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Freshening of the intermediate water of the south china {2. between the 1960s and the 1980s

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Chinese Journal of oceanology and Limnology 2012年第6期30卷 1010-1015页

作者：刘长建王东晓陈举杜岩谢强 State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences south china {2. Marine Engineering Surveying Center State Oceanic Administration Graduate University of Chinese Academy of Sciences Sanya institute of Deep-sea Science and Engineering Chinese Academy of Sciences

Variation in intermediate water salinity in the south china {2. (SCS) between the 1960s and 1980s was studied using historical hydrographic data. The results demonstrate that the water was significantly fresher in the 1980s than in the 1960s, indicating that vertical mixing at intermediate water depth was reduced in the 1980s. This was partially because of the change of the SCS meridional overturning circulation (MOC) connecting local intermediate water with deep water. Data assimilation showed a 0.5Sv (1 Sv=10 6m 3/s) reduction in the strength of the MOC, which is about one third of the mean SCS MOC. Because the SCS MOC is linked to the Pacific Ocean, such an interdecadal variation in the intermediate water SCS may reflect anthropogenic climate change in the world ocean.

关键词： decadal variability intermediate water meridional overturning circulation south china {2. (SCS)

珠江口海域沉积物对汞、镉吸附的热力学和动力学

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海洋通报 1985年第4期 25-29页

作者：罗伟权何清溪陈泽琼陈国清方平中国科学院南海海洋研究所中国科学院南海海洋研究所

为了解重金属在水体中的迁移,探讨河口区域对它们的自净能力,我们曾研究过珠江口海域沉积物对汞、镉的吸附及其解吸作用,并找到了影响吸附作用的重要环境因素。本文仅是报道珠江口海域沉积物对汞、镉吸附的热力学和动力学的研究结果,... 详细信息

为了解重金属在水体中的迁移,探讨河口区域对它们的自净能力,我们曾研究过珠江口海域沉积物对汞、镉的吸附及其解吸作用,并找到了影响吸附作用的重要环境因素。本文仅是报道珠江口海域沉积物对汞、镉吸附的热力学和动力学的研究结果,这些结果对进一步弄清汞、镉在珠江口海域水体中的迁移机制是有益的。

关键词：解吸作用吸附作用重要环境因素自净迁移机制吸附速率吸附等温线吸附量活化能净化作用

3-D observations of a red tide event in the offshore water along the western Guangdong coast

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Acta Oceanologica Sinica 2015年第1期34卷 159-161页

作者： xie Lingling chen Qingxiang HU Jianyu ZHANG Shuwen YI Xiaofei chen Fajin DENG Rui DENG Xiaodong WANG Jing QI Yiquan Guangdong Province Key Laboratory for Coastal Ocean Variation and Disaster Prediction Technologies Guangdong Ocean University State Key Laboratory of Marine Environmental Science Xiamen University Guangdong Key Laboratory for Urbanization and Geo-simulation School of Geography and PlanningSun Yat-sen University State Key Laboratory of Tropic Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences

From November 2. to 2., 2.14, a red tide event occurred in the offshore water off the Hailing Island located at the western Guangdong coast. The red tide appeared as pink strips distributed within 3 km in the offshore water and extended for about 10 km along the shoreline. During the flood tide, the pink seawater rushed to the beach with breaking waves, forming foam strips on the beach. Guangdong Province Key Laboratory for Coastal Ocean Variation and Disaster Prediction Technologies, Guangdong Ocean University, emergently responded to the event and organized three-dimensional observations from the air, onboard and on beach. The preliminary analyses of the cruise data and water samples indicate that the event was induced by non- toxic Noctiluca scintillans, of which the concentration reaches as high as 4 2.0 cells/L near the surface and 2.00 cells/L at the bottom.

关键词： red tide Noctiluca scintillans marine pollution Hailing Island south china {2.

RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells

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World Journal of Gastroenterology 2011年第32期17卷 3700-3708页

作者： Xin-Ke Zhou Sheng-Song Tang Gao Yi Min Hou Jin-Hui chen Bo Yang Ji-fang Liu Zhi-Min He Department of Pharmacology University of South China Hengyang 421001 Hunan Province China institute of Cancer Research Affiliated Tumor Hospital of Guangzhou Medical College Guangzhou 510095 Guangdong Province China Laboratory of Applied Marine Biology Southem China Sea Institute of Oceanology Chinese Academy of Science Guangzhou 510300 Guangdong Province China

AIM: To explore the effects of siRNA silencing of PIK3CA on proliferation, migration and invasion of gastric cancer cells and to investigate the underlying mechanisms. METHODS: The mutation of PIK3CA in exons 9 and 2. of gastric cancer cell lines HGC-2., SGC-7901, BGC-82., MGC-803 and MKN-45 was screened by polymerase chain reaction (PCR) followed by sequencing. BGC-82. cells harboring no mutations in either of the exons, and HGC-2. cells containing PIK3CA mutations were employed in the current study. siRNA targeting PIK3CA was chemically synthesized and was transfect- ed into these two cell lines in vitro . mRNA and protein expression of PIK3CA were detected by real-time PCR and Western blotting, respectively. We also measured phosphorylation of a serine/threonine protein kinase (Akt) using Western blotting. The proliferation, migration and invasion of these cells were examined separately by 3-(4,5-dimethylthiazol-2.yl)-2.5-diphenyltet-razolium bromide (MTT), wound healing and Transwell chambers assay. RESULTS: The siRNA directed against PIK3CA effectively led to inhibition of both endogenous mRNA and protein expression of PIK3CA, and thus significantly down-regulated phosphorylation of Akt (P 3CA resulted in an obvious reduction in tumor cell proliferation activity, migration and invasion potential (P 1). Intriguing, mutant HGC-2. cells exhibited stronger invasion ability than that shown by wild-type BGC-82. cells. Knockdown of PIK3CA in mutant HGC-2. cells contributed to a reduction in cell invasion to a greater extent than in non-mutant BGC-82. cells. CONCLUSION: siRNA mediated targeting of PIK3CA may specifically knockdown the expression of PIK3CA in gastric cancer cells, providing a potential implication for therapy of gastric cancer.

关键词： Gastric cancer Metastasis PIK3CA PI3K/ Akt pathway RNAi

Research on Secondary Metabolites from Marine Fungi in the Different Medium

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Research on Secondary Metabolites from Marine Fungi in the D...

中国物理海洋学研究70年：发展历程、学术成就概览

全国第九届海洋生物技术与创新药物学术会议

作者： Bing-Xin Liu yun Deng Xiao-Jie chen Ling-fang Lei Xian-Jun Su Cui-Xian Zhang School of Chinese Materia Medica Guangzhou University of TCM

Because of high pressure,high salty,low temperature and other special environment,marine microorganisms produced in a great variety and novel chemical structures of the second ***,through the strategy of"One strain many compounds(referred OSMAC)"activating the silence pathway of microorganisms to obtain novel structures of secondary metabolites has been a focus in this area with broad *** order to research influence on different medium with secondary metabolites from marine fungi derived-marine invertebrate of south{2. sea,symbiotic fungus were isolated from the coral,soft coral,and sea star,*** we choose one symbiotic fungi strain(NG15-0-3)which was cultured in the different fermentation medium(Fungi NO.1,Fungi NO.3,Fungi NO.4,D,E,GPY),in order to observe the difference of secondary matelibites from different *** to the TLC(see Fig.1),NG15-0-3 produced different secondary *** the GPY,D or E medium,NG15-0-3 could produce a large numbers of anthraquinones and other kinds of compounds by TLC analysis by UV,KOH and H2.O4/vanillin chromogenic ***,symbiotic fungi NG15-0-3 was cultured in the GPY fermentation medium,and 15 compounds were isolated from the ethyl acetate extractions of *** structures belong to dihydroisoxazole coumarins,anthraquinones,cyclic dipeptides,imidazoles and monodehydro-2.*** a results,above all confirmed that cultivation in different medium could obtain various secondary ***,it is worthy of researching on relationship between changing marine-derived microbes growth medium with stimulating significant bioactive novel compounds.

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海洋学报 2019年第10期41卷 23-64页

作者：魏泽勋郑全安杨永增刘克修徐腾飞王凡胡石建谢玲玲李元龙杜岩周磊林霄沛胡建宇朱建荣李均益张正光侯一筠刘泽田纪伟黄晓冬管玉平刘志宇杨庆轩赵玮宋振亚刘海龙董昌明于卫东连涛陈朝晖史久新雷瑞波刘煜于福江尹宝树陈戈王岩峰李整林熊学军汪嘉宁李晓峰王永刚自然资源部第一海洋研究所山东青岛266061 马里兰大学马里兰州学院市20742 国家海洋信息中心天津300171 中国科学院海洋研究所山东青岛266071 广东海洋大学广东湛江524088 中国科学院南海海洋研究所广东广州510301 上海交通大学上海200030 中国海洋大学山东青岛266100 厦门大学福建厦门361005 华东师范大学上海200241 中国科学院大气物理研究所北京100029 南京信息工程大学江苏南京210044 国家海洋环境预报中心北京100081 自然资源部第二海洋研究所浙江杭州310012 中国极地研究中心上海200136 中国科学院声学研究所北京100190 中国科学院大学北京100049

本文概略评述新中国成立70年来物理海洋学各分支研究领域的发展历程和若干学术成就。中国物理海洋学研究起步于海浪、潮汐、近海环流与水团,以及以风暴潮为主的海洋气象灾害的研究。随着国力的增强,研究领域不断拓展,涌现了大量具有广... 详细信息

本文概略评述新中国成立70年来物理海洋学各分支研究领域的发展历程和若干学术成就。中国物理海洋学研究起步于海浪、潮汐、近海环流与水团,以及以风暴潮为主的海洋气象灾害的研究。随着国力的增强,研究领域不断拓展,涌现了大量具有广泛影响力的研究成果,其中包括:提出了被国际广泛采用的“普遍风浪谱”和“涌浪谱”,发展了第三代海浪数值模式;提出了“准调和分析方法”和“潮汐潮流永久预报”等潮汐潮流的分析和预报方法;发现并命名了“棉兰老潜流”,揭示了东海黑潮的多核结构及其多尺度变异机理等,系统描述了太平洋西边界流系;提出了印度尼西亚贯穿流的南海分支(或称南海贯穿流);不断完善了中国近海陆架环流系统,在南海环流、黑潮及其分支、台湾暖流、闽浙沿岸流、黄海冷水团环流、黄海暖流、渤海环流,以及陆架波方面均取得了深刻的认识;从大气桥和海洋桥两个方面对太平洋–印度洋–大西洋洋际相互作用进行了系统的总结;发展了浅海水团的研究方法,基本摸清了中国近海水团的分布和消长特征与机制,在大洋和极地水团分布及运动研究方面也做出了重要贡献;阐明了南海中尺度涡的宏观特征和生成机制,揭示了中尺度涡的三维结构,定量评估了其全球物质与能量输运能力;基本摸清了中国近海海洋锋的空间分布和季节变化特征,提出了地形、正压不稳定和斜压不稳定等锋面动力学机制;构建了“南海内波潜标观测网”,实现了对内波生成–演变–消亡全过程机理的系统认识;发展了湍流的剪切不稳定理论,提出了海流“边缘不稳定”的概念,开发了海洋湍流模式,提出了湍流混合参数化的新方法等;在海洋内部混合机制和能量来源方面取得了新的认识,并阐述了混合对海洋深层环流、营养物质输运等过程的影响;研发了全球浪–潮–流耦合模式,推出一系列海洋与气候模式;发展了可同化主要海洋观测数据的海洋数据同化系统和用于ENSO预报的耦合同化系统;建立了达到国际水准的非地转(水槽/水池)和地转(旋转平台)物理模型实验平台;发展了ENSO预报的误差分析方法,建立了海洋和气候系统年代际变化的理论体系,揭示了中深层海洋对全球气候变化的响应;初步建成了中国近海海洋观测网;持续开展南北极调查研究;建立了台风、风暴潮、巨浪和海啸的业务化预报系统,为中国气象减灾提供保障;突破了国外的海洋技术封锁,研发了万米水深的深水水听器和海洋光学特性系列测量仪器;建立了溢油、危险化学品漂移扩散等预测模型,为伴随海洋资源开发所带来的风险事故的应急处理和预警预报提供科学支撑。文中引用的大量学术成果文献(每位第一作者优选不超过3篇)显示,经过70年的发展,中国物理海洋学研究培养了一支实力雄厚的科研队伍,这是最宝贵的成果。这支队伍必将成为中国物理海洋学研究攀登新高峰的主力军。

关键词：物理海洋学海浪潮汐海平面大洋环流水团陆架与边缘海环流海洋中尺度过程湍流与混合数值模拟与数据同化实验室模拟大洋与气候海冰与极地考察海洋气象与灾害海洋物理学海洋环境