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TDP-43 is a key molecule accelerating development of Alzheimer’s disease following traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 955-956页

作者： chu chen Department of Cellular and Integrative Physiology Long School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in ***,no effective therapies are currently available for the prevention and treatment of *** is largely due to our limited understanding of the mechanisms underlying the neuropathogenesis of *** has widely been recognized that AD is heterogeneous and that multi-factors are contributing to the pathogenesis of *** evidence suggests that traumatic brain injury(TBI)is an important risk factor for the development of AD and dementia later in life(Guo et al.,2000;Johnson et al.,2010).However,the precise mechanism by which TBI contributes to developing AD has yet to be elucidated.

关键词： Alzheimer traumatic

Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes

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Neural Regeneration Research 2023年第5期18卷 1023-1024页

作者： chu chen Department of Cellular and Integrative Physiology Long School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Traumatic brain injury(TBI)is a temporary or permanent disruption of brain function caused by external *** has been recognized as an important risk factor for the development of Alzheimer’s disease and dementia later... 详细信息

关键词： inflammation Alzheimer TBI

Homeostatic regulation of brain functions by endocannabinoid signaling

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Neural Regeneration Research 2015年第5期10卷 691-692页

作者： chu chen Neuroscience Center of Excellence School of MedicineLouisiana State University Health Sciences Center

Humans have been using Cannabis and its extracts for a few thousand years as a medicinal and recreational drug. How- ever, the chemical component in Cannabis sativa, △9-tet- rahydrocannabinol （△9-THC）, an exogenous cannabinoid, remained unknown until it was isolated and identified as the main psychoactive ingredient （Gaoni and Mechoulam, 1964）.

关键词： CB Homeostatic regulation of brain functions by endocannabinoid signaling

An Improved Model of the Jovian Magnetosphere

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Chinese Physics Letters 2014年第3期31卷 184-186页

作者： LU Bin chen chu-Xin Key Laboratory of Geospace Environment Department of Geophysics and Planetary Sciences School of Earth and Space Sciences University of Science and Technology of China Hefei 230026

The Jovian magnetosphere is modulated by the solar wind and centrifugal force. The configuration of the magnetic field in the previous model of the magnetosphere including the centrifugal force is consistent with the observations at low magnetic latitude （Λ〈50°）, while there is a substantial difference between the results of the model and the observations at high magnetic latitude （Λ≥50°）, especially in the distant magnetotail. Based on the previous model, a new configuration of the Jovian magnetosphere in the night side is suggested by a three-step transformation in this study. The new magnetosphere obtained by the transformation method is flattened in the z-direction and stretched in the x-direction in distant magnetotail, which agree with general knowledge.

关键词： Magnetosphere

Stability analysis of the extended ADI-FDTD technique including lumped models

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Science in China(Series F) 2008年第10期51卷 1607-1613页

作者： chen ZhiHui chu QingXin College of Electronic and Information Engineering South China University of Technology Guangzhou 510640 China

The numerical stability of the extended alternating-direction-implicit-finite-difference-time-domain （ADI-FDTD） method including lumped models is analyzed. Three common lumped models are investigated： resistor, capacitor, and inductor, and three different formulations for each model are analyzed： the explicit, semi-implicit and implicit schemes. Analysis results show that the extended ADI-FDTD algorithm is not unconditionally stable in the explicit scheme case, and the stability criterion depends on the value of lumped models, but in the semi-implicit and implicit cases, the algorithm is stable. Finally, two simple microstrip circuits including lumped elements are simulated to demonstrate validity of the theoretical results.

关键词： ADI-FDTD extended algorithm lumped model numerical stability

An Internal Heating Model to Elucidate the Shape of a Small Planetary Body

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Chinese Physics Letters 2012年第1期29卷 295-298页

作者： LI Gen chen chu-Xin School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026

Small planetary bodies usually have irregular *** they are large enough to be heated to a partial melting status,the deforming force of gravity could overcome the internal forces and make the shape transfigure from potato-like to *** have developed a model to calculate the thermal history of a planetoid and apply the model to asteroids,since ample evidence has shown that many asteroids could have undergone *** revealing the relation between the shape and the ratio of the melt part,we also examine the surface roughness of these asteroids and suggest that 280km would be a critical radius for an asteroid to develop a virtually globular contour.

关键词： Small Internal planet

Achieving strength-ductility synergy in a non-equiatomic Cr_(10)Co_(30)Fe_(30)Ni_(30)high-entropy alloy with heterogeneous grain structures

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Rare Metals 2022年第8期41卷 2864-2876页

作者： chen-Liang chu Wei-Ping chen Jun-chen Liu Qiang chen Zhi-Qiang Fu Guangdong Key Laboratory for Advanced Metallic Materials Processing South China University of TechnologyGuangzhou510641China Southwest Technology and Engineering Research Institute Chongqing400039China

Cold rolling and post-deformation annealing(PDA)heat treatments were used to produce heterogeneous grain structures(HGS)in a single-phase face-centered cubic(fcc)Cr_(10)Co_(30)Fe_(30)Ni_(30)high-entropy alloy(HEA).The microstructural evolution and microstructure-property relationship of the HEA were systematically studied under different *** could be achieved in PDA-treated samples at 875℃for 20 s and at 900℃for 20 s(PDA-900-20 s).PDA-900-20 s sample exhibits the most excellent combination of strength and ductility,showing a tensile yield strength of~590 MPa,an ultimate strength of~706 MPa and a total elongation of~23.9%.Additionally,compared with the homogenized counterpart exhibiting homogenous grains,PDA-900-20 s sample displays a notable increment of~413%in yield strength and simultaneously maintains a good *** dominated strengthening mechanisms in PDA-900-20 s sample are grain-boundary strengthening and heterogeneous deformation-induced(HDI)strengthening,whereas the good ductility is mainly resulted from the HDI ***,the present study provides an effective and simple pathway to overcome the strength-ductility tradeoff of typical fcc HEAs through heterogeneous microstructure.

关键词： High-entropy alloy Heterogeneous grain structures Hetero-deformation-induced hardening Mechanical properties Strengthening mechanism

Model of the Crustal Magnetic Field in the Martian Aurora Zone

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Chinese Physics Letters 2011年第11期28卷 286-288页

作者： TONG Dong-Sheng chen chu-Xin School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026

It is well known that aurorae are prominent on planets with a global magnetic field and occur where open magnetic field lines *** UV spectrometer used for investigating the characteristics of the atmosphere of Mars(SPICAM)on board the Mars Express made the first observation of auroral-type emission in the cusp region of the strong crustal magnetic field on Mars and found that the arc of the Martian aurora zone is very narrow in width,which obviously differs from that of other *** on the observation,we put forward a model of a crustal magnetic field on the Martian aurora zone through the morphology of Martian *** the model,equivalent currents are proposed;the topology and magnitude of the magnetic field generated by these equivalent currents are consistent with that of the crustal magnetic field in the Martian aurora *** morphology of the Martian aurora zone generated through the model matches well with the observations made by the Mars Express orbiter.

关键词： zone crustal currents

Visualizing Meiotic Chromosome Pairing and Segregation in Interspecific Hybrids of Rice by Genomic in situ Hybridization

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Rice science 2021年第1期28卷 69-80页

作者： Liu Mao-Sen Tseng Shih-Hsuan chen Ting-chu chung Mei-chu Institute of Plant and Microbial Biology Academia SinicaNankangTaipei 11529TaiwanChina

Meiotic disturbances in F1 hybrids and their progenies are still major problems in wide *** investigate the genome affinity reflected in chromosome pairing and segregation,we studied chromosome behaviors during meiosis in two interspecific F1 hybrids[***×***(Om×Oa,BCE genome)and Oa×***(Or,EHJ genome)]by using both traditional staining methods and genomic in situ hybridization(GISH).GISH analysis has been successfully performed on mitotic chromosomes to distinguish different Oryza genomes,but relatively fewer systematic analyses of meiotic chromosomes of interspecific hybrids have been *** the hybrids,highly irregular chromosome behaviors through meiosis resulted in producing microspores with unbalanced *** diakinesis of these two hybrids,most chromosomes present as univalent,with low frequency as bivalents and occasionally as *** a pollen mother cell,2 to 8 bivalents and 0 to 4 trivalents were observed in the hybrid Oa×Or,and 1 to 8 bivalents and 0 to 5 trivalents were observed in the hybrid Om×*** results indicated that 51.52%bivalents in Oa×Or and 79.65%bivalents in Om×Oa involved allosyndetic association,which indicates that recombination and introgression should be possible if viable backcrosses can be recovered even from triploid *** this study,we revealed that the meiotic disturbance due to low affinities between parental genomes is the major reason for the sterility of these two triploid interspecific *** two hybrids showing vigor in reproductive growth are potential genetic resources in future breeding programs.A better understanding of genomic affinities between these distant Oryza species can facilitate planning an effective breeding program by using wide hybridization,and efficient and routine GISH analysis is helpful to monitor alien introgression in the process.

关键词： Oryza wide hybridization genomic affinity allosyndesis autosyndesis pollen viability