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The occurrence characteristics of oil in shales matrix from organic geochemical screening data and pore structure properties:An experimental study Author links open overlay panel

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Petroleum Science 2024年第1期21卷 1-13页

作者： Zi-Zhi Lin jun-Qian Li Shuang-Fang Lu Qin-Hong Hu Peng-Fei Zhang jun-Jie Wang Qi Zhi Hong-Sheng Huang Na Yin Yue Wang Tian-chen Ge National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025HainanChina College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

The occurrence characteristics of shale oil are of great significance to the movability of shale *** this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin were quantitatively evaluated by organic geochemistry and microscopic pore structure characterization *** Multiple Isothermal Stages Pyrolysis(MIS)experiment results show that the content of total oil,adsorbed oil,and free oil in the shales are 3.15-11.25 mg/g,1.41-4.95 mg/g,and 1.74-6.51 mg/g,*** which the silicon-rich shale has the best *** relative content of free oil shows an increasing trend in pores with pore diameters greater than 3 *** the relative content of free oil reaches 100%,the pore size of silicon-rich shale is about 200 nm,while that of calcium-rich shale,clay-rich shale,and siliceous mixed shale is about 10 *** occurrence law of adsorbed oil is opposite to that of free oil,which indicates that shale oil will occur in the pores and fractures in a free state in a more extensive pore size range(>200 nm).This study also enables us to further understand the occurrence characteristics of shale oil under the interaction of occurrence state and occurrence space.

关键词： Shale oil Occurrence characteristics Sequential solvent extraction Low-temperature nitrogen adsorption Funing Formation Dongtai Depression

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Risk factors for delayed intracranial hemorrhage secondary to ventriculoperitoneal shunt:A retrospective study

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World Journal of Clinical Cases 2022年第21期10卷 7302-7313页

作者： jun-chen chen Shou-Xing Duan Ze-Bin Xue Sen-Yuan Yang Yong Li Run-Long Lai Dian-Hui Tan Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Pediatric Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Pediatric Surgery Huazhong University of Science and Technology Union Shenzhen HospitalShenzhen 518052Guangdong ProvinceChina

BACKGROUND Delayed intracranial hemorrhage(DICH),a potential complication of ventriculoperitoneal(VP)shunts,has been associated with high mortality,but its risk factors are still *** To investigate the risk factors of DICH after VP *** We compared the demographic and clinical characteristics of DICH and non-DICH adult patients with VP shunts between January 2016 and December *** The 159 adult VP shunt patients were divided into 2 groups according to the development of DICH:the DICH group(n=26)and the non-DICH group(n=133).No statistically significant difference was found in age,sex,laboratory examination characteristics or preoperative modified Rankin Scale(mRS)score between the DICH and non-DICH groups(P>0.05);however,a history of an external ventricular drain(EVD)[P=0.045;odds ratio(OR):2.814;95%CI:1.024-7.730]and postoperative brain edema around the catheter(P<0.01;OR:8.397;95%CI:3.043-23.171)were associated with a high risk of DICH.A comparison of preoperative mRS scores between the DICH group and the non-DICH group showed no significant difference(P=0.553),while a significant difference was found in the postoperative mRS scores at the 3-mo follow-up visit(P=0.024).CONCLUSION A history of EVD and postoperative brain edema around the catheter are independent risk factors for DICH in VP shunt *** patients with a high mRS score are vulnerable to poor clinical outcomes.

关键词： Delayed intracranial hemorrhage Ventriculoperitoneal shunt Hydrocephalus Risk factor Retrospective study

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Chemoradiotherapy plus tislelizumab for mismatch repair proficient rectal cancer with supraclavicular lymph node metastasis:A case report

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2219-2224页

作者： Wen-Tao Zhong Yuan Lv Qian-Yu Wang Ran An Gang chen jun-Feng Du The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery The 7^(th)Medical Center of PLA General HospitalBeijing 100700China Department of Pathology The 7^(th)Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND According to the latest report,colorectal cancer is still one of the most prevalent cancers,with the third highest incidence and mortality *** of advanced rectal cancer with distant metastases is usually unsatisfactory,especially for mismatch repair proficient(pMMR)rectal cancer,which leads to poor prognosis and *** SUMMARY We report a case of a pMMR rectal adenocarcinoma with metastases of multiple lymph nodes,including the left supraclavicular lymph node,before treatment in a 70-year-old *** received full courses of chemoradiotherapy(CRT)followed by 4 cycles of programmed death 1 inhibitor Tislelizumab,and a pathologic complete response(pCR)was achieved,and the lesion of the left supraclavicular lymph node also *** pMMR advanced rectal cancer with preserved intact distant metastatic lymph nodes may benefit from full-course CRT combined with immunotherapy.

关键词： Rectal cancer Metastasis Chemoradiotherapy Immunotherapy Prognosis Case report

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MODULATION OF SYMPATHETIC NERVE ON POLYMODAL NOCICEPTORS IN RATS

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针刺研究 1989年第Z1期 101-102页

作者： Zhu jun Hu sanjue Fan Jinzhi Department of Physiology, the Fourth Military Medical University xian, China

Single fiber rcording technique and tail flick test of rat were used in thepresent study. The unit discharges evoked by mechanical stimuli and tail flicklatency responsed to noxious heat stimuli as indices of the activity of polymodalnociceptor were examined during and after sympathetic stimulation. Stimula-tion of the peripheral end of the lumbosaeral sympathetic trunk increased thedischarges of polymodal nociceptors at first and then inhibited markedly. Thedepression of the unit discharges lasted for more than ten min. Injection of

关键词： MODULATION OF SYMPATHETIC NERVE ON POLYMODAL NOCICEPTORS IN RATS test

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Novel Efficient Method for Synthesis of N_(1,4)-Disubstituted-1,4-benzodiazepine-2,5-diones

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Chemical Research in Chinese Universities 2009年第3期25卷 312-316页

作者： WANG Qiu-yan YU Jing-jun LU Cui-fen chen Zu-xing YANG Gui-chun Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education School of Chemistry and Chemical Engineering Hubei University Wuhan 430062 P. R. China

A novel and efficient method was developed for the liquid-phase synthesis of Nj,4-disubstitutedbenzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterifieation, ＂Ulmn reaction＂, acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.

关键词： 1,4-Benzodiazepine-2,5-dione Liquid-phase Dipeptides

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The Interoperability of Distributed DBMSs in a CORBA-Based Multidatabase System

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Wuhan University Journal of Natural Sciences 2002年第4期7卷 408-414页

作者： Sarem Mudar Li Rui-xuan Xiao Wei-jun Lu Zheng-ding chen Chuan-bo Huazhong University of Science and Technology

One way of achieving interoperability among heterogeneous, distributed DBMSs is through a multidatabase system. Recently, there is an increasing use of CORBA implementation in developing multidatabase systems. Panorama is a multidatabase system that has been implemented on the top of CORBA compliant namely VisiBroker. It aims to achieve interoperability among Oracle, Sybase and other different DBMSs through the registration of these DBMSs to Panorama and through the single global query language PanoSQL designed for this system. In this paper, we first introduce CORBA for the interoperability in multidatabase systems. Then, a general view for our designed multidatabase system, Panorama, has been given. In section four, we introduce the global query language PanoSQL designed to achieve interoperability among the different DBMSs implemented in Panorama. Then, as an example, we present the registration of Oracle to Panorama in order to achieve interoperability in this system. And finally, a conclusion and the future work for this system have been given.

关键词： interoperability heterogeneity CORBA global query language multidatabase systems

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Telomere-to-telomere and gap-free reference genome assembly of the kiwifruit Actinidia chinensis

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Horticulture Research 2023年第2期10卷 134-146页

作者： junyang Yue Qinyao chen Yingzhen Wang Lei Zhang chen Ye Xu Wang Shuo Cao Yunzhi Lin Wei Huang He xian Hongyan Qin Yanli Wang Sijia Zhang Ying Wu Songhu Wang Yi Yue Yongsheng Liu School of Horticulture Anhui Agricultural UniversityHefeiAnhui 230036China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhenGuangdong 518124China Institute of Fruit and Tea Hubei Academy of Agricultural SciencesWuhanHubei 430064China School of Information and Computer Anhui Agricultural UniversityHefeiAnhui 230036China Ministry of Education Key Laboratory for Bio-resource and Eco-environment College of Life ScienceState Key Laboratory of Hydraulic and Mountain River EngineeringSichuan UniversityChengduSichuan 610064China Department of Bioinformatics Anhui Double Helix Gene Technology CorporationHefeiAnhui 230022China Comprehensive Testing Ground Xinjiang Academy of Agricultural SciencesUrumqiXinjiang 830012China Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural SciencesChangchunJilin 130112China

Kiwifruit is an economically and nutritionally important fruit crop with extremely high contents of vitamin ***,the previously released versions of kiwifruit genomes all have a mass of unanchored or missing ***,we report a highly continuous and completely gap-free reference genome of Actinidia chinensis cv.‘Hongyang’,named Hongyang v4.0,which is the first to achieve two de novo haploid-resolved haplotypes,HY4P and ***4P and HY4A have a total length of 606.1 and 599.6 Mb,respectively,with almost the entire telomeres and centromeres assembled in each *** comparison with Hongyang v3.0,the integrity and contiguity of Hongyang v4.0 is markedly improved by filling all unclosed gaps and correcting some misoriented regions,resulting in∼38.6–39.5 Mb extra sequences,which might affect 4263 and 4244 protein-coding genes in HY4P and HY4A,***,our gap-free genome assembly provides the first clue for inspecting the structure and function of ***,centromeric regions are characterized by higher-order repeats that mainly consist of a 153-bp conserved centromere-specific monomer(Ach-CEN153)with different copy numbers among *** enrichment analysis of the genes located within centromeric regions demonstrates that chromosome centromeres may not only play physical roles for linking a pair of sister chromatids,but also have genetic features for participation in the regulation of cell *** availability of the telomere-to-telomere and gap-free Hongyang v4.0 reference genome lays a solid foundation not only for illustrating genome structure and functional genomics studies but also for facilitating kiwifruit breeding and improvement.

关键词： breeding linking assembly

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Mitigation of black carbon emissions could immediately reduce 6.3% of glacier melting in the Qilian Mountains

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Advances in Climate Change Research 2024年第4期15卷 725-736页

作者： Ji-Zu chen Wen-Tao DU Shi-Chang KANG xiang QIN Wei-jun SUN Li-Hui LUO Yang LI jun-Hua YANG You-Yan JIANG Qilian Shan Station of Glaciology and Eco-environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Geography and Environment Shandong Normal UniversityJinan 250014China Zhangye Meteorological Bureau Zhangye 734000China Lanzhou Regional Climate Center Lanzhou 730020China Institute of International Rivers and Eco-security Yunnan UniversityKunming 650500China Gansu Provincial Industry Technology Center of Inteligent Equipment and Big Data for Disaster Prevention Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China

Global warming in tandem with surface albedo reduction caused by black carbon(BC)deposition on glaciers accelerated glacier melting;however,their respective contributions remain *** in the Qilian Mountains are crucial for the development of oases in the Hexi Corridor;however,their area has decreased by more than 20%over the past ***,this study developed a dynamic deposition model for light-absorbing particles(LAPs),coupled with a surface energy and mass balance *** comprehensively assessed the effects of BC and warming on the melting of a typical glacier in the Qilian Mountains based on the coupled *** on the glacier surface caused 13.1%of annual glacier-wide melting,of which directly deposited atmospheric BC reduced the surface albedo by 0.02 and accounted for 9.1%of glacier *** air temperature during 2000-2010 has increased by 1.5℃ relative to that during the 1950s,accounting for 51.9%of current glacier ***,BC emission have increased by 4.6 times compared to those of the early Industrial Revolution recorded in an ice core,accounting conservatively for 6.3%of current glacier *** BC emissions has a limited influence on current glacier melting;however,in the long-term,mitigation should exert a noteworthy impact on glacier melting through the self-purification of glaciers.

关键词： Glacier Melting Black carbon Simulation Qilian Mountains

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Two new isospirostanol sapogenins from Reineckia carnea

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Chinese Chemical Letters 2012年第11期23卷 1240-1242页

作者： Yao Wang Na Han Ling Li chen Zhi Hui Liu Li Bo Zou jun Yin School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Development and Utilization Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Two new isospirostanol sapogenins named （25R）-5/%spirostane-（1αα 3a）-diol （1） and （25R）-5/%spirostane-（1α, 2α, 3α, 4α）- tetrol （2） were isolated from the whole herb ofReineckia carnea （Andr.） Kunth... 详细信息

关键词： Reineckia carnea (Andr) Kunth. Chemical constituent Isospirostanol sapogenin

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4-HNE Induces Apoptosis of Human Retinal Pigment Epithelial Cells by Modifying HSP70

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Current Medical Science 2019年第3期39卷 442-448页

作者： Lei-lei YANG Hao chen jun WANG Ting XIA Hong SUN Chun-hui YUAN Shi-liang LIU Jian-bin chen Department of Ophthalmology Wuhan Fourth Hospital (Puai Hospital) Huazhong University of Science and Technology Wuhan 430030China Department of Pathology Zhongnan Hospital of Wuhan University Wuhan 430070China Department of Laboratory Medicine Wuhan Medical and Health Center for Women and Children Huazhong University of Science and Technology Wuhan 430016 China Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The role of heat shock protein 70 (HSP70) in apoptosis of human retinal pigment epithelial cells (ARPE-19) induced by 4-hydroxy-2-nonenal (4-HNE) was explored. Different concentrations of 4-HNE were used to stimulate ARPE-19 cells, and apoptosis was measured by flow cytometry. The expression of apoptotic-related proteins, HSP70, X-linked inhibitorof- apoptosis (XIAP), Bcl-2, and Bax were quantified by Western blotting. HSP70 and XIAP overexpression plasmids, or their corresponding siRNAs were transfected into ARPE-19 cells using Lipofectamine. 2000. Co-immunoprecipitation and Western blotting were used to detect the effect of 4-HNE on the expression of HSP70 and the binding level between 4-HNE and HSP70. The results showed that 4-HNE induced late apoptosis in ARPE-19 cells, accompanied by elevated levels of 4-HNE-modified IISP70, but it did not affect HSP70 protein expression. 4-HNE-modified HSP70 down-regulated the expression of the apoptosis inhibitory protein XIAP. Overexpression of HSP70 or XIAP inhibited 4-HNE-induced apoptosis of ARPE-19 cells. It was suggested that 4-HNE could promote XIAP degradation by modification of HSP70 to induce late apoptosis of human retinal pigment epithelial cells.

关键词： 4-hydroxy-2-nonenal HSP70 XIAP human retinal pigment epithelial cells apoptosis

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