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Development of a telehealth monitoring service after colorectal surgery:A feasibility study

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World Journal of Gastrointestinal Surgery 2017年第9期9卷 193-199页

作者： Damian D Bragg Helena Edis Sian Clark Simon L Parsons Binoy Perumpalath Dileep N Lobo charles a maxwell-armstrong Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute of Health Research(NIHR)Nottingham Biomedical Research CentreNottingham University Hospitals and University of NottinghamQueen’s Medical CentreNottingham NG7 2UHUnited Kingdom

AIM To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery,within an enhanced recovery *** Florence(FLO) is a National Health Service telehealth solution utilised for monitoring chronic health conditions,such as hypertension,using *** were designed to monitor the well-being,basic physiological observations and any patient-reported symptoms,and provide support messages to patients undergoing colorectal surgery within an enhanced recovery after surgery protocol for 30 d after *** interactions with FLO and physiological readings were recorded and patients were invited to provide *** Over a four-week period,16 out of 17 patients used the FLO telehealth service at *** patients did not receive telephone follow-up at three days,as per our standard protocol,unless they reported being unwell or did not make use of the *** patients were readmitted within 30 d,and two of these were identified as being unwell by FLO prior to *** adverse events attributable to the use of the technology were *** The utilisation of telehealth in the early follow-up of patients who have undergone major colorectal surgery after discharge is *** use of this technology may assist in the early recognition and management of complications after discharge.

关键词： Telehealth Remote monitoring Colorectalsurgery Telephone follow up Readmission

Data-driven Bayesian model-based prediction of fatigue crack nucleation in Ni-based superalloys

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npj Computational Materials 2022年第1期8卷 354-368页

作者： maxwell Pinz George Weber Jean charles Stinville Tresa Pollock Somnath Ghosh Civil&Systems Engineering Johns Hopkins UniversityBaltimoreMD21218USA Materials Department University of CaliforniaSanta BarbaraCA93106USA Departments of Civil&Systems Engineering Mechanical Engineeringand Materials Science&EngineeringJohns Hopkins UniversityBaltimoreMD21218USA

This paper develops a Bayesian inference-based probabilistic crack nucleation model for the Ni-based superalloy René88DT under fatigue loading.A data-driven,machine learning approach is developed,identifying underlying mechanisms driving crack *** experimental set of fatigue-loaded microstructures is characterized near crack nucleation sites using scanning electron microscopy and electron backscatter diffraction images for correlating the grain morphology and crystallography to the location of crack nucleation sites.A concurrent multiscale model,embedding experimental polycrystalline microstructural representative volume elements(RVEs)in a homogenized material,is developed for fatigue *** RVE domain is modeled by a crystal plasticity finite element *** anisotropic continuum plasticity model,obtained by homogenization of the crystal plasticity model,is used for the exterior domain.A Bayesian classification method is introduced to optimally select informative state variable predictors of crack *** this principal set of state variables,a simple scalar crack nucleation indicator is formulated.

关键词： crack fatigue superalloy

Donor age and body weight determine the effects of fecal microbiota transplantation on growth performance,and fecal microbiota development in recipient pigs

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1483-1498页

作者： Xiaofan Wang Tsungcheng Tsai Bin Zuo Xiaoyuan Wei Feilong Deng Ying Li charles V.maxwell Hua Yang Yingping Xiao Jiangchao Zhao Department of Animal Science Division of AgricultureUniversity of ArkansasFayettevilleARUSA Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding College of Life Science and EngineeringFoshan UniversityFoshan 528225China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhouChina

Background:The application of fecal microbiota transplantation(FMT)to improve swine growth performance has been sporadically *** of these studies used a single microbiota source and thus the effect of donor characteristics on recipient pigs’fecal microbiota development and growth performance is largely ***:In this study,we collected feces from six donors with heavy(H)or light(L)body weight and different ages(d 42,nursery;d 96,growing;and d 170,finisher)to evaluate their effects on the growth performance and fecal microbiota development of recipient ***,recipients that received two doses of FMT from nursery and finisher stages donor at weaning(21±2 days of age)inherited the donor’s growth pattern,while the pigs gavaged with grower stage material exerted a numerically greater weight gain than the control pigs regardless of donor *** from heavier donors(NH,GH,and FH)led to the recipients to have numerically increased growth compared to their lighter counterparts(NL,GL,and FL,respectively)throughout the growing and most finishing *** benefit could be attributed to the enrichment of ASV25 Faecalibacterium,ASV61 Faecalibacterium,ASV438 Coriobacteriaceae_unclassified,ASV144 Bulleidia,and ASV129 Oribacterium and decrease of ASV13 Escherichia during nursery *** microbiota transplantation from growing and finishing donors influenced the microbial community significantly in recipient pigs during the nursery *** of older donors’gut microbiota expedited recipients’microbiota maturity on d 35 and 49,indicated by increased estimated microbiota *** ageassociated bacterial taxa included ASV206 Ruminococcaceae,ASV211 Butyrivibrio,ASV416 Bacteroides,ASV2 Streptococcus,and ASV291 *** body weight differences between GL and GH pigs on d 104 were associated with the increased synthesis of the essential amino acid,lysine and methionine,mixed acid fermentation,expedited glycolysis,and sucrose/galactose degradation

关键词： Colonization FMT Growth performance Swine gut microbiome

David Jones and charles Olson in Time and Space

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Journal of Foreign Languages and Cultures 2020年第2期4卷 104-113页

作者： charles Alexander Chax Press/University of Houston-Victoria

David Jones and charles Olson concern themselves with large issues of space and time,and how humans are entwined with *** essay seeks to show that Olson's project of space and Jones's with time are very much of the same mettle,that both poems offer a kind of transcendence of one-dimensionality,that time expands to become space,and that,in space,one is confronted with the presence of all time as a *** essay addresses Jones's The Anathemata and a few of his maps and paintings,as well as Olson's Maximus Poems,particularly its visual/spatial poetics.

关键词： time space history map geography

Best practices for model-based and simulation-aided engineering of power transmission and motion control systems

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Chinese Journal of Aeronautics 2019年第1期32卷 186-199页

作者： Jean-charles MARE Institut Clément Ader (CNRS UMR 5312)

This paper deals with the modelling and simulation of aircraft systems, in particular for power transmission and control. It is intended to review, propose and disseminate best practices for making model-based/simulation-aided engineering more efficient at any phase of the system life cycle. The proposals are aimed at creating value, not only by increasing the performance of the product under study but also by shortening the time to market, capitalizing knowledge, mitigating risks and facilitating concurrent engineering. The needs associated with the engineering activities are firstly identified to define a set of requirements for the models. Then, these requirements are used to drive the considerations leading to model development, focusing in particular on the process,modelled physical effects, modelling level, model architecting and concurrent engineering. The third part deals with the model implementation, giving special consideration to the different types of models, causalities, parameterization, implementation and verification. Each part is illustrated by examples related to safety critical actuators.

关键词： Actuator Aerospace Architecture Causality Modelling Motion control Power transmission Simulation

Gottfried Konecny:the ambassador of photogrammetry and remote sensing for 75 years

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Geo-Spatial Information Science 2021年第1期24卷 27-32,I0006页

作者： charles K.Toth Department of Civil Environmental and Geodetic EngineeringThe Ohio State UniversityColumbusOHUSA

A 90th birthday would be a milestone celebration for any person,but exceptionally rare if the person is still active after 75 years of working and serving the photogrammetric and remote sensing communities *** unprecedented career is the motivation to reflect on the technological developments of the past 75 years in the light of Gottfried Konecny’s lifetime achievements.I started to get to know Gottfried not long before he officially retired from the Institute for Photogrammetry and Engineering Surveys in ***,I was not even born when he,as a young and talented scholar supported by the Fulbright Scholarship from the US Government,arrived at the Ohio State University(OSU),which has been my professional home for three *** the second half of Gottfried’s 75-year career,the technological changes have been phenomenal,and,furthermore,shown an accelerating trend in the past few *** is absolutely remarkable how Gottfried has been able to keep up with these rapid changes and advancing technologies and exploits them for mapping and,in general,for all the users of the geospatial field at ***,his open-minded and kind personality has been always a major plus to his technical skills and experiences,and ultimately helped him assist many colleagues to advance their careers,and along the way developed and increased the use of geospatial data and systems in support of many countries worldwide.

关键词： Photogrammetry remote sensing space observation

Rapid and Cost-Effective Gene Targeting in Rat Embryonic Stem Cells by TALENs

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Journal of Genetics and Genomics 2012年第6期39卷 275-280页

作者： charles Ashton Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC Department of Cell and NeurobiologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA

The rat is the preferred animal model in many areas of biomedical research and drug development. Genetic manipulation in rats has lagged behind that in mice due to the lack of efficient gene targeting tools. Previously, we generated a knockout rat via conventional homologous recombination in rat embryonic stern （ES） cells. Here, we show that efficient gene targeting in rat ES cells can be achieved quickly through transcription activator-like effector nuclease （TALEN）-mediated DNA double-strand breaks. Using the Golden Gate cloning technique, we constructed a pair of TALEN targeting vectors for the gene of interest in 5 days. After gene transfection, the targeted rat ES cell colonies were isolated, screened, and confirmed by PCR without the need of drug selection. Our results suggest that TALEN-mediated gene targeting is a superior means of establishing genetically modified rat ES cell lines with high efficiency and short turnaround time.

关键词： TAL effector BMPR2 Rat ES cells Gene-targeting

Enhancing manual P-phase arrival detection and automatic onset time picking in a noisy microseismic data in underground mines

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International Journal of Mining Science and Technology 2018年第4期28卷 683-691页

作者： Mborah charles Ge Maochen Department of Mining and Nuclear Engineering Missouri University of Science and Technology

Accurate detection and picking of the P-phase onset time in noisy microseismic data from underground mines remains a big challenge. Reliable P-phase onset time picking is necessary for accurate source location needed for planning and rescue operations in the event of failures. In this paper, a new technique based on the discrete stationary wavelet transform （DSWT）and higher order statist!cs, is proposed for processing noisy data from underground mines. The objectives of this method are to （1） Improve manual detection and tPicking of P-phase onset; and （ii） provide an automatic means of detecting and picking P-phase onset me accurately. The DSWT is first used to filter the signal over several scales. The manual P-phase onset detection and picking are then obtained by computing the signal energy across selected scales with frequency bands that capture the signal of interest. The automatic P-phase onset, on the other hand, is achieved by using skewness- and kurtosis-based criterion applied to selected scales in a time-frequency domain. The method was tested using synthetic and field data from an underground limestone mine. Results were compared with results obtained by using the short-term to long-term average （STA/LTA） ratio and that by Reference Ge et al. （2009）. The results show that the me!hod provides a more reliable estimate of the P-phase onset arrival than the STA]LTA method when the signal to noise ratio is very low. Also, the results obtained from the field data matched accurately with the results from Reference Ge et al. （2009）.

关键词： Manual P-phase detection Automatic onset picking Noisy microseismic data Kurtosis Skewness

Interaction between animal personality and animal cognition

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Current Zoology 2011年第4期57卷 491-498页

作者： Claudio CARERE charles LOCURTO Department of Ecology and Sustainable Economic Development Centro Ittiogenico Sperimentale Universith degli Studi della Tuscia Borgo Le Saline 01016 Tarquinia (Vt) Italy Department of Psychology College of The Holy Cross 1 College St PO Box 75A Worcester MA 01610 USA

The study of animal personality has attracted considerable attention, as it has revealed a number of similarities in personality between humans and several nonhuman species. At the same time the adaptive value and evolutionary maintenance of different personalities are the subject of debate. Since Pavlov＇s work on dogs, students of comparative cognition have been aware that animals display vast individual differences on cognitive tasks, and that these differences may not be entirely accounted for differences in cognitive abilities. Here, we argue that personality is an important source of variation that may affect cognitive performance and we hypothesise mutual influences between personality and cognition across an individual＇s lifespan. In particular, we suggest that： 1） personality profiles may be markers of different cognitive styles; 2） success or failure in cognitive tasks could affect different personalities differently; 3） ontogenetic changes of personality profiles could be reflected in changes in cognitive performance. The study of such interplay has implications in animal welfare as well as in neuroscience and in translational medicine [Current Zoology 57 （4）： 491-498, 2011].

关键词： Animal personality Coping style Cognition