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Food Science and Human Wellness 2024年

作者： Huizhen Li Yang chen Huiting Fang Xinmei Guo Xuecong Liu jianxin Zhao Wei chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Jinqiao Biotechnology Co.， Ltd. Huai'an， Jiangsu， China National Engineering Research Center for Functional Food， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University

Ulcerative colitis (UC) is a long-term inflammatory disorder that has evolved into a worldwide challenge. The development of new therapies against UC is imperative as all current therapies for UC are flawed in some way. Thus， the present study aimed to assess the palliative effects of Lactobacillus rhamnosus MP108 on UC in mice and to explore its potential mechanisms. The results showed that L. rhamnosus MP108 ameliorated the symptoms of UC， including preventing body weight loss， DAI elevation， and colon shortening， and attenuated colonic pathological damage. L. rhamnosus MP108 dramatically increased the number of goblet cells， MUC2 level， and tight junction protein level in the colon and remarkably inhibited epithelial cell apoptosis， thereby strengthening the intestinal barrier. L. rhamnosus MP108 pronouncedly diminished pro-inflammatory cytokine levels and strikingly augmented anti-inflammatory cytokine levels， in turn suppressing inflammation. Furthermore， L. rhamnosus MP108 conspicuously boosted the proportion of short-chain fatty acids (SCFAs) producers in gut microbiota， contributing to increased levels of acetate and butyrate. Therefore， L. rhamnosus MP108 might alleviate UC via improving the intestinal barrier， inhibiting inflammation， and modulating intestinal microbiota.

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Single-nucleus RNA and ATAC sequencing analyses provide molecular insights into early pod development of peanut fruit

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Plant Communications 2024年第8期5卷 50-68页

作者： Yuanyuan Cui Yanning Su jianxin Bian Xue Han Haosong Guo Zhiyuan Yang Yijun chen Lihui Li Tianyu Li Xing Wang Deng Xiaoqin Liu Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory for Advanced Agricultural Sciences at WeifangShandong 261325China School of Advanced Agricultural Sciences Peking UniversityBeijing 100083China

Peanut(Arachis hypogaea L.)is an important leguminous oil and economic crop that produces flowers aboveground and fruits *** fruit-pod development,which significantly affects peanut production,involves complex molecular mechanisms that likely require the coordinated regulation of multiple genes in different *** investigate the molecular mechanisms that underlie peanut fruitpod development,we characterized the anatomical features of early fruit-pod development and integrated single-nucleus RNA-sequencing(snRNA-seq)and single-nucleus assay for transposase-accessible chromatin with sequencing(snATAC-seq)data at the single-cell *** identified distinct cell types,such as meristem,embryo,vascular tissue,cuticular layer,and stele cells within the shell *** specific cell types were used to examine potential molecular changes unique to each cell type during pivotal stages of fruit-pod ***-seq analyses of differentially expressed genes revealed cell-type-specific insights that were not previously obtainable from transcriptome analyses of bulk *** instance,we identified MADS-box genes that contributes to the formation of parenchyma cells and gravity-related genes that are present in the vascular cells,indicating an essential role for the vascular cells in peg ***,our single-nucleus analysis provides comprehensive and novel information on specific cell types,gene expression,and chromatin accessibility during the early stages of fruit-pod *** information will enhance our understanding of the mechanisms that underlie fruit-pod development in peanut and contribute to efforts aimed at improving peanut production.

关键词： peanut pod development single-nucleus RNA-seq single-nucleus ATAC-seq in situ RNA hybridization

官能化的金属有机框架在气体小分子分离中的应用

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化工进展 2020年第6期39卷 2235-2240页

作者：李积慧陈建新河北工业大学化工学院天津300130

金属有机框架是由金属中心与有机配体自组装形成的一类结构可设计的新型多孔材料。吸附分离是金属有机框架的重要用途之一。本文介绍了以金属有机框架为多孔平台设计合成具有目标导向的官能化金属有机框架的途径以及官能化金属有机框架... 详细信息

金属有机框架是由金属中心与有机配体自组装形成的一类结构可设计的新型多孔材料。吸附分离是金属有机框架的重要用途之一。本文介绍了以金属有机框架为多孔平台设计合成具有目标导向的官能化金属有机框架的途径以及官能化金属有机框架在二氧化碳与氮气、甲烷分离,烷烃与烯烃分离,低碳烷烃等小分子气体分离纯化中的作用。表明官能化的金属有机框架由于官能团活性位点的存在,在二氧化碳、烯烃、烷烃等气体小分子分离中相对未经修饰的金属有机框架具有更高的分离选择性。官能化的金属有机框架的目标导向使其在化工分离领域具有更广阔的应用前景。目前材料合成难以量产限制了官能化的金属有机框架在化工分离方面的普及,随着合成方法的不断简化官能化金属有机框架在化工分离中会有更广泛的应用。

关键词：金属有机框架官能化吸附分离目标导向气体小分子

“出走一代”的启蒙困境——继承叙事视野下的“五四”新文学

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中华文化论坛 2020年第5期 67-75,156页

作者：陈建新西南科技大学四川成都610000

“五四”新文学中的反继承叙事作品,塑造了一大批出走者的形象。他们是文化弑父者,力图用自己的出走和反叛来完成对社会的启蒙。“出走一代”出走之后,普遍陷入迷惘之中,并没有完成启蒙的任务。启蒙话语的核心是个人的独立,理性的成长,... 详细信息

“五四”新文学中的反继承叙事作品,塑造了一大批出走者的形象。他们是文化弑父者,力图用自己的出走和反叛来完成对社会的启蒙。“出走一代”出走之后,普遍陷入迷惘之中,并没有完成启蒙的任务。启蒙话语的核心是个人的独立,理性的成长,而“出走一代”无法从人性的深处完成自我认识、自我反思和自我革命,构建独立完整的自我,完成自我启蒙。

关键词：继承叙事出走一代启蒙独立的自我 “五四”新文学

Robust,self-adhesive,and low-contact impedance polyvinyl alcohol/polyacrylamide dual-network hydrogel semidry electrode for biopotential signal acquisition

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SmartMat 2024年第2期5卷 67-82页

作者： Guangli Li Ying Liu Yuwei chen Yonghui Xia Xiaoman Qi Xuan Wan Yuan Jin Jun Liu Quanguo He Kanghua Li jianxin Tang Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Sciences and ChemistryHunan University of TechnologyZhuzhouChina Department of Neurology Zhuzhou People's HospitalZhuzhouChina Zhuzhou Institute for Food and Drug Control ZhuzhouChina

Herein,we fabricated a flexible semidry electrode with excellent mechanical performance,satisfactory self-adhesiveness,and low-contact impedance using physical/chemical crosslinked polyvinyl alcohol/polyacrylamide dual-network hydrogels(PVA/PAM DNHs)as an efficient saline *** resultant PVA/PAM DNHs showed admirable adhesive and compliance to the hairy scalp,facilitating the establishment of a robust electrode/skin interface for biopotential signal ***,the PVA/PAM DNHs steadily released trace saline onto the scalp to achieve the minimized potential drift(1.47±0.39 mV/min)and low electrode–scalp impedance(18.2±8.9 kΩ@10 Hz).More importantly,the application feasibility of real-world brain−computer interfaces(BCIs)was preliminarily validated by 10 participants using two classic BCI *** mean temporal cross-correlation coefficients between the semidry and wet electrodes in the eyes open/closed and the N200 speller paradigms are 0.919±0.054 and 0.912±0.050,*** electrodes demonstrate anticipated neuroelectrophysiological responses with similar *** semidry electrode could also effectively capture robust P-QRS-T peaks during electrocardiogram *** their outstanding advantages of fast setup,user-friendliness,and robust signals,the proposed PVA/PAM DNH-based electrode is a promising alternative to wet electrodes in biopotential signal acquisition.

关键词： brain-computer interface dual-network hydrogel electrocardiogram signals electroencephalography signals semidry electrode

Quantitative analysis of collagen morphology in breast cancer from millimeter scale using multiphoton microscopy

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创新光学健康科学杂志(英文) 2023年第4期16卷 48-57页

作者： Yulan Liu Shunwu Xu Deyong Kang Xingxin Huang Shuoyu Xu Lianhuang Li Liqin Zheng Lida Qiu Zhenlin Zhan Xiahui Han jianxin chen Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Provincial Key Laboratory of Photonics Technology Fujian Normal University Fuzhou 350007P.R.China School of Electronic and Mechanical Engineering Fujian Polytechnic Normal University Fuqing Fujian 350300P.R.China Department of Pathology Fujian Medical University Union Hospital Fuzhou 350001 P.R.China Department of General Surgery Nanfang Hospital Southern Medical University Guangzhou 510515P.R.China College of Physics and Electronic Information Engineering Minjiang University Fuzhou 350108P.R.China

The tumor microenvironment(TME)is now recognized as an important participant of tumor *** the most abundant extracellular matrix component in TME,collagen plays an important role in tumor *** imaging study of collagen morphological feature in TME is of great significance for understanding the state of *** microscopy(MPM),based on second harmonic generation(SHG)and two-photon excitation fluorescence(TPEF),can be used to monitor the morphological changes of biological tissues without *** this study,we used MPM for large-scale imaging of early invasive breast cancer from the tumor center to normal tissues far from the *** found that there were signi¯cant di®erences in collagen morphology between breast cancer tumor boundary,near tumor transition region and normal tissues far from the ***,the morphological feature of eight collagen¯bers was extracted to quantify the variation trend of collagen in three *** results may provide a new perspective for the optimal negative margin width of breast-conserving surgery and the understanding of tumor metastasis.

关键词： Breast cancer tumor microenvironment collagen¯ber morphology multiphoton microscopy

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一种校准混合滤波器组现实偏差的方法

仪器仪表学报 2010年第9期31卷 1972-1978页

作者：刘素娟杨玥陈建新北京工业大学电子信息与控制工程学院北京100124

现实误差的存在严重制约了并行采样混合滤波器组(HFB)模拟数字转换器(ADC)系统的重构精度,因此,本文首先分析了模拟偏差和通路失配误差对HFB ADC系统的影响。然后,提出一种频率相关等效模型(FDEM)。该模型整合了现实偏差对分解滤波器组... 详细信息

现实误差的存在严重制约了并行采样混合滤波器组(HFB)模拟数字转换器(ADC)系统的重构精度,因此,本文首先分析了模拟偏差和通路失配误差对HFB ADC系统的影响。然后,提出一种频率相关等效模型(FDEM)。该模型整合了现实偏差对分解滤波器组的影响,并且为数字综合滤波器组提供出准确的校准对象。最后,设计并实现了一个两通路12 b精度,200 MHz采样速度的HFB ADC系统。实验结果表明,应用FDEM方法后,93%频谱范围内(7%的过采样)混叠误差的平均无杂散动态范围(SFDR)可以从35 dB提升到87 dB,验证了该方法的实际可行性。

关键词：混合滤波器组模拟数字转换器分解滤波器组综合滤波器组通路失配偏差

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InAs/GaSbⅡ类超晶格红外探测技术

红外与激光工程 2011年第5期40卷 786-790页

作者：陈建新林春何力中国科学院上海技术物理研究所成像材料与器件国防重点实验室上海200083

由于Ⅱ类超晶格探测器在红外成像探测技术上极大的应用价值和前景,对这一低维半导体结构的研究持续不衰。近年来,Ⅱ类超晶格探测器在国际上发展极为迅速,已经实现了高性能的中波和长波超晶格焦平面探测器并进行了成像试验。改变超晶格... 详细信息

由于Ⅱ类超晶格探测器在红外成像探测技术上极大的应用价值和前景,对这一低维半导体结构的研究持续不衰。近年来,Ⅱ类超晶格探测器在国际上发展极为迅速,已经实现了高性能的中波和长波超晶格焦平面探测器并进行了成像试验。改变超晶格的周期,它的吸收截止波长可覆盖3-30μm的宽广范围。由于现代分子束外延材料生长技术,可以在单原子层的精度控制材料生长,因此截止波长由周期决定这一特性使得Ⅱ类超晶格探测器在实现红外焦平面均匀性方面独具优势。Ⅲ-Ⅴ族化合物材料与器件工艺的成熟性使得InAs/GaSb正成为一种很有竞争力的红外探测新技术。简要介绍了新型InAs/GaSb Ⅱ类超晶格红外探测技术,包括该技术的基本原理、材料生长、器件制备及其发展方向。

关键词： Ⅱ类超晶格红外探测器半导体

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建设高水平大学培养高素质人才

高教探索 2003年第3期 21-23,20页

作者：陈建新华南理工大学

建设高水平大学应始终把培养高素质人才作为根本使命和首要任务。本文提出建设高水平大学 ,培养高素质人才的办学理念。

关键词：办学理念大学人才培养教育创新质量标准办学定位

氨甲酰基硅烷与酮反应合成α-硅氧基酰胺衍生物

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有机化学 2014年第10期34卷 2124-2129页

作者：姚远李伟东陈建新山西师范大学化学与材料科学学院临汾041004 山西省临汾市实验中学临汾041000

N,N-二甲摹氨甲酰基三甲基硅烷与一系列芳基酮、不饱和芳基酮在无水无氧、105℃、甲苯作溶剂的条件下反应，合成了α-三甲基硅氧基酰胺衍生物，收率60％~89％，其结构用元素分析、^1H NMR、^13C NMR和IR等方法进行了表征．烷基烷基酮、... 详细信息

N,N-二甲摹氨甲酰基三甲基硅烷与一系列芳基酮、不饱和芳基酮在无水无氧、105℃、甲苯作溶剂的条件下反应，合成了α-三甲基硅氧基酰胺衍生物，收率60％~89％，其结构用元素分析、^1H NMR、^13C NMR和IR等方法进行了表征．烷基烷基酮、烷基芳基酮、烷基不饱和芳基酮与N，N-二甲基氨甲酰基三甲基硅烷不反应．通过研究反应的影响因素发现，反应底物酮中与羰基相连的芳环上取代基的电子效应是该加成反应的重要影响因素，芳环上取代基的给电子能力越强，反应越慢．

关键词：氨甲酰基硅烷酮 α-三甲基硅氧基酰胺亲核加成合成方法