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The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells

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Bone Research 2022年第1期10卷 95-106页

作者： Zhenqing Liu Hye-lim Lee Jin Sook Suh peng Deng Chang-Ryul Lee Olga Bezouglaia Mojan Mirnia Vivian Chen Michael Zhou Zhong-Kai Cui Reuben HKim Min Lee Tara Aghaloo Christine Hong Cun-Yu Wang Division of Oral Biology and Medicine School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Anatomy&Neurobiology University of CaliforniaIrvine(UCI)IrvineCA 92697USA Department of Orofacial Sciences School of DentistryUniversity of CaliforniaSan Francisco(UCSF)San FranciscoCA 94143USA School of Dentistry University of CaliforniaSan Francisco(UCSF)San FranciscoCA 94143USA Division of Diagnostic and Surgical Sciences School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA School of Dentistry University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Division of Advanced Prosthodontics School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Division of Constitutive and Regenerative Sciences School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA

Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopausal osteoporosis, induces osteogenesis by activating the estrogen receptor signaling pathway and upregulating the expression of osteogenic genes, such as bone morphogenetic proteins(BMPs). The epigenetic regulation of estrogen-mediated osteogenesis,however, is still unclear. In this report, we found that estrogen significantly induced the expression of lysine-specific demethylase 6B(KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of ***, upon estrogen stimulation, estrogen receptor-α(ERα) was recruited to the KDM6B promoter, directly enhancing KDM6B expression. Subsequently, KDM6B was recruited to the BMP2 and HOXC6 promoters, resulting in the removal of H3K27me3 marks and activating the transcription of BMP2 and HOXC6, the master genes of osteogenic differentiation. Furthermore, we found that estrogen enhanced DMSC osteogenesis during calvarial bone regeneration and that estrogen’s pro-osteogenic effect was dependent on KDM6B in vivo. Taken together, our results demonstrate the vital role of the ERα/KDM6B regulatory axis in the epigenetic regulation of the estrogen-dependent osteogenic response.

关键词： expression stimulation ERα

Static analysis of ultra-thin beams based on a semi-continuum model

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Acta Mechanica Sinica 2011年第5期27卷 713-719页

作者： Cheng Li Zhi-Jun Zheng Ji-Lin Yu C.W. lim CAS Key Laboratory of Mechanical Behaviorand Design of Materials University of Science and Technology of China230027 Hefei China Department of Building and Construction City University of Hong KongTat Chee Avenue KowloonHong Kong SAR China

A linear semi-continuum model with discrete atomic layers in the thickness direction was developed to investigate the bending behaviors of ultra-thin beams with nanoscale *** theoretical results show that the deflection of an ultra-thin beam may be enhanced or reduced due to different relaxation *** the relaxation coefficient is greater/less than one,the deflection of micro/nano-scale structures is enhanced/reduced in comparison with macro-scale ***,two opposite types of size-dependent behaviors are observed and they are mainly caused by the relaxation *** with the classical continuum model,exact nonlocal stress model and finite element model （FEM） verify the validity of the present semi-continuum *** particular,an explanation is proposed in the debate whether the bending stiffness of a micro/nano-scale beam should be greater or weaker as compared with the macro-scale *** characteristics of bending stiffness are proved to be associated with the relaxation coefficients.

关键词： Bending stiffness · MEMS/NEMS · Relaxation coefficient · Semi-continuum model · Size-dependence

Stretchable magnesium-air battery based on dual ions conducting hydrogel for intelligent biomedical applications

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InfoMat 2023年第3期5卷 45-57页

作者： Xingcan Huang Yiming Liu Wooyoung Park Zhao Zhao Jiyu Li chee Kent lim Tsz Hung Wong Chun Ki Yiu Yuyu Gao Jingkun Zhou HuLi Ling Zhao Jian Li Binbin Zhang Ya Huang Rui Shi Dengfeng Li Jiaying Mo Jinpei Wang Chao Zhang Yuhang Li Zuankai Wang Xinge Yu Department of Biomedical Engineering City University of Hong KongKowloonHong Kongthe People's Republic of China Institute of Solid Mechanics Beihang University(BUAA)Beijingthe People's Republic of China Hong Kong Center for Cerebra-Cardiovascular Health Engineering Hong Kong Science ParkKowloonNew TerritoriesHong Kongthe People's Republic of China School of Energy and Environment City University of Hong KongKowloonHong Kongthe People's Republic of China Department of Mechanical Engineering City University of Hong KongKowloonHong Kongthe People's Republic of China Aircraft and Propulsion Laboratory Ningbo Institute of Technology Beihang University(BUAA)Ningbothe People's Republic of China Shenzhen Research Institute City University of Hong Kong Shenzhenthe People's Republic of China

Flexible and bio-integrated electronics have attracted great attention due to their enormous contributions to personalized medical *** sources,serving as one of the most important components,have been suffering from many problems,including deficient biocompatibility,poor stretchability,and unstable electrical outputs under deformed conditions,which limits the practical applications in flexible and bio-integrated ***,we reported a fully stretchable magnesium(Mg)–air battery based on dual-ions-conducting hydrogels(SDICH).The high-performance battery enables long-term operation with lighting 120 lighting emitting diodes(LEDs)for over 5 *** from the advanced materials and mechanical designs,the battery exhibits stability electrical outputs under stretching,which allows to operate ordinarily under various mechanical deformations without performance ***,the great biocompatibility of the battery offers great opportunity for biomedical applications,which is demonstrated by a self-adaption wound dressing *** in vitro and in vivo results prove that the self-adaption wound dressing can effectively prevent wound inflammation and promote wound *** exploiting thermal feedback mechanics,the system can adjust antibiotic release rate and dosage spontaneously according to the real-time wound *** proposed fully stretchable Mg-air battery and self-adaption wound dressing display great potential in skin-integrated electronics and personalized medicine.

关键词： bioelectronics flexible electronics Mg-air battery stretchable battery wound healing

Transverse vibration of pre-tensioned nonlocal nanobeams with precise internal axial loads

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Science China(Technological Sciences) 2011年第8期54卷 2007-2013页

作者： LI Cheng lim C. W. YU JiLin ZENG QingChuan Department of Modern Mechanics University of Science and Technology of China Hefei 230026 China Department of Building and Construction City University ofHong Kong Tat Chee Avenue Kowloon Hong Kong SAR China China and USTC-CityU Joint Advanced Research Centre Suzhou 215123 China College of Water Conservancy and tlydropower Engineering Hohai University Nanjing 210098 China

This paper investigates the transverse vibration of a simply supported nanobeam with an initial axial tension based on the nonlocal stress field theory with a nonlocal size parameter. Considering an axial elongation due to transverse vibration, the internal axial tension is not precisely equal to the external initial tension. A sixth-order nonlinear partial differential equation that governs the transverse vibration for such nonlocal nanobeam is derived. Using a perturbation method, the relation between natural frequency and nonlocal nanoscale parameter is derived and the transverse vibration mode is solved. The external axial tension and nonlocal nanoscale parameter are proven to play significant roles in the nonlinear vibration behavior of nonlocal nanobeams. Such effects enhance the natural frequency and stiffness as compared to the predictions of the classical continuum mechanics models. Additionally, the frequency is higher if the precise internal axial load is considered with respect to that when only the approximate internal axial tension is assumed.

关键词： nonlocal stress natural frequency free vibration nonlocal nanoscale

Functionalized graphene oxide-reinforced electrospun carbon nanofibers as ultrathin supercapacitor electrode

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Journal of Energy Chemistry 2017年第4期26卷 790-798页

作者： W.K.chee H.N.lim Y.Andou Z.Zainal A.A.B.Hamra I.Harrison M.Altarawneh Z.T.Jiang N.M.Huang Department of Chemistry Faculty of ScienceUniversiti Putra Malaysia Functional Device Laboratory Institute of Advanced TechnologyUniversiti Putra Malaysia Graduate School of Life Science and Systems Engineering Eco-Town Collaborative R&D Center for the Environment and RecyclingKyushu Institute of Technology Department of Electrical and Electronic Engineering Faculty of EngineeringUniversity of Nottingham Surface Analysis and Materials Engineering Research Group School of Engineering and Information TechnologyMurdoch University Faculty of Engineering Xiamen University of Malaysia

Graphene oxide has been used widely as a starting precursor for applications that cater to the needs of tunable graphene. However, the hydrophilic characteristic limits their application, especially in a hydrophobic condition. Herein, a novel non-covalent surface modification approach towards graphene oxide was conducted via a UV-induced photo-polymerization technique that involves two major routes; a UV-sensitive initiator embedded via pi-pi interactions on the graphene planar rings, and the polymerization of hydrophobic polymeric chains along the surface. The functionalized graphene oxide successfully achieved the desired hydrophobicity as it displayed the characteristic of being readily dissolved in organic solvent. Upon its addition into a polymeric solution and subjected to an electrospinning process,non-woven random nanofibers embedded with graphene oxide sheets were obtained. The prepared polymeric nanofibers were subjected to two-step thermal treatments that eventually converted the polymeric chains into a carbon-rich conductive structure. A unique morphology was observed upon the addition of the functionalized graphene oxide, whereby the sheets were embedded and intercalated within the carbon nanofibers and formed a continuous structure. This reinforcement effectively enhanced the electrochemical performance of the carbon nanofibers by recording a specific capacitance of up to 140.10 F/g at the current density of 1 A/g, which was approximately three folds more than that of pristine *** also retained the capacitance up to 96.2% after 1000 vigorous charge/discharge cycles. This functionalization technique opens up a new pathway in tuning the solubility nature of graphene oxide towards the synthesis of a graphene oxide-reinforced polymeric structure.

关键词： Non-covalent functionalization Functionalized graphene oxide Electrospinning Carbon nanofiber Supercapacitor electrode

The quality of escalator signage for public safety in Malaysia:an observational study

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Global Health Journal 2021年第4期5卷 198-203页

作者： Chii-Chii Chew chee-Tao Chang Xin-Jie lim Hasni-Adha Ibrahim Hamiazwa Azmi Nur-Ilyana Wahabi Nur-Shuhaida Hamdan Nurul-Atiqah Nazan Nur-Haliana Karim Nurfarahdila-Ahmad Malawi Ying-Ling Oon Norshazila-Julia MS Amar-Singh HSS Clinical Research Center Hospital Raja Permaisuri BainunLevel 4Ambulatory Care CenterJalan Raja Ashman ShahIpohPerak 30450Malaysia Allied Health Science College Sultan Azlan Shah Ministry of HealthTanjong RambutanIpohPerak Darul Ridzuan 31250Malaysia Department of Paediatric Hospital Raja Permaisuri BainunMinistry of HealthJalan Raja Ashman ShahIpohPerak 30450Malaysia

Objective:Escalator signage could be playing a vital role to alert users for safe use of *** study aimed to evaluate the availability,standardization,and content of safety information on escalator signage in the shopping ***:An observational study was conducted from November 2017 to February 2018 to assess the availability,standardization of safety information among the signage inside the shopping mall,and the content of safety information for public safety in Malaysia.A checklist was developed by adapting escalator safety guidelines from seven countries and regions including *** collctors identified from the selected states were required to capture three photographs at different angles of the escalator signage for each ascending and descending directions at each entrance of the *** analysis was performed;each criterion was presented in frequency and ***:A total of 268 escalators from 84 shopping malls in 9 states of Malaysia were *** operating escalators were not equipped with *** than one-ifth(23.0%)of the signage was not standardized within the *** majority of safety information was displayed in the form of a pictogram,a minority of signage displayed information in both pictogram and text format:"children must hold hand"(12.7%)and"be careful of long clothing"(10.8%),***,"toddlers should be carried"(8.6%)and"take extra care with rubber shoes/tied shoes/laces"(30.2%)were found absent in most of the ***:Escalator signage was present in almost all of the escalators ***,non-standardization of the signage of escalators should warrant the attention of relevant authorities to revise the safety guideline s and improve the quality of escalator.

关键词： Elevators and escalators Safety Transportation facilities Environment and public health Malaysia

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DMFC燃料电池便携式应用前景

电子产品世界 2009年第1期16卷 70-73页

作者： peng lim MTI公司

由于电池技术跟不上电子产品的发展速度,便携式电源亟待创新。直接甲醇燃料电池(DMFC)技术可确保更长的运行时间,并可在任何远离电网电源的地方即时充电,因而可提供真正的移动性。

关键词： DMFC 燃料电池便携产品甲醇

集成了500V启动单元的ICE3BS02离线开关电源电流模式控制器

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电子设计应用 2004年第5期 118-119页

作者： lim chee Siong Simon Jeoh Meng Kiat Infineon公司

概述ICE3BS02是开关电源电流控制脉宽调制器.它尤其适用于LCD显示器、打印机和笔记本电脑的适配器、DVD播放器、机顶盒及工业辅助电源的AC/DC电源.本文将介绍此款IC的特点.

关键词： ICE3BS02 开关电源电流控制脉宽调制器 “主动”间歇模式自动重启模式过压保护输出过载保护系统开环保护

Quantitative Poincar recurrence in continued fraction dynamical system

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Science China Mathematics 2012年第1期55卷 131-140页

作者： peng Li TAN Bo WANG BaoWei School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China

Let T ： X → X be a transformation. For any x C [0, 1） and r 〉 O, the recurrence time Tr（x） of x under T in its r-neighborhood is defined as Tr（X） = inf{k ≥ 1： d（Tk（x）,x）〈 r}.For 0 ≤ α ≤ β ∞ co, le... 详细信息

Let T ： X → X be a transformation. For any x C [0, 1） and r 〉 O, the recurrence time Tr（x） of x under T in its r-neighborhood is defined as Tr（X） = inf{k ≥ 1： d（Tk（x）,x）〈 r}.For 0 ≤ α ≤ β ∞ co, let E（α,β） be the set of points with prescribed recurrence time as follows E（α,β）={x∈X：lim inf r→0 logTr（x）/-logr=α,lim sup r→0 logTr（x）/-logr=β}.In this note, we consider the Gauss transformation T on [0, 1）, and determine the size of E（α,β）by showing that dimH E（α,β） = 1 no matter what a and/~ are. This can be compared with Feng and Wu＇s result [Nonlinearity, 14 （2001）, 81-85] on the symbolic space.

关键词： recurrence continued fraction Hausdorff dimension