Donor age and body weight determine the effects of fecal microbiota transplantation on growth performance,and fecal microbiota development in recipient pigs

作     者：Xiaofan Wang Tsungcheng Tsai Bin Zuo Xiaoyuan Wei Feilong Deng Ying Li Charles V.Maxwell Hua Yang Yingping Xiao Jiangchao Zhao Xiaofan Wang;Tsungcheng Tsai;Bin Zuo;Xiaoyuan Wei;Feilong Deng;Ying Li;Charles V.Maxwell;Hua Yang;Yingping Xiao;Jiangchao Zhao

作者机构：Department of Animal ScienceDivision of AgricultureUniversity of ArkansasFayettevilleARUSA Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise BreedingCollege of Life Science and EngineeringFoshan UniversityFoshan 528225China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-productsInstitute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhouChina 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2022年第13卷第5期

页      面：1483-1498页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 

基　　金：partially supported by a USDA NIFA grant(2018-67015-27479) Walmart Foundation(Project#61626817) 

主　　题：Colonization FMT Growth performance Swine gut microbiome 

摘      要：Background:The application of fecal microbiota transplantation(FMT)to improve swine growth performance has been sporadically *** of these studies used a single microbiota source and thus the effect of donor characteristics on recipient pigs’fecal microbiota development and growth performance is largely ***:In this study,we collected feces from six donors with heavy(H)or light(L)body weight and different ages(d 42,nursery;d 96,growing;and d 170,finisher)to evaluate their effects on the growth performance and fecal microbiota development of recipient ***,recipients that received two doses of FMT from nursery and finisher stages donor at weaning(21±2 days of age)inherited the donor’s growth pattern,while the pigs gavaged with grower stage material exerted a numerically greater weight gain than the control pigs regardless of donor *** from heavier donors(NH,GH,and FH)led to the recipients to have numerically increased growth compared to their lighter counterparts(NL,GL,and FL,respectively)throughout the growing and most finishing *** benefit could be attributed to the enrichment of ASV25 Faecalibacterium,ASV61 Faecalibacterium,ASV438 Coriobacteriaceae_unclassified,ASV144 Bulleidia,and ASV129 Oribacterium and decrease of ASV13 Escherichia during nursery *** microbiota transplantation from growing and finishing donors influenced the microbial community significantly in recipient pigs during the nursery *** of older donors’gut microbiota expedited recipients’microbiota maturity on d 35 and 49,indicated by increased estimated microbiota *** ageassociated bacterial taxa included ASV206 Ruminococcaceae,ASV211 Butyrivibrio,ASV416 Bacteroides,ASV2 Streptococcus,and ASV291 *** body weight differences between GL and GH pigs on d 104 were associated with the increased synthesis of the essential amino acid,lysine and methionine,mixed acid fermentation,expedited glycolysis,and sucrose/galactose degradation