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The burden of mental health in lymphatic filariasis

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Infectious Diseases of Poverty 2015年第1期4卷 275-282页

作者： Thanh G.N.Ton charles Mackenzie David H.Molyneux Precision Health Economics 55512 th AvenueSuite 1650OaklandCA 94607USA Filariasis Programmes Support Unit Department of ParasitologyLiverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK lSTM NTDs Department of ParasitologyLiverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK

Background:Neglected Tropical Diseases(NTDs)afflict around one billion individuals in the poorest parts of the world with many more at *** filariasis is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions,particularly lymphedema and *** illness has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the *** estimates of the burden of depressive illness of any neglected tropical disease have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for patients but also their ***:We developed a mathematical model to calculate the burden of Disability-Adjusted life Years(DAlY)attributable to depressive illness in lymphatic filariasis and that of their caregivers using standard methods for calculating *** of numbers with clinical disease was based on published estimates in 2012 and the numbers with depressive illness from the available ***:We calculated that the burden of depressive illness in filariasis patients was 5.09 million disability-adjusted life years(DAlYs)and 229,537 DAlYs attributable to their *** figures are around twice that of 2.78 million DAlYs attributed to filariasis by the Global Burden of Disease study of ***:lymphatic filariasis and other neglected tropical diseases,notably Buruli Ulcer,cutaneous leishmaniasis,leprosy,yaws,onchocerciasis and trachoma cause significant co morbidity associated with mental illness in *** to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected tropical *** prevalence of depressive illness in caregivers who support those who suffer from these conditions is *** assessments are critical for neglected tropical diseases whi

关键词： lymphatic filariasis Mental health Global burden of disease DAlYS Filariasis morbidity Caregivers

Simultaneous determination of 3-chlorotyrosine and 3-nitrotyrosine in human plasma by direct analysis in real time–tandem mass spectrometry

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Acta Pharmaceutica Sinica B 2015年第5期5卷 482-486页

作者： Yuqiao Song Jie liao Cheng Zha Bin Wang charles C.liu Medical Experiment and Analysis Center of PlA General Hospital ASPEC Technologies limited Beijing

A novel method for the simultaneous determination of 3-nitrotyrosine(NT) and 3-chlorotyrosine(CT) in human plasma has been developed based on direct analysis in real time–tandem mass spectrometry(DART–MS/MS). Analysis was performed in the positive ionization mode using multiple reaction monitoring(MRM) of the ion transitions at m/z 216.2/170.1 for CT, m/z 227.2/181.1 for NT and m/z 230.2/184.2 for the internal standard, d^3-NT. The assay was linear in the ranges 0.5–100 μg/m l for CT and 4–100 μg/m l for NT with corresponding limits of detection of 0.2 and 2 μg/m l. Intra- and inter-day precisions and accuracies were respectively lso evaluated. The method is potentially useful for high throughput analysis although sensitivity needs to be improved before it can be applied in clinical research.

关键词： 3-Nitrotyrosine 3-Chlorotyrosine Determintion DART–MS/MS Human plasma

Tailoring properties of hybrid perovskites by domain-width engineering with charged walls

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npj Computational Materials 2018年第1期4卷 26-31页

作者： lan Chen charles Paillard Hong Jian Zhao JorgeÍñiguez Yurong Yang laurent Bellaiche Physics Department and Institute for Nanoscience and Engineering University of ArkansasFayettevilleArkansas 72701USA Materials Research and Technology Department Luxembourg Institute of Science and Technology(LIST)5 Avenue des Hauts-FourneauxL-4362 Esch/AlzetteLuxembourg National laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Charged ferroelectric domain walls are fascinating electrical topological defects that can exhibit unusual ***,in the search for novel phenomena,we perform and analyze first-principles calculations to investigate the effect of domain width on properties of domains with charged walls in the photovoltaic material consisting of methylammonium lead iodide hybrid *** report that such domains are stable and have rather low domain wall energy for any investigated width(that is,up to 13 lattice constants).Increasing the domain width first linearly decreases the electronic band gap from≃1.4 eV to about zero(which therefore provides an efficient band-gap engineering),before the system undergoes an insulator-to-metal transition and then remains metallic(with both the tail-to-tail and head-to-head domain walls being conductive)for the largest *** these results can be understood in terms of:(i)components of polarization along the normal of the domain walls being small in magnitude;(ii)an internal electric field that is basically independent of the domain width;and(iii)rather negligible charge transfer between *** findings deepen the knowledge of charged ferroelectric domain walls and can further broaden their potential for applications,particularly in the context of halide perovskites for photovoltaics.

关键词： properties walls perovskite

The secondary injury cascade after spinal cord injury:an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand charles M.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.Mishra Taylor l.Marti Phoebe M.Omuro Rylie M.Roddick Jae Sung lee William l.Murphy Amgad S.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public HealthMadisonWIUSA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin-MadisonMadisonWIUSA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA Forward BIO Institute University of Wisconsin-MadisonMadisonWIUSA

After spinal cord injury,there is an extensive infiltration of immune cells,which exacerbates the injury and leads to further neural ***,a major aim of current research involves targeting the immune response as a treatment for spinal cord *** much research has been performed analyzing the complex inflammatory process following spinal cord injury,there remain major discrepancies within previous literature regarding the timeline of local cytokine *** objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury,identify sexual dimorphisms in terms of cytokine levels,and determine local cytokines that significantly change based on the severity of spinal cord *** were inflicted with either a mild contusion,moderate contusion,severe contusion,or complete transection,7 mm of spinal cord centered on the injury was harvested at varying times post-injury,and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex *** demonstrated pro-inflammatory cytokines including tumor necrosis factorα,interleukin-1β,and interleukin-6 were all upregulated after spinal cord injury,but returned to uninjured levels within approximately 24 hours post-injury,while chemokines including monocyte chemoattractant protein-1 remained upregulated for days *** contrast,several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days *** spinal cord injury,tissue inhibitor of metalloproteinase-1,which specifically affects astrocytes involved in glial scar development,increased more than all other cytokines tested,reaching 26.9-fold higher than uninjured *** a mild injury,11 cytokines demonstrated sexual dimorphisms;however,after a severe contusion only leptin levels were different between female and male *** conclusion,pro-inflammatory cytokines in

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in lrp5

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Bone Research 2023年第3期11卷 595-606页

作者： Cassandra R.Diegel Ina Kramer charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun liu Jennifer l.Harris Michaela Kneissel Bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and Regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest l.Baker Helena Batatinha charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine