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A randomized comparative study of using enoxaparin instead of unfractionated heparin in the intervention treatment of coronary heart disease

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Chinese Medical Journal 2006年第5期119卷 355-359页

作者： chen ji-lin chen Jue QIAO Shu-bin GUO Yuan-lin WU Yong-jian DAI Jun YUAN jin-qing QIN Xue-wen YANG Yue-jin GAO Run-lin Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background Low molecular weight heparin （LMWH） was more effective than unfractionated heparin （UFH） in treating acute coronary syndrome （ACS）. However, it remains uncertain whether LMWH can be used in patients undergoing percutaneous coronary intervention （PCI） instead of UFH. This study aimed to evaluate the efficacy and safety of using enoxaparin instead of UFH in the intervention treatment of patients with coronary heart disease （CHD） .Methods From October 2003 to Febuary 2005, 966 patients with CHD were enrolled into this study. Among 966 patients, 455 patients received the PCI, including 283 patients with Non-ST segment elevation ACS （NSTEACS）, 511 patients did not received PCI due to mild, moderate lesions or were suitable for coronary artery bypass graft （CABG）. The 966 patients were randomized to enoxaparin group （484 patients） and UFH group （482 patients）. Patients in the enoxaparin group were given enoxaparin at least twice subcutaneously （1 ms/kg, q12 h） before catheterization. Plasma anti-Xa activity was determined 1-8 hours after the last dose of enoxaparin was determined. The catheterization was performed within 8 hours after the last dose of enoxaparin. The sheath was removed immediately after the procedure. Patients in the UFH group were given UFH 25 mg intravenously before coronary angiography. Additional 65 mg was given intravenously if PCI was to be performed. The sheath was removed 4 hours after the procedure. Results A total of 227 patients in the enoxaparin group and 228 patients in the UFH group received PCI. In the enoxaparin group, one patient developed acute thrombosis during PCI and resulted in acute myocardial infarction （AMI）, no acute or subacute thrombosis was found during hospitalization. In the UFH group, no acute or subacute thrombosis occurred during PCI procedure and hospitalization. Therefore, the incidence of major adverse cardiovascular events （MACEs） during the hospitalization was 0.44% in the enoxaparin group and 0 in the

关键词： enoxaparin unfractionated heparin percutaneous coronary intervention

A novel algorithm for evaluating cement azimuthal density based on perturbation theory in horizontal well

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Petroleum Science 2024年第1期21卷 244-251页

作者： ji-lin Fan Feng Zhang Qian chen Hao-chen Song Lu-Yu Zhong Yue-Xiang Dai National Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of Petroleum(East China)Qingdao 266580ShandongChina China National Logging Corporation Xi'an 710076ShaanxiChina Sinopec Matrix Corporation Qingdao 266001ShandongChina

Cement density monitoring plays a vital role in evaluating the quality of cementing projects,which is of great significance to the development of oil and ***,the presence of inhomogeneous cement distribution and casing eccentricity in horizontal wells often complicates the accurate evaluation of cement azimuthal *** this regard,this paper proposes an algorithm to calculate the cement azimuthal density in horizontal wells using a multi-detector gamma-ray detection *** spatial dynamic response functions are simulated to obtain the influence of cement density on gamma-ray counts by the perturbation theory,and the contribution of cement density in six sectors to the gamma-ray recorded by different detectors is obtained by integrating the spatial dynamic response *** with the relationship between gamma-ray counts and cement density,a multi-parameter calculation equation system is established,and the regularized Newton iteration method is employed to invert casing eccentricity and cement azimuthal *** approach ensures the stability of the inversion process while simultaneously achieving an accuracy of 0.05 g/cm^(3) for the cement azimuthal *** accuracy level is ten times higher compared to density accuracy calculated using calibration ***,this algorithm enhances the accuracy of cement azimuthal density evaluation,provides valuable technical support for the monitoring of cement azimuthal density in the oil and gas industry.

关键词： Cement azimuthal density Perturbation theory Casing eccentricity Spatial dynamic response function Regularized Newton iteration

Semantic segmentation-based semantic communication system for image transmission

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Digital Communications and Networks 2024年第3期10卷 519-527页

作者： jiale Wu Celimuge Wu Yangfei lin Tsutomu Yoshinaga Lei Zhong Xianfu chen Yusheng ji The University of Electro-Communication Tokyo182-8585Japan Toyota Motor Corporation Tokyo112-8701Japan VTT Technical Research Centre of Finland OuluFinland National Institute of Informatics(NII) Tokyo101-8430Japan

With the rapid development of artificial intelligence and the widespread use of the Internet of Things, semantic communication, as an emerging communication paradigm, has been attracting great interest. Taking image transmission as an example, from the semantic communication's view, not all pixels in the images are equally important for certain receivers. The existing semantic communication systems directly perform semantic encoding and decoding on the whole image, in which the region of interest cannot be identified. In this paper, we propose a novel semantic communication system for image transmission that can distinguish between Regions Of Interest (ROI) and Regions Of Non-Interest (RONI) based on semantic segmentation, where a semantic segmentation algorithm is used to classify each pixel of the image and distinguish ROI and RONI. The system also enables high-quality transmission of ROI with lower communication overheads by transmissions through different semantic communication networks with different bandwidth requirements. An improved metric θPSNR is proposed to evaluate the transmission accuracy of the novel semantic transmission network. Experimental results show that our proposed system achieves a significant performance improvement compared with existing approaches, namely, existing semantic communication approaches and the conventional approach without semantics.

关键词： Semantic Communication Semantic segmentation Image transmission Image compression Deep learning

Effect of Final Kissing Balloon Dilatation after One-stent Technique at Left-main Bifurcation： A Single Center Data

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Chinese Medical Journal 2015年第6期128卷 733-739页

作者： Zhan Gao Bo XU Yue-jin Yang Shu-Bin Qiao Yong-jian Wu Tao chen Liang Xu jin-Qing Yuan Jue chen Xue-Wen Qin Min Yao Hai-8o Liu Shi-jie You Ye-lin Zhao Hong-Bing Yan ji-lin chen Run-lin Gao State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Beijing 100037 China Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu 210029 China

Background:Whether final kissing balloon (FKB) dilatation after one-stent implantation at left-main (LM) bifurcation site remains ***,this large sample and long-term follow-up study comparatively assessed the impact of FKB in patients with unprotected LM disease treated with one-stent ***:Total 1528 consecutive patients underwent LM percutaneous coronary intervention in one center from January 2004 to December 2010 were enrolled; among them,790 patients treated with one drug-eluting stent crossover LM to left anterior descending (LAD) with FKB (n =230) or no FKB (n =560) were comparatively *** outcome was the rate of major adverse cardiovascular events,defined as a composite of death,myocardial infarction (MI) and target vessel revascularization (TVR).Results:Overall,The prevalence of true bifurcation lesions,which included Medina classification (1,1,1),(1,0,1),or (0,1,1),was similar between-groups (non-FKB:37.0％ ***:39.6％,P =0.49).At mean 4 years follow-up,rates of major adverse cardiovascular events (non-FKB:10.0％ ***:7.8％,P =0.33),death,MI and TVR were not significantly different *** multivariate propensity-matched regression analysis,FKB was not an independent predictor of adverse ***:For patients treated with one-stent crossover LM to LAD,clinical outcomes appear similar between FKB and non-FKB strategy.

关键词： Angioplasty Balloon Bifurcation Percutaneous Coronary Angioplasty Unprotected Left-main

Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel

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Chinese Medical Journal 2015年第6期128卷 774-779页

作者： Xiao-Fang Tang Ya-ling Han jia-Hui Zhang jing Wang Yin Zhang Bo Xu Zhan Gao Shu-Bin Qiao Jue chen Yuan Wu ji-lin chen Run-lin Gao Yue-jin Yang jin-Qing Yuan Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology Institute of Cardiovascular Research of People's Liberation Army Shenyang Northern Hospital Shenyang Liaoning 110840 China Department of Cardiology Centre for Coronary Heart Disease State Key Laboratory of Cardiovascular DiseaseFuwai Hospita/i National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background:Several platelet function tests are currently used to measure responsiveness to antiplatelet *** study was to compare two tests,light transmittance aggregometry (LTA) and modified thrombelastography (mTEG),for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI).Methods:Prospective,observational,single-center study of 789 Chinese patients undergoing PCI was *** study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year ***:MACEs occurred in 32 patients (4.1％).Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r =0.733,P ＜ 0.001).ROC-curve analysis demonstrated that LTA (area under the curve [AUC]:0.677; 95％ confidence interval [CI]:0.643-0.710; P =0.0009),and mTEG (AUC:0.684; 95％ CI:0.650-0.716; P =0.0001) had moderate ability to discriminate between patients with and without *** occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4％ vs.2.7％; P ＜ 0.001),and by TEG (6.7％ vs.2.6％; P ＜ 0.001).Kaplan-Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year ***:The correlation between LTA and mTEG is relatively high in Chinese *** measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI.

关键词： Clopidogrel High On-treatment Platelet Reactivity Light Transmittance Aggregometry Thrombelastography

Comparison of drug eluting stents with bare metal stents in daily practice for bifurcation lesions in Chinese patients

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Chinese Medical Journal 2006年第14期119卷 1157-1164页

作者： KANG Sheng YANG Yue-jin XU Bo chen ji-lin QIAO Shu-bin YAO Min chen Jue WU Yong-jian LIU Hai-bo DAI Jun YUAN jin-qing LI jian-jun GAO Run-lin Department of Cardiology Cardiovascular Institute ＆ Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 China

Background Recently, numerous randomized and controlled trials have demonstrated great advantages of drug eluting stents （DES） with respect to significant reduction of restenosis and recurrence of symptoms and improvement of clinical outcomes after percutaneous coronary intervention （PCI）. Little is known about the comparative effects between DES and bare metal stents （BMS） for bifurcation angioplasty in the Chinese population. We compared the inpatient and 7-month follow-up outcomes between DES and BMS for the treatment of bifurcation lesions. Methods From April 2004 to October 2005, 291 Chinese patients [85.9% male, mean age （57.8± 10.4） years] underwent DES （387 lesions） and/or BMS （297 lesions） implantation for bifurcation lesions. Clinical and angiographic follow-up was performed at 7 months. Results Compared with BMS group, patients in DES group had significantly lower rates of restenosis at main branch （9.5% vs 28.7%, P 〈 0.001） or side branch （14.5% vs 37.0%, P 〈 0.001） and major adverse cardiac events （MACE）（14.0% vs 26.3%, P = 0.000）. The occurrence rate of late in-stent thrombosis did not differ between the two groups in both main （0.8% vs 0, P = 0.224） and side branches （1.4% vs 0, P =0.198）. Target lesion revascularization （TLR） was less frequent in DES group for main branch （8.3% vs 21.3%, P 〈 0.001） and for side branch （7.6% vs 23.5%, P 〈 0.001）. Multivariate regression analysis revealed that total stent length （OR = 1.029, P = 0.01）, postprocedural in-stent minimum lumen diameter （OR = 0.476, P = 0.03） and stent type （OR = 3.988, P = 0.0001） were independent predictors of TLR for main branch. Prior history of coronary intervention （OR = 2.424, P =0.041）, angulated lesion （OR = 2.337, P = 0.033）, postdilation （OR = 0.267, P = 0.035） and stent type （DES vs BMS, OR = 5.459, P = 0.000） were independent predictors of TLR for side branch. Conclusion The implantation of DES may be associated with greater reduction of restenosis and TLR than BMS in bi

关键词： percutaneous coronary intervention drug eluting stent bare metal stent bifurcation

Effects of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel responsiveness and clinical outcome in patients with acute coronary syndromes undergoing stent-based coronary intervention

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Chinese Medical Journal 2013年第6期126卷 1069-1075页

作者： TANG Xiao-fang ZHANG jia-hui WANG jing HAN Ya-ling XU Bo QIAO Shu-bin WU Yong-jian chen Jue WU Yuan chen ji-lin GAO Run-lin YANG Yue-jin YUAN jin-qing Department of Cardiology Fu Wai Hospital and Cardiovascular Institute National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology Institute of Cardiovascular Research of People's Liberation Army Shenyang Northern Hospital Shenyang Liaoning 110840 China

Background The CYP2C19 G681A single polymorphism has been proven to affect clopidogrel responsiveness. However, the effect of coexisting polymorphisms of other genes has not yet been reported in the Chinese population. This study investigated the effect of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel responsiveness and adverse clinical events in Chinese patients. Methods In 577 Han Chinese patients undergoing stent placement because of acute coronary syndrome had platelet reactivity assessed by thromboelastography, and the CYP2C19 G681A and P2Y12 C34T polymorphisms were detected by the ligase detection reaction. Primary clinical endpoints included cardiovascular death, nonfatal myocardial infarction, target vessel revascularization, and stent thrombosis. The secondary clinical endpoints were thrombolysis in myocardial infarction bleeding. The follow-up period was 12 months. Results Genotyping revealed 194 carriers of the wild type GG genotype of CYP2C19 and the wild type CC genotype of P2Y12 （group 1）, 102 carriers of the wild type GG genotype of CYP2C19 and the mutational T allele of P2Y12 （group 2）, 163 carriers of the mutational A allele of CYP2C19 and the wild type CC genotype of P2Y12 （group 3）, and 118 carriers of the mutational A allele of CYP2C19 and the mutational T allele of P2Y12 （group 4）. Group 4 had the lowest ADP-inhibition （49.74＋32.61） and the highest prevalence of clopidogrel low response （29.7%） of the four groups. The rate of the composite of primary clinical endpoints increased more in group 4 （8.5%） than in the other three groups; the rate of composite primary endpoints in group 2 （2.9%） and group 3 （3.7%） were not significantly different than that of group 1 （1.5%）. Conclusion Coexisting polymorphisms of different genes affected clopidogrel responsiveness and clinical outcome more than single polymorphism in Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention.

关键词： clopidogrel acute coronary syndromes CYP2 C19 P2 Y12 platelet reactivity

Short and long-term outcomes of two drug eluting stents in bifurcation lesions

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Chinese Medical Journal 2007年第3期120卷 183-186页

作者： chen ji-lin GAO Run-lin YANGYue-jin QIAO Shu-bin QIN Xue-wen YAO Min XU Bo LIU Hai-bo WU Yong-jian YUAN jin-qing chen Jue WU Yuan DAI Jun Cardiovascular Institute and Fuwai Hospital Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100037 China

Background Because no large prospective studies are available, this study evaluated the clinical outcomes of two drug eluting stents in bifurcation lesions. Methods Lesions with diameter of side branch ≥2.5 mm were selected. From October 2003 to June 2005, 112 patients with 113 bifurcation lesions were treated by two drug eluting stents （DESs）, technique. The location of bifurcation lesions were left anterior descending coronary artery/diagonal in 62 patients, left main distal bifurcation in 32, left circumflex coronary artery/obtute marginal branch in 18 and right coronary artery distal bifurcation in 1. Procedures for bifurcation lesions were crush or modified crush technique in 64, ＂T＂ stenting technique in 27, modified ＂Y＂ stenting, kiss stenting, ＂V＂ stenting as well as culotte stenting technique in 11, 5, 3 and 3, respectively. Among 226 lesions, 91 Cypher or Cypher select stents, 74 TAXUS and 67 Firebird were used. Final kiss balloon dilation was performed in 60 （93.7%） with crush technique after stenting. Results Success rate of percutaneous coronary intervention for the bifurcation lesions was 100%. One patient, who developed inhospital acute myocardial infarction due to subacute thrombosis, was successfully treated by a second intervention. Major adverse cardiac events rate in-hospital was 0.89% （1/112） and during followup was 7.14% （8/112）, No death occurred during the followup of all patients. Angiographic followup was effected for 46 patients, restenosis for eight, coronary artery bypass grafting for 1 and a repeat intervention for 5. Restenosis involving TAXUS, Cypher and Firebird was 5 （5/18, 27.8%）, 2 （2/17, 11.8%） and 1 （1/11, 9.1%）, respectively （P〉0.05）. Total restenotic rate was 17.4% （8/46）. Conclusions When ostium of side branch has severe stenosis and 〉12.5 mm in diameter, two-stent strategy in this bifurcation lesion is safe and effective, and the outcomes are satisfactory. Restenotic rates were not different between TAXUS, Cypher and F

关键词： bifurcation lesion drug eluting stent treatment outcome

PROGNOSIS OF UNPROTECTED LEFT MAIN CORONARY ARTERY STENTING AND THE FACTORS AFFECTING THE OUTCOMES IN CHINESE

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Chinese Medical Journal 2006年第1期119卷 14-20页

作者： GAO Run-lin XU Bo chen ji-lin HAN Ya-ling LI Zhan-quan LUE Shu-zheng QI Xiao-yong HUO Yong WANG Le-feng chen Jun-zhu SHEN Wei-feng FANG Wei-yi jiA San-qing on behalf of Chinese Registry of Unprotected Left Main Coronary Artery Stenting investigators

Background The long term prognosis of unprotected left main coronary artery （LMCA） stenting is controversial This study was conducted to evaluate the immediate and long term outcomes of LMCA stenting in Chinese patients and to determine which factors affect the outcomes. Methods From May 1997 to March 2003, 224 patients in 23 hospitals underwent elective unprotected LMCA stenting with bare metal stents. Their clinical records were analysed to ascertain immediate and long term outcomes of LMCA stenting as well as factors influencing the prognosis. Results Stents were implanted into LMCA successfully in 223 cases （99.6 %）. One death （0.5%） and one case of non-Q wave nonfatal myocardial infarction （MI） occurred in hospital. The mean follow-up time was （15.6±12.3） months. Cardiac death developed in 10 cases （4.5%）, noncardiac death in 2 cases （0.9%）, nonfatal MI in 4 cases （1.8%）, target lesion revascularization （TLR） of LMCA in 26 cases （11.7%） and TLR of nonLMCA in 37 cases （16.5%）. Univariate analysis showed that cardiac death correlated with left ventricular ejection fraction （LVEF 〈 40%）, female gender and LMCA combined with multivessel disease; that major adverse cardiac events （MACE） correlated with LVEF 〈 40%, bifurcation lesion and incomplete revascularization. Logistic regression analysis revealed that LVEF 〈 40% and female gender were independent predictors of cardiac death and MACE. Follow-up angiography was performed in 102 cases （45.7%）. The restenosis rate was 31.4%. Conclusions Long-term outcomes of stenting for selected patients with unprotected LMCA stenosis is acceptable. It should be performed in inoperable or low risk patients with LVEF ≥40% and isolated LMCA disease or LMCA combined with multivessel diseases in whom complete revascularization can be obtained.

关键词： stenting left main coronary artery prognosis