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新疆兵团水利数据资源整合与共享的设计

价值工程 2023年第5期42卷 55-58页

作者：陈平星新疆兵团勘测设计院(集团)有限责任公司乌鲁木齐830002

伴随着水利信息化的深度发展,数据资源共享与交换的需求越来越迫切。根据当前新疆兵团水利信息化建设的现实情况,本文阐述了在面对存储方式不同、提供方式各异的数据资源情况下,通过采用数据资源的物理集中、逻辑集中以及综合门户网站... 详细信息

伴随着水利信息化的深度发展,数据资源共享与交换的需求越来越迫切。根据当前新疆兵团水利信息化建设的现实情况,本文阐述了在面对存储方式不同、提供方式各异的数据资源情况下,通过采用数据资源的物理集中、逻辑集中以及综合门户网站建设等方式,实现了新疆兵团水利数据资源的整合与共享交换。

关键词：水利信息化数据资源整合与共享数据管理

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新疆兵团水利基础数据库管理系统的设计

价值工程 2023年第15期42卷 12-14页

作者：陈平星新疆兵团勘测设计院(集团)有限责任公司乌鲁木齐830002

随着新疆兵团第一次全国水利普查工作的结束,普查数据的管理与应用成为一项重要的工作任务.本文阐述了新疆兵团水利管理部门以水利普查数据资源为基础,基于SOA架构开发水利基础数据库管理系统实现了水利普查数据的展示检索、统计分析、... 详细信息

随着新疆兵团第一次全国水利普查工作的结束,普查数据的管理与应用成为一项重要的工作任务.本文阐述了新疆兵团水利管理部门以水利普查数据资源为基础,基于SOA架构开发水利基础数据库管理系统实现了水利普查数据的展示检索、统计分析、更新和共享交换等应用.

关键词：水利普查数据库管理系统

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基于三维模型的地名地址管理系统设计与实现

工程建设与设计 2023年第15期 142-144页

作者：陈平星新疆兵团勘测设计院(集团)有限责任公司乌鲁木齐830002

地名地址数据是信息化建设的基础数据,建设地名地址管理系统是一种非常有效的数据管理方式。论文结合地名地址数据的特点,设计了基于三维模型可视化技术的地名地址业务管理系统,实现了地名地址数据的规范化管理和业务应用。

关键词：地名地址三维模型门牌管理系统

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E-PRedictor: an approach for early prediction of pull request acceptance

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Science China(Information Sciences) 2025年

作者： Kexing chen Lingfeng BAO xing HU Xin XIA Xiaohu YANG State Key Laboratory of Blockchain and Data Security Zhejiang University Software Engineering Application Technology Lab

A pull request (PR) is an event in Git where a contributor asks project maintainers to review code he/she wants to merge into a project. The PR mechanism greatly improves the efficiency of distributed software development in the opensource community. Nevertheless, the massive number of PRs in an open-source software (OSS) project increases the workload of developers. To reduce the burden on developers, many previous studies have investigated factors that affect the chance of PRs getting accepted and built prediction models based on these factors. However, most prediction models are built on the data after PRs are submitted for a while (e.g., comments on PRs), making them not useful in practice. Because integrators still need to spend a large amount of effort on inspecting PRs. In this study, we propose an approach named E-PRedictor (earlier PR predictor) to predict whether a PR will be merged when it is created. E-PRedictor combines three dimensions of manual statistic features (i.e., contributor profile, specific pull request, and project profile) and deep semantic features generated by BERT models based on the description and code changes of PRs. To evaluate the performance of E-PRedictor, we collect475192 PRs from 49 popular open-source projects on GitHub. The experiment results show that our proposed approach can effectively predict whether a PR will be merged or not. E-PRedictor outperforms the baseline models (e.g., Random Forest and VDCNN) built on manual features significantly. In terms of F1@Merge, F1@Reject, and AUC (area under the receiver operating characteristic curve), the performance of E-PRedictor is 90.1%, 60.5%, and 85.4%, respectively.

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

盐酸奥洛他定片治疗慢性特发性荨麻疹疗效和安全性的多中心临床研究

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中国医院药学杂志 2017年第16期37卷 1629-1634页

作者：陈岚陈辉陈兴平雷铁池季必华华中科技大学同济医学院附属同济医院湖北武汉430030 武汉大学人民医院湖北武汉430060 皖南医学院弋矶山医院安徽芜湖241001

目的:观察盐酸奥洛他定片治疗慢性特发性荨麻疹的临床疗效及安全性。方法:采用随机、双盲双模拟、阳性药物平行对照、多中心的试验方法,试验组和对照组共纳入150例。分别采用盐酸奥洛他定片,每次1片,每日2次;氯雷他定片,每次1片,每日1... 详细信息

目的:观察盐酸奥洛他定片治疗慢性特发性荨麻疹的临床疗效及安全性。方法:采用随机、双盲双模拟、阳性药物平行对照、多中心的试验方法,试验组和对照组共纳入150例。分别采用盐酸奥洛他定片,每次1片,每日2次;氯雷他定片,每次1片,每日1次,2组分别给予盐酸奥洛他定和氯雷他定模拟片,连续给药4周。疗程结束时以症状体征总积分下降指数、总有效率及疾病总体改善情况等来评估其临床疗效,以不良事件及不良反应、实验室检查来评估其安全性。结果:纳入符合方案分析集(PPS)的病例数为143例,试验组72例,对照组71例。总有效率分别为83.33%和80.28%(P>0.05)。25例患者发生43例次不良事件(试验组14人20例次,对照组11人23例次),其中37例次不良事件与药物相关,主要表现为口干、头晕、嗜睡、乏力、上腹痛、谷丙转氨酶ALT升高、谷草转氨酶AST升高等。2组间不良事件及不良反应发生率差异无统计学意义(P>0.05),无严重不良事件发生。结论:盐酸奥洛他定片治疗慢性特发性荨麻疹,疗效显著,安全性好。

关键词：盐酸奥洛他定氯雷他定慢性特发性荨麻疹多中心临床研究

TAP1及其mRNA在尖锐湿疣皮损中的表达

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中国麻风皮肤病杂志 2005年第3期21卷 172-174页

作者：陈兴平张杏平华中科技大学同济医学院附属同济医院皮肤科武汉430030

目的:通过检测TAP1及其mRNA在尖锐湿疣皮损中的表达情况,进一步探讨尖锐湿疣免疫学发病机制。方法:采用免疫组织化学方法及逆转录-聚合酶链反应(RT-PCR)分别检测TAP1及其mRNA在尖锐湿疣皮损中的表达,并与正常包皮组织作对照。结果:尖锐... 详细信息

目的:通过检测TAP1及其mRNA在尖锐湿疣皮损中的表达情况,进一步探讨尖锐湿疣免疫学发病机制。方法:采用免疫组织化学方法及逆转录-聚合酶链反应(RT-PCR)分别检测TAP1及其mRNA在尖锐湿疣皮损中的表达,并与正常包皮组织作对照。结果:尖锐湿疣皮损中TAP1及其mRNA表达水平与正常包皮组织相比均显著降低。结论:尖锐湿疣皮损中TAP1及其mRNA表达水平显著降低,以致MHC-I类抗原递呈途径存在缺陷,这可能成为人乳头瘤病毒逃逸宿主免疫监视的一条重要途径。

关键词：尖锐湿疣皮损 TAP1 mRNA表达 RNA 正常包皮免疫组织化学方法免疫学发病机制抗原递呈

外排泵基因在白念珠菌生物膜耐药性产生中的作用

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中国皮肤性病学杂志 2008年第9期22卷 519-521页

作者：杨继君陈兴平武汉市华中科技大学同济医学附属同济医院皮肤科湖北武汉430030

目的观察白念珠菌在生物膜形成不同时期对氟康唑的敏感性,及外排泵基因在生物膜耐药性产生过程中的作用。方法采用96孔微量培养皿进行白念珠菌生物膜的培养,用MTT法检测其对氟康唑的敏感性,并用半定量RT-PCR法测定生物膜形成不同时期CDR... 详细信息

目的观察白念珠菌在生物膜形成不同时期对氟康唑的敏感性,及外排泵基因在生物膜耐药性产生过程中的作用。方法采用96孔微量培养皿进行白念珠菌生物膜的培养,用MTT法检测其对氟康唑的敏感性,并用半定量RT-PCR法测定生物膜形成不同时期CDR1、CDR2及MDR1基因表达的差异性。结果白念珠菌生物膜在较早期(2h)对氟康唑仍然敏感(2～4μg/mL),随着白念珠菌生物膜的不断成熟,其耐药性不断增高;CDR1及CDR2基因在生物膜形成的早中期及成熟期的表达明显上调,尤其早期的高表达更为明显,而MDR1基因的表达只在生物膜形成早期有明显的高表达。结论白念珠菌生物膜的耐药性随着其结构的成熟而不断增高;CDR1,CDR2及MDR1基因在生物膜形成早期有明显的高表达,但与生物膜耐药性的增加并不一致。因此,生物膜的耐药性可能是多种机制作用的结果。

关键词：生物膜白念珠菌耐药外排泵