Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

作     者：Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh 

作者机构：Faculty of DentistryNational University of Singapore119085Singapore Institute of Molecular and Cell BiologyAgency for ScienceTechnology and Research138648Singapore Department of Orthopaedic SurgeryYong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical EngineeringFaculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering ProgramLife Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering ProgramNUS Graduate SchoolNational University of Singapore119077Singapore 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2022年第9卷第4期

页      面：841-844页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：This work was funded by National University of Singapore(No.R221000114114,R221000134114) National Medical Research Council Singapore(No.R221000123213) SKL and WST are supported by the Agency for Science,Technology and Research under its Health and Biomedical Sciences Industry Alignment Fund Pre-Positioning(No.H19H6a0026) 

主　　题：healing clinical macrophage 

摘      要：Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.