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Theoretical analysis and engineering application of controllable shock wave technology for enhancing coalbed methane in soft and low‑permeability coal seams

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International Journal of Coal Science & Technology 2024年第2期11卷 123-142页

作者： Guodong Qiao Zegong Liu Yongmin Zhang changping yi Kui Gao Shigui Fu Youzhi Zhao School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001AnhuiChina Institute of Energy Hefei Comprehensive National Science CenterHefei 230031AnhuiChina School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049ShanxiChina Division of Mining and Geotechnical Engineering LuleåUniversity of TechnologyLuleåSweden

Coalbed methane(CBM)is a significant factor in triggering coal and gas outburst disaster,while also serving as a clean *** the increasing depth of mining operations,coal seams that exhibit high levels of gas content and low permeability have become increasingly *** controllable shockwave(CSW)technology has proven effective in enhancing CBM in laboratory settings,there is a lack of reports on its field applications in soft and low-permeability coal *** study establishes the governing equations for stress waves induced by *** numerical inversion was employed to analyse the dynamic response of the coal seam during CSW ***,quantitative calculations were performed for the crushed zone,fracture zone,and effective CSW influence range,which guided the selection of field test *** results of the field test unveiled a substantial improvement in the gas permeability coefficient,the average rate of pure methane flowrate,and the mean gas flowrate within a 10 m radius of the antireflection *** enhancements were notable,showing increases of 3 times,13.72 times,and 11.48 times,***,the field test performed on the CSW antireflection gas extraction hole cluster demonstrated a noticeable improvement in CBM *** antireflection,the maximum peak gas concentration and maximum peak pure methane flow reached 71.2%and 2.59 m^(3)/min,*** findings will offer valuable guidance for the application of CSW antireflection technology in soft and low-permeability coal seams.

关键词： CSW antireflection in coal seams CBM extraction enhancement Soft and low-permeability coal seams Field test

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An empirical approach for predicting burden velocities in rock blasting

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 767-773页

作者： Zong-Xian Zhang Li-Yuan Chi changping yi Oulu Mining School University of OuluOuluFI-90014Finland State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijingChina Division of Mining and Geotechnical Engineering Lulea University of TechnologyLuleaSweden

An analytical relation between burden velocity and ratio of burden to blasthole diameter is developed in this *** relation is found to be consistent with the measured burden velocities of all 37 full-scale blasts found from published *** blasts include single-hole blasts,multi-hole blasts,and simultaneously-initiated blasts with various borehole diameters such as 64 mm,76 mm,92 mm,115 mm,142 mm and 310 *** boreholes were fully *** agreement between measured and calculated burden velocities demonstrates that this relation can be used to predict the burden velocity of a wide range of full-scale blast with fully-coupled explosive charge and help to determine a correct delay time between adjacent holes or rows in various full-scale blasts involved in tunnelling(or drifting),surface and underground mining production blasts and underground opening slot *** addition,this theoretical relation is found to agree with the measured burden velocities of 9 laboratory small-scale blasts to a certain *** predict the burden velocity of a small-scale blast,a further study or modification to the relation is necessary by using more small-scale blasts in the future.

关键词： Burden velocity Rock blasting Kinetic energy Delay time Tunnelling Minin

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Time-frequency characteristics of blasting vibration signals measured in milliseconds

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Mining Science and Technology 2011年第3期21卷 349-352页

作者： Zhao Mingsheng ZhangJianhua yi changping School of Resources and Environment Engineering Wuhan University of Technology Wuhan 430070 China

In order to study the time-frequency characteristics of blasting vibration signals, measured in milliseconds, we carried out site blasting vibration tests at an open pit of the Jinduicheng Mine. Based on recorded field data and applying a combination of RSPWVD and wavelet, we analyzed the time-fre- quency characteristics of recorded field data, summarized the time-frequency characteristics of blasting vibration signals in different frequency bands and present detailed information of blasting vibration sig- nals in milliseconds of high time-frequency resolutions. Because RSPWVD can be seen as of definite physical significance to signal energy distribution in time and frequency domains, we studied the energy distribution of blasting vibration signals for various milliseconds intervals from a perspective of energy distribution. The results indicate that the effect of milliseconds intervals on time-frequency characteris- tics of blasting vibration signals is significant; the length of delay time directly affects the energy distri- bution of blasting vibration signals as well as the duration of energy in ffeauencv bands.

关键词： Blasting vibrationMillisecond blastingWavelet analysis RSPWVD Time-frequency characteristics

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Cyber-physical Integrated Planning of Distribution Networks Considering Spatial-temporal Flexible Resources

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Protection and Control of Modern Power Systems 2024年第3期9卷 142-156页

作者： Shutan Wu Qi Wang Qichao Chen changping Yu yi Tang Southeast University NanjingChina the School of Electrical Engineering Southeast UniversityNanjing 210096China the State Grid Economic and Technological Research Institute CO .LTD.BeijingChina System Automation Research Institute Southeast University

The rapid development of cyber technology and the increase of flexible resources have transformed the distribution network into a cyber-physical distribution system,while the accompanying multidimensional uncertainties have brought new planning *** this paper,an innovative approach is proposed to effectively leverage distributed resources while considering the impact of cyber-physical coupling in distribution network planning.A cyber-physical integrated planning model of the distribution network is proposed,considering the effects of spatial-temporal flexible resources and multi-network ***,a three-layer optimization model is established and analyzed by the simulate anneal-particle swarm optimization *** upper layer achieves the optimization of the location and configuration of energy storage systems and smart terminal *** middle layer optimizes the data load migration strategy using spatial-temporal flexible resources to solve the voltage exceeding problem caused by high penetration of distributed power access,while the lower layer optimizes the cyber side communication topology,improving the convergence speed and control performance of the distribution ***,the optimization model is analyzed iteratively with objective functions including total planning cost,operation excess loss and distributed control ***,the effectiveness and economy of the proposed planning scheme is verified and compared to traditional methods.

关键词： Cyber-physical distribution system distributed resources integrated planning model spatialtemporal migration

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爆炸荷载作用下中隔墩应力场的影响因素分析

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岩土力学 2001年第1期22卷 21-25页

作者：朱传云喻胜春易长平武汉大学水电学院湖北武汉430072

针对影响中隔墩动应力分布的各种因素，包括中隔墩的宽度、力学参数、两侧岩体的爆破开挖顺序等，分别建立不同的有限元计算模型，利用ANSYS5．5．2有限元分析软件对中隔墩在爆炸荷载作用下的应力分布情况进行了计算、分析。还对沿中隔... 详细信息

针对影响中隔墩动应力分布的各种因素，包括中隔墩的宽度、力学参数、两侧岩体的爆破开挖顺序等，分别建立不同的有限元计算模型，利用ANSYS5．5．2有限元分析软件对中隔墩在爆炸荷载作用下的应力分布情况进行了计算、分析。还对沿中隔墩高程分布的质点振速的放大效应进行了讨论。结果表明中隔墩的宽度、力学参数、两侧岩体的爆破开挖顺序对中隔墩的应力分布均有很大的影响。实际施工中应对这些因素进行严格控制，以确保中隔墩的安全与稳定。

关键词：爆炸荷载中隔墩应力场水电工程爆破开挖顺序

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爆破地震波的能量衰减规律研究

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岩石力学与工程学报 2010年第A1期29卷 3364-3369页

作者：李洪涛卢文波舒大强杨兴国易长平四川大学水利水电学院四川成都610065 武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 武汉理工大学资源与环境工程学院湖北武汉430070

爆破地震对建筑物的影响实质上是一种能量的传递与转化过程,从爆破振动控制的方面考虑,了解爆破地震波传播过程中的衰减特性,才能对建筑物受影响程度做出必要而又相对准确的估计。基于地震学相关理论,研究爆破地震波的能量衰减规律,表... 详细信息

爆破地震对建筑物的影响实质上是一种能量的传递与转化过程,从爆破振动控制的方面考虑,了解爆破地震波传播过程中的衰减特性,才能对建筑物受影响程度做出必要而又相对准确的估计。基于地震学相关理论,研究爆破地震波的能量衰减规律,表明峰值能量随距离的衰减系数同振速衰减系数呈2倍关系,对于同一场次的爆破而言,爆破地震的总能量同峰值振速的平方近似成正比例。针对实例工程的分析结果印证理论推导的正确性。实例分析同时表明,爆破地震的能量衰减是以米计的,这一点有别于天然地震。在运用天然地震方法处理爆破地震时应该注意到这一区别。

关键词：爆炸力学爆破地震能量衰减规律地震学

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Neddylation Regulation of Immune Responses

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Research 2024年第3期2023卷 545-559页

作者： Hongmei Mao Xin Lin yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences HangzhouZhejiang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

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爆破振动预测研究综述

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现代矿业 2011年第5期27卷 1-5页

作者：易长平冯林王刚黄立茂武汉理工大学

爆破振动过大会引起各种破坏现象,对爆破振动进行有效预测是优化爆破方案和采取防护措施的前提。从试验研究、理论研究、数值模拟及其他几个方面总结了国内外在爆破振动强度和频率预测领域的研究方法和研究成果。

关键词：爆破振动强度频率预测

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Enhanced Sampling Simulations on Transition-Metal-Catalyzed Organic Reactions:Zirconocene-Catalyzed Propylene Polymerization and Sharpless Epoxidation

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CCS Chemistry 2024年第4期6卷 964-975页

作者： Xu Han Tian-Yu Sun yi Isaac Yang Jun Zhang Jing Qiu Zhaoping Xiong Nan Qiao Yun-Dong Wu yi Qin Gao Institute of Theoretical and Computational Chemistry College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Shenzhen Bay Laboratory Shenzhen 518132 changping Laboratory Beijing 102200 Laboratory of Health Intelligence Huawei Cloud Computing Technologies Co.Ltd.Guizhou 550025

The bond breaking and forming in chemical reactions is a typical rare event,which is one of the difficult problems in molecular dynamics *** enhanced sampling methods have been developed to extend the time scale covered by molecular ***,the difficulties of obtaining appropriate collective variables from complicated reaction pathways and a controlled sampling over the desired phase space remain as ***,we use MetaITS,which combines metadynamics and integrated tempered sampling,to increase the sampling efficiency for chemical *** with collective variables obtained by harmonic linear discriminant analysis can efficiently decrease the main energy barrier of chemical ***,integrated tempered sampling can enhance the exploration of other degrees of *** this study,we applied the MetaITS method to two transition-metal-catalyzed organic reactions with complicated reaction *** simulated here a zirconocene-catalyzed propylene polymerization to investigate the regioselectivity and temperature *** also studied a Sharpless epoxidation reaction,for which both chiral products are observed through simulation.

关键词： molecular dynamics enhanced sampling metadynamics integrated tempering sampling propylene polymerization Sharpless epoxidation

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Tumor initiation and early tumorigenesis:molecular mechanisms and interventional targets

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2900-2935页

作者： Shaosen Zhang Xinyi Xiao Yonglin yi Xinyu Wang Lingxuan Zhu Yanrong Shen Dongxin Lin Chen Wu Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BeijingChina Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical College100021 BeijingChina changping Laboratory 100021 BeijingChina Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China CAMS Oxford Institute Chinese Academy of Medical Sciences100006 BeijingChina

Tumorigenesis is a multistep process,with oncogenic mutations in a normal cell conferring clonal advantage as the initial ***,despite pervasive somatic mutations and clonal expansion in normal tissues,their transformation into cancer remains a rare event,indicating the presence of additional driver events for progression to an irreversible,highly heterogeneous,and invasive ***,researchers are emphasizing the mechanisms of environmental tumor risk factors and epigenetic alterations that are profoundly influencing early clonal expansion and malignant evolution,independently of inducing ***,clonal evolution in tumorigenesis reflects a multifaceted interplay between cell-intrinsic identities and various cell-extrinsic factors that exert selective pressures to either restrain uncontrolled proliferation or allow specific clones to progress into ***,the mechanisms by which driver events induce both intrinsic cellular competency and remodel environmental stress to facilitate malignant transformation are not fully *** this review,we summarize the genetic,epigenetic,and external driver events,and their effects on the co-evolution of the transformed cells and their ecosystem during tumor initiation and early malignant evolution.A deeper understanding of the earliest molecular events holds promise for translational applications,predicting individuals at high-risk of tumor and developing strategies to intercept malignant transformation.

关键词： alterations mechanisms restrain

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