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Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo

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Bioactive Materials 2022年第2期7卷 420-434页

作者： Sarah Al-Maawi Sandra Rother Norbert Halfter Karen M.Fiebig Juliane Moritz Stephanie Moeller Matthias Schnabelrauch charles james kirkpatrick Robert Sader Hans-Peter Wiesmann Dieter Scharnweber Vera Hintze Shahram Ghanaati Clinic for Maxillofacial and Plastic Surgery Goethe UniversityFrankfurt Am MainGermany Institute of Materials Science Max Bergmann Center of BiomaterialsTU DresdenBudapester Str.2701069DresdenGermany Biomaterials Department INNOVENT e.V.Prüssingstr.27B07745JenaGermany Department of Cellular and Molecular Medicine Glycobiology Research and Training CenterUniversity of CaliforniaSan DiegoLa JollaCAUSA

Sulfated glycosaminoglycans(sGAG)show interaction with biological mediator *** collagen-based biomaterials are widely used in clinics,their combination with high-sulfated hyaluronan(sHA3)is *** study aims to functionalize a collagen-based scaffold(Mucograft®)with sHA3 via electrostatic(sHA3/PBS)or covalent binding to collagen fibrils(sHA3+EDC/NHS).Crosslinking without sHA3 was used as a control(EDC/NHS Ctrl).The properties of the sHA3-functionalized materials were *** vitro growth factor and cytokine release after culturing with liquid platelet-rich fibrin was performed by means of *** cellular reaction to the biomaterials was analyzed in a subcutaneous rat *** study revealed that covalent linking of sHA3 to collagen allowed only a marginal release of sHA3 over 28 days in contrast to electrostatically bound ***3+EDC/NHS scaffolds showed reduced vascular endothelial growth factor(VEGF),transforming growth factor beta 1(TGF-β1)and enhanced interleukin-8(IL-8)and epithelial growth factor(EGF)release in vitro compared to the other *** sHA3/PBS and EDC/NHS Ctrl scaffolds showed a high proinflammatory reaction(M1:CD-68+/CCR7+)and induced multinucleated giant cell(MNGC)formation in *** sHA3+EDC/NHS scaffolds reduced the proinflammatory macrophage M1 response and did not induce MNGC formation during the 30 ***3+EDC/NHS scaffolds had a stable structure in vivo and showed sufficient integration into the implantation region after 30 days,whereas EDC/NHS Ctrl scaffolds underwent marked disintegration and lost their initial *** summary,functionalized collagen(sHA3+EDC/NHS)modulates the inflammatory response and is a promising biomaterial as a stable scaffold for full-thickness skin regeneration in the future.

关键词： Sulfated hyaluronan Collagen Wound healing Cellular reaction Multinucleated giant cells

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Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components--Guidance of the inflammatory response as basis for osteochondral regeneration

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Bioactive Materials 2017年第4期2卷 208-223页

作者： Mike Barbeck Tiziano Serra Patrick Booms Sanja Stojanovic Stevo Najman Elisabeth Engel Robert Sader charles james kirkpatrick Melba Navarro Shahram Ghanaati Private Office BerlinGermany Institute for Bioengineering of Catalonia(IBEC) Biomaterials for Regenerative MedicineBarcelonaSpain Clinic of Oro-Maxillofacial and Plastic Surgery FORM-LabGoethe University FrankfurtFrankfurtGermany University of Ni's Faculty of MedicineDepartment for Cell and Tissue EngineeringInstitute of Biology and Human GeneticsNi'sSerbia Technical University of Catalonia(UPC) Dpt.Materials Science and MetallurgySpain CIBER en Bioingenieria Biomateriales y Nanomedicina(CIBER-BBN)Spain

The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the(molecular)weight loss and the morphological and mechanical variations after immersion in *** in vivo study focused on analysis of the tissue reactions and differences in the implant bed vascularization using an established subcutaneous implantation model in CD-1 mice and established histological and histomorphometrical *** scaffold parts kept their structural integrity,while changes in morphology were observed,especially for the PLA/G5 *** properties decreased with progressive degradation,while the PLA/G5 scaffolds presented higher compressive modulus than PLA *** tissue reaction to PLA included low numbers of BMGCs and minimal vascularization of its implant beds,while the addition of G5 lead to higher numbers of BMGCs and a higher implant bed *** revealed that the use of a bi-layered scaffold shows the ability to observe distinct in vivo response despite the physical proximity of PLA and PLA/G5 ***,the results showed that the addition of G5 enables to reduce scaffold weight loss and to increase mechanical ***,the addition of G5 lead to a higher vascularization of the implant bed required as basis for bone tissue regeneration mediated by higher numbers of BMGCs,while within the PLA parts a significantly lower vascularization was found optimally for chondral ***,this data show that the analyzed bi-layered scaffold may serve as an ideal basis for the regeneration of osteochondral tissue ***,the results show that it might be able to reduce the number of experimental animals required as it may be possible to analyze the tissue response to more than one implant in one experimental animal.

关键词： Bioactive glass Polylactic acid(PLA) Bi-layer scaffold Multinucleated giant cells Bone substitute Vascularization Calcium phosphate glass

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Otolaryngology residency program factors associated with female resident representation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 7-11页

作者： Julia E.Canick james C.Campbell charles R.Woodard Lars J.Grimm Alissa M.Collins Duke University School of Medicine DurhamNorth CarolinaUSA Department of Head and Neck Surgery&Communication Sciences Duke University School of MedicineDurhamNorth CarolinaUSA Department of Radiology Duke University School of MedicineDurhamNorth CarolinaUSA

Objective:Female representation in the field of otolaryngology is *** is the first point at which medical school graduates specialize in a chosen field and thus represents an opportunity to recruit and train more female *** study sought to identify program factors associated with greater female representation among resident ***:Departmental websites of all 124 otolaryngology residency programs in the United States and Puerto Rico were examined for a list of *** programs with a resident roster available,the genders of residents,faculty,program directors,and chairpersons were *** and city population for each program was also recorded,as was female resident *** were compared using Pearson Chi‐squared univariate ***:1,632 residents and 2,605 faculty were included in the analysis of 109 *** median female resident representation was 40%.Programs with larger faculty sizes,more female faculty,and urban location were associated with an above‐median female resident *** with a larger residency cohort approached significance regarding above‐median female resident *** female faculty representation,program director gender,chairperson gender,and US region were not associated with variation in female resident ***:Greater female otolaryngology residency representation was associated with programs having an urban location and greater numbers of female and total *** was also likely that a larger resident cohort size may affect female resident *** proportions of female faculty,program director,and chairperson gender,as well as the US region,were not associated with variation in female resident gender representation.

关键词： gender program director recruitment residency training

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The Transmission,Establishment and Cross-cultural Integration of Chinese Medicine in the Mainstream Healthcare,through the Eyes of a Generation of Visionaries and Pioneers

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Chinese Medicine and Culture 2024年第1期7卷 1-4页

作者： Ioannis Solos charles Buck Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom

It has historically been very difficult to trace the history of the westward transmission of Chinese medicine through the accounts of its protagonists. Many of the early scholars such as Jack Worsley, Dick Van Buren, and Joe Goodman were reluctant to divulge information about the source of their knowledge, or their professional qualifications. Others, such as John Shen and Hong Yuan-bain were early 20th century immigrants who transmitted highly personalized versions of acupuncture and Chinese medicine to select disciples. Eventually, a new class of scholars appeared, including names such as Ted Kaptchuk, Peter Deadman, Nigel Wiseman, William Morris, Peter Eckman, John Mc Donald, charles Buck, and the late Giovanni Maciocia who looked for answers back in China, developed translation methodologies and terminology, compiled the main textbooks currently in use at TCM colleges, overcame enormous scholastic adversity, developed courses and pursued the regulation and accreditation of TCM in various countries. This special issue synopsizes the path towards the global acculturation of TCM over the last 50 years, the main protagonists, the enormous accomplishments they have achieved for the profession, their philosophy, their clinical perspectives and visions for the future.

关键词： Chinese medicine Cross-cultural integration Westward transmission james Reston Acupuncture History

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Further Studies of the Cap Pushing Response in Honey Bees (Apis mellifera)

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Natural Science 2024年第5期16卷 45-64页

作者： Riley J. Wincheski Kiri Li N. Stauch Laura M. Grossner Maya B. Zepeda james W. Grice charles I. Abramson Department of Psychology Oklahoma State University Stillwater USA Laboratory of Comparative Psychology and Behavioral Biology Oklahoma State University Stillwater USA Department of Earth and Environmental Sciences California State University Fresno USA

The Cap Pushing Response (CPR) is a free-flying technique used to study learning and memory in honey bees (Apis mellifera). The series of experiments outlined in this paper aimed to test whether honey bees exhibit the cognitive concept of “expectancy” utilizing the CPR in a weight differentiation paradigm. Five previous experiments in our laboratory have explored whether the concept of expectancy can account for honey bee performance and have all failed to support the cognitive interpretation. The first experiment examined if bees could differentiate between the two caps in the amount of force they used to push the cap and the distance the cap was pushed when the caps were presented one at a time. The second experiment explored cap weight preference by presenting bees with a choice between the two caps. The third and fourth experiments tested the bee’s ability to expect reward or punishment based on cap weight. Results revealed that bees were found to have a strong preference for the light cap and therefore were not able to expect reward or punishment based on cap weight. These experiments contribute to the debate on whether bees have “cognitive” representations and continue to support the behaviorist interpretation.

关键词： Apis mellifera Cap Pushing Response Cognition Learning

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In-vitro digestibility,protein digestibility corrected amino acid,and sensory properties of banana-cassava gluten-free pasta with soy protein isolate and egg white protein addition

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Food Science and Human Wellness 2023年第2期12卷 520-527页

作者： Adetiya Rachman Margaret ABrennan james Morton Damir Torrico charles S.Brennan Department of Wine Food and Molecular BiosciencesLincoln UniversityChristchurch 7647New Zealand Riddet Research Institute Palmerston North 4442New Zealand Indonesia Institute for Agricultural Research and Development Jakarta 12540Indonesia

Soy protein isolate and egg white protein were added to cassava-banana gluten-free pasta and the effects on the nutritional quality,digestibility properties,protein digestibility corrected amino acid(PDCAA),and sensory acceptance of the pasta was ***-cassava composite flour(75:25)was blended with soy protein isolate or egg white protein at the following rates:0,5,10,and 15 g/100 g *** pasta samples were analysed for total phenolic content(TPC),antioxidant activity,amino acid profiles,protein content,starch digestibility,protein digestibility and protein digestibility corrected amino acid score(PDCAAS).Addition of both proteins decreased starch digestibility,increased protein digestibility,improved the balance of the amino acid profile,and PDCAAS whereas only soy protein isolate enhanced the TPC and antioxidant capacity of the banana-cassava *** egg white protein-fortified banana-cassava pasta had better customer acceptance and purchase intent than soy protein isolate inclusion.

关键词： Banana flour Cassava flour Gluten-free pasta Digestibility properties Amino acid Sensory evaluation

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Foundations of medical decision-making for older adults with cardiovascular disease

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Journal of Geriatric Cardiology 2015年第4期12卷 335-339页

作者： Hannah I Lipman Ankur Kalra james N kirkpatrick Department of Medicine Divisions of Geriatrics and Cardiology Montefiore Medical Center of the Albert Einstein College of Medicine Bronx N~ USA Minneapolis Heart Institute at Abbott Northwestern Hospital Department of Medicine Division of Cardiology Hennepin County Medical Center Minneapo- lis MN USA Cardiovascular Division Department of Medicine University of Pennsylvania' Department of Medical Ethics and Health Policy University of Pennsylvania Philadelphia PA USA

为了帮助更老的成年人做好心血管的疾病，遨游复杂决定，临床医生们必须知道医药道德的信条并且有好通讯技巧。决策能力和知情同意的元素被考察，用说明基本概念的相关临床的例子。分享的决策模型，临床医生和病人一起由工作决定照顾的... 详细信息

为了帮助更老的成年人做好心血管的疾病，遨游复杂决定，临床医生们必须知道医药道德的信条并且有好通讯技巧。决策能力和知情同意的元素被考察，用说明基本概念的相关临床的例子。分享的决策模型，临床医生和病人一起由工作决定照顾的计划，被描述。实现分享的决策的有用通讯技术被建议。

关键词：心血管疾病决策依据老年人医疗临床医生决策能力医学伦理决策模型

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Review of Mercury's dynamic magnetosphere:Post-MESSENGER era and comparative magnetospheres

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Science China Earth Sciences 2022年第1期65卷 25-74页

作者： Weijie SUN Ryan MDEWEY Sae AIZAWA Jia HUANG james A.SLAVIN Suiyan FU Yong WEI charles F.BOWERS Department of Climate and Space Sciences and Engineering University of MichiganAnn ArborMl 48109USA Institut de Recherche en Astrophysique et Planetologie CNRS-UPS-CNESToulouse 31400France Department of Geophysics Graduate School of ScienceTohoku UniversitySendai 980-8578Japan School of Earth and Space Sciences Peking UniversityBeijing 100871China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100864China

This review paper summarizes the research of Mercury’s magnetosphere in the Post-MESSENGER era and compares its dynamics to those in other planetary magnetospheres,especially to those in Earth’s *** review starts by introducing the planet Mercury,including its interplanetary environment,magnetosphere,exosphere,and conducting *** frequent and intense magnetic reconnection on the dayside magnetopause,which is represented by the flux transfer event"shower",is reviewed on how they depend on magnetosheath plasma β and magnetic shear angle across the magnetopause,followed by how it contributes to the flux circulation and magnetosphere-surface-exosphere *** the next,Mercury’s magnetosphere under extreme solar events,including the core induction and the reconnection erosion on the dayside magnetosphere,as well as the responses of the nightside magnetosphere,are ***,the dawn-dusk properties of the plasma sheet,including the features of the ions,the structure of the current sheet,and the dynamics of magnetic reconnection,are *** last topic is devoted to the particle energization in Mercury’s magnetosphere,which includes the energization of the Kelvin-Helmholtz waves on the magnetopause boundaries,reconnection-generated magnetic structures,and the cross-tail electric *** each chapter,the last section discusses the open questions related to each topic,which can be considered by the simulations and the future spacecraft *** end this paper by summarizing the future Bepi Colombo opportunities,which is a joint mission of ESA and JAXA and is en route to Mercury.

关键词： Mercury’s magnetosphere Flux transfer event shower Extreme solar events Core induction Reconnection erosion Dawn-dusk asymmetry Substorm current wedge Particle energization Kelvin-Helmholtz wave

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Modelling the regenerative niche:a major challenge in biomaterials research

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Regenerative Biomaterials 2015年第4期2卷 267-272页

作者： C.james kirkpatrick REPAIR-Lab Institute of PathologyUniversity Medical CenterJohannes Gutenberg University MainzD-55101 MainzGermany Department of Biomaterials Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden

By definition,biomaterials are developed for clinical *** the field of regenerative medicine their principal function is to play a significant,and,if possible,an instructive role in tissue *** the last analysis the latter involves targeting the‘regenerative niche’.The present paper will address the problem of simulating this niche in the laboratory and adopts a life science approach involving the harnessing of heterotypic cellular communication to achieve this,that is,the ability of cells of different types to mutually influence cellular ***,co-culture systems using human cells are the methodological focus and will concern four exemplary fields of regeneration,namely,bone,soft tissue,lower respiratory tract and airway *** working hypothesis underlying this approach is that in vitro models of higher complexity will be more clinically relevant than simple monolayer cultures of transformed cell lines in testing innovative strategies with biomaterials for regeneration.

关键词： biomaterial-cell interaction regenerative mechanism stem cells

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Effects of biochar on soil water retention curves of compacted clay during wetting and drying

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Biochar 2022年第1期4卷 1117-1130页

作者： james Tsz Fung Wong Ka Lai Chow Xun Wen Chen charles Wang Wai Ng Ming Hung Wong Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongSARChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongSARChina Consortium on Health EnvironmentEducation and Research(CHEER)Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongSARChina Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China State Environmental Protection Key Laboratory of Integrated Surface Water Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Compacted clay possesses a low water permeability and has been widely used in geo-environmental facilities such as landfill cover *** studies revealed the potential applications of compacted biochar-amended clay(BAC)as an alternative landfill cover ***,the effects of biochar on the soil water retention curves(SWRCs)of clay at low suction are not *** study can help fill this knowledge gap by measuring the wetting and drying SWRCs of clay and BAC(20%biochar).Soils were compacted in instrumented soil columns and subjected to a wetting and drying cycle,and soil water content and suction were measured along with the soil *** was saturated faster when compared with *** drying,the soil water content of clay at 65 mm depth dropped to almost zero,while about 5%of water was retained in *** showed that biochar increased the soil water retention capacity of compacted clay upon *** showed that biochar-clay composite possesses a higher soil water retention capacity at a low soil suction range(<1000 kPa)compared with clay *** revealed the benefits of using compacted biochar-clay composite as a hydraulic barrier to minimize desiccation-induced cracks and potentially promote its serviceability,especially in arid and semi-arid *** composite is also a carbon sink material that can reduce landfill gas emissions and pollutant leaching.

关键词： Soil amendment Biochar-clay composite Soil carbon Soil suction Soil depth

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