Impact of Coronary Chronic Total Occlusion on Long-term Clinical Outcome in Patients with Unprotected Left Main Disease Undergoing Percutaneous Coronary Intervention

作     者：Imad Sheiban Filippo Figini Valeria Gaspartto Claudio Moretti Filippo Leonardo Shaoliang Chen Fabrizio D’Ascenzo Imad Sheiban;Filippo Figini;Valeria Gaspartto;Claudio Moretti;Filippo Leonardo;Shaoliang Chen;Fabrizio D’Ascenzo

作者机构：Interventional CardiologyP.Pederzoli HospitalPeschiera del GardaVerona 37019Italy Division of CardiologyChivasso HospitalChivassoTorino 10034Italy Cardiology and Catheter LaboratoryNanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of CardiologyUniversity of TurinTurin 8-10124Italy. 

出 版 物：《Cardiology Discovery》 (心血管病探索（英文）)

年 卷 期：2022年第2卷第3期

页      面：145-151页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Percutaneous coronary interventions Left main coronary artery disease Coronary chronic total occlusion Myocardial viability 

摘      要：Objectives:Reported data regarding the prevalence,prognostic impact,and safety and efficacy of revascularization of coronary chronic total occlusion(CTO)in patients with left main coronary artery(LMCA)disease who undergo percutaneous coronary intervention(PCI)are *** aim of the present study was to compare clinical outcomes among patients with LMCA disease undergoing *** were compared between those with and without coronary CTO and between those with CTO who had successful and unsuccessful CTO recanalization ***:All consecutive patients with significant LMCA disease(50%stenosis at coronary angiography)who underwent PCI between July 2014 and December 2018 were retrospectively included in our *** primary endpoint of the study was long-term *** endpoints included the incidence of myocardial infarction,repeat percutaneous or surgical revascularization,stroke,and stent ***:Between July 2014 and December 2018,578 patients underwent PCI for LMCA disease at Pederzoli Hospital and University of Turin were *** were divided into 3 groups:group A:374(65%)patients without CTO,group B:108(19%)patients with untreated or unsuccessfully treated CTO,and group C:96(17%)patients with successfully treated *** a median follow-up of(1090±279)days,there were no statistically significant differences between the groups in terms of the primary and secondary ***,there was a trend towards higher mortality in patients with untreated or unsuccessfully treated CTO(13%vs.19%vs.14%in groups A,B,and C,respectively;P=0.12).The primary and secondary endpoints were further analyzed based on the presence or absence of myocardial viability:subgroup C1:54(56%)patients with successful percutaneous transluminal coronary angioplasty(PTCA)having viability,and subgroup C2:42(44%)patients with successful PTCA not having *** was a trend toward a statistically significant higher rate of death among patients