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AUTOMATIC PATENT DOCUMFNT SUMMArIZATION FOr COLLABOrATIVE KNOWLEDGE SYSTEMS AND SErVICES

Journal of Systems Science and Systems Engineering 2009年第1期18卷 71-94页

作者： Amy J.C. TrAPPEY charles V. TrAPPEY Chun-Yi WU Dept. of Industrial Engineering and Management National Taipei University of Technology Taiwan China Dept. of lndustrial Engineering and Engineering Management National Tsing Hua University Taiwan China Dept. of Management Science National Chiao Tung University Taiwan China

Engineering and research teams often develop new products and technologies by referring to inventions described in patent databases. Efficient patent analysis builds r＆D knowledge, reduces new product development time, increases market success, and reduces potential patent infringement. Thus, it is beneficial to automatically and systematically extract information from patent documents in order to improve knowledge sharing and collaboration among r＆D team members. In this research, patents are summarized using a combined ontology based and TF-IDF concept clustering approach. The ontology captures the general knowledge and core meaning of patents in a given domain. Then, the proposed methodology extracts, clusters, and integrates the content of a patent to derive a summary and a cluster tree diagram of key terms. Patents from the International Patent Classification （IPC） codes B25C, B25D, B25F （categories for power hand tools） and B24B, C09G and H011 （categories for chemical mechanical polishing） are used as case studies to evaluate the compression ratio, retention ratio, and classification accuracy of the summarization results. The evaluation uses statistics to represent the summary generation and its compression ratio, the ontology based keyword extraction retention ratio, and the summary classification accuracy. The results show that the ontology based approach yields about the same compression ratio as previous non-ontology based research but yields on average an 11% improvement for the retention ratio and a 14% improvement for classification accuracy.

关键词： Semantic knowledge service key phrase extraction document summarization text mining,patent document analysis

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A new approach to quantifying vehicle induced turbulence for complex traffic scenarios

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Chinese Journal of Chemical Engineering 2016年第1期24卷 71-78页

作者： Yesul Kim Li Huang Sunling Gong charles Q.Jia Department of Chemical Engineering and Applied Chemistry University of Toronto200 College Street Toronto ON MSS 3E5 Canada Air Quality research Division Environment CanadaTorontoON M3H 5T4 Canada

Traffic-related pollutants adversely affect air quality, especially in regions near major roadways. The vehicleinduced turbulence(VIT) is a significant factor that controls the initial dilution, dispersion, and ultimately the chemical and physical fate of pollutants by altering the conditions in the microenvironment. This study used a computational fluid dynamics(CFD) software FLUENT to model the vehicle-induced turbulence(VIT) generated on roadways, with a focus on impact of vehicle-vehicle interactions, traffic density and vehicle composition on turbulent kinetic energy(TKE). We show, for the first time, that the overall TKE from multiple vehicles traveling in series can be estimated by superimposing the TKE of each vehicle, without considering the distance between them while the distance is greater than one vehicle length. This finding is particularly significant since it enables a new approach to VIT simulations where the overall TKE is calculated as a function of number of vehicles. We found that the interactions between vehicles traveling next to each other in adjacent lanes are insignificant,regardless the directions of the traffic flow. Consequently, simulations of different traffic scenarios can be substantially simplified by treating two-way traffic as one-way traffic, with less than 5% difference in the overall volume-averaged TKE. We also developed equations that allow the estimation of the overall volume-averaged TKE as a function of the number and the type of vehicles.

关键词： Computational fluid dynamics Turbulent kinetic energy Vehicle-induced turbulence road-induced turbulence Mixed traffic

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I3C and DIM induce apoptosis of SMMC 7721 and HepG2 hepatic tumor cells by down-regulating survivin expression

I3C and DIM induce apoptosis of SMMC 7721 and HepG2 hepatic ...

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广东省环境诱变剂学会、广东省预防医学会卫生毒理专业委员会2010年学术会议

作者： charles r.Ashby Jr College of Pharmacy and Allied Health Professions St.John's UniversityQueensNew YorkNY 11439

Background The indole derivatives indole-3-carbinol(I3C) and 3,3'-diindolylmethane(DIM) have been purported to be chemopreventive for certain ***,there are limited data regarding the effects of I3C and DIM on hepatic tumor cells and their mechanism of action remains to be ***,in this study,using two distinct hepatic tumor cell lines,SMMC 7721 and HepG2,we determined the in vitro effect of I3C and DIM on cell proliferation,apoptosis,mitochondrial function and the expression of proteins involved in these processes. results I3C and DIM produced a significant decrease in the proliferation of SMMC 7721 and HepG2 cells and a significant increase in their rate of apoptosis in a time-and concentration-dependent *** inhibition of survivin expression by I3C and DIM produced an arrest in the cell cycle at the G0/G1 ***, I3C and DIM produced an activation of mitochondrial signaling,accompanied by a decrease in the mitochondrial membrane potential,cytochrome c release and the activation of caspase-9 and caspase-3. Conclusions Overall,these findings indicate that I3C and DIM significantly inhibited the proliferation of SMMC 7721 and *** could occur via a number of mechanisms,including the inhibition of survivin expression,as well as the activation of apoptosis.

关键词： Indole-3-carbinol cell proliferation apoptosis survivin

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review of 5-FU resistance mechanisms in colorectal cancer:clinical significance of attenuated on-target effects

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Cancer Drug resistance 2023年第2期6卷 257-272页

作者： William H.Gmeiner charles Chidi Okechukwu Department of Cancer Biology and Comprehensive Cancer Center Wake Forest University School of MedicineWinston-SalemNC 27157USA Integrative Physiology and Pharmacology Graduate Program InstitutionWake Forest University School of MedicineWinston-SalemNC 27157USA

The emergence of chemoresistant disease during chemotherapy with 5-Fluorouracil-based(5-FU-based)regimens is an important factor in the mortality of metastatic CrC(mCrC).The causes of 5-FU resistance are multifactorial,and besides DNA mismatch repair deficiency(MMr-D),there are no widely accepted criteria for determining which CrC patients are not likely to be responsive to 5-FU-based ***,there is a need to systematically understand the mechanistic basis for 5-FU treatment failure and an urgent need to develop new approaches for circumventing the major causes of 5-FU *** this manuscript,we review mechanisms of 5-FU resistance with an emphasis on:(1)altered anabolic metabolism limiting the formation of the primary active metabolite Fluorodeoxyuridylate(5-Fluoro-2'-deoxyuridine-5'-O-monophosphate;FdUMP);(2)elevated expression or activity of the primary enzymatic target thymidylate synthase(TS);and(3)dysregulated programmed cell death as important causes of 5-FU ***,these causes of 5-FU resistance can potentially be overcome through the use of next-generation fluoropyrimidine(FP)polymers(e.g.,CF10)that display reduced dependence on anabolic metabolism and more potent TS inhibitory activity.

关键词： Fluoropyrimidine 5-FU resistance colorectal cancer chemotherapy precision medicine thymidylate synthase

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记忆T细胞的功能表型和迁徙途径的关系

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国外医学（免疫学分册） 1992年第2期15卷 96-98页

作者： charles r Mackay 李晓露

免疲记忆是脊椎动物免疫系统的一个功能特征,它针对已接触过的抗原,为机体提供快速和增强的免疫反应。现在认为免疫记忆是长命细胞群的一部分,其出现频率高于天然状态前体(naive precursors),循环到身体各部位,从而提供了一个系统的免... 详细信息

免疲记忆是脊椎动物免疫系统的一个功能特征,它针对已接触过的抗原,为机体提供快速和增强的免疫反应。现在认为免疫记忆是长命细胞群的一部分,其出现频率高于天然状态前体(naive precursors),循环到身体各部位,从而提供了一个系统的免疫保护机制。

关键词：记忆T细胞功能表型迁徙途径

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八十年代的北美图书馆网络(上)

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现代图书情报技术 1990年第2期 44-49页

作者： charles r. Hildreth 王华风邵品洪

一、回顾八十年代被称为“图书馆协作和协作网络的黄金时代”。基于大型机的、集中式的,支持编目共享和ILL(馆际互借)活动的联机网络系统和数据库不断地开发和建立。而且,在北美图书馆界,这种局面似乎将永远维持下去。[第一段]

关键词：北美洲图书馆网络

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八十年代的北美图书馆网络(下)

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现代图书情报技术 1991年第2期 26-31页

作者：王华风邵品洪 charles r. Hildreth 美

一、书目服务社迎接新的挑战没有一种图书馆计算机网络模型能够满足当前北美和加拿大图书馆网络和计算机的资源共享活动的要求。夸天的网络环境是非集中的、多边的、利用分布式处理进而更加侧重局部处理。[第一段]

关键词：北美洲图书馆网络

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Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity,recapitulating key features of FUS proteinopathy

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Protein & Cell 2011年第2期2卷 141-149页

作者： Kazuo Fushimi charles Long Neha Jayaram Xiaoping Chen Liming Li Jane Y.Wu Department of Neurology Center for Genetic MedicineLurie Comprehensive Cancer CenterNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA Department of Molecular Pharmacology and Biological Chemistry Northwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA

Mutations in the fused in sarcoma/translocated in liposarcoma(FUS/TLS)gene have been associated with amyotrophic lateral sclerosis(ALS).FUS-positive neuropathology is reported in a range of neurodegenerative diseases,including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology(FTLDU).To examine protein aggregation and cytotoxicity,we expressed human FUS protein in *** of either wild type or ALS-associated r524S or P525L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased ***,yeast cells expressing human FUS protein recapitulate key features of FUSpositive neurodegenerative ***,a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates,suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated *** N-terminus of FUS,containing the QGSY and G rich regions,is sufficient for the formation of aggregates but not *** C-terminal domain,which contains a cluster of mutations,did not show aggregation or *** to TDP-43 when expressed in yeast,FUS protein has the intrinsic property of forming aggregates in the absence of other human *** the other hand,the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5%sarkosyl,unlike TDP-43 when expressed in yeast ***,TDP-43 and FUS display distinct domain requirements in aggregate formation and cytotoxicity.

关键词： FUS/TLS protein aggregation cytotoxicity

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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

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骨研究:英文版 2023年第3期11卷 595-606页

作者： Cassandra r.Diegel Ina Kramer charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun Liu Jennifer L.Harris Michaela Kneissel Bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in Lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

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Impact of intrarectal chromofungin treatment on dendritic cellsrelated markers in different immune compartments in colonic inflammatory conditions

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World Journal of Gastroenterology 2021年第47期27卷 8138-8155页

作者： Kunal Kapoor Nour Eissa Diane Tshikudi charles N Bernstein Jean-Eric Ghia Department of Immunology University of ManitobaWinnipeg R3E0T5MBCanada Children's Hospital research Institute of Manitoba University of ManitobaWinnipeg R3E0T5MBCanada Section of Gastroenterology Department of Internal MedicineRady Faculty of Health SciencesUniversity of ManitobaWinnipeg R3E0T5MBCanada University of Manitoba IBD Clinical and research Centre University of ManitobaWinnipeg R3E0T5MBCanada

BACKGrOUND Chromofungin(CHr:chromogranin-A 47-66)is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial *** colitis(UC)is characterized by a colonic decrease of CHr and a dysregulation of dendritic CD11c+*** To investigate the association between CHr treatment and dendritic cells(DCs)-related markers in different immune compartments in *** A model of acute UC-like colitis using dextran sulphate sodium(DSS)was used in addition to biopsies collected from UC *** Intrarectal CHr treatment reduced the severity of DSS-induced colitis and was associated with a significant decrease in the expression of CD11c,CD40,CD80,CD86 and interleukin(IL)-12p40 in the inflamed colonic mucosa and CD11c,CD80,CD86 IL-6 and IL-12p40 within the mesenteric lymph nodes and the ***,CHr treatment decreased CD80 and CD86 expression markers of splenic CD11c+cells and decreased NF-κB expression in the colon and of splenic CD11c+*** vitro,CHr decreased CD40,CD80,CD86 IL-6 and IL-12p40 expression in naïve bone marrow-derived CD11c+DCs stimulated with *** studies demonstrated an impact of CHr on the NF-κB *** patients with active UC,CHr level was reduced and showed a negative linear relationship with CD11c and *** CHr has protective properties against intestinal inflammation via the regulation of DC-related markers and CD11c+*** could be a potential therapy of UC.

关键词： Chromofungin Chromogranin-A Colitis Cytokines Dendritic cells Gut hormones

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