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Acta Seismologica Sinica(English Edition) 2001年第5期14卷 512-523页

作者： chen lian-wang Institute of Crustal Dynamics China Seismological Bureau Beijing China Center for Analysis and Prediction China Seismological Bureau Beijing China

Using three dimensional (3D) viscoelastic finite element method (FEM) we study the dynamic evolution pattern of the coseismic change of Coulomb failure stress and postseismic change, on time scale of hundreds years, of rheological effect induced by the MS=7.2 Xingtai earthquake on March 22, 1966. Then, we simulate the coseismic disturbance in stress field in North China and dynamic change rate on one-year scale caused by the Xingtai earthquake and Tangshan earthquake during 15 years from 1966 to 1980. Finally, we discuss the triggering of a strong earthquake to another future strong earthquake.

关键词： Xingtai earthquake Coulomb failure stress dynamic stress evolution 3D viscoelastic model P315.72 + 6

Experimental study on operative methods of pancreaticojejunostomy with reference to anastomotic patency and postoperative pancreatic exocrine function

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World Journal of Gastroenterology 2008年第3期14卷 441-447页

作者： Ming-Dong Bai liang-Qun Rong lian-chen wang Hai Xu Rui-Fang Fan Pei wang Xiao-Peng chen Liu-Bin Shi Shu-You Peng Department of General Surgery The Second Affiliated HospitalXuzhou Medical College Xuzhou 221006 Jiangsu Province China Department of Hepatobiliary Surgery Lanzhou General Hospital Lanzhou Command PLA Lanzhou 730050Gansu Province China Second Department of Health Care Lanzhou General Hospital Lanzhou Command PLA Lanzhou 730050 GansuProvince China Department of General Surgery Affiliated Yijishan Hospital Wannan Medical College Wuhu 241001 AnhuiProvince China Department of General Surgery Affiliated Huashan Hospital College of Medicine Fudan University Shanghai 200433China Department of General Surgery Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou310016 Zhejiang Province China

AIM:To assess the patency of pancreaticoenterostomy and pancreatic exocrine function after three surgical methods. METHODS: A pig model of pancreatic ductal dilation was made by ligating the main pancreatic duct. After 4 wk ligation, a total of 36 piglets were divided randomly into four groups. The piglets in the control group underwent laparotomy only; the others were treated by three anastomoses: (1) end-to-end pancreaticojejunostomy invagination (EEPJ); (2) end-to-side duct-to- mucosa sutured anastomosis (ESPJ); or (3) binding pancreaticojejunostomy (BPJ). Anastomotic patency was assessed after 8 wk by body weight gain, intrapancreatic ductal pressure, pancreatic exocrine function secretin test, pancreatography, and macroscopic and histologic features of the anastomotic site. RESULTS: The EEPJ group had significantly slower weight gain than the ESPJ and BPJ groups on postoperative weeks 6 and 8 (P < 0.05). The animals in both the ESPJ and BPJ groups had a similar body weight *** ductal pressure was similar in ESPJ and BPJ. However, pressure in EEPJ was significantly higher than that in ESPJ and BPJ (P < 0.05). All three functional parameters, the secretory volume, the flow rate of pancreatic juice, and bicarbonate concentration, were significantly higher in ESPJ and BPJ as compared to EEPJ (P < 0.05). However, the three parameters were similar in ESPJ and BPJ. Pancreatography performed after EEPJ revealed dilation and meandering of the main pancreatic duct, and the anastomotic site exhibited a variable degree of occlusion, and even blockage. Pancreatography of ESPJ and BPJ, however, showed normal ductal patency. Histopathology showed that the intestinal mucosa had fused with that of the pancreatic duct, with a gradual and continuous change from one to the other. For EEPJ, the portion of the pancreatic stump protruding into the jejunal lumen was largely replaced by cicatricial fibrous tissue. CONCLUSION: A mucosa-to-mucosa pancreatico- jejunostomy

关键词： Pancreaticojejunostomy Animal model anastomotic patency Pancreatic exocrine function Histopathology Pancreatography

Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells

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World Journal of Gastroenterology 2007年第12期13卷 1788-1793页

作者： Ming-Quan Song Jin-Shui Zhu Jin-lian chen Long wang Wei Da Li Zhu Wei-Ping Zhang Department of Gastroenterology The Sixth Affiliated Hospital of Shanghai Jiaotong University Shanghai 200233 China

AIM: To investigate the synergistic effect of oxymatrine(OM) and angiogenesis inhibitor NM-3 on modulatingapoptosis in human gastric cancer cell lines SGC-7901,MKN-45, MKN-74. METHODS: Human gastric cancer lines SGC-7901,MKN-45, MKN-74 were treated with OM in the absenceand presence of NM-3. The inhibitory rates weredetected by MTT assay. Synergistic effect of OM andNM-3 on the growth of survivin, bcl-2, bax and p53 inSGC-7901 cells were examined by semiquantitative RT-PCR and Western blotting, and their growth inhibitoryeffects were also observed on SGC-7901 tumor xenograftin nude ***: OM combined with NM-3 exhibited asynergistic inhibitory effect on the growth of SGC-7901,MKN-45 and MKN-74 cells in a time-dependent ***-four hours after treatment with OM, NM-3 aloneand their combination, mRNA expression of survivin andbcl-2 in SGC-7901 cells decreased, p53 mRNA expressionincreased. OM (4 g/L) combined with NM-3 significantlyincreased the expression of p53 mRNA and decreasedthe expression of survivin and bcl-2 compared witheither agent alone (193% ± 34% vs 129% ± 12%;44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%,P < 0.05). Western blotting showed that the synergisticeffect of OM and NM-3 on protein translation of survivin,bcl-2 and p 53 was in accordance with their ***, OM/NM-3 combination obviously exhibitedantitumor growth effect in xenografted human gastriccancer cells SGC-7901 compared with either agent ***: OM combined with NM-3 has synergisticinhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo.

关键词： NM-3 compound Oxymatrine Gastric cancer Apoptosis

Recent Advances in Nickel Catalyzed Carbonylative Reactions via the Insertion of Carbon Monoxide

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Chinese Journal of Chemistry 2024年第2期42卷 177-189页

作者： Xinzhou chen Gang chen Zhong lian Department of Dermatology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China

Carbonyl compounds have attracted considerable attention due to their extensive applications in drug ***,they are important synthetic intermediates for the construction of carbon-carbon and carbon-heteroatom ***-metal-catalyzed carbonylation via the insertion of co is one of the most efficient and straightforward strategies to access carbonyl ***,most of the transition-metal-catalyzed carbonylative reactions require expensive and toxic noble-metal ***,there is a growing demand for the exploration of nickel-catalyzed carbonylative reactions via the insertion of CO due to the earth abundance and low cost of *** with the well-established palladium-catalyzed carbonylative reactions,nickel-catalyzed analogous transformations have been relatively *** is primarily because CO strongly binds to nickel,often resulting in catalyst *** recent years,some research groups have focused on using CO surrogates or NN_(2) pincer nickel catalyst to circumvent the formation of Ni(CO)_(4).Nickel-catalyzed carbonylation has been applied in the construction of carbonyl-containing compounds,such as ketones,carboxylic acids,thioesters,acyl chloride and carboxamides.

关键词： Carbonylation Nickel catalysis Carbon monoxide C1 chemistry Carbonyl-containing compounds

Recent advances in fabrication and functions of neuromorphic system based on organic field effect transistor

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International Journal of Extreme Manufacturing 2024年第2期6卷 273-295页

作者： Yaqian Liu Minrui lian Wei chen Huipeng chen School of Physics and Electronic Engineering Zhengzhou University of Light IndustryHenan 450002People’s Republic of China Institute of Optoelectronic Display National&Local United Engineering Lab of Flat Panel Display TechnologyFuzhou UniversityFuzhou 350002People’s Republic of China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207People’s Republic of China Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore Department of Physics National University of Singapore3 Science Drive 3Singapore 117543Singapore

The development of various artificial electronics and machines would explosively increase the amount of information and data,which need to be processed via in-situ *** synapse devices can store and process signals in a parallel way,thus improving fault tolerance and decreasing the power consumption of artificial *** organic field effect transistor(OFET)is a promising component for bioinspired neuromorphic systems because it is suitable for large-scale integrated circuits and flexible *** this review,the organic semiconductor materials,structures and fabrication,and different artificial sensory perception systems functions based on neuromorphic OFET devices are ***,a summary and challenges of neuromorphic OFET devices are *** review presents a detailed introduction to the recent progress of neuromorphic OFET devices from semiconductor materials to perception systems,which would serve as a reference for the development of neuromorphic systems in future bioinspired electronics.

关键词： organic field effect transistor neuromorphic systems synaptic transistor sensory perception systems device fabrication

Immunological disturbance effect of exogenous histamine towards key immune cells

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Food Science and Human Wellness 2024年第4期13卷 1856-1863页

作者： Yanan Liu Huan Li Chong wang Shanjun chen Renjie lian Weiqiang wang Linglin Fu Yanbo wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Jinghai Group Co. Ltd.Rongcheng 264307China Jinhua Jinnian Ham Co. Ltd.Jinhua 321041China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

Histamine in food has attracted widespread attention due to the potential toxicity and associated health ***,its influences on immunological components,especially the function of key immune cells,are still poorly *** this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T *** results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of ***,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to *** the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine *** concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune *** work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

关键词： Histamine Immunological disturbance Food allergy Immune factor Edible safety

A novel triple periodic minimal surface-like plate lattice and its data-driven optimization method for superior mechanical properties

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 217-238页

作者： Yanda wang Yanping lian Zhidong wang Chunpeng wang Daining FANG State Key Laboratory for Turbulence and Complex Systems&Center for Applied Physics and Technology College of EngineeringPeking UniversityBeijing 100871China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China

Lattice structures can be designed to achieve unique mechanical properties and have attracted increasing attention for applications in high-end industrial equipment,along with the advances in additive manufacturing(AM)*** this work,a novel design of plate lattice structures described by a parametric model is proposed to enrich the design space of plate lattice structures with high connectivity suitable for AM *** parametric model takes the basic unit of the triple periodic minimal surface(TPMS)lattice as a skeleton and adopts a set of generation parameters to determine the plate lattice structure with different topologies,which takes the advantages of both plate lattices for superior specific mechanical properties and TPMS lattices for high connectivity,and therefore is referred to as a TPMS-like plate lattice(TLPL).Furthermore,a data-driven shape optimization method is proposed to optimize the TLPL structure for maximum mechanical properties with or without the isotropic *** this method,the genetic algorithm for the optimization is utilized for global search capability,and an artificial neural network(ANN)model for individual fitness estimation is integrated for high efficiency.A set of optimized TLPLs at different relative densities are experimentally validated by the selective laser melting(SLM)fabricated *** is confirmed that the optimized TLPLs could achieve elastic isotropy and have superior stiffness over other isotropic lattice structures.

关键词： lattice structure triple periodic minimal surface(TPMS) plate lattice structural optimization machine learning

The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit

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Biomedical and Environmental Sciences 2024年第7期37卷 726-738页

作者： Fang Xue Wenchao chen Xia lian Guanghui He Jingyuan Tian Yinghong Liu Gaiqing wang Department of Neurology The Second Clinical School of MedicineShanxi Medical UniversityTaiyuan 030002ShanxiChina The Second Clinical School of Medicine Shanxi Medical UniversityTaiyuan 030002ShanxiChina Department of Clinical lab The First People’s Hospital of ZhaotongZhaotong 657000YunnanChina Department of Neurology Sanya Central Hospital(Hainan Third People’s Hospital)Hainan Medical UniversitySanya 57200HainanChina

Objective Intracranial hemorrhage(ICH),the second most common subtype of stroke,exacerbates the disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of neurotoxic *** clearance capacity of the brain plays a crucial role in maintaining BBB homeostasis and facilitating patient recovery after *** study aimed to investigate the effect of circadian rhythms on BBB function,neuronal damage,and clearance *** The transwell model and hemoglobin were co-cultured to simulate the BBB environment after *** intervention with different light groups,neuronal apoptosis was determined,glial phagocytosis was analyzed,the expression of endogenous clearing-related proteins aquaporin 4(AQP4)and low-density lipoprotein receptor-related protein 1(LRP1)was detected by western blotting and immunofluorescence dual standard method,and the expression of the tight junction protein occludin and melatonin receptor 1A(MTNR1A)was quantitatively *** Circadian rhythms play a key role in maintaining the integrity of the BBB,reducing oxidative stress-induced neuronal damage,and improving microglial ***,the expression of occludin and MTNR1A in neurovascular unit(NVU)co-cultured with hemoglobin improved the expression of AQP4 and LRP1,the key proteins in the NVU's endogenous brain clearance *** Circadian rhythm(alternating black and white light)protects the NVU BBB function after ICH,promotes the expression of proteins related to the clearance of the hematoma,provides new evidence for the clinical treatment of patients recovering from ICH,and improves the circadian rhythm to promote brain metabolism and hematoma clearance.

关键词： Blood-brain barrier Circadian rhythm Neurovascular unit Melatonin receptor 1A Aquaporin-4

Unveiling oscillatory nature for sustainable fuel production

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National Science Review 2024年第5期11卷 90-91页

作者： Ning Han Ye wang Bao-lian Su Department of Materials Engineering State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers and Esters College of Chemistry and Chemical Engineering Xiamen University Laboratory of Inorganic Materials Chemistry(CMI) University of Namur State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

A century ago, in 1923, Franz Fischer and Hans Tropsch introduced the groundbreaking Fischer–Tropsch (FT) synthesis, a heterogeneous catalytic process used to convert synthesis gas (syngas,CO+H2) into multi-carbon hydrocarbons [1]. Over the past 100 years, FT synthesis has emerged as a pivotal method for converting non-petroleum resources into exceptionally clean fuels or valuable chemicals via syngas [2–4].

关键词： CO HYDROGENATION CATALYSTS BEHAVIOR KINETICS

Weed biology andmanagement in the multi-omics era:Progress and perspectives

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Plant Communications 2024年第4期5卷 16-35页

作者： Ke chen Haona Yang Di Wu Yajun Peng Lei lian lianyang Bai Lifeng wang Key Laboratory of Indica Rice Genetics and Breeding in the Middle and Lower Reaches of Yangtze River Valley Ministry of Agriculture and Rural AffairsHunan Rice Research InstituteHunan Academy of Agricultural SciencesChangsha 410125China State Key Laboratory of Hybrid Rice Hunan Academy of Agricultural SciencesChangsha 410125China Longping Branch College of BiologyHunan UniversityChangsha 410125China Huangpu Research Institute of Longping Agricultural Science and Technology Guangzhou 510715China Hunan Weed Science Key Laboratory Hunan Agricultural Biotechnology Research InstituteHunan Academy of Agricultural SciencesChangsha 410125China Qingdao Kingagroot Compounds Co.Ltd Qingdao 266000China

Weeds pose a significant threat to crop production,resulting in substantial yield *** addition,they possess robust weedy traits that enable them to survive in extreme environments and evade human *** recent years,the application of multi-omics biotechnologies has helped to reveal the molecular mechanisms underlying these weedy *** this review,we systematically describe diverse applications of multi-omics platforms for characterizing key aspects of weed biology,including the origins of weed spe-cies,weed classification,and the underlying genetic and molecular bases of important weedy traits such as crop–weed interactions,adaptability to different environments,photoperiodicflowering responses,and herbicide *** addition,we discuss limitations to the application of multi-omics techniques in weed science,particularly compared with their extensive use in model plants and *** this regard,we provide a forward-looking perspective on the future application of multi-omics technologies to weed science *** powerful tools hold great promise for comprehensively and efficiently unraveling the intricate molecular genetic mechanisms that underlie weedy *** resulting advances will facilitate the development of sustainable and highly effective weed management strategies,promoting greener practices in agriculture.

关键词： weeds multi-omics weed management genomics RNA-seq