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Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization

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Chinese Chemical Letters 2022年第9期33卷 4331-4334页

作者： Xingyu heng Ruyan feng Lijuan Zhu Liyin yu Gaojian chen hong chen College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow UniversitySuzhou 215006China

Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and ***(LPS)can promote DCs maturation by binding receptor on DCs surface,but their clinical application is limited due to biological *** many LPS analogues have been developed,complex synthesis and purification hinder their practical ***,we propose a novel and simple strategy to synthesize LPS analogues with adjustable structural *** monomer units similar to the key functional groups of LPS,we synthesize LPS analogues with different group ratios by RAFT *** obtained analogues have little negative effect on cell *** with LPS,the analogues show greater promoting effect on DCs *** the analogues can be applied to different scenarios since the degrees of promoting DCs maturation by LPS analogues with different group ratios are *** strategy provides a new direction for synthesizing LPS analogues,and it has the potential to produce LPS analogues on a large scale with tunable promoting DCs maturation effect.

关键词： LPS analogues Glycopolymer RAFT polymerization Dendritic cells(DCs) Immune enhancement

Bioinspired hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers

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National Science Review 2020年第1期7卷 73-83页

作者： Huai-Ling Gao Ran Zhao chen Cui Yin-Bo Zhu Si-Ming chen Zhao Pan yu-feng Meng Shao-Meng Wen Chuang Liu heng-An Wu Shu-hong yu Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in Nanoscience Hefei Science Center of CAS Department of Chemistry University of Science and Technology of China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China

Bio-sourced nanocellulosic materials are promising candidates for spinning high-performance sustainable macrofibers for advanced applications. Various strategies have been pursued to gain nanocellulose-based macrofibers with improved strength. However, nearly all of them have been achieved at the expense of their elongation and toughness. Inspired by the widely existed hierarchical helical and nanocomposite structural features in biosynthesized fibers exhibiting exceptional combinations of strength and toughness, we report a design strategy to make nanocellulose-based macrofibers with similar characteristics. By combining a facile wet-spinning process with a subsequent multiple wet-twisting procedure, we successfully obtain biomimetic hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers, realizing impressive improvement in their tensile strength, elongation and toughness simultaneously. The achievement certifies the validity of the bioinspired hierarchical helical and nanocomposite structural design proposed here. This bioinspired design strategy provides a potential platform for further optimizing or creating many more strong and tough nanocomposite fiber materials for diverse applications.

关键词： bioinspired nanocomposite hierarchical helical macrofibers strength and toughness bacterial cellulose

Determination of chlorogenic acid by flow injection irreversible biamperometry

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Chinese Chemical Letters 2007年第4期18卷 431-434页

作者： Li Jun Li Qi feng chen Lai Bo yu Zhao heng Zhong Jun feng Hao cheng hong Xing Kong Jian Ling Wu Department of Biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 China College of Chemistry and Chemical Engineering Guangxi University Nanning 530004 China

A flow injection irreversible biamperometric method for the determination of chlorogenic acid is described. The proposed method is based on the electrochemical oxidation of chlorogenic acid at pretreated platinum electrode and the reduction of permanganate at another electrode to form an irreversible biamperometric detection system. Under the external potential difference （z^v） of 0 V, in the 0.05 mol/L sulfuric acid, chlorogenic acid can be determined over the range 0.8-120 mg/L with a sample measurement frequency of 80 samples/h. The detection limit is 0.18 mg/L. The proposed method exhibits the satisfactory reproducibility with a relative standard derivation （R.S.D.） of 2.21% for 19 successive determinations of 40 mg/L.

关键词： Flow injection Irreversible biamperometry Chlorogenic acid Honeysuckle

Hierarchical Silver Indium Tungsten Oxide Mesocrystals with Morphology-, Pressure-, and Temperature-Dependent Luminescence Properties

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Nano Research 2010年第6期3卷 395-403页

作者： Bo Hu Li-heng Wu Zhi Zhao Meng Zhang Shao-feng chen Shu-Juan Liu hong-Yan Shi Ze-Jun Ding Shu-hong yu Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryDepartment of Materials Science and Engineeringthe National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Division of Instruments Center for Physical Science Hefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Department of Physics Hefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Highly hierarchical structures of silver indium tungsten oxide(AgIn(WO_(4))_(2))mesocrystals can be rationally fabricated via the microwave-assisted synthesis method by tuning the initial concentrations of the *** spectra of hierarchical AgIn(WO_(4))_(2) mesocrystals were measured to investigate the correlation between the morphology,pressure,and temperature and their luminescence *** materials showed interesting white emission when excited by visible light of wavelength 460 ***(WO_(4))_(2) materials having different morphologies displayed notable differences in photogenerated emission *** emission was strongly correlated with the surface nanostructures of outgrowths,with larger amounts of outgrowths leading to stronger emission *** pressure-and temperature-dependent photoluminescence properties of these materials have also been investigated under hydrostatic pressures up to 16 GPa at room temperature and in the temperature range from 10 to 300 K.

关键词： Photoluminescence AgIn(WO_(4))_(2) mesocrystal morphology high-pressure temperature

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

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Signal Transduction and Targeted Therapy 2022年第2期7卷 519-530页

作者： Lu feng chen Li Lin-Wen Zeng Deng Gao yu-Hao Sun Li Zhong heng Lin hong-Bing Shu Shu Li Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityMedical Research InstituteFrontier Science Center for Immunology and MetabolismResearch Unit of Innate Immune and Inflammatory DiseasesChinese Academy of Medical SciencesWuhan University430071 WuhanChina

Interleukin-3(IL-3)is a hematopoietic growth factor and critical regulator of inflammatory response such as ***-3 binds to IL-3 receptorα(IL-3Rα),which is then associated with IL-3Rβto initiate *** IL-3-triggered physiological and pathological effects are regulated at the receptor level is ***,we show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered ***3 is associated with IL-3Rα,mediates its K48-linked polyubiquitination at K377 and promotes its proteasomal ***3-deficiency promotes IL-3-triggered transcription of downstream effector genes and IL-3-induced expansion of myeloid *** the cecal ligation and puncture(CLP)model of sepsis,MARCH3-deficiency aggravates IL-3-ampified expression of inflammatory cytokines,organ damage and inflammatory *** findings suggest that regulation of IL-3Rαby MARCH3 plays an important role in IL-3-triggered physiological functions and inflammatory diseases.

关键词： inflammatory ubiquitin damage MARCH

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激波管双爆轰驱动段性能的数值模拟研究

力学学报 2007年第3期39卷 343-349页

作者：李进平姜宗林陈宏冯珩俞鸿儒中国科学院力学研究所高温气体动力学重点实验室北京100080

采用频散可控的耗散格式(DCD),求解Euler方程和一种改进的二阶段化学反应模型,对氢氧反向-正向双爆轰驱动段激波管进行了数值模拟．计算结果表明:当辅驱动段与主驱动段初始压力比小于临界值时, Taylor波仍会出现,但波扇夹角较单一前向... 详细信息

采用频散可控的耗散格式(DCD),求解Euler方程和一种改进的二阶段化学反应模型,对氢氧反向-正向双爆轰驱动段激波管进行了数值模拟．计算结果表明:当辅驱动段与主驱动段初始压力比小于临界值时, Taylor波仍会出现,但波扇夹角较单一前向爆轰驱动段小,入射激波马赫数衰减率变小;当初始压力比等于临界值时,主驱动段中的Taylor波完全被消除,入射激波马赫数不再衰减．当初始压力比大于临界值时,在主驱动段中能产生过驱动爆轰波,不仅Taylor波被完全消除,而且驱动能力较单一前向爆轰驱动段强.

关键词：爆轰波双爆轰驱动段激波管 Taylor波

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探求高效裂解生产乙烯的新途径

力学与实践 2005年第4期27卷 7-13页

作者：俞鸿儒单希壮陈宏冯珩中国科学院力学研究所高温气体动力学实验室北京100080

乙烯是裂解反应过程中的中间产物,其收率随反应时间变化.在最佳反应时间,收率最高.裂解反应温度愈高,峰值收率愈高,最佳反应时间则愈短.当前通用的竖管裂解炉难以满足大幅度提高乙烯收率并降低生产成本的要求.评述了几种激波加热方法的... 详细信息

乙烯是裂解反应过程中的中间产物,其收率随反应时间变化.在最佳反应时间,收率最高.裂解反应温度愈高,峰值收率愈高,最佳反应时间则愈短.当前通用的竖管裂解炉难以满足大幅度提高乙烯收率并降低生产成本的要求.评述了几种激波加热方法的优缺点.简要描述了我们目前正在研究中的反向射流混合加热方法.

关键词：乙烯裂解反应中间产物激波化学反应工艺

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

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Signal Transduction and Targeted Therapy 2022年第1期7卷 295-309页

作者： Meng-Li Wu feng-Liang Liu Jing Sun Xin Li Xiao-Yan He hong-Yi Zheng Yan-heng Zhou Qihong Yan Ling chen Guo-Ying yu Junbiao Chang Xia Jin Jincun Zhao Xin-Wen chen Yong-Tang Zheng Jian-Hua Wang College of Life Science Henan Normal UniversityXinxiang 453007China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China Shanghai Public Health Clinical Center Affiliated to Fudan University Shanghai 201508China University of Chinese Academy of Sciences Beijing 100039China

SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 *** the primary mediators that initiate the uncontrolled hypercytokinemia is essential for *** cells(MCs)are strategically located at the mucosa and beneficially or detrimentally regulate immune *** this study,we showed that SARS-CoV-2-triggered MC degranulation initiated alveolar epithelial inflammation and lung ***-CoV-2 challenge induced MC degranulation in ACE-2 humanized mice and rhesus macaques,and a rapid MC degranulation could be recapitulated with Spike-RBD binding to ACE2 in cells;MC degranulation altered various signaling pathways in alveolar epithelial cells,particularly,the induction of pro-inflammatory factors and consequential disruption of tight ***,the administration of clinical MC stabilizers for blocking degranulation dampened SARS-CoV-2-induced production of pro-inflammatory factors and prevented lung *** findings uncover a novel mechanism for SARS-CoV-2 initiating lung inflammation,and suggest an off-label use of MC stabilizer as immunomodulators for COVID-19 treatments.

关键词： inflammation lung alveolar

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超声速气流与反向射流的混合

空气动力学学报 2006年第4期24卷 430-432页

作者：冯珩陈宏单希壮李斌俞鸿儒中国科学院力学研究所高温气体动力学研究开放实验室北京100080

在不同的反向射流喷射角度条件下,对反向射流混合加热方案的混合效果进行了实验研究。采用空气和氢气燃烧混合物作为超声速载气流,常温下的空气作为反向射流。将混合前后流场的温度分布作为衡量载气流与反向射流混合效果的标志。实验结... 详细信息

在不同的反向射流喷射角度条件下,对反向射流混合加热方案的混合效果进行了实验研究。采用空气和氢气燃烧混合物作为超声速载气流,常温下的空气作为反向射流。将混合前后流场的温度分布作为衡量载气流与反向射流混合效果的标志。实验结果表明:混合均匀度随混合距离的增加而提高;反向射流的喷射角度在40°角附近时混合均匀度最佳;增大反向射流初始压力可有效提高反向射流与载气流的流量比,从而提高混合效率。

关键词：超声速混合裂解激波