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Ultra-high extinction ratio optical pulse generation with a thin film lithium niobate modulator for distributed acoustic sensing

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Photonics Research 2024年第1期12卷 40-50页

作者： YUAN SHEN XIAOQIAN SHU LINGMEI MA shaoliang YU GENGXIN chen LIU LIU RENYOU GE BIGENG chen YUNJIANG RAO Research Center for Optical Fiber Sensing Zhejiang LaboratoryHangzhou 311100China Research Center for Intelligent Optoelectronic Computing Zhejiang LaboratoryHangzhou 311100China International Research Center for Advanced Photonics College of Optical Science and EngineeringZhejiang UniversityHangzhou 310058China Fiber Optics Research Center(FORC) Key Laboratory of Optical Fiber Sensing and CommunicationsUniversity of Electronic Science and Technology of ChinaChengdu 611731China

We experimentally demonstrate ultra-high extinction ratio(ER)optical pulse modulation with an electro-optical modulator(EOM)on thin film lithium niobate(TFLN)and its application for fiber optic distributed acoustic sensing(DAS).An interface carrier effect leading to a relaxation-tail response of TFLN EOM is discovered,which can be well addressed by a small compensation component following the main driving *** ultrahigh ER>50 dB is achieved by canceling out the tailed response during pulse modulation using the EOM based on a cascaded Mach–Zehnder interferometer(MZI)*** modulated optical_(√)pulses are then utilized as a probe light for a DAS system,showing a sensitivity up to-62.9 dB·rad∕Hz~2(7 pε/Hz)for 2-km single-mode sensing *** crosstalk suppression of 24.9 dB along the fiber is also obtained when the ER is improved from 20 dB to 50 dB,clearly revealing its importance to the sensing performance.

关键词： modulator pulse interferometer

Impact of Coronary Chronic Total Occlusion on Long-term Clinical Outcome in Patients with Unprotected Left Main Disease Undergoing Percutaneous Coronary Intervention

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Cardiology Discovery 2022年第3期2卷 145-151页

作者： Imad Sheiban Filippo Figini Valeria Gaspartto Claudio Moretti Filippo Leonardo shaoliang chen Fabrizio D’Ascenzo Interventional Cardiology P.Pederzoli HospitalPeschiera del GardaVerona 37019Italy Division of Cardiology Chivasso HospitalChivassoTorino 10034Italy Cardiology and Catheter Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology University of TurinTurin 8-10124Italy.

Objectives:Reported data regarding the prevalence,prognostic impact,and safety and efficacy of revascularization of coronary chronic total occlusion(CTO)in patients with left main coronary artery(LMCA)disease who undergo percutaneous coronary intervention(PCI)are *** aim of the present study was to compare clinical outcomes among patients with LMCA disease undergoing *** were compared between those with and without coronary CTO and between those with CTO who had successful and unsuccessful CTO recanalization ***:All consecutive patients with significant LMCA disease(>50%stenosis at coronary angiography)who underwent PCI between July 2014 and December 2018 were retrospectively included in our *** primary endpoint of the study was long-term *** endpoints included the incidence of myocardial infarction,repeat percutaneous or surgical revascularization,stroke,and stent ***:Between July 2014 and December 2018,578 patients underwent PCI for LMCA disease at Pederzoli Hospital and University of Turin were *** were divided into 3 groups:group A:374(65%)patients without CTO,group B:108(19%)patients with untreated or unsuccessfully treated CTO,and group C:96(17%)patients with successfully treated *** a median follow-up of(1090±279)days,there were no statistically significant differences between the groups in terms of the primary and secondary ***,there was a trend towards higher mortality in patients with untreated or unsuccessfully treated CTO(13%vs.19%vs.14%in groups A,B,and C,respectively;P=0.12).The primary and secondary endpoints were further analyzed based on the presence or absence of myocardial viability:subgroup C1:54(56%)patients with successful percutaneous transluminal coronary angioplasty(PTCA)having viability,and subgroup C2:42(44%)patients with successful PTCA not having *** was a trend toward a statistically significant higher rate of death among patients

关键词： Percutaneous coronary interventions Left main coronary artery disease Coronary chronic total occlusion Myocardial viability

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肺动脉去神经术治疗肺动脉高压研究进展

中国科学：生命科学 2022年第5期52卷 767-772页

作者：张航陈绍良南京医科大学附属南京医院南京210029

交感神经过度激活在肺动脉高压(pulmonary arterial hypertension, PAH)的进展中起着重要作用.肺动脉去神经术(pulmonary artery denervation, PADN)是最近提出的利用10个电极的消融导管治疗PAH的介入方法.本综述介绍了肺动脉交感神经... 详细信息

交感神经过度激活在肺动脉高压(pulmonary arterial hypertension, PAH)的进展中起着重要作用.肺动脉去神经术(pulmonary artery denervation, PADN)是最近提出的利用10个电极的消融导管治疗PAH的介入方法.本综述介绍了肺动脉交感神经的定位, PADN的关键步骤,以及目前在PAH或混合型毛细管后和前性肺动脉高压(combined pre-capillary and post-capillary PH, Cpc-PH)患者的临床试验结果.

关键词：肺动脉高压交感神经肺动脉去神经术消融 10个电极的消融导管临床试验

A New Coronavirus Estimation Global Score for Predicting Mortality During Hospitalization in Patients with COVID-19

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Cardiology Discovery 2022年第2期2卷 69-76页

作者： Hesong Zeng Xingwei He Wanjun Liu Jing Kan Liqun He Jinhe Zhao Cynthia chen Junjie Zhang shaoliang chen Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhanHubei 430030China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Wuhan First HospitalWuhanHubei 430022China Division of Cardiology Tianyou Hospital affiliated to Wuhan University of Science&TechnologyWuhanHubei 430064China Mailman School of Public Health Columbia UniversityNew YorkNew York 10027USA College of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210002China.

Objective:Coronavirus disease 2019(COVID-19)exists as a *** during hospitalization is multifactorial,and there is urgent need for a risk stratification model to predict in-hospital death among COVID-19 *** we aimed to construct a risk score system for early identification of COVID-19 patients at high probability of dying during in-hospital ***:In this retrospective analysis,a total of 821 confirmed COVID-19 patients from 3 centers were assigned to developmental(n=411,between January 14,2020 and February 11,2020)and validation(n=410,between February 14,2020 and March 13,2020)*** on demographic,symptomatic,and laboratory variables,a new Coronavirus estimation global(CORE-G)score for prediction of in-hospital death was established from the developmental group,and its performance was then evaluated in the validation ***:The CORE-G score consisted of 18 variables(5 demographics,2 symptoms,and 11 laboratory measurements)with a sum of 69.5 ***-of-fit tests indicated that the model performed well in the developmental group(H=3.210,P=0.880),and it was well validated in the validation group(H=6.948,P=0.542).The areas under the receiver operating characteristic curves were 0.955 in the developmental group(sensitivity,94.1%;specificity,83.4%)and 0.937 in the validation group(sensitivity,87.2%;specificity,84.2%).The mortality rate was not significantly different between the developmental(n=85,20.7%)and validation(n=94,22.9%,P=0.608)***:The CORE-G score provides an estimate of the risk of in-hospital *** is the first step toward the clinical use of the CORE-G score for predicting outcome in COVID-19 patients.

关键词： Hospital mortality Coronavirus estimation global score COVID-19 Goodness-of-fit Receiver operating characteristics Risk stratification

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基于分时电价的虚拟电厂经济性优化调度

电网技术 2016年第3期40卷 826-832页

作者：袁桂丽陈少梁刘颖房方华北电力大学控制与计算机工程学院北京市昌平区102206

大规模不可控新能源和可控能源构建成虚拟电厂,可以降低新能源入网时,其输出功率不确定性对电网安全的影响,提高供电可靠性。配电网分时电价可以激励虚拟电厂参与电网削峰填谷,降低发电成本,获得更好的效益。为此设计了基于分时电价的... 详细信息

大规模不可控新能源和可控能源构建成虚拟电厂,可以降低新能源入网时,其输出功率不确定性对电网安全的影响,提高供电可靠性。配电网分时电价可以激励虚拟电厂参与电网削峰填谷,降低发电成本,获得更好的效益。为此设计了基于分时电价的虚拟电厂运行策略,以各时段内获得收益最大为目标,构建了基于分时电价的虚拟电厂经济性优化调度模型,采用粒子群算法得到虚拟电厂各能源的出力。分析了虚拟电厂可控分布式电源出力系数和不可控分布式电源预测误差对虚拟电厂经济性的影响,对比分析了4种储能系统场景下虚拟电厂的经济性。仿真结果表明所建模型合理,当大规模新能源电力接入电网时,基于分时电价的虚拟电厂采用抽水蓄能和储能电池联合运行,能获得更好的经济效益和电能质量。

关键词：虚拟电厂新能源分时电价运行策略优化调度模型抽水蓄能储能电池

Antiviral Abidol is Associated with the Reduction of In-Hospital Mortality in COVID-19 Patients

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Cardiology Discovery 2021年第1期1卷 37-43页

作者： Hesong Zeng Xingwei He Wanjun Liu Jing Kan Liqun He Jinhe Zhao Cynthia chen Junjie Zhang shaoliang chen Department of Cardiology Tongji HospitalTongji Medical CollegeHuazhong Univerisity of Science&TechnologyWuhan 430030China Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Cardiology Wuhan First HospitalWuhan 430022China Department of Cardiology Tianyou Hospital Affiliated to Wuhan University of Science&TechnologyWuhan 430064China Mailman School of Public Health Columbia UniversityNewYorkNew York 10027USA College of Pharmacy Nanjing Medical UniversityNanjing 210002China

Objective:Coronavirus disease 2019(COVID-19)is a global public health *** are no specific antiviral agents for the treatment of *** regarding the effect of Abidol on in-hospital mortality is *** present study aimed to evaluate the treatment effect of Abidol for patients with COVID-19 before and after propensity score matching(PSM).Methods:This retrospective cohort study analyzed 1019 patients with confirmed COVID-19 in China from December 22,2019 to March 13,*** were divided to Abidol(200mg,tid,5-7days,n=788,77.3%)and No-Abidol(n=231,22.7%)*** primary outcome was the mortality during ***:Among 1019 COVID-19 patients,the age was(60.4±14.5)***-treated patients,compared with No-Abidoltreated patients,had a shorter duration from onset of symptoms to admission,less frequent renal dysfunction,lower white blood cell counts(lymphocytes<0.8)and erythrocyte sending rate,lower interleukin-6,higher platelet counts and plasma IgG and oxygen saturation,and less frequent myocardial *** mortality during hospitalization before PSM was 17.9% in Abidol group and 34.6% in No-Abidol(hazard ratio(HR)=2.610,95% confident interval(CI):1.980–3.440),all seen in severe and critical *** PSM,the in-hospital death was 13.6% in Abidol and 28.6% in No-Abidol group(HR=2.728,95%CI:1.598–4.659).Conclusions:Abidol-treatment results in less in-hospital death for severe and critical patients with *** randomized study is warranted to confirm the findings from this study.

关键词： Abidol Coronavirus induced disease Inflammation In-hospital death

基于Markov模型对我国晚期胰腺癌3种化疗方案的药物经济学研究

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中国药房 2018年第6期29卷 784-789页

作者：汤少梁陈文静南京中医药大学卫生经济管理学院南京210023

目的:评价吉西他滨(G)、吉西他滨联合奥沙利铂(GM)、吉西他滨联合替吉奥(GS)3种方案治疗晚期胰腺癌的经济性。方法:本研究从患者角度出发,构建Markov模型,对我国18~75岁晚期胰腺癌患者接受3种化疗方案的长期成本和健康产出进行计算;采... 详细信息

目的:评价吉西他滨(G)、吉西他滨联合奥沙利铂(GM)、吉西他滨联合替吉奥(GS)3种方案治疗晚期胰腺癌的经济性。方法:本研究从患者角度出发,构建Markov模型,对我国18~75岁晚期胰腺癌患者接受3种化疗方案的长期成本和健康产出进行计算;采用成本-效果分析等方法,结合意愿支付水平(WTP)判断其经济性,并进行敏感性分析。结果:成本-效果分析结果显示,G方案治疗晚期胰腺癌患者成本-效果比(C/E)为145 228.52元/12.26质量调整生命月(QALMs),GM方案的C/E为154 783.88元/11.39 QALMs,GS方案的C/E为315 485.28元/23.26 QALMs,G方案为优选方案。增量成本-效果(ICER)分析结果显示,GS与G方案的ICER为15 479.64,超过本研究设定的WTP(12 563元);而GM与G方案的ICER为-10 999.89,GM属于绝对劣势的方案。敏感性分析结果表明,G方案***方案的ICER结果不稳定,受模型中的参数影响较大;而G方案***方案和GM方案***方案对比的ICER分析结果均较为稳定。G方案较GS方案更具成本-效果;GM方案虽然较GS方案更具经济性,但是优越性相对不明显。结论:在意愿支付水平内,成本-效果分析结果显示吉西他滨单药治疗为最优方案,但敏感性分析结果尚不能确定哪一种方案为最优方案。

关键词：晚期胰腺癌 Markov模型成本-效果分析敏感性分析

Biodistribution of fullerene derivative C_(60)(OH)_x(O)_y

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Chinese Science Bulletin 2001年第19期46卷 1615-1618页

作者： LI Qingnuan, XIU Yan, ZHANG Xiaodong, LIU Ruili, DU Qianqian, SUN Xiaoguang, chen shaoliang & LI Wenxin1. Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China 2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China Shanghai Institute of Nuclear Research Chinese Academy of Sciences Shanghai China Department of Nuclear Medicine Zhongshan Hospital Fudan University Shanghai China

The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C60 derivatives as drugs or drug carriers, a simple water-soluble derivative C60(OH)x(O)y was labeled with 99mTc. A r-counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to find out to what extent the C60 itself determines the biodistribution of derivatives.

关键词： C60(OH)x(O)y 99mTc-labeling activity test SPECT imaging biodistribution.

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ATT7022C在电参数测量中的应用研究

现代电子技术 2020年第24期43卷 13-16页

作者：陈少良田秀霞上海电力大学上海200090

为满足高速发展的社会趋势,设计一种以单片机STC12C5A60S2为控制核心和电能计量芯片ATT7022C为基础的电参数测量终端,并结合Visual Studio 2017开发数据监控界面,其中,主要包括12864液晶显示、存储、RS 232通信等模块,实现了对关键测量... 详细信息

为满足高速发展的社会趋势,设计一种以单片机STC12C5A60S2为控制核心和电能计量芯片ATT7022C为基础的电参数测量终端,并结合Visual Studio 2017开发数据监控界面,其中,主要包括12864液晶显示、存储、RS 232通信等模块,实现了对关键测量数据的实时监控功能。实验结果表明:所测数据均符合误差国家标准GB/T 17215.322—2008《0.2S级和0.5S级静止式有功电能表》要求;该方案具有能耗低、精度高、高效低廉易推广等优点,并且对电网输配电和电力能源结构合理配置具有促进作用,在设计工业及家庭用电智能测量设备及扩展应用方面均有较好的实用价值。

关键词： ATT7022C应用电参数测量方案设计监控界面开发数据监控实验测试