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In vivo astrocyte reprogramming following spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 487-488页

作者： Yannick N.Gerber Florence e.Perrin MMDN University of MontpellierEPHEINSERMMontpellierFrance Institut Universitaire de France(IUF) ParisFrance

Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury *** absence of spontaneous axonal regeneration after injury results from neuron-intrinsic and neuron-extrinsic ***,not only adult neurons display limited capability to regrow axons but also the injury environment contains inhibitors to axonal regeneration and a lack of growth-promoting *** other cell populations that respond to the lesion,reactive astrocytes were first considered as only detrimental to spontaneous axonal ***,astrocytes.

关键词： injury impairment programming

Scanning transmission electron microscopy and atom probe tomography analysis of non-stoichiometry long-period-stacking-ordered structures in Mg-Ni-Y/Sm alloys

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Journal of Magnesium and Alloys 2024年第3期12卷 954-965页

作者： Yimeng Chen Manuel Legrée Jean-Louis Bobet Alexander Kvit CAMeCA Instruments Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Materials Science Department University of WisconsinMadisonWI 53706USA

The long-period-stacking-ordered(LPSO)structure affects the mechanical,corrosion and hydrolysis properties of Mg *** current work employs high angle annular dark field-scanning transmission electron microscopy(HAADF-STeM)and atom probe tomography(APT)to investigate the structural and local chemical information of LPSO phases formed in Mg-Ni-Y/Sm ternary alloys after extended isothermal *** on the alloying elements and their concentrations,Mg-Ni-Y/Sm develops a two-phase LPSO+α-Mg structure in which the LPSO phase contains defects,hybrid LPSO structure,and Mg ***-STeM and APT indicate non-stoichiometric LPSO with incomplete Ni_(6)(Y/Sm)_(8) *** addition,the APT quantitatively determines the local composition of LPSO and confirms the presence of Ni within the Mg bonding *** results provide insight into a better understanding of the structure and hydrolysis properties of LPSO-Mg alloys.

关键词： Magnesium alloys Long-range ordering Atom probe tomography(APT) STeM HAADF Hydrolysis properties.

The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： D A Baghdasaryan V A Harutynyan e M Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

A bacterial protein Rhp-PSP inhibits plant viral proliferation through endoribonuclease activity

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Journal of Integrative Agriculture 2024年第6期23卷 1967-1978页

作者： Lijie Chen Qianze Peng Xiaohua Du Weixing Zhang Ju’e Cheng Shu’e Sun Deyong Zhang Pin Su Yong Liu Longping Branch College of BiologyHunan UniversityChangsha 410082China State Key Laboratory of Hybrid Rice/Institute of Plant Protection Hunan Academy of Agricultural SciencesChangsha 410125China

Plant virus causes massive crop losses ***,there is currently no effective measure to control plant viral ***,we identify an antiviral protein Rhp-PSP,produced by the bacterial Rhodopseudomonas palustris strain *** this study,we discover that the antiviral activity of Rhp-PSP relies on its endoribonuclease *** the arginine(R)residue at position 129 onto alanine(A)abolishs its endoribonuclease activity on coat protein(CP)RNA of tobacco mosaic virus(TMV),consequentially,compromises the antiviral activity of *** investigation demonstrates that,the mutant Rhp-PSP^(R129A)is unable to form the homotrimer as the wild type,indicating the importance of quaternary junction for the endoribonuclease *** of Rhp-PSP in Nicotiana benthamiana significantly enhances the resistance against TMV of seedlings,while expression of Rhp-PSP^(R129A)did not,confirming that endoribonuclease activity is responsible for the antiviral activity of *** addition,foliar spray of Rhp-PSP solution on tomato and pepper plants significantly reduces the disease index of viral diseases,indicating that Rhp-PSP shows potential to develop antiviral agent in practice.

关键词： Rhodopseudomonas palustris Rhp-PSP tobacco mosaic virus endoribonuclease antiviral activity

The WhatsApp Application as a Teledentistry Tool in Oral and Maxillofacial Surgery in Cameroon

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Open Journal of Stomatology 2024年第8期14卷 362-372页

作者： Karl Guy Grégoire Kwedi Ruth Karen Katia Kwedi Fred-Cyrille Goethe Doualla charles eboa Kwedi charles Bengondo Messanga Department of Oral Maxillofacial and Periodontal Surgery Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon Department of Public Health School of Health Sciences Catholic University of Central Africa Yaound Cameroon Society & education Technologies Yaound Cameroon Health Medical School Douala Cameroon

Introduction: Technological advances have greatly influenced the healthcare sector. The ability to transmit information and deliver services using telecommunication tools continues to transform the way healthcare is delivered around the world. The aim of this study was to highlight the epidemiological, clinical and therapeutic profile of oral and maxillofacial surgery patients consulted using the WhatsApp application. Methodology: This was a three-year descriptive study with a retrospective data collection, from 2021 to 2023, of WhatsApp communications between our team and oral and maxillofacial surgeons in Cameroon. In this study, the type/content of messages received, the epidemiological data of practitioners and patients, the various pathologies diagnosed and the procedures performed were evaluated. Results: 319 communications were received for a total of 146 cases. Written messages associated with images (photographs and/or X-rays) were the most frequently received, at 85.62%. Hospitals in urban areas were the most represented at 93.84%. Oral health professionals in the private sector sent more messages (65.75%). In terms of diagnoses, tumour and cystic pathologies were the most common (28.08%), followed by impacted/retained teeth (22.6%). Patients were referred to our hospital for treatment in 62.33% of cases. Conclusion: The WhatsApp application is an easy-to-use telecommunications tool. It facilitates exchanges between practitioners and improves patient care in oral and maxillofacial surgery.

关键词： Teledentistry WhatsApp Oral and Maxillofacial Surgery Cameroon

男性运动员睡眠障碍的神经机制探究:基于复杂网络模型

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中国体育科技 2024年第2期60卷 11-20页

作者：李秦陇车开萱 charles JSteward 赵丽周越北京体育大学北京100084 考文垂大学英国考文垂CV15FB

目的:通过使用无目标不加权及目标加权的复杂网络模型方法,分析睡眠障碍运动员睡前神经机能状态与睡眠质量的复杂作用方式,揭示运动员发生睡眠障碍的神经机能状态特征。方法:在睡眠实验室内使用多导睡眠仪监测14名男性睡眠障碍运动员4... 详细信息

目的:通过使用无目标不加权及目标加权的复杂网络模型方法,分析睡眠障碍运动员睡前神经机能状态与睡眠质量的复杂作用方式,揭示运动员发生睡眠障碍的神经机能状态特征。方法:在睡眠实验室内使用多导睡眠仪监测14名男性睡眠障碍运动员4晚完整睡眠,并在睡前使用便携式脑电仪、超慢波涨落潮技术、Polar H10心率胸带和心境状态量表,分别测试或评估中枢机能状态、脑内神经递质水平、自主神经状态以及情绪状态。基于测试数据分别建立无目标不加权,以及以睡眠质量为目标的加权复杂网络模型。结果:1)无目标不加权的复杂网络模型中,介数中心性结果提示,慌乱、精力和愤怒情绪、α抑制%、去甲肾上腺素(Ne)和多巴胺、相邻窦性R-R间期差值大于50 ms所占百分比(PNN50)、平均R-R间隔、平均心率(MHR)和睡眠总时间是此网络的关键影响节点。特征向量中心性分析结果显示,上述指标中除PNN50、Ne和MHR外,抑郁、紧张和疲劳情绪与其他指标仍是网络的重要连接节点。2)在以睡眠质量为目标的加权复杂网络模型中,目标介数中心性结果发现,情绪状态在到达睡眠质量指标的最短路径中出现频率最高(48.57%),其次神经递质和睡眠指标频率相同(14.29%),而中枢神经机能状态和自主神经状态出现的频率最低(11.43%)。目标特征向量中心性结果表明,情绪状态成为影响睡眠质量最重要的影响因素,出现频率为82.86%,其次是自主神经状态出现频率为8.57%,而中枢神经机能状态、神经递质和睡眠指标出现频率相同(2.86%)。结论:运动员睡眠障碍的主要表现为总时长短,睡眠期间觉醒时间长导致睡眠效率低。复杂网络模型方法揭示了情绪(主要为消极情绪)是睡眠质量低和睡眠障碍发生的主要影响节点和关键因素,其中愤怒、慌乱情绪与脑内神经递质(5-HT和DA)、中枢疲劳程度相关,中枢疲劳程度和自主神经协调性与精力状态相关。

关键词：睡眠质量情绪状态神经系统复杂网络模型

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evaluation of Hydrocarbon Potential Using AVO Analysis in the FORMAT Field, Niger Delta Basin, Nigeria

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Open Journal of Geology 2024年第3期14卷 403-430页

作者： charles Chibueze Ugbor Onyebuchi Samuel Onyeabor Ifeanyi Celestine Ugwuoke Department of Geology University of Nigeria Nsukka Enugu State Nigeria

The study involved the evaluation of the hydrocarbon potential of FORMAT Field, coastal swamp depobelt Niger delta, Nigeria to obtain a more efficient reservoir characterization and fluid properties identification. Despite advances in seismic data interpretation using traditional 3D seismic data interpretation, obtaining adequate reservoir characteristics at the finest level had proved very challenging with often disappointing results. A method that integrates the amplitude variation with offfset (AVO) analysis is hereby proposed to better illuminate the reservoir. The Hampson Russell 10.3 was used to integrate and study the available seismic and well data. The reservoir of interest was delineated using the available suite of petrophysical data. This was marked by low gamma ray, high resistivity, and low acoustic impedance between a true subsea vertical depth (TVDss) range of 10,350 - 10,450 ft. The AVO fluid substitution yielded a decrease in the density values of pure gas (2.3 - 1.6 g/cc), pure oil (2.3 - 1.8 g/cc) while the Poisson pure brine increased (2.3 to 2.8 g/cc). Result from FORMAT 26 plots yielded a negative intercept and negative gradient at the top and a positive intercept and positive gradient at the Base which conforms to Class III AVO anomaly. FORMAT 30 plots yielded a negative intercept and positive gradient at the top and a positive intercept and negative gradient at the Base which conforms to class IV AVO anomaly. AVO attribute volume slices decreased in the Poisson ratio (0.96 to - 1.0) indicating that the reservoir contains hydrocarbon. The s-wave reflectivity and the product of the intercept and gradient further clarified that there was a Class 3 gas sand in the reservoir and the possibility of a Class 4 gas sand anomaly in that same reservoir.

关键词： AVO Analysis Hydrocarbon Potential Fluid Properties Reservoir Characterization Petrophysical Data Hampson Russel

Simultaneous Waveform Inverse Modelling for Litho-Fluid Prediction in an Old Marginal, “Agbbo”Field, Onshore Niger Delta, Nigeria

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Journal of Geoscience and environment Protection 2024年第5期12卷 40-59页

作者： charles Chibueze Ugbor Peter Ogobi Odong Chukwuemeka Austine Okonkwo Department of Geology University of Nigeria Nsukka Nigeria Department of Geology and Mining Enugu State University of Science and Technology Enugu Nigeria

Simultaneous waveform inversion was used to predict lithofacies and fluid type across the field. Very often, characterizing reservoirs in terms of lithology and fluid type using conventional methods is replete with uncertainties, especially in marginal fields. An approach is employed in this study that integrated rock physics and waveform inverse modelling for lithology and fluid-type characterization to appropriately identify potential hydrocarbon saturated zones and their corresponding lithology. Seismic and well-log data were analyzed using Hampson Russel software. The method adopted includes lithofacies and fluid content analysis using rock physics parameters and seismic simultaneous inverse modelling. Rock physics analysis identified 2 broad reservoirs namely: HDZ1 and HDZ2 reservoirs. Results from the inverse modelling showed that low values of acoustic impedance from 19,743 to 20,487 (ft/s)(g/cc) reflect hydrocarbon-bearing reservoirs while medium to high values shows brine and shale respectively, with brine zone ranging from 20,487 to 22,531 (ft/s)(g/cc) and shale above 22,531 (ft/s)(g/cc). Two lithofacies were identified from inversion analysis of Vp/Vs and Mu-Rho, namely: sand and shale with VpVs 1.95 values respectively. Mu-Rho > 12.29 (GPa)(g/cc) and epresent sand and shale respectively. From 3D volume, it was observed that a high accumulation of hydrocarbon was observed to be saturated at the north to the eastern part of the field forming a meandering channel. Sands were mainly distributed around the northeastern to the southwestern part of the field, that tends to be away from Well 029. This was also validated by the volume of rigidity modulus (Mu-Rho) showing high values indicating sands fall within the northeastern part of the field.

关键词： Simultaneous Waveform Inversion Lithofacies Fluid Type Rock Physics Hydrocarbon Acoustic Impedance Mu-Rho Reservoir

Integrated Geological and Geophysical Mapping for Groundwater Potential Studies at ekwegbe-Agu and environs, enugu State, Nigeria

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Open Journal of Geology 2024年第4期14卷 513-547页

作者： charles Chibueze Ugbor Ugochukwu Kingsley Ogbodo Osita Kelechi eze Department of Geology University of Nigeria Nsukka Nigeria

The study integrates both the geological and geophysical mapping techniques for groundwater potential studies at ekwegbe-Agu and the environs, enugu state, Nigeria for optimal citing of borehole. Located in the Anambra Basin between latitudes 6˚43'N and 6˚47'N and longitudes 7˚28'e and 7˚32'e, it is stratigraphycally underlain by, from bottom to top, the enugu/Nkporo, Mamu and Ajali Formation respectively, a complex geology that make citing of productive borehole in the area problematic leading to borehole failure and dry holes due to inadequate sampling. The study adopted a field and analytic sampling approach, integrating field geological, electrical resistivity and self-potential methods. The software, SedLog v3.1, InterpexIx1Dv.3, and Surfer v10 were employed for the data integration and interpretation. The result of the geological field and borehole data shows 11 sedimentary facies consisting of sandstone, shales and heterolith of sandstone/shale, with the aquifer zone mostly prevalent in the more porous sand-dominated horizons. Mostly the AK and HK were the dominant curve types. An average of 6 geo-electric layers were delineated across all transects with resistivity values ranging from 25.42 - 105.85 Ωm, 186.38 - 3383.3 Ωm, and 2992 - 6286.4 Ωm in the enugu, Mamu and Ajali Formations respectively. The resistivity of the main aquifer layer ranges from 1 to 500 Ωm. The aquifer thickness within the study area varies between 95 and 140 m. The western and northwestern part of the study area which is underlain mainly by the Ajali Formation showed the highest groundwater potential in the area and suitable for citing productive boreholes.

关键词： Seismic ekwegbe-Agu Groundwater Resistivity Field Mapping Borehole Logging