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Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins

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Science China(Life Sciences) 2017年第2期60卷 138-151页

作者： Meng Wu wei wei Jiwei Chen Rong Cong Tieliu Shi Jiwen Li Jiemin wong James X.Du Shanghai Key Laboratory of Regulatory Biology the Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Collaborative Innovation Center for Cancer Medicine Sun Yat-Sen University Cancer CenterGuangzhou 510060China University de Lyon Ecole Normale Supdrieure de LyonCNRS USR 3010Laboratoire Joliot-CurieLyon 69364France

Histone methylation is believed to provide binding sites for specific reader proteins, which translate histone code into biological function. Here we show that a family of acidic domain-containing proteins including nucleophosmin （NPM 1）, pp32, SET/TAF 113, nucleolin （NCL） and upstream binding factor （UBF） are novel H3K4me2-binding proteins. These proteins exhibit a unique pattern of interaction with methylated H3K4, as their binding is stimulated by H3K4me2 and inhibited by H3K4mel and H3K4me3. These proteins contain one or more acidic domains consisting mainly of aspartic and/or glutamic residues that are necessary for preferential binding of H3K4me2. Furthermore, we demonstrate that the acidic domain with sufficient length alone is capable of binding H3K4me2 in vitro and in vivo. NPM1, NCL and UBF require their acidic domains for association with and transcriptional activation ofrDNA genes. Interestingly, by defining acidic domain as a sequence with at least 20 acidic residues in 50 continuous amino acids, we identified 655 acidic domain-containing protein coding genes in the human genome and Gene Ontology （GO） analysis showed that many of the acidic domain proteins have chromatin-related functions. Our data suggest that acidic domain is a novel histone binding motif that can differentially read the status of H3K4 methylation and is broadly present in chromatin-associated proteins.

关键词： histone methylation H3K4mel H3K4me2 H3K4me3 acidic domain histone code transcription chromatin

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Field synergy analysis of pollutant dispersion in street canyons and its optimization by adding wind catchers

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Building Simulation 2021年第2期14卷 391-405页

作者： Tingzhen Ming Huina Han Zhen Zhao Renaud de Richter Yongjia Wu wei Li Nyuk Hien wong School of Civil Engineering and Architecture Wuhan University of TechnologyNo.122 Luoshi RoadHongshan DistrictWuhan430070China School of Architectural Engineering Huanggang Normal UniversityNo.146 Xingang Second RoadHuanggang438000China School of design and environment National University of Singapore4 Architecture Drive117566SingaporeSingapore Tour-Solaire.Fr 8 Impasse des PapillonsF34090MontpellierFrance School of Engineering&Applied Science Aston UniversityBirminghamB47ETUK

The microenvironment,which involves pollutant dispersion of the urban street canyon,is critical to the health of pedestrians and *** objectives of this work are twofold:(i)to effectively assess the pollutant dispersion process based on a theory and(ii)to adopt an appropriate stratigy,i.e.,wind catcher,to alleviate the pollution in the street *** dispersion in street canyons is essentially a convective mass transfer *** the convective heat transfer process and the mass transfer process are physically similar and the applicability of field synergy theory to turbulence has been verified in the literature,we apply the field synergy theory to the study of pollutant dispersion in street *** this paper,a computational fluid dynamics(CFD)simulation is conducted to investigate the effects of wind catcher,wind speed and the geometry of the street canyons on pollutant *** to the field synergy theory,Sherwood number and field synergy number are used to quantitatively evaluate the wind catcher and wind speed on the diffusion of pollutants in asymmetric street *** results show that adding wind catchers can significantly improve the air quality of the step-down street canyon and reduce the average pollutant concentrations in the street canyon by 75%.Higher wind speed enhances diffusion of pollutants differently in different geometric street canyons.

关键词： street canyon field synergy theory CFD simulation pollutant dispersion wind catcher

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Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 40-46页

作者： Jeonghun Baek Chun Wai Mai wei Meng Lim Lai Chun wong School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Chemistry School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Technology School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia

AIM:To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial(ARPE)-19 cells in ***:ARPE-19 cells were cultured in Dulbecco’s Modified Eagle Medium-F-12 supplemented with 10%foetal bovine serum and 1%penicillin–streptomycin in a humidified 5%CO_(2) incubator maintained at 37℃.Cells were treated with 247μmol/L lutein,49μmol/L zeaxanthin and 1%(v/v)of either coconut oil,corn oil,peanut oil,olive oil,sunflower oil,soybean oil,castor oil,or linseed oil for *** and zeaxanthin concentration in the cells were quantified by high performance liquid ***:Among the oils tested,the highest lutein and zeaxanthin uptake was observed with coconut oil while the lowest was observed with linseed ***:ARPE-19 uptake of lutein and zeaxanthin are found to be dependent on the type of oils.

关键词： lutein zeaxanthin adult retinal pigment epithelial-19 cells vegetable oil

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Pre-emptive TIPSS in Acute Variceal Bleeding:Current Status,Controversies,and Future Directions

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1223-1228页

作者： Yu Jun wong wei Ling Danielle Ho Juan G.Abraldes Department of Gastroenterology and Hepatology Changi General HospitalSingapore Duke-NUS Medical School Singa-pore Division of Gastroenterology University of AlbertaEdmontonCanada

Acute variceal bleeding(AVB)is associated with signifi-cant short-term morbidity and ***-emptive tran-sjugular intrahepatic portosystemic shunt(p-TIPSS)is recommended to prevent rebleeding in AVB patients with a high risk of *** the benefit of prevent-ing rebleeding and de-novo ascites,the uptake of p-TIPSS remains low because logistic challenges in the real-world *** this review,we summarize the current evidence and controversies on p-TIPSS including patient selection for p-TIPSS,particularly in the setting of NASH cirrhosis and acute-on-chronic liver failure,the role of sarcopenia,renal impairment in the setting of ***,we summarize both pharmacological and nonpharmacological strategies to optimize outcomes in patients undergoing p-TIPSS.

关键词： Transjugular intrahepatic portosystemic shunt Hemorrhage Portal hypertension Cirrhosis

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Phenolic constituents and anticancer properties of Morus alba(white mulberry) leaves

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Journal of Integrative Medicine 2020年第3期18卷 189-195页

作者： Eric wei Chiang Chan Siu Kuin wong Joseph Tangah Tomomi Inoue Hung Tuck Chan Faculty of Applied Sciences UCSI University56000 CherasKuala LumpurMalaysia School of Foundation Studies Xiamen University Malaysia43900 SepangSelangorMalaysia Forest Research Centre Sabah Forestry Department90009 SandakanSabahMalaysia Centre for Environmental Biology and Ecosystem Studies National Institute for Environmental Studies(NIES)OnogawaTsukuba 305-0053Japan Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves(MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins(benzofurans), caffeoylquinic acids(phenolic acids) and morachalcones(chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were Pub Med,Pub Med Central, Science Direct, Google, Google Scholar, J-Stage, Pub Chem and China National Knowledge Infrastructure.

关键词： Flavonoids Benzofurans Cytotoxic Moracins Morachalcones Chalcomoracin

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An overview of Pu-erh tea and its health-promoting effects of lipid-lowering and anti-obesity

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Journal of Chinese Pharmaceutical Sciences 2021年第8期30卷 623-633页

作者： Eric wei Chiang Chan Siu Kuin wong Hung Tuck Chan Faculty of Applied Sciences UCSI University56000 Cher asKuala LumpurMalaysia School of Foundation Studies Xiamen University MalaysiaBandar Sunsuria43900 SepangSelangorMalaysia Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

As a dark tea,Pu-erh tea(PET)is produced from sun-dried leaves of Camellia sinensis *** mainly in Yunnan Province of *** microorganisms are involved in the fermentation of *** them,Aspergillus niger is most *** is believed that the longer the preservation period,the better is the quality and taste of PET,which is commercially available as loose,compressed or instant tea *** components of PET include flavones,flavanols,flavonols,phenolic acids,alkaloids and *** this overview,the lipid-lowering and anti-obesity effects of PET were discussed based on animal models and human trials,and our study provided some insights into possible mechanisms of bioactive compounds,such as theabrownin,catechins,lovastatin and gallic *** bioactivities of PET and some information on Fuzhuan brick tea were also *** of information cited were from Google Scholar,Pub Med,Pub Med Central,Science Direct,J-Stage,Pub Chem,Directory of Open Access Journals(DOAJ),and China National Knowledge Infrastructure(CNKI).

关键词： Pu-erh tea Fuzhuan brick tea Fermentation Lipid-lowering Anti-obesity

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Chemical Analyses of Palm Kernel Oil-Based Polyurethane Prepolymer

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Materials Sciences and Applications 2012年第2期3卷 78-86页

作者： chee Sien wong Khairiah Haji Badri 不详

Polyurethane (PU) was prepared from palm kernel oil-based monoester polyol (PKO-p) via prepolymerization method at NCO/OH ratio of 200/100, 150/100, 100/100, and 75/100 at ambient temperature under nitrogen gas atmosphere. The structure of the synthesized prepolymerized PKO-p PU was determined using FTIR and 13C NMR. The disapperance of NCO peak in the FTIR spectrum at 2270 cm–1 - 2250 cm–1 cm showed that MDI has completely reacted to form PU. The appearance of C=O peak at 1700 cm–1 indicated that hydrogen bonding was formed between the soft segmented chain of the PKO-p and the hard segmented MDI. Hence, urethane bond was the main polymeric chain in the PU.

关键词： Palm Kernel Oil Prepolymerization Polyurethane Soft Segment Hard Segment

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Alpinia zerumbet, a ginger plant with a multitude of medicinal properties： An update on its research findings

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Journal of Chinese Pharmaceutical Sciences 2017年第11期26卷 775-788页

作者： Eric wei Chiang Chan Siu Kuin wong Hung Tuck Chan Faculty of Applied Sciences UCSI University Cheras 56000 Kuala Lumpur Malaysia School of Science Monash University Sunway Petaling Jaya 46150 Selangor Malaysia Secretariat International Society for Mangrove Ecosystems c/o Faculty of Agriculture University of the Ryukyus 903-0129 Okinawa Japan

In this review, the botany and uses of Alpinia zerumbet(yan shan jiang) are described, and the current knowledge of its phytochemistry, pharmacological properties, and clinical trials is summarized. An important ginger crop in East Asia, A. zerumbet has many uses, both medicinal and non-medicinal. Leaves are used to produce essential oils and herbal teas. Rhizomes are consumed as spices, and stem fibers are made into paper, fabrics, and handicrafts. In Brazil, tea from A. zerumbet leaves is believed to have hypotensive, diuretic, and anti-ulcerogenic properties. This species possesses many medicinal properties due to its chemical constituents, including flavonoids, phenolic acids, phenylpropanoids, kava pyrones, sterols, and terpenoids. Extracts of A. zerumbet display antioxidant, antimicrobial, insecticidal, anthelmintic, tyrosinase and melanogenesis inhibitory, anti-atherogenic, anti-aging, anti-glycation, integrase and neuraminidase inhibitory, lifespan prolongation, hair growth promotion, anticancer, antidepressant, anxiolytic, anti-obesity, analgesic, anti-inflammatory, hypolipidemic, anti-ulcerogenic, anti-platelet, osteoblastic, osteogenic, thrombolytic, and cardiac arrhythmogenic activities. Essential oils of A. zerumbet leaves have antimicrobial, larvicidal, antinociceptive, hypotensive, vasorelaxant, myorelaxant, antispasmodic, antidepressant, anxiolytic, anti-neuraminidase, anti-atherogenic, anti-aging, anti-melanogenic, anti-tyrosinase, cytoprotective, cardiodepressive, antipsychotic, analgesic, anti-inflammatory, and tissue healing activities. Clinical trials conducted in Brazil showed that extracts of A. zerumbet have hypotensive and diuretic effects whereas topical application of the essential oil has positive therapeutic effects on patients with fibromyalgia. Spanning two continents of Asia and South America, A. zerumbet is truly a multi-purpose ginger plant with promising medicinal properties.

关键词： Alpinia zerumbet Shell ginger Phytochemistry Pharmacology Clinical trials

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Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

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Genes & Diseases 2022年第4期9卷 841-844页

作者： Shang Jiunn Chuah chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen wong Asher Ah Tong Lim Sai Kiang Lim wei Seong Toh Faculty of Dentistry National University of Singapore119085Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering Program Life Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering Program NUS Graduate SchoolNational University of Singapore119077Singapore

Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.

关键词： healing clinical macrophage

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Genipin and geniposide from Gardenia jasminoides:An overview of their anti-cancer and other pharmacological properties

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Journal of Chinese Pharmaceutical Sciences 2022年第1期31卷 1-12页

作者： Eric wei Chiang Chan Siu Kuin wong Hung Tuck Chan Faculty of Applied Sciences UCSI University56000 CherasKuala LumpurMalaysia School of Foundation Studies Xiamen University MalaysiaBandar Sunsuria43900 SepangSelangorMalaysia Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Genipin and geniposide are iridoids from the fruits of Gardenia *** compounds have a methyl acetate(-COOCH_(3))group at C4 and a hydroxyl(-OH)group at *** an iridoid glucoside with a glucose moiety at C1,geniposide is also known as genipin-1-O-β-*** the glucose moiety,genipin is an iridoid and the aglycone of ***-OH group at C1 of genipin is responsible for its cytotoxic *** without the-OH group at C1 lacks the cytotoxic *** are more publications on the anti-cancer properties of genipin than *** have reported the potentiation of genipin when used in combination with anti-cancer *** anti-cancer properties of geniposide have been investigated using human intestinal microflora that hydrolyzes geniposide to *** genipin and geniposide exert antiproliferative and apoptotic activities via different molecular targets and *** pharmacological properties of genipin and geniposide include antidepressant,antidiabetic,anti-inflammatory,anti-obesity,anti-thrombotic,hepatoprotective,and neuroprotective *** research on genipin and geniposide is suggested.

关键词： Iridoid Iridoid glucoside Anti-cancer Cytotoxicity

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