Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats

作     者：Ligang Yang Chao Yang Zhixiu Song Min Wan Hui Xia Xian Yang Dengfeng Xu Da Pan Hechun Liu Shaokang Wang Guiju Sun Ligang Yang;Chao Yang;Zhixiu Song;Min Wan;Hui Xia;Xian Yang;Dengfeng Xu;Da Pan;Hechun Liu;Shaokang Wang;Guiju Sun

作者机构：Key Laboratory of Environmental Medicine and Engineering of Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Second Clinical Medical CollegeNanjing University of Chinese MedicineNanjing 210023China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第4期

页      面：1157-1166页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by National Key Research and Development Plan(2016YFD0400604) National Natural Science Foundation of China(82073551) 

主　　题：Polyunsaturated fatty acid n-6 Fatty acids n-3 Fatty acids Postprandial metabolism Hypertriglyceridemia 

摘      要：Postprandial metabolism plays major roles in many pathological *** n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological *** study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)*** postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio *** HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio *** 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG *** postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG *** 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC *** results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.