检索结果-南通市图书馆

Chinese Journal of Cancer 2015年第3期34卷 115-120页

作者： rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar charles r Ashby Jr Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's University Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of Health Department of Basic Pharmaceutical Sciences College of PharmacyThe University of Louisiana

Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of *** is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) ***:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDr1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 ***:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDr1-WT,and HEK293/ABCC10 ***,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the ***:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters.

关键词： ATP酶活性阻力家族会员亚科 HEK293 化疗药物紫杉醇

利用EQuan^TM环境分析系统直接进样技术(20ml)LC-MS/MS分析饮用水样品中飞克级含量除草剂化合物

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环境化学 2009年第2期28卷 317-318页

作者： Jonathan r Beck charles Yang 赛默飞世尔科技公司美国加州圣河塞

随着人们对环境中除草剂以及其它化学药物残留的毒性作用关注程度的增加,实现对饮用水以及食物中这些物质的准确检测的需要显得更加迫切.

关键词：环境分析除草剂水样品饮用水进样技术高效液相色谱-串联质谱化合物系统

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图书情报科学的研究现状

图书馆 1992年第3期 67-70页

作者：陈曙 charles r.McClure 上海师范大学图书馆 Syracuse大学图书情报学院

近年来,许多图书馆界的有识之士对图书情报学(简称LIS)产生了极大的兴趣。为此,他们期望吸引更多年富力强的图书情报专家,从中造就LIS研究的中坚骨干。这些人应当既重视基础研究,又不忽视应用研究,解决实际问题,从而推动学术工作的进展。

关键词：图书馆学情报学研究现状

CLUSTErING PATENTS USING NON-EXHAUSTIVE OVErLAPS

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 162-181页

作者： charles V. TrAPPEY Amy J.C. TrAPPEY Chun-Yi WU Department of Management Science National Chiao Tung University Taiwan China Department of Industrial Engineering & Management National Taipei University of Technology Taiwan China Department of lndustrial Engineering & Engineering Management National Tsing Hua University Taiwan China

Patent documents are unique external sources of information that reveal the core technology underlying new inventions. Patents also serve as a strategic data source that can be mined to discover state-of-the-art technical development and subsequently help guide r＆D investments. This research incorporates an ontology schema to extract and represent patent concepts. A clustering algorithm with non-exhaustive overlaps is proposed to overcome deficiencies with exhaustive clustering methods used in patent mining and technology discovery. The non-exhaustive clustering approach allows for the clustering of patent documents with overlapping technical findings and claims, a feature that enables the grouping of patents that define related key innovations. Legal advisors can use this approach to study potential cases of patent infringement or devise strategies to avoid litigation. The case study demonstrates the use of non-exhaustive overlaps algorithm by clustering US and Japan radio frequency identification （rFID） patents and by analyzing the legal implications of automated discovery of patent infringement.

关键词： Data mining patent analysis patent infringement non-exhaustive overlap clustering ontology schema

Strain control of layer-resolved negative capacitance in superlattices

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npj Computational Materials 2020年第1期6卷 127-130页

作者： raymond Walter Sergey Prosandeev charles Paillard L.Bellaiche Department of Physics and Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Department of Mathematical Sciences University of ArkansasFayettevilleAR 72701USA Identity Engineering Kinesso LLCConwayAR 72032USA Institute of Physics and Physics Department of Southern Federal University Rostov-na-Donu 344090Russia Laboratoire Structures Propriétés et Modélisation des SolidesCentraleSupélecUMR CNRS 8580UniversitéParis-Saclay91190 Gif-sur-YvetteFrance

Negative capacitance in BaTiO_(3)/SrTiO_(3) superlattices is investigated by Monte Carlo simulations in an atomistic effective Hamiltonian model,using fluctuation formulas for responses to the local macroscopic field that incorporates depolarizing *** show that epitaxial strain can tune the negative capacitance of the BaTiO_(3) ferroelectric layer and the overall capacitance of the *** addition,we predict and explain an original switching of the negative capacitance from the BaTiO3 layer to the SrTiO_(3) layer at low temperatures for intermediate strains.

关键词： capacitance layer resolved

Structure of [Co(im)6]SiF6：Short Hydrogen Bonds Involving SiF62- Ions

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Chinese Journal of Structural Chemistry 2017年第6期36卷 965-970页

作者： NAZIr Sadia ArIF Muhammad rASHID Muhammad Abid WHITWOOD Adrian charles Department of Chemistry Govt. College Women University Faisalabad 3800 Pakistan Institute of Chemical Sciences Bahhauddin Zakariya University Multan 60800 Pakistan Department of Chemistry University of Agriculture Faisalabad 38040 Pakistan Department of Chemistry University of York Heslington York YO10 5DD UK

A new complex C（18）H（24）CoF6N（12）Si has been synthesized by the reaction of cobalt（II） fluoride tetrahydrate with imidazole in a glass vessel. SiF62-was generated by in situ reaction of fluoride on silica. This complex has been characterized by different techniques such as elemental analysis, Ir studies, magnetic measurements, electronic absorption measurements and single-crystal X-ray structure determination. The crystals are hexagonal in the r-3 space group, with a = 13.225（6）, b = 13.225（6）, c = 12.517（11） A, and g = 120°. In complex [Co（im）6]SiF6, the cobalt atom is six-coordinated to adopt a regular octahedral geometry and the SiF62-ion acts as the counter anion. The crystal displays a network structure and SiF62- bridging hexagram formation by N-（39）···F-Si interactions between imdazole and SiF62-. SiF62-plays an important role in assembling the supramolecular aggregates.

关键词： anion binding imidazole SiF62- hydrogen bonds transitionmetal fluoride complexes

Inhibition of African swine fever virus in liquid and feed by medium-chain fatty acids and glycerol monolaurate

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Journal of Animal Science and Biotechnology 2021年第2期12卷 569-578页

作者： Joshua A.Jackman Astghik Hakobyan Hovakim Zakaryan charles C.Elrod School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Group of Antiviral Defense Mechanisms Institute of Molecular Biology of NASYerevanArmenia Natural Biologics Inc. NewfieldNY 14867USA. Department of Animal Science Cornell UniversityIthacaNY 14853USA

Background:The ongoing African swine fever virus(ASFv)epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high *** has been recently identified that feed and feed ingredients,along with drinking water,can serve as transmission vehicles and might facilitate transboundary spread of ***,it is important to test the antiviral activity of regulatory compatible,antiviral feed additives that might inhibit ASFv infectivity in *** promising group of feed additive candidates includes medium-chain fatty acids(MCFA)and monoglyceride derivatives,which are known to disrupt the lipid membrane surrounding certain enveloped viruses and ***:The antiviral activities of selected MCFA,namely caprylic,capric,and lauric acids,and a related monoglyceride,glycerol monolaurate(GML),to inhibit ASFv in liquid and feed conditions were investigated and suitable compounds and inclusion rates were identified that might be useful for mitigating ASFv in feed *** assays showed that all tested MCFA and GML inhibit *** was more potent than MCFA because it worked at a lower concentration and inhibited ASFv due to direct virucidal activity along with one or more other antiviral ***-dependent feed experiments further showed that sufficiently high GML doses can significantly reduce ASFv infectivity in feed in a linear manner in periods as short as 30 min,as determined by infectious viral titer ***-linked immunosorbent assay(ELISA)experiments revealed that GML treatment also hinders antibody recognition of the membrane-associated ASFv p72 structural protein,which likely relates to protein conformational changes arising from viral membrane ***:Together,the findings in this study indicate that MCFA and GML inhibit ASFv in liquid conditions and that GML is also able to reduce ASFv infectivity in feed,which may help to curb disease tr

关键词： African swine fever virus Antiviral Feed pathogen mitigation MCFA Medium-chain fatty acids Monoglycerides

The Expansion and Diversification of Pentatricopeptide repeat rNA-Editing Factors in Plants

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Molecular Plant 2020年第2期13卷 215-230页

作者： Bernard Gutmann Santana royan Mareike Schallenberg-rudinger Henning Lenz Ian r.Castleden rose McDowell Michael AVacher Julian Tonti-Filippini charles SBond Volker Knoop Ian D.Small Australian research Council Centre of Excellence in Plant Energy Biology The University of Western AustraliaCrawleyPerth 6009WAAustralia School of Molecular Sciences The University of Western AustraliaCrawleyPerth 6009WAAustralia IZMB-Institut fur Zellulare und Molekulare Botanik Abteilung Molekulare EvolutionUniversitat BonnKirschallee 153115 BonnGermany Present address:EditForce Inc. West zone#429Kyushu University744 MotookaNishi-KuFukuokaJapan Present address:IBG-2:Plant Sciences Forschungszentrum Jiilich GmbH52425 JulichGermany Present address:Australian eHealth research Centre Commonwealth Scientific and Industrial Research OrganisationFloreatPerth 6014WAAustralia

The rNA-binding pentatricopeptide repeat(PPr)family comprises hundreds to thousands of genes in most plants,but only a few dozen in algae,indicating massive gene expansions during land plant *** nature and timing of these expansions has not been well defined due to the sparse sequence data available from early-diverging land plant *** this study,we exploit the comprehensive OneKP datasets of over 1000 transcriptomes from diverse plants and algae toward establishing a clear picture of the evolution of this massive gene family,focusing on the proteins typically associated with rNA editing,which show the most spectacular variation in numbers and domain composition across the plant *** characterize over 2250000 PPr motifs in over 400000 *** lycophytes,polypod ferns,and hornworts,nearly 10%of expressed protein-coding genes encode putative PPr editing factors,whereas they are absent from algae and complex-thalloid *** show that rather than a single expansion,most land plant lineages with high numbers of editing factors have continued to generate novel sequence *** identify sequence variations that imply functional differences between PPr proteins in seed plants versus non-seed plants and variations we propose to be linked to seed-plant-specific editing ***,using the sequence variations across the datasets,we develop a structural model of the catalytic DYW domain associated with C-to-U editing and identify a clade of unique DYW variants that are strong candidates as U-to-C rNA-editing factors,given their phylogenetic distribution and sequence characteristics.

关键词： rNA editing rNA-binding protein organelles

In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,Zn alloying and polymer coating

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Journal of Magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar J.Luňácková M.Jex M.Žaloudková r.Vrbová M.Bartoš P.Klein L.Vištejnová J.Dušková E.Filová Z.Sucharda M.Steinerová S.Habr K.Balík A.Singh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic research Center for Structural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of Mg-based *** low-alloyed Mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was ***,Mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： Magnesium resorbable Mg wire Mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation

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D波段双球镜准光系统测量低耗介质

强激光与粒子束 2012年第2期24卷 445-448页

作者：高源慈余国芬李恩郭高凤 charles r.Jones 电子科技大学电子工程学院成都611731 芬德雷大学北卡罗来纳中央大学

采用双球镜准光腔、频谱仪和锁相返波管组建了D波段低损耗介质测试系统,该系统通过频谱仪和外置谐波混频器得到腔体谐振测试数据,并用拟合或积分方法从谐振曲线中求解出准光腔的品质因数。测得双球镜开腔的固有品质因数大于8×105,使该... 详细信息

采用双球镜准光腔、频谱仪和锁相返波管组建了D波段低损耗介质测试系统,该系统通过频谱仪和外置谐波混频器得到腔体谐振测试数据,并用拟合或积分方法从谐振曲线中求解出准光腔的品质因数。测得双球镜开腔的固有品质因数大于8×105,使该系统在工作波段可测量损耗角正切为10-5量级的低损耗介质。用该系统测出的石英、人造金刚石和蓝宝石的介电常数和损耗,与报道的结果一致,并测得4H-SiC在132.07GHz的介电常数实部为9.598,损耗角正切为6.1×10-5。

关键词：准光学开放腔锁相返波管损耗角正切高功率真空输出窗