical Journal 2007年第13期120卷 1155-1158页

作者： chen Chun-Chieh YEN Chi-Hua WU Wei-Ya HU Suh-Woan chen shiuan-chih William R. Bell LEE Meng-chih Department of Family Medicine Chung Shan Medical University Hospital Taichung 402 Taiwan China Institute of Stomatology Chung Shan Medical University Hospital Taichung 402 Taiwan China Department of Haematology The Johns Hopkins University School of Medicine Baltimore Maryland USA Institute of Medicine Chung Shan Medical University Taichung 402 Taiwan China Visiting Professor Tongji Medical College Huazhong University of Science and Technology and Xi＇an Jiaotong University China

Background The public vaccination program of hepatitis B virus （HBV） was launched during 1984 in Taiwan, China. However, the long-lasting protective efficacy of HBV vaccination among adolescents older than 15 years of age was seldom recorded. Methods A seroepidemiological survey was conducted among 4575 first-year university students in Taiwan, China during 2000 to 2003, including the serological data of HBV by testing HBV surface antigen （HBsAg）, surface antibody （anti-HBs）, HBV core antibody （anti-HBc） and demographic information. Results HBsAg carrier rate among male university students born before the initiation of the HBV vaccination program decreased from 12.8% to 4.8% among those born after the vaccination program （P〈0.001, Х^2 test for linear trend）. Similarly, HBsAg carrier rate among female university students born before the initiation of the HBV vaccination program decreased from 8.1% to 2.7% among those born after the vaccination program （P〈0.001, Х^2 test for linear trend）. Both male and female students in eastern Taiwan had the highest HBsAg carrier rate compared with the other places. Using multiple logistic regression analysis, compared with students born after July 1984, the adjusted OR of HBsAg carrier rate decreased from 3.10 for students born before June 1981 to 1.56 for students born from July 1983 to June 1984 （95% CI 1.96-4.91, P〈0.001; 95% CI1.06-2.28, P=0.024; respectively）. Conclusions Public vaccination provides long-lasting protection again HBV infection among the university students in Taiwan, China older than 18 years of age. There is a geographic variation of HBV infection among young adults in Taiwan China.

关键词： hepatitis B virus epidemiology adolescent vaccination

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Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Shraboni Dey Tanni Sethi Sowmya Sagireddy Jawaria Chatta Ashish Goel Sneha Nagpaul Eric Pin-shiuan chen Chiranjeeve Saravanan Sheeja Gangan Joel Thomas Sarah Potiguara Vignesh K Nagesh Daniel Elias Charlene Mansour Prajakta H Ratnaparkhi Priyanshu Jain Midhun Mathew Taylor Porter Shadiya Sultan Shailaja Abbisetty Linh Tran Megha Chawla Abraham Lo Simcha Weissman Christina Cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Therapy John Theurer Cancer CenterHackensackNJ 07601United States

BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare and aggressive peripheral T-cell lymphoma with historically dismal outcomes,representing less than one percent of non-Hodgkin *** its rarity,the true incidence of HSTCL is unknown and most data have been extrapolated through case *** the best of our knowledge,the largest and most up to date study addressing the epidemiology and outcomes of patients with HSTCL in the United States covered a period from 1996 to 2014,with a sample size of 122 *** To paint the most updated epidemiological picture of *** A total of 186 patients diagnosed with HSTCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from the Surveillance,Epidemiology,and End Results *** analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with a P value<0.01 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio of greater than 1 representing adverse prog-nostic *** Overall,the outlook for this rare malignancy is very *** this retrospective cohort study of the United States population,non-Hispanic blacks and the elderly had a higher *** data highlights the need for larger prospective studies to investigate factors associated with worse prognosis in one ethnic group,such as treatment delays,which have been shown to increase mortality in this racial/ethnic group for other cancers.

关键词： Extra nodal lymphoma Mortality Survival Racial disparity Age

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Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats

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World Journal of Gastroenterology 2013年第18期19卷 2761-2771页

作者： Yu-Feng Tian chih-Tsueng He Yu-Ting chen Po-shiuan Hsieh Division of General Surgery Department of Surgery Yung Kung Campus Chi-Mei Medical Center Department of Health and Nutrition Chia Nan University of Pharmacy and Science Tainan 717 Taiwan Division of Endocrinology and Metabolism Department of Internal Medicine Tri-Service General Hospital Taipei 114 Taiwan Department of Physiology and Biophysics National Defense Medical Center Department of Medical Research Tri-Service General Hospital Taipei 114 Taiwan

AIM: To examine the effect of α-lipoic acid (LA) on mild portal endotoxemia-induced steatohepatitis and associated pancreatic abnormalities in fructose-fed rats. METHODS: Rats were randomly assigned into two groups with a regular or 60% fructose-enriched diet for 8 wk. After fructose feeding for 4 wk, rats were further divided into four subgroups: with intraportal saline (F PV ), with intraportal saline plus administration of LA (F PV + LA ), with lipopolysaccharide (LPS) infusion (F PLPS ), and with LPS infusion plus administration of LA (F PLPS + LA ). Rats were treated with LPS using intraportal infusion while LA was administered orally. Metabolite levels, superoxide levels, inflammatory markers, malondialdehyde content, glutathione content and toll-like receptor 4 (TLR4 ) gene expression were all measured using standard biochemical techniques. Pancreatic insulin secretion was evaluated by a hyperglycemic clamp technique. Histology of liver and pancreas tissues were evaluated using hematoxylin and eosin staining and immunohistochemistry. RESULTS: Fructose-induced elevation in plasma C-reactive protein, amylase, superoxide, white blood cell count as well as in hepatic and pancreatic contents of malondialdehyde, tumor necrosis factor alpha and interleukin-6 were increased in animals treated with LPS and reversed with LA administration. The augmented hepatic gene expression of TLR4 in fructose-fed rats was further increased in those with intraportal LPS infusion, which was partially reversed by LA administration. Pathological examination showed inflammatory changes and leukocyte infiltration in hepatic and pancreatic islets of animals treated with LPS but were rarely observed in those with LA treatment. In addition to affects on the liver, impaired pancreatic insulin secretion seen in fructose-fed rats was deteriorated in with LPS treatment and partially reversed with LA administration. CONCLUSION: These data suggest LA could significantly suppress mild portal-endot

关键词： Lipoic acid Oxidative stress Steatohepatitis Portal endotoxemia Insulin secretion Fructose

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A comparative study of pancreas transplantation between type 1 and 2 diabetes mellitus

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 443-453页

作者： Bor-shiuan Shyr Bor-Uei Shyr Shih-Chin chen Che-Chuan Loong Yi-Ming Shyr Shin-E Wang Division of General Surgery Department of SurgeryTaipei Veterans General Hospitaland National Yang Ming UniversityTaipei Division of Transplant Surgery Department of SurgeryTaipei Veterans General Hospitaland National Yang Ming UniversityTaipei

Background:Pancreas transplantation remains the best long-term treatment option to achieve physiological euglycemia and insulin independence in patients with labile diabetes mellitus(DM).It is widely accepted as an optimal procedure for type 1 DM(T1DM),but its application in type 2 DM(T2DM)is not unanimously ***:In total,146 diabetes patients undergoing pancreas transplantation were included in this *** data and outcomes were compared between the T1DM and T2DM ***:Majority(93%)of the pancreas transplantations in T2DM were for uremic *** occurred in 106(73%)patients,including 70(48%)with early complications before discharge and 79(54%)with late complications during follow-up ***,rejection of pancreas graft occurred in 37(25%)*** rejection rate in T2DM recipients was significantly lower than that in *** short-and long-term outcomes for endocrine function in terms of fasting blood sugar and hemoglobin A1c levels and graft survival rates are comparable between the T2DM and T1DM ***:T2DM is not inferior to T1DM after pancreas transplantation in terms of surgical risks,immunological and endocrine outcomes,and graft survival ***,pancreas transplantation could be an effective option to treat selected uremic T2DM patients without significant insulin resistance.

关键词： Type 2 diabetes mellitus(T2DM) pancreas transplantation

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Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction

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Neural Regeneration Research 2020年第5期15卷 922-928页

作者： Dao-Xia Guo Zheng-Bao Zhu Chong-Ke Zhong Xiao-Qing Bu Li-Hua chen Tan Xu Li-Bing Guo Jin-Tao Zhang Dong Li Jian-Hui Zhang Zhong Ju Chung-shiuan chen Jing chen Yong-Hong Zhang Jiang He Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLAUSA Department of Neurology Siping Central HospitalSipingJilin ProvinceChina Department of Neurology the 88th Hospital of People’s Liberation ArmyTaianShandong ProvinceChina Department of Internal Medicine Feicheng City People’s HospitalFeichengShandong ProvinceChina Department of Neurology Tongliao Municipal HospitalInner Mongolia Autonomous RegionChina Department of Neurology Kerqin District First People’s Hospital of Tongliao CityInner Mongolia Autonomous RegionChina Department of Medicine Tulane University School of MedicineNew OrleansLAUSA

Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic *** C (CysC) has been found to be a neuroprotective factor in animal ***,the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different *** prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 *** from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after *** to the MMSE score,308 patients (52.9%) had post-stroke cognitive *** adjusting for potential confounding factors,the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30–0.98),compared with the lowest *** correlation between serum CysC and cognitive dysfunction was modified by renal function *** observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (Plinearity = 0.044),but not in those with abnormal renal *** serum CysC levels were correlated with a low risk of 3-month cognitive dysfunction in patients with acute ischemic stroke,especially in those with normal renal *** current results suggest that CysC is a protective factor for post-stroke cognitive dysfunction,and could be used to treat post-stroke cognitive *** CATIS study was approved by the Institutional Review Boards at Soochow University from China (approval No.2012-02) on December 30,2012,and was registered at *** (identifier ***01840072) on April 25,2013.

关键词： abnormal renal function cognitive dysfunction cystatin C ischemic stroke Mini-Mental State Examination neural regeneration neuroprotective effect normal renal function

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A Face Identification Algorithm using Two Dimensional Binary Principal Component Analysis

A Face Identification Algorithm using Two Dimensional Binary...

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2010 International Symposium on Computer,Communication, Control and Automation

作者： chen-Chung Liu shiuan-You Chin National Chin-Yi university of Technology Department of Electronic Engineering

Face is the most common biometric used by humans, its applications range from static, mug-shot verification to a dynamic, uncontrolled face identification in a cluttered background. The main objective of this paper is to construct an effective human face identification system. The presented algorithm combines the scaling process, histogram equalization process, binary two dimensional principal component analysis (B2DPCA) process, and support vector machine (SVM) scheme to construct a human face identification algorithm. The experimental results show that the presented algorithm has good efficiency for human face identification.

关键词： identification, Binary 2D Principal Component Analysis, histogram equalization

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Hierarchical Clustering Investment Portfolio-An Example Using the Taiex 50 Stocks

Hierarchical Clustering Investment Portfolio-An Example Usin...

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The Seventh International Conference on Information and Management Sciences

作者： Tung-Shou chen Jeanne chen Yi-shiuan Guo Graduate School of Computer Science and Information Technology National Taichung Institute of Technology Taichung404 TaiwanChina

＜正＞In today’s investment environment,investors have many selections of diversified investment methods,such as the stock shares,funds,bonds,and *** Taiex 50 stocks are the collaborative efforts of the Taiwan Stock Exchange（TSEC）and the Financial Times and the London Stock Exchange（FTSE）to select the top 50 stocks based on prices from the Central Trade Market of *** Taiex 50 is a good reference to investors. Although investors have a variety of investing methods, it is still difficult to predict stock values and investment risks in order to get the best investments with higher returns and lower *** proposed method is to use the Taiex 50 stock index as *** hierarchical clustering method is used to analyze the clustering patterns of the Taiex 50 where stocks from the higher cluster plane make the stock *** experimental data are based on historical data for years 2005 and 2006 Price-Earning Ratio（PER）taken from the Taiwan’s Price-book *** portfolio from the clustering analysis shows higher return rates than the Taiex 50 *** clustering analysis portfolio can be used by investors as a reference to select stocks that are of low investment risks and higher returns.

关键词： Hierarchical clustering portfolio Price-Earnings Ration(PER) Price-Book Ratio(PBR) Taiex 50 stocks

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Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation

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Frontiers of Medicine 2010年第1期4卷 59-66页

作者： Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing chen Cashell E.JAQUISH Dabeeru C.RAO James E.HIXSON Jian-Feng HUANG Chung-shiuan chen Charles GU Ji-Chun chen Jie CAO Shu-Feng chen Paul K.WHELTON Jiang HE Dong-Feng GU Department of Evidence-based Medicine and Population Genetics Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Chinese National Human Genome Center at Beijing Beijing 100176China Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA National Heart Lungand Blood InstituteNational Institute of HealthBethesdaMD 20892USA Washington University in St.Louis School of Medicine St.LouisMO 63110USA University of Texas School of Public Health HoustonTX 77030USA Loyola University Medical Center MaywoodIL 60153USA

Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular ***,blood pressure(BP)responses to potassium supplementation vary among *** study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to *** conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north *** measurements were obtained at the end of each intervention period using a random-zero *** identiﬁed signiﬁcant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all P<0.0001)that remained signiﬁcant after adjustment for multiple *** participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A *** addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple *** and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A *** summary,our study identified novel associations between

关键词： blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3)

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Gelsolin can up-regulate the trans-activity of ERa in Her-2/neu over-expressing breast cancer cells

Gelsolin can up-regulate the trans-activity of ERa in Her-2/...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Yuping Li See Wai Kenneth Yau Jingjing Ye Ki Lui Dujin Zhou shiuan chen Third Military Medical University Beckman Research Institute o f City of Hope CA 91010 Beckman Research Institute of City of Hope CA 91010

To better understand the mechanism of ERa-mediated regulation in Her-2/neu overexpressing breast cancer cells, we have searched for cytosolic protein(s) that interacts with ERα.Through immunoprecipitation with ERαantibody and mass spectrometric analysis,we identified the protein gelsolin(GSN) that only interacted with ERa in the estradiol (E2)- treated,ERα-transfected and Her-2/neu over-expressing breast cancer cell line *** is an actin severing protein for cytoskeleton reorganization,cell morphology and *** protein was found to serve as a coactivator when SK-BR-3 cells were transfected with pCI-ERαand pCI-GSN and treated with *** gelsolin-mediated inductive effect was also detected in two additional Her-2/

关键词： gelsolin coactivator ERa Her-2/neu breast cancer cells

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Molecular mechanism of inflammatory pain

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World Journal of Anesthesiology 2014年第1期3卷 71-81页

作者： Yeu-shiuan Su Wei-Hsin Sun chih-cheng chen Department of Life Sciences National Central University Jhongli 32054Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 115Taiwan Taiwan Mouse Clinic-National Phenotyping and Drug Testing Center Academia Sinica Taipei 115Taiwan

Chronic inflammatory pain resulting from arthritis, nerve injury and tumor growth is a serious public health issue. One of the major challenges in chronic inflammatory pain research is to develop new pharmacologic treatments with long-term efficacy and few side effects. The mediators released from inflamed sites induce complex changes in peripheral and central processing by directly acting on transducer receptors located on primary sensory neurons to transmit pain signals or indirectly modulating pain signals by activating receptors coupled with G-proteins and second messengers. High local proton concentration(acidosis) is thought to be a decisive factor in inflammatory pain and other mediators such as prostaglandin, bradykinin, and serotonin enhance proton-induced pain. Proton-sensing ion channels [transient receptor potential V1(TRPV1) and the acid-sensing ion channel(ASIC) family] are major receptors for direct excitation of nociceptive sensory neurons in response to acidosis or inflammation.G-protein-coupled receptors activated by prostaglandin, bradykinin, serotonin, and proton modulate functions of TRPV1, ASICs or other ion channels, thus leading to inflammation- or acidosis-linked hyperalgesia. Although detailed mechanisms remain unsolved, clearly different types of pain or hyperalgesia could be due to complex interactions between a distinct subset of inflammatory mediator receptors expressed in a subset of nociceptors. This review describes new directions for the development of novel therapeutic treatments in pain.

关键词： Acid-sensing ion channel Acidosis G-protein-coupled receptor Inflammation Proton-sensing ion channel Transient receptor potential V1

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