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Global Geology 2013年第3期16卷 159-163页

作者： XU Xiaohui chen hui'e WANG Gangcheng College of Construction Engineering Jilin University

On the basis of geological investigating work and experimental studies on slide zone soil of one landslide in Tibet,the authors analyzed granulometric composition,clay mineral composition and physical and mechanical properties for the soil in the slide *** soil samples are gravel containing fine *** larger than 2 mm occupy the main proportion with the content 51.5%--68.5%.The relative content of clay minerals is *** clay minerals are illite smectite mixed layer and kaolinite,and their relative contents are 6%--13% and 4%-11%,*** main mineral ingredient is quartz and the relative content is over 30%.Therefore,the soil’s hydrophily is *** cohesion and internal friction angle are high,causing preferable physical-mechanical features of slide zone *** the basis of the obtained data,the landslide stability is evaluated by means of limit equilibrium *** safety factors are 3.191 and 1.92 respectively under both natural and normal water level *** study results show that the landslide is *** can provide the appropriate basis and reference for landslide stability evaluation and landslide control in Tibet.

关键词： slide zone soil granulometric composition clay mineral composition physical-mechanical proper-ty landslide stability analysis

Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

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Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-hui chen Ai-hui Tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate

Preventing formation of intermetallic compounds in ultrasonic-assisted Sn soldering of Mg/Al alloys through pre-plating a Ni coating layer on the Mg substrate

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Journal of Magnesium and Alloys 2024年第2期12卷 726-741页

作者： Yingzong Liu Yuanxing Li hui chen Zongtao Zhu Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031PR China

Magnesium and aluminum alloys are widely used in various industries because of their excellent properties,and their reliable connection may increase application of *** compounds(IMCs)affect the joint performance of Mg/*** this study,AZ31 Mg alloy with/without a nickel(Ni)coating layer and 6061 Al alloy were joined by ultrasonic-assisted soldering with Sn-3.0Ag-0.5Cu(SAC)*** effects of the Ni coating layer on the microstructure and mechanical properties of Mg/Al joints were systematically *** Ni coating layer had a significant effect on formation of the Mg_(2)Sn IMC and the mechanical properties of Mg/Al *** blocky Mg_(2)Sn IMC formed in the Mg/SAC/Al joints without a Ni coating *** content of the Mg_(2)Sn IMC increased with increasing soldering temperature,but the joint strength *** joint without a Ni coating layer fractured at the blocky Mg_(2)Sn IMC in the solder,and the maximum shear strength was 32.2 *** pre-plating Ni on the Mg substrate,formation of the blocky Mg_(2)Sn IMC was inhibited in the soldering temperature range 240–280℃and the joint strength ***,when the soldering temperature increased to 310℃,the blocky Mg_(2)Sn IMC precipitated again in the *** electron microscopy showed that some nano-sized Mg_(2)Sn IMC and the(Cu,Ni)_(6)Sn_(5)phase formed in the Mg(Ni)/SAC/Al joint soldered at 280℃,indicating that the Ni coating layer could no longer prevent diffusion of Mg into the solder when the soldering temperature was higher than 280℃.The maximum shear strength of the Mg(Ni)/SAC/Al joint was 58.2 MPa for a soldering temperature of 280℃,which was 80.7%higher than that of the Mg/SAC/Al joint,and the joint was broken at the Mg(Ni)/SAC ***-plating Ni is a feasible way to inhibit formation of IMCs when joining dissimilar metals.

关键词： Ultrasonic-assisted soldering Mg_(2)Sn Ni coating layer Shear strength

Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation

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Food Science and Human Wellness 2024年第5期13卷 2502-2518页

作者： hui chen Lingli chen Wenjun Wang Jiangxi Key Laboratory of Natural Products and Functional Food College of Food Science and EngineeringJiangxi Agricultural UniversityNanchang 330045China

Ferroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation and it is implicated in various diseases,such as liver disease,acute kidney injury,cardiovascular disease,neurodegenerative disease and ***-based reactive oxygen species(ROS),particularly lipid hydroperoxides in the cellular membrane can lead to membrane disruption and cell death mediated by *** are three necessary stages involving in the process of lipid peroxidation regulation in ferroptosis,including the synthesis of membrane phospholipids,initiation of lipid peroxidation and clearance of lipid *** this review,we summarized the molecular modulation mechanisms of lipid peroxidation in ferroptosis from the above three stages,as well as various ferroptosis modulators targeting lipid peroxidation,including commonly used products,natural bioactive compounds and ***,these findings suggest the vital role of lipid peroxidation in ferroptosis,and targeting lipid peroxidation in ferroptosis is potential to treat ferroptosis-associated diseases.

关键词： Ferroptosis Lipid peroxidation Mechanisms Natural bioactive compounds Selenocompounds

Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

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Journal of Iron and Steel Research International 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He Xin-hui chen hui Li Kai-hua Shi hui-wen Xiong Xin Xiang Li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

Electromagnetic fields in ultra-peripheral relativistic heavy-ion collisions

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Nuclear Science and Techniques 2024年第2期35卷 103-109页

作者： Jie Zhao Jin-hui chen Xu-Guang Huang Yu-Gang Ma Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200438China

Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic *** these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon *** exchange of photons can induce photonuclear and two-photon interactions and excite *** excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other ***,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ***,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted *** a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.

关键词： Electromagnetic fields Neutrons Ultra-peripheral relativistic heavy-ion collisions(UPC)

A target parameter estimation method via atom-reconstruction in radar mainlobe jamming

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Journal of Systems Engineering and Electronics 2024年第2期35卷 350-360页

作者： ZHOU Bilei LIU Weijian LI Rongfeng chen hui ZHANG Liang DU Qinglei LI Binbin chen Hao Air Force Early Warning Academy Wuhan 430019China Aerospace Nanhu Electronic Information Technology Co. Ltd.Jingzhou 434000China

Mainlobe jamming(MLJ)brings a big challenge for radar target detection,tracking,and *** suppression of MLJ is a hard task and an open problem in the electronic counter-counter measures(ECCM)*** parameters and target direction estimation is difficult in radar MLJ.A target parameter estimation method via atom-reconstruction in radar MLJ is proposed in this *** proposed method can suppress the MLJ and simultaneously provide high estimation accuracy of target range and ***,the eigen-projection matrix processing(EMP)algorithm is adopted to suppress the MLJ,and the target range is estimated effectively through the beamforming and pulse *** the target angle can be effectively estimated by the atom-reconstruction *** any prior knowledge,the MLJ can be canceled,and the angle estimation accuracy is well ***,the proposed method does not have strict requirement for radar array construction,and it can be applied for linear array and planar ***,the proposed method can effectively estimate the target azimuth and elevation simultaneously when the target azimuth(or elevation)equals to the jamming azimuth(or elevation),because the MLJ is suppressed in spatial plane dimension.

关键词： mainlobe jamming anti-jamming atom-reconstruction radar

Cross-species transmission and host range genes in poxviruses

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Virologica Sinica 2024年第2期39卷 177-193页

作者： chen-hui Yang A-Ling Song Ye Qiu Xing-Yi Ge College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410012China

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread ofMPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-likesymptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods tovertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported andresulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodeshundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This reviewbriefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes thecurrent knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus aredescribed and their impacts on viral host range are discussed in depth. We hope that this review will provide acomprehensive perspective about the current progress of researches on cross-species transmission and HRGvariation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.

关键词： Poxvirus Host range gene(HRG) Host spectrum Cross-species transmission

Novel Hf_(x)Ta_(1−x)C solid solution nanowire toughened HfC coating:An effective strategy for synchronous enhanced mechanical and anti-ablation performance

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Journal of Advanced Ceramics 2024年第5期13卷 590-601页

作者： hui chen Yulei Zhang Yanqin Fu Wenhan Gai Junhao Zhao Haohui Zhang Shaanxi Key Laboratory of Fiber Reinforced Light Composite Materials Northwestern Polytechnical UniversityXi’an 710072China Henan Key Laboratory of High Performance Carbon Fiber Reinforced Composites Institute of Carbon Matrix CompositesHenan Academy of SciencesZhengzhou 450046China

Ultra-high-temperature ceramic nanowires have shown increasing potential for use as thermal structural ***,novel single-crystal Hf_(0.5)Ta_(0.5)C solid solution nanowires were synthesized and incorporated with a HfC coating to construct a robust structure with Hf_(0.5)Ta_(0.5)C solid solution nanowires uniformly distributed and interconnected within the *** novel Hf_(0.5)Ta_(0.5)C solid solution nanowires could effectively hinder crack propagation through crack tip pinning and crack *** mechanism substantially enhanced the elastic modulus and fracture toughness of the HfC coating by 53.29%and 59.67%,*** toughened HfC coating displayed superior fracture toughness and good interfacial binding strength with the substrate to resist severe oxidation and ***,the high thermal conductivity of the toughened HfC coating promoted heat ***,in comparison to the pure HfC coating,the toughened HfC coating displayed smaller mass and linear ablation rates of−0.35 mg·s^(−1)and−0.46μm·s^(−1),which decreased by 39.66%and 36.98%,*** work not only simultaneously enhances the mechanical properties and ablation resistance of HfC-coated carbon/carbon(C/C)composites but also provides novel prospects for advanced ultrahigh-temperature ceramic nanowires under extreme conditions.

关键词： Hf_(x)Ta_(1−x)C solid solution nanowires HfC coating carbon/carbon(C/C)composites mechanical performance ablationresistance

Regulations of m^(6)A and other RNA modifications and their roles in cancer

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Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-hui chen Kun-Xiong Guo Jing Li Shu-hui Xu huifang Zhu Guang-Rong Yan Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer