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Increased salt sensitivity induced by sensory denervation: role of superoxide

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Acta Pharmacologica Sinica 2004年第12期25卷 60-66页

作者： Alex F ChEN,Donna h wang Department of Medicine and Pharmacology & toxicology Michigan State University East Lansing MI 48824 USA Department of Medicine and Pharmacology & toxicology Michigan State University East Lansing MI 48824 USA

AIM: to test the hypothesis that production of superoxide in mesenteric resistance arteries is increased and con- tributes to the development of hypertension induced by sensory denervation plus high salt intake. MEthODS: Newborn Wistar rats were given capsaicin 50 mg/kg sc on the 1st and 2nd d of life. After weaning, male rats were grouped as follows and treated for 3 weeks with: capsaicin pretreatment plus normal sodium diet (0.5 %, CAP-NS), CAP plus high sodium diet (4 %, CAP-hS), control plus NS (CON-NS), or CON-hS. Both tail-cuff systolic blood pressure and mean arterial pressure (MAP) were measured in each of the groups. Western blot analysis was used for measurement of manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) in the mesenteric resistance arteries. Lucigenin chemiluminescence assay was used for superoxide production in the mesenteric resistance arteries. the Griess method was used for measurement of nitrite/nitrate levels in plasma. RESULtS: Both tail-cuff pressure and MAP were higher in CAP-hS compared with CAP-NS, CON-hS, and CON- NS rats (Pth MnSOD and eNOS in the mesenteric resistance arteries were increased in CAP-hS compared with CAP-NS, CON-hS, and CON-NS (Phowever, nitrite/nitrate levels in plasma were not different among 4 groups. Acute iv administration of tempol, a membrane-permeable superoxide scavenger, de- creased MAP in both CAP-hS and CON-hS when compared with their respective controls. however, the de- creases of MAP between these two groups were not different. Chronic treatment with tempol failed to prevent the development of hypertension in CAP-hS rats. Superoxideproduction in the mesenteric resistance arteries was increased in CAP-hS compared with CAP-NS, CON-hS, and CON-NS (Phowever, chronic treatment with tempol did not prevent the increase of mesenteric superoxideproduction in CAP-hS rats. CONCLUSIONS: Regardless of increased vascular MnSOD levels, salt

关键词： superoxides tempol afferent neurons capsaicin denervation dietary sodium chloride nitric oxide

Stochastic Distribution Control of Singular Systems: Output PDF Shaping

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自动化学报 2005年第1期31卷 151-160页

作者： h.YUE A.J.A.LEPRAND h.wang InstituteofAutomation ChineseAcademyofSciencesBeijing100080P.R.China ControlSystemsCentre TheUniversityofManchesterManchesterM601QDUK instituteofAutomation ChineseAcademyofSciencesBeijing100080P.R.China／／ControlSystemsCentreTheUniversityofManchesterManchesterM601QDUK

this paper presents a new algorithm designed to control the shape of the output probability density function (PDF) of singular systems subjected to non-Gaussian input. the aim is to select a control input uk such that the output PDF is made as close as possible to a given *** on the B-spline neural network approximation of the output PDF, the control algorithm is formulated by extending the developed PDF control strategies of non-singular systems to singular systems. It has been shown that under certain conditions the stability of the closed-loop system can be guaranteed. Simulation examples are given to show the effectiveness of the proposed control algorithm.

关键词：随机分布控制单系统 PDF显示输出动态随机系统概率密度函数

Editorial for Multiscale&Multifield Coupling in Geomechanics

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1919-1921页

作者： Min wang Pengzhi Pan Andrew h.C.Chan Y.t.Feng t-3 Fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia College of Engineering Swansea UniversityWalesUK

We are delighted to serve as guest editors for this special issue in the Journal of Rock Mechanics and Geotechnical *** purpose of this special issue is dedicated to gathering the latest research work on Multiscale&Multifield Coupling in Geomechanics,where we delve into the intricate interplay of various fields and scales that govern the behavior of *** total,30 manuscripts from USA,China,UK,Germany,Canada,India and United Arab Emirates are selected to be included in this issue.

关键词： materials. gathering mechanics

Superconducting fluctuation induced conductance corrections near a pair-breaking quantum phase transition in doubly connected ultrathin cylinders of Al

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Science China(Physics,Mechanics & Astronomy) 2020年第3期63卷 89-97页

作者： Ke Zhang ZongLi wang Da Xu YaZhe wang h.wang Ying Liu Department of Physics Zhejiang UniversityHangzhou 310027China Key Laboratory of Artificial Structures and Quantum Control(MOE)and Shanghai Center for Complex Physics School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Materials Research Institute and Department of Physics Pennsylvania State UniversityUniversity ParkPA 16802USA Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

We report measurements on ultrathin,doubly connected superconducting cylinders of Al that exhibit a destructive regime,which refers to the loss of superconductivity in a doubly connected superconductor near applied half flux quanta due to the sample topology and the small size of the sample.A depairing quantum phase transition(QPt)between a superconducting and metallic state tuned by the magnetic flux enclosed in the quasi one-dimensional(1D)cylinder was found at the onset of the destructive *** on magnetic flux and temperature dependent sample resistance as well as current-voltage characteristics revealed the presence of both thermally activated and quantum phase slips near the depairing *** the superconducting side of the QPt,thermally activated phase slips as described by the Langer-Ambegaokar and McCumber-halperin(LAMh)theory were found to describe the sample resistance as the system was pushed towards the QPt by a magnetic field applied along the cylinder ***,deviation from this behavior was found at low temperatures,signaling the presence of the quantum phase *** importantly,we observed a highly unusual negative slope in the resistance versus temperature curves on the metallic side of the QPt as predicted by the diagrammatic calculation of the dc conductivities in a 1D system near a depairing *** work suggests that fluctuations from both the phase and the amplitude of the superconducting order parameter are important for the superconductor-to-metal depairing QPt.

关键词： mesoscopic superconductor quantum phase transition superconducting fluctuation

Is there more than one stickiness criterion?

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Friction 2023年第6期11卷 1027-1039页

作者： Anle wang Martin h.MüSER Department of Material Science and Engineering Saarland UniversitySaarbrücken66123Germany INM—Leibniz Institute for New Materials Saarbrücken66123Germany

Adhesion between an elastic body and a smooth,rigid substrate can lead to large tensile stresses between ***,most macroscopic objects are microscopically rough,which strongly suppresses adhesion.A fierce debate has unfolded recently as to whether local or global parameters determine the crossover between small and large ***,we report simulations revealing that the dependence of the pull-off force Fn on the surface energyγdoes not only have two regimes of high and low adhesion but up to four *** are related to contacts,which at the moment of rupture consist of(i)the last individual hertzian-shaped contact,in which is linear inγ,(ii)a last meso-scale,individual patches with super-linear scaling,(iii)many isolated contact patches with extremely strong scaling,and(iv)a dominating largest contact patch,for which the pull-off stress is no longer negligible compared to the maximum,microscopic pull-off ***(iii)can be seen as a transition *** is located near the point where the surface energy is half the elastic energy per unit area in conformal contact.A criterion for the transition between regimes(i)and(ii)appears difficult to grasp.

关键词： adhesion pull-off force rough contact stickiness

Superconducting anisotropy and vortex pinning in CaKFe_(4)As_(4) and KCa_(2)Fe_(4)As4F_(2)

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Chinese Physics B 2021年第2期30卷 131-137页

作者： A B Yu Z huang C Zhang Y F Wu t wang t Xie C Liu h Li W Peng h Q Luo G Mu h Xiao L X You t hu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Beijing Academy of Quantum Information Sciences Beijing 100193China Center for high Pressure Science and technology Advanced Research Beijing 100094China CAS Center for Excellence in Superconducting Electronics(CENSE) Shanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

the vortex pinning determining the current carrying capacity of a superconductor is an important property to the applications of superconducting *** layered superconductors,the vortex pinning can be enhanced by a strong interlayer interaction in accompany with a suppression of superconducting anisotropy,which remains to be investigated in iron based superconductors(FeSCs)with the layered ***,based on the transport and magnetic torque measurements,we experimentally investigate the vortex pinning in two bilayer FeSCs,CaKFe_(4)As_(4)(Fe1144)and KCa_(2)Fe_(4)As4F_(2)(Fe12442),and compare their superconducting anisotropyγ.While the anisotropyγ≈3 for Fe1144 is much smaller thanγ≈15 in Fe12442 around tc,a higher flux pinning energy as evidenced by a higher critical current density is found in Fe1144,as compared with the case of *** combination with the literature data of Ba_(0.72)K_(0.28)Fe2As_(2) and Nd Fe As_(O0.82)F_(0.18),we reveal an anti-correlation between the pinning energy and the superconducting anisotropy in these Fe *** results thus suggest that the interlayer interaction can not be neglected when considering the vortex pinning in Fe SCs.

关键词： iron based superconductors vortex pinning anisotropy

A MAthEMAtICAL MODEL FOR thE StABILItY OF thEhYDRIDES OF Ca CONtAINING RNi_5 COMPOUNDS

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Acta Metallurgica Sinica(English Letters) 1998年第2期11卷 116-120页

作者： X.h.wang Zhejiang Univ Hangzhou China

In this paper, a mathematical model for the stability of hydrides of Ca containing compounds was proposed on the basis of introducing the geometrical and electric factors. the data on (R, Ca)Ni5 compounds are in good agreement with the theoretical curve obtained from the model. For Ml1-x CaxNi5 compounds, the variation of dissociation pressure with cell volume is the joint effects of geometrical and electric factors, and the controlling factor changes gradually from geometrical factor to electric factor with increasing x.

关键词： hydride hydrogen storage alloy intermetallic compound rare earth

A review on the application of modified continuum models in modeling and simulation of nanostructures

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Acta Mechanica Sinica 2016年第1期32卷 83-100页

作者： K.F.wang B.L.wang t.Kitamura Graduate School at Shenzhen Harbin Institute of Technology Department of Mechanical Engineering Kyoto University

Analysis of the mechanical behavior of nanos- tructures has been very challenging. Surface energy and non- local elasticity of materials have been incorporated into the traditional continuum analysis to create modified continuum mechanics models. this paper reviews recent advancements in the applications of such modified continuum models in nanostructures such as nanotubes, nanowires, nanobeams, graphenes, and nanoplates. A variety of models for these nanostructures under static and dynamic loadings are men- tioned and reviewed. Applications of surface energy and nonlocal elasticity in analysis of piezoelectric nanomateri- als are also mentioned. this paper provides a comprehensive introduction of the development of this area and inspires fur- ther applications of modified continuum models in modeling nanomaterials and nanostructures.

关键词： Surface elasticity Nonlocal continuum Nanotubes Nanobeams Nanoplates Modeling andsimulations

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan wang Lina huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMt6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical h3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons