检索结果-南通市图书馆

Real-time arrival picking of rock microfracture signals based on convolutional-recurrent neural network and its engineering application

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 761-777页

作者： bing-Rui chen Xu Wang Xinhao Zhu Qing Wang Houlin Xie State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Accurately picking P-and S-wave arrivals of microseismic(MS)signals in real-time directly influences the early warning of rock mass failure.A common contradiction between accuracy and computation exists in the current arrival picking ***,a real-time arrival picking method of MS signals is constructed based on a convolutional-recurrent neural network(CRNN).This method fully utilizes the advantages of convolutional layers and gated recurrent units(GRU)in extracting short-and long-term features,in order to create a precise and lightweight arrival picking ***,the synthetic signals with field noises are used to evaluate the hyperparameters of the CRNN model and obtain an optimal CRNN *** actual operation on various devices indicates that compared with the U-Net method,the CRNN method achieves faster arrival picking with less performance *** application of large underground caverns in the Yebatan hydropower station(YBT)project shows that compared with the short-term average/long-term average(STA/LTA),Akaike information criterion(AIC)and U-Net methods,the CRNN method has the highest accuracy within four sampling points,which is 87.44%for P-wave and 91.29%for S-wave,*** sum of mean absolute errors(MAESUM)of the CRNN method is 4.22 sampling points,which is lower than that of the other *** the four methods,the MS sources location calculated based on the CRNN method shows the best consistency with the actual failure,which occurs at the junction of the shaft and the second ***,the proposed method can pick up P-and S-arrival accurately and rapidly,providing a reference for rock failure analysis and evaluation in engineering applications.

关键词： Rock mass failure Microseismic event P-wave arrival S-wave arrival Deep learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang,China

引用

Biomedical and Environmental Sciences 2024年第9期37卷 993-1002页

作者： Qingjun Jia Meichun zeng Qi chen Hangzhou Center for Disease Control and Prevention(Hangzhou Health Supervision Institution) Hangzhou 310021ZhejiangChina Department of Pathology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003ZhejiangChina

Objective This study aimed to investigate the prevalence of Epstein-Barr virus(EBV)infection in patients with and without *** A total of 26,648 participants who underwent whole-blood EBV DNA(WBEBV)assays between January 1,2020,and August 31,2023,were *** chi-square test was used for categorical data analysis,and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of *** Positive rates were 10.2%and 25.4%for healthy controls(HC)and patients,*** positivity rate for EBV-associated neoplasms(EN)was the highest at 7.53%,followed by leukemia(Le)at 5.49%.The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia(APH)was 31.9%,followed by 30.5%for *** WBEBV of patients with transplants(TP),especially living-related transplants(LT),was the highest among all *** at diagnosis was used to differentiate between infectious mononucleosis(IM)and chronic active Epstein-Barr virus(CAEBV),with a sensitivity of 67.4%(95%confidence interval[CI]:57.6-75.8)and specificity of 72%(95%CI:63.3-79.3).We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT,IM,and Lymphocyte Leukemia(LL).Conclusion This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases,including the stages and *** EBV detection rate was higher in patients with malignant disease than in those with benign *** study provides clinicians with baseline information regarding EBV-associated diseases.

关键词： Epstein-Barr virus Epstein-Barr virus DNA Whole blood Epstein-Barr virus DNA Viral load

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soil properties and not plant factors affect both abundant and rare microbial taxa after thinning in a mixed stand of Cunninghamia lanceolata and Sassafras tzumu

引用

Journal of Forestry Research 2024年第2期35卷 81-94页

作者： Wanxia Peng Tongqing Song Hu Du Feng Wang Fuping zeng Yang Wang Shulin chen Yinzhu chen Key Laboratory of Agro‑Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125People’s Republic of China Guangxi Industrial Technology Research Institute for Karst Desertification Control Nanning 530001People’s Republic of China Huanjiang Observation and Research Station for Karst Ecosystems Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125People’s Republic of China Hubei Ecology Polytechnic College Wuhan 430200People’s Republic of China Hubei Tongshan Damushan State Forest Farm Tongshan 437652People’s Republic of China

Thinning is an effective management step for sustainable forest development,yet less attention is paid to the restoration of soil microbiota after *** this study,both abundant and rare soil microbial communities(i.e.,bacterial,fungal),were evaluated under various thinning treatments in a mixed stand of Cunninghamia lanceolata and Sassafras tzumu using Mi Seq *** did not significantly change either abundant or rare bacterial and fungal community composition,but affected their alpha *** Shannon–Wiener indexes of rare fungal taxa under medium thinning were significantly lower than in the light thinning(P<0.05 level).Xanthobacteraceae dominated the abundant bacterial taxa,and Saitozyma and Mortierlla the abundant fungal *** most common rare bacterial taxa varied;there was no prevalent rare fungal taxa under different *** addition,soil available nitrogen,total phosphorus,and p H had significant effects on rare bacterial ***,especially available phosphorus,but not nitrogen,affected abundant and rare soil *** results indicate that soil properties rather than plant factors affect abundant and rare microbial communities in soils of mixed ***,through mediating soil properties,influences both abundant and rare bacterial and fungal communities in the mixed *** and *** stand.

关键词： Diversity Abundant taxa Rare taxa Thinning Mixed stand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroimmune regulation in the pancreas

引用

Fundamental Research 2024年第2期4卷 201-205页

作者： Xiaofan Ding Jianhui chen Wenwen zeng Institute for Immunology and School of Basic Medical Sciences Tsinghua Universityand Tsinghua-Peking Center for Life SciencesBeijing 100084China Beijing Key Laboratory for Immunological Research on Chronic Diseases Beijing 100084China

The pancreas exerts endocrine and exocrine functions in energy *** neural innervation and immune milieu are both crucial in supporting pancreatic *** neuronal network connects the pancreas with the central nervous system(CNS)and the enteric nervous system(ENS)and sustains metabolic *** nerves in the pancreas are categorized as spinal sensory afferent fibers,vagal sensory afferent nerves,autonomic fibers of both sympathetic and parasympathetic divisions,and fibers from the ENS and intrapancreatic *** innervate different regions and various cell types,which collectively determine physiological *** have established that the diverse pathological conditions,including pancreatitis,diabetes,and pancreatic tumor,are attributed to aberrant immune reactions;however,it is largely not clear how the neuronal network may influence the disease *** by the recent advances illuminating the organ-wide neuronal architecture and the dysfunctions in pancreatic disorders,this review will highlight emerging opportunities to explore the cellular interrelationship,particularly the neuroimmune components in pancreatic health and diseases.

关键词： Neuroimmune Pancreas Pancreatic neuronal innervation Neuroimmune and pancreatic diseases Metabolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nb-and Ta-doped(Hf,Zr,Ti)C multicomponent carbides with enhanced oxidation resistance at 2500℃

引用

Journal of Advanced Ceramics 2024年第3期13卷 332-344页

作者： Shiyan chen Jinming Wang Zhaoke chen Weilong Song Yi zeng Xingchao Li Tongqi Li Xiang Xiong State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Aerospace Research Institute of Materials&Processing Technology China Academy of Launch Vehicle TechnologyBeijing 100076China

Enhancing oxidation resistance of multicomponent carbides above 2000℃is critical for their thermal protection *** this purpose,novel Nb-and Ta-doped(Hf,Zr,Ti)C multicomponent carbides were designed to improve their oxidation resistance at 2500℃.The results demonstrated that Nb and Ta doping reduced the oxidation rate constant by 16.67%and 25.17%,respectively,thereby significantly improving the oxidation resistance of(Hf,Zr,Ti)*** enhancement was attributed to the changes in oxycarbide composition and distribution within the oxide layer by adding Nb and *** to the different oxidation tendencies of the constituent elements,a distinctive structure was formed in which(Hf,Zr)O_(2)served as a skeleton,and various oxycarbides were dispersed throughout the oxide *** doped Nb and Ta were retained within oxycarbides,retarding the diffusion of oxygen into the *** importantly,the addition of Nb and Ta reduced the size of oxycarbides,decreasing both size and quantity of the pores in the oxide layer and facilitating the formation of a more effective oxygen barrier.

关键词： (Hf,Zr,Ti)C oxidation behaviour ultra-high-temperature oxidation Nb and Ta doping oxycarbides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The 2022 Extreme Heatwave in Shanghai,Lower Reaches of the Yangtze River Valley:Combined Influences of Multiscale Variabilities

引用

Advances in Atmospheric Sciences 2024年第4期41卷 593-607页

作者： Ping LIANG Zhiqi ZHANG Yihui DING zeng-Zhen HU Qi chen Key Laboratory of Cities’Mitigation and Adaptation to Climate Change in Shanghai Shanghai Regional Climate CenterChina Meteorological AdministrationShanghai 200030China National Climate Center China Meteorological AdministrationBeijing 100081China Climate Prediction Center NCEP/NWS/NOAACollege ParkMD 20740USA

In the summer of 2022,China(especially the Yangtze River Valley,YRV)suffered its strongest heatwave(HW)event since *** this study,we examined the influences of multiscale variabilities on the 2022 extreme HW in the lower reaches of the YRV,focusing on the city of *** found that about 1/3 of the 2022 HW days in Shanghai can be attributed to the long-term warming trend of global *** mid-summer of 2022,an enhanced western Pacific subtropical high(WPSH)and anomalous double blockings over the Ural Mountains and Sea of Okhotsk,respectively,were associated with the persistently anomalous high pressure over the YRV,leading to the extreme *** Pacific Decadal Oscillation played a major role in the anomalous blocking pattern associated with the HW at the decadal time ***,the positive phase of the Atlantic Multidecadal Oscillation may have contributed to regulating the formation of the double-blocking *** warming of both the warm pool of the western Pacific and tropical North Atlantic at the interannual time scale may also have favored the persistency of the double blocking and the anomalously strong *** the subseasonal time scale,the anomalously frequent phases 2-5 of the canonical northward propagating variability of boreal summer intraseasonal oscillation associated with the anomalous propagation of a weak Madden-Julian Oscillation suppressed the convection over the YRV and also contributed to the ***,the 2022 extreme HW originated from multiscale forcing including both the climate warming trend and air-sea interaction at multiple time scales.

关键词： extreme heatwave multiscale variability air-sea interaction warming trend Yangtze River Valley Shanghai

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modularly assembled multiplex prime editors for simultaneous editing of agronomically important genes in rice

引用

Plant Communications 2024年第2期5卷 67-78页

作者： Ajay Gupta Bo Liu Saad Raza Qi-Jun chen bing Yang Division of Plant Science and Technology Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China Donald Danforth Plant Science Center St.LouisMO 63132USA

Prime editing(PE)technology enables precise alterations in the genetic code of a genome of *** offers great potential for identifying major agronomically important genes in plants and editing them into superior variants,ideally targeting multiple loci simultaneously to realize the collective effects of the ***,we report the development of a modular assembly-based multiplex PE system in rice and demon-strate its efficacy in editing up to four genes in a single transformation *** duplex PE(DPE)system achieved a co-editing efficiency of 46.1%in the T0 generation,converting TFIIAg5 to xa5 and xa23 to *** resulting double-mutant lines exhibited robust broad-spectrum resistance against multiple Xanthomonas oryzae pathovar oryzae(Xoo)strains in the T1 *** addition,we success-fully edited OsEPSPS1 to an herbicide-tolerant variant and OsSWEET11a to a Xoo-resistant allele,achieving a co-editing rate of 57.14%.Furthermore,with the quadruple PE(QPE)system,we edited four genes—two for herbicide tolerance(OsEPSPS1 and OsALS1)and two for Xoo resistance(TFIIAg5 and OsSWEET11a)—using one construct,with a co-editing efficiency of 43.5%for all four genes in the T0 *** performed multiplex PE usingfive more constructs,including two for triplex PE(TPE)and three for QPE,each targeting a different set of *** editing rates were dependent on the activity of pegRNA and/or *** instance,optimization of ngRNA increased the PE rates for one of the targets(OsSPL13)from 0%to 30%but did not improve editing at another target(OsGS2).Overall,our modular assembly-based system yielded high PE rates and streamlined the cloning of PE reagents,making it feasible for more labs to utilize PE for their editing *** have significant implications for advancing gene editing techniques in plants and may pave the way for future agricultural applications.

关键词： prime editing rice bacterial blight herbicide tolerance multiplex genome editing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： bing-chen Zhang Chun-Mei Lai Bang-Yue Luo Jing-Wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of straight-chain C_(49)H_(100) alkane using a modular splicing strategy

引用

Journal of Energy Chemistry 2024年第5期92卷 414-421页

作者： bing Ma Jingqing Tian Xueling Lang Shutao Lei Bolong Li chen Zhao Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China School of Materials Science and Engineering Nankai UniversityTianjin 300350China

Ultra-long n-alkanes are highly valuable in both scientific research and as major constituents of specialty high-melting-point *** conventional methods(e.g.,Fischer–Tropsch(FT),ethylene oligomerization,and polyethylene cracking)typically resulting in wide n-alkane distributions,the elaborate design strategy presented herein allows the direct synthesis of pure,long n-alkanes using a modular splicing method with acetone,furfural,and fatty acid anhydrides or acyl chlorides as *** herein approach is based on a simple four-step catalytic reaction scheme involving C–C chain elongation and C–O bond *** synthesized pure n-alkanes had a carbon chain length as high as C_(49)(total yield of 49%).The synthesis approach also allows to selectively prepare n-alkanes with even and odd carbon numbers ranging from C15 to C_(49).This process represents a great breakthrough in the synthesis of long-chain pure n-alkanes,surpassing the carbon number limitations reported in previous methodologies.

关键词： Straight-chain alkane Aldol condensation F-Cacylation Hydrodeoxygenation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The roles of macrophage migration inhibitory factor in retinal diseases

引用

Neural Regeneration Research 2024年第2期19卷 309-315页

作者： Hongbing Zhang Xianjiao Zhang Hongsong Li bing Wang Pei chen Jiamin Meng Shaanxi Institute of Ophthalmology Xi’anShaanxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Department of Pathology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina

Macrophage migration inhibitory factor(MIF),a multifunctional cytokine,is secreted by various cells and participates in inflammatory reactions,including innate and adaptive *** are some evidences that MIF is involved in many vitreoretinal *** example,MIF can exacerbate many types of uveitis;measurements of MIF levels can be used to monitor the effectiveness of uveitis *** also alleviates trauma-induced and glaucoma-induced optic nerve ***,MIF is critical for retinal/choroidal neovascularization,especially complex *** exacerbates retinal degeneration;thus,anti-MIF therapy may help to mitigate retinal *** protects uveal melanoma from attacks by natural killer *** mechanism underlying the effects of MIF in these diseases has been demonstrated:it binds to cluster of differentiation 74,inhibits the c-Jun N-terminal kinase pathway,and triggers mitogen-activated protein kinases,extracellular signal-regulated kinase-1/2,and the phosphoinositide-3-kinase/Akt *** also upregulates Toll-like receptor 4 and activates the nuclear factor kappa-B signaling *** review focuses on the structure and function of MIF and its receptors,including the effects of MIF on uveal inflammation,retinal degeneration,optic neuropathy,retinal/choroidal neovascularization,and uveal melanoma.

关键词： diabetic retinopathy glaucoma macrophage migration inhibitory factor migration inhibitory factor receptor optic neuropathy retinal degeneration retinal neovascular uveal melanoma uveitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：