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Chinese Journal of Mechanical Engineering 2017年第4期30卷 782-795页

作者： wan Zhang min-Ping Jia Lin Zhu Xiao-An Yan School of Mechanical Engineering Southeast UniversityNanjing 211189 China

Computational intelligence is one of the most powerful data processing tools to solve complex nonlinear problems, and thus plays a significant role in intelligent fault diagnosis and prediction. However, only few com- prehensive reviews have summarized the ongoing efforts of computational intelligence in machinery condition moni- toring and fault diagnosis. The recent research and devel- opment of computational intelligence techniques in fault diagnosis, prediction and optimal sensor placement are reviewed. The advantages and limitations of computational intelligence techniques in practical applications are dis- cussed. The characteristics of different algorithms are compared, and application situations of these methods are summarized. Computational intelligence methods need to be further studied in deep understanding algorithm mech- anism, improving algorithm efficiency and enhancing engineering application. This review may be considered as a useful guidance for researchers in selecting a suit- able method for a specific situation and pointing out potential research directions.

关键词： Computational intelligence Machinerycondition monitoring Fault diagnosis Neural networkFuzzy logic Support vector machine - Evolutionaryalgorithms

Microstructural evolution and mechanical properties of brazed IN718 ultrathin-walled capillary structure using different particulate reinforced filler alloy

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Chinese Journal of Aeronautics 2022年第3期35卷 550-564页

作者： Wenpeng HAN min wan Rui ZHAO Hui KANG Yuantong RAO School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China

The development of hypersonic precooled combined cycle engine provides a reliable power system for the future intercontinental navigation and reusable space orbital *** compact heat exchanger precooler is the key component of the cooling cycle system,which provides efficient heat management for the hypersonic *** investigation mainly focused on the manufacturing process of precooler,and the typical structure of the precooler,ultrathin-walled capillary structure,was facilitated by the vacuum brazing using the particle reinforced composite filler *** effects of different types and contents of the reinforced particle on the spreading behaviour,microstructural evolution,mechanical performance changes were investigated in *** the cooling process,the nucleation and growth of the c-Ni solid solution on the surface of the reinforced particles was the main reason for the microstructure *** to the Ni particles,the more obvious mechanical properties improvement could be achieved by using IN718 particles reinforced composite filler *** tensile strength and elongation of the brazed ultrathin-walled structure present 9.36%and 47.27%higher than that using initial filler ***,the micro-hardness distribution result revealed that the reinforced particles reduced the overall micro-hardness of the brazed region,dispersed the eutectic structure and increased the hardness dispersion,which would reduce the stress concentration tendency and improve the structural properties.

关键词： Composite filler alloy Hypersonic Precooler Mechanical properties Ultrathin-walled structure Vacuum brazing

Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss

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Current Medical Science 2023年第2期43卷 367-375页

作者： chao-ye DUAN wan-lin FAN Fei CHEN Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneCologne50937Germany Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective To explore the role of extracellular vesicles(EVs)in the pathogenesis of glaucoma caused by E50K *** A photoreceptor cell line,RGC-5,was transfected with empty plasmids and plasmids expressing wild-type(WT)optineurin(OPTN)or E50K OPTN to investigate the effects of OPTN glaucoma as well as to identify the role of EVs in glaucoma *** RGC-5 cells were also stimulated with glutamate,and their viability was evaluated using flow cytometry or CCK-8 *** were extracted,labeled with PKH-26,and added into the medium for normal RGC-5 culture,and the status of the cells was observed *** WT OPTN overexpression,E50K OPTN,and glutamate stimulation induced apoptosis of RGC-5 ***,when glutamate stimulation was used as an add-on treatment,the degree of apoptosis in WT OPTN-overexpressing RGC-5 cells was significantly lower than that in E50K OPTN-expressing and normal RGC-5 *** viability of normal RGC-5 cells was reduced when co-cultured with WT OPTN-overexpressing RGC-5 or E50K OPTN-overexpressing *** released by the latter two transfected lines similarly reduced normal RGC-5 *** Our results indicate that WT OPTN overexpression may lead to photoreceptor ***,overexpression also confers a degree of protection against high concentrations of extracellular ***,EVs released by transfected RGC-5 cells may regulate the cell *** findings may improve our understanding of the mechanisms of cell-cell interactions in pathological conditions,providing a basis for the use of EVs as novel targets for early diagnosis and treatment of glaucoma.

关键词： E50K mutation extracellular vesicles glaucoma optineurin RGC-5 photoreceptor cell line

Micromanufacturing technologies of compact heat exchangers for hypersonic precooled airbreathing propulsion: A review

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Chinese Journal of Aeronautics 2021年第2期34卷 79-103页

作者： Bao MENG min wan Rui ZHAO Zhengping ZOU Huoxing LIU School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Energy and Power Engineering Beihang UniversityBeijing 100191China

The Hypersonic Precooled Combined Cycle Engine(HPCCE), which introduces precooler into traditional hypersonic engine, is regarded as the most promising propulsion system for realizing a single-stage-to-orbit vehicle. The unique demands lead to the application of the compact heat exchangers, which can realize high thrust-to-weight ratio, sufficient specific impulse and high compression ratio. However, it is challenging to accurately manufacture the compact heat exchanger due to its extremely high heat dissipation capacity, remarkable compactness, superior adaptability and harsh operating condition. This review summarizes the precooling schemes of combined cycle propulsions and describes the demands and key issues in the fabrication of a compact heat exchanger for HPCCE. The investigation focuses on the application of various micromanufacturing methods of heat exchangers constructed from tubes of less than 1 mm in diameter and microchannels of less than 200 micrometers. Various micromanufacturing processes, which include microforming, micromachining, stereolithography, chemical etching, 3 D printing, joining and other advanced microfabricating processes, were reviewed. In addition, the technologies are compared in terms of dimensional tolerance, material compatibility, and process applicability. Furthermore, the boundaries of the micromanufacturing constraints are specified as references for the design of compact heat exchangers. Ultimately, the technological difficulties and development trends are discussed for the fabrication of compact heat exchangers for HPCCE.

关键词： Compact heat exchangers Hypersonic precooled engine Microchannels Micromanufacturing Microtube

Hydrodynamic Analysis and Power Conversion for Point Absorber WEC with Two Degrees of Freedom Using CFD

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China Ocean Engineering 2018年第6期32卷 718-729页

作者： GUO Wei ZHOU Ya-hui ZHANG wan-chao ZHAO Qiao-sheng State Key Laboratory of Hydrodynamics China Ship Scientific Research Center School of Naval Architecture and Ocean Engineering Jiangsu University of Science and Technology

Point absorber wave energy device with multiple degrees of freedom(DOF) is assumed to have a better absorption ability of mechanical energy from ocean waves. In this paper, a coaxial symmetric articulated point absorber wave energy converter with two degrees of freedom is presented. The mechanical equations of the oscillation buoy with power take-off mechanism(PTO) in regular waves are established. The three-dimensional numerical wave tank is built in consideration of the buoy motion based upon the CFD method. The appropriate simulation elements are selected for the buoy and wave parameters. The feasibility of the CFD method is verified through the contrast between the numerical simulation results of typical wave conditions and test results. In such case, the buoy with single DOF of heave, pitch and their coupling motion considering free(no PTO damping) and damped oscillations in regular waves are simulated by using the verified CFD method respectively. The hydrodynamic and wave energy conversion characteristics with typical wave conditions are analyzed. The numerical results show that the heave and pitch can affect each other in the buoy coupling motion, hydrodynamic loads, wave energy absorption and flow *** total capture width ratio with two coupled DOF motion is higher than that with a single DOF motion. The wave energy conversion of a certain DOF motion may be higher than that of the single certain DOF motion even though the wave is at the resonance period. When the wave periods are high enough, the interaction between the coupled DOF motions can be neglected.

关键词： CFD simulation wave energy conversion numerical tank coupling motion capture width ratio

A peep into mitochondrial disorder： multifaceted from mitochondrial DNA mutations to nuclear gene modulation

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Protein & Cell 2015年第12期6卷 862-870页

作者： chao Chen Ye Chen min-Xin Guan School of Medicine Institute of Genetics Zhejiang University Hangzhou 310058 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University Hangzhou 310058 China

Mitochondrial genome is responsible for multiple human diseases in a maternal inherited pattern, yet phenotypes of patients in a same pedigree frequently vary largely. Genes involving in epigenetic modification, RNA processing, and other biological pathways, rather than ＂threshold effect＂ and environmental factors, provide more specific explanation to the aberrant phenotype. Thus, the double hit theory, mutations both in mito- chondrial DNA and modifying genes aggravating the symptom, throws new light on mitochondrial dysfunc- tion processes. In addition, mitochondrial retrograde signaling pathway that leads to reconfiguration of cell metabolism to adapt defects in mitochondria may as well play an active role. Here we review selected examples of modifier genes and mitochondrial retrograde signaling in mitochondrial disorders, which refine our understanding and will guide the rational design of clinical therapies.

关键词： mitochondrial disorder mitochondrial DNAmutation nuclear modifier gene mitochondrial retrogradesignaling

Diagenetic mineralogy and its effect on the reservoir properties of the sandstones of the Permian of S120 block(Sulige gas field),Ordos Basin,NW China

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Journal of Palaeogeography 2022年第3期11卷 360-386页

作者： Qi wan Ai-Ping Fan Ren-chao Yang Nils Lenhardt Shandong Provincial Key Laboratory of Depositional mineralization&Sedimentary minerals Shandong University of Science and TechnologyQingdao266590China Laboratory for Marine mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China Department of Geology University of PretoriaPrivate Bag X200028PretoriaSouth Africa

The characteristics of diagenetic minerals and their effects on reservoir quality of the tight sandstones of the Permian in Sulige gas field of the Ordos Basin were studied through observations on thin sections,scanning electron microscopy,energy dispersive spectroscopy analysis and electron microprobe *** minerals in the Permian sandstones consist of illite,kaolinite,chlorite,siliceous and calcite *** amounts of intercrystalline pores between kaolinite and illite provide channels for acidic fluids flow and thereby were conducive to the formation of clastic solution pores,intergranular solution pores and composite *** chlorite occurs in the form of three morphotypes as grain-coating,pore-lining and ***-coating and pore-lining chlorite with different crystal shapes occur as coatings on the framework ***-filling chlorite precipitated as discrete flaky plates in pore *** microcrystals developed but quartz overgrowth did not develop because of the occurrence of porelining ***,in turn,led to the preservation of primary pores by occupying potential nucleation sites for quartz overgrowth and thereby preventing quartz microcrystals from merging into quartz *** process is regarded as the most important for influencing the quality of the lithophysical *** cement was mainly precipitated during a late diagenetic stage and has a negative effect on the reservoir *** study provides important insights into analyzing the relationship between diagenetic minerals and reservoir quality and the results are directly applicable to the exploration and development of tight sandstone reservoirs all over the world.

关键词： Ordos basin Sulige gas field Permian Diagenetic processes Siliceous cement Chlorite

Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats

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Food Science and Human Wellness 2023年第4期12卷 1157-1166页

作者： Ligang Yang chao Yang Zhixiu Song min wan Hui Xia Xian Yang Dengfeng Xu Da Pan Hechun Liu Shaokang wang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of ministry of Education School of Public HealthSoutheast UniversityNanjing 210009China Second Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023China

Postprandial metabolism plays major roles in many pathological *** n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological *** study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)*** postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio *** HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio *** 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG *** postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG *** 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC *** results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.

关键词： Polyunsaturated fatty acid n-6 Fatty acids n-3 Fatty acids Postprandial metabolism Hypertriglyceridemia

Recent advances in hard carbon anodes with high initial Coulombic efficiency for sodium-ion batteries

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Nano Materials Science 2023年第2期5卷 189-201页

作者： Yanhua wan Yao Liu Dongliang chao Wei Li Dongyuan Zhao Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai200433China

Initial Coulombic efficiency(ICE)has been widely adopted in battery research as a quantifiable indicator for the lifespan,energy density and rate performance of *** carbon materials have been accepted as a promising anode family for sodium-ion batteries(SIBs)owing to their outstanding ***,the booming application of hard carbon anodes has been significantly slowed by the low ICE,leading to a reduced energy density at the cell *** offers a challenge to develop high ICE hard carbon anodes to meet the applications of high-performance ***,we discuss the definition and factors of ICE and describe several typical strategies to improve the ICE of hard carbon *** strategies for boosting the ICE of such anodes are also systematically categorized into several aspects including structure design,surface engineering,electrolyte optimization and *** key challenges and perspectives in the development of high ICE hard carbon anodes are also outlined.

关键词： Sodium-ion battery Hard carbon Initial Coulombic efficiency Interface engineering Anode

Potential shift of bacterial community structure and corrosion-related bacteria in drinking water distribution pipeline driven by water source switching

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Frontiers of Environmental Science & Engineering 2021年第2期15卷 117-126页

作者： Yue Hu Ding Dong Kun wan chao Chen Xin Yu Huirong Lin Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhou 215163China College of Environment&Ecology Xiamen UniversityXiamen 361102China School of Environment Tsinghua UniversityBeijing 100084China Department of Environmental Science and Engineering College of Chemical EngineeringHuaqiao UniversityXiamen 361021China

As a result of pollution in the present water sources,cities have been forced to utilize cleaner water *** are few reports regarding the potential shift of bacterial community structure driven by water source switching,especially that of corrosion-related *** types of finished water were used for simulation,the polluted source water from the Qiantang and Dongtiaoxi Rivers(China)was replaced by cleaner water from Qiandao Lake(China).Here,we discussed the transition effects through three simulated *** bacterial characteristics were identified using the highthroughput sequencing and heterotrophic plate count *** was observed that the level of culturable bacteria declined by 2–3 orders of magnitude after water source *** bacterial community released from the pipeline reactor was significantly different under different finished water,and it exhibited large variation at the genus ***(58.2%)and Phreatobacter(14.5%)clearly replaced Novosphingobium,Aquabacterium,and Cupriavidus as new dominant genera in system A,which could be attributed to the lower carbon and nitrogen content of the new water *** corrosion-inhibiting bacteria decreased after switching,they still maintained dominant in three reactors(6.6%,15.9%,and 19.7%).Furthermore,potential opportunistic pathogens such as Sphingomonas were *** study shows that after transition to a high quality water source,the total culturable bacteria released was in a downtrend,which leads to a great reduction in the risk of bacterial leakage in the produced drinking water.

关键词： Drinking water biosafety Water source switching Drinking water distribution system Transition effects High-throughput sequencing