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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan chenzhe Ma Bin Qi Qingqiang min ming Li Huabing chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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实验室模拟真空紫外辐照设备的研制

淮海工学院学报（自然科学版） 2005年第2期14卷 10-13页

作者：陈荣敏严川伟淮海工学院机械工程系江苏连云港222005 中国科学院金属研究所辽宁沈阳110016

为开展真空紫外辐射及真空紫外线与其它空间环境复合效应的地面模拟实验,研制了真空辐照模拟设备。选用氘灯作紫外光源并合理设计光路,简单适用。采用扩散泵和机械泵作高真空抽气系统组成模拟系统,以达到地外紫外线辐照条件。并利用该... 详细信息

为开展真空紫外辐射及真空紫外线与其它空间环境复合效应的地面模拟实验,研制了真空辐照模拟设备。选用氘灯作紫外光源并合理设计光路,简单适用。采用扩散泵和机械泵作高真空抽气系统组成模拟系统,以达到地外紫外线辐照条件。并利用该设备初步进行了有机硅温控涂层的辐照实验,结果表明真空紫外导致其光学性能下降,必须加以防护。

关键词：真空紫外辐照地面模拟氘灯扩散泵

替罗非班在75岁以上老年冠心病患者介入治疗中的应用效果

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中外医疗 2021年第3期40卷 85-87页

作者：杨顺清陈荣敏盐城市第三人民医院心内科江苏盐城224000

目的探究介入治疗中应用替罗非班在75岁以上老年冠心病患者治疗中的应用效果。方法便利选择2015年1月-2019年12月该院收治的接受介入治疗的75岁以上老年冠心病患者76例,将其随机分为两组,其中接受常规治疗患者为对照组(38例),接受替罗... 详细信息

目的探究介入治疗中应用替罗非班在75岁以上老年冠心病患者治疗中的应用效果。方法便利选择2015年1月-2019年12月该院收治的接受介入治疗的75岁以上老年冠心病患者76例,将其随机分为两组,其中接受常规治疗患者为对照组(38例),接受替罗非班治疗患者为观察组(38例),对比两组患者3个月后无复流、胸痛及再次血运重建发生率,比较两组2 d、1个月心脏不良事件发生率;对比两组患者血量情况。结果观察组无复流发生率(5.26%)、胸痛发生率(2.63%)、再次血运重建发生率(2.63%),均低于对照组的(23.68%、23.68%及21.05%),差异有统计学意义(P<0.05)。观察组2 d、1个月心脏不良事件发生率分别为2.63%与5.26%,均少于对照组的23.68%与26.32%,差异有统计学意义(χ^(2)=7.370、6.333,P<0.05)。观察组发生轻度出血患者5例(13.16%),低于对照组的13例(34.21%),差异有统计学意义(χ^(2)=4.659,P<0.05)。结论 75岁以上老年冠心病患者在介入治疗中应用替罗非班治疗,不良事件发生率低,预后效果改善作用明显。

关键词：老年冠心病介入治疗替罗非班

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视频监控系统多网域技术研究与设计

计算机与现代化 2012年第12期 103-105页

作者：陈泯融曾庆好张德雷深圳大学信息工程学院广东深圳518060 深圳现代通信与信息处理重点实验室广东深圳518060 深圳市铁越电气有限公司广东深圳518054

视频监控系统在专业行业中的应用越来越广泛,针对专业行业网络结构复杂、多种网络并存、网络安全等级划分不均匀、IP地址容量有限的现状,提出视频监控的多网域设计模型,该模型采用统一的配置,各网域客户端通过本网域IP地址实现自动匹配... 详细信息

视频监控系统在专业行业中的应用越来越广泛,针对专业行业网络结构复杂、多种网络并存、网络安全等级划分不均匀、IP地址容量有限的现状,提出视频监控的多网域设计模型,该模型采用统一的配置,各网域客户端通过本网域IP地址实现自动匹配的网域应用模式,并从系统框架和实现方案分别进行详尽的描述,阐述系统方案的可实现性。应用实践表明,该模型在解决视频监控的多网域应用问题时简单、高效。

关键词：多网域视频监控跨域访问

结合生成对抗网络及多角度注意力的图像翻译模型

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计算机系统应用 2023年第4期32卷 283-292页

作者：杨百冰陈泯融叶勇森华南师范大学计算机学院广州510631

本文提出一个新的无监督图像翻译模型,该模型结合了生成对抗网络和多角度注意力,称为MAGAN.多角度注意力引导翻译模型将注意力集中在不同域间最具有判别性的区域.与现存的注意力方法不同的是,空间激活映射一方面捕获通道间的依赖,减少... 详细信息

本文提出一个新的无监督图像翻译模型,该模型结合了生成对抗网络和多角度注意力,称为MAGAN.多角度注意力引导翻译模型将注意力集中在不同域间最具有判别性的区域.与现存的注意力方法不同的是,空间激活映射一方面捕获通道间的依赖,减少翻译图像的特征扭曲;另一方面决定网络对最具判别性区域的空间位置的关注程度,使翻译的图像更具有目标域风格.在空间激活映射的基础上,结合类激活映射,可以获得图像的全局语义信息.此外,根据空间激活程度对图像特征信息的影响,设计不同的注意力结构分别训练生成器和判别器.实验结果表明,本文模型在selfie2anime、cat2dog、horse2zebra和vangogh2photo这4个数据集上的KID分数分别达到9.48、6.32、6.42和4.28,性能优于大部分主流模型,并且与基线模型UGATIT相比,在selfie2anime、cat2dog和horse2zebra这3个数据集上的距离值分别减少了2.13、0.75和0.64,具有明显的性能优势.

关键词：生成对抗网络图像翻译图像风格迁移多角度注意力无监督网络图像生成

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不同右心室心尖部起搏百分比对心功能的影响

中国综合临床 2011年第3期27卷 256-259页

作者：陈荣敏宋建平邹操苏州大学附属第一医院心内科59病区 215006

目的探讨在不同心室起搏百分比（CUM％VP，即起搏心室率占总心室率的百分比）时长期右心室心尖部起搏（RVA）对基础心功能正常患者心室结构和心功能的影响。方法选取安装起搏器时基础心功能正常、因行起搏器更换和门诊复诊起搏器的患者... 详细信息

目的探讨在不同心室起搏百分比（CUM％VP，即起搏心室率占总心室率的百分比）时长期右心室心尖部起搏（RVA）对基础心功能正常患者心室结构和心功能的影响。方法选取安装起搏器时基础心功能正常、因行起搏器更换和门诊复诊起搏器的患者为研究对象，CUM％VP≥85％组78例，CUM％VP≤40％组63例。以新发心力衰竭、死亡及左心室重构、功能受损为终点，比较2组之间的发生率；同时观察左心室舒张末期内径（LVEDD）、左心室射血分数（LVEF）、室间隔厚度（IVS）从基线至随访结束时的改变（ALVEDD、ALVEF、AIVS）。结果两次评估相隔的平均时间CUN％VP≥85％组为7．4年，CUM％VP≤40％组为7．7年。起搏前2组患者年龄、性别、总起搏时间、起搏模式、基础疾病及心脏超声指标等情况基本相似，差异无统计学意义（P均〉0．05）；随访结束时，CUM％VP≥85％组与CUM％VP≤40％组ALVEDD分别为（3．8±0．5）、（1．4±0．4）mm（t=4．540，P〈0．01），ALVEF分别为（-6．5±1．2）％、（-3．3±1．0）％（t=2．578，P=0．011），而AIVS比较差异无统计学意义；随访结束时2组均无死亡，CUM％VP≥85％组和CUM％VP≤40％组左心室重构、功能受损发生率分别为25．6％（20／78）、6．3％（4／36），差异有统计学意义（X^2=9．183，P=0．002）；新发心力衰竭发生率分别为10．3％（8／78）、1．6％（1／36），2组比较差异有统计学意义（X^2=4．383，P=0．036）。结论基础心功能正常患者长期右心室心尖部起搏（RVA）存在发生心室重构、功能受损和心力衰竭的可能，起搏时间越长、CUM％VP越高其发生风险越大。

关键词：右心室心尖部起搏心功能心室起搏百分比超声心动图

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi Jiang Jingqi chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Fabrication and Mechano-sensing Characteristics of Bending Polypyrrole Actuator

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 240-245页

作者： chen Jinyou HU Wei School of Automotive Engineering Hunan Financial&Industrial Vocational-technical CollegeHengyang 421002China College of Mechanical and Electrical Engineering Hunan Agricultural UniversityChangsha 410128China

To prepare a conductive polymer actuator with decent performance,a self-built experimental platform for the preparation of polypyrrole film is *** of the essential goals is to examine the mechanical characteristics of the actuator in the presence of various combinations of process parameters,combined with the orthogonal test method of"four factors and three levels".The bending and sensing characteristics of actuators of various sizes are methodically examined using a self-made bending polypyrrole *** functional relationship between the bending displacement and the output voltage signal is established by studying the characteristics of the actuator sensor subjected to various degrees of *** experimental results reveal that the bending displacement of the actuator tip almost exhibits a linear variation as a function of length and *** the voltage reaches 0.8 V,the bending speed of the actuator tends to be ***,the mechanical properties of the self-assembled polypyrrole actuator are verified by the design and fabrication of the microgripper.

关键词： conductive polymer polypyrrole mechanical characteristics actuators sensing characteristics

Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： chen Wuxing chen Shuang YU Yan ZHANG Jiangyi XU Haiyang GUO Wei School of mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

A Lightweight Multiscale Feature Fusion Network for Solar Cell Defect Detection

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Computers, Materials & Continua 2025年第1期82卷 521-542页

作者： Xiaoyun chen Lanyao Zhang Xiaoling chen Yigang Cen Linna Zhang Fugui Zhang School of Mechanical Engineering Guizhou UniversityGuiyang550025China School of Computer Science and Technology Beijing Jiaotong UniversityBeijing100044China

Solar cell defect detection is crucial for quality inspection in photovoltaic power generation *** the production process,defect samples occur infrequently and exhibit random shapes and sizes,which makes it challenging to collect defective ***,the complex surface background of polysilicon cell wafers complicates the accurate identification and localization of defective *** paper proposes a novel Lightweight Multiscale Feature Fusion network(LMFF)to address these *** network comprises a feature extraction network,a multi-scale feature fusion module(MFF),and a segmentation ***,a feature extraction network is proposed to obtain multi-scale feature outputs,and a multi-scale feature fusion module(MFF)is used to fuse multi-scale feature information *** order to capture finer-grained multi-scale information from the fusion features,we propose a multi-scale attention module(MSA)in the segmentation network to enhance the network’s ability for small target ***,depthwise separable convolutions are introduced to construct depthwise separable residual blocks(DSR)to reduce the model’s parameter ***,to validate the proposed method’s defect segmentation and localization performance,we constructed three solar cell defect detection datasets:SolarCells,SolarCells-S,and *** and SolarCells-S are monocrystalline silicon datasets,and PVEL-S is a polycrystalline silicon *** results show that the IOU of our method on these three datasets can reach 68.5%,51.0%,and 92.7%,respectively,and the F1-Score can reach 81.3%,67.5%,and 96.2%,respectively,which surpasses other commonly usedmethods and verifies the effectiveness of our LMFF network.

关键词： Defect segmentation multi-scale feature fusion multi-scale attention depthwise separable residual block