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Genes & Diseases 2024年第2期11卷 542-545页

作者： Jiyan Wang Tao He Qingle Gao Hongkai Chang Xintong Dai Juze Yang Shuangping Liu Shuai Zhang changliang shan Chunze Zhang State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Departments of Pathology Characteristic Medical Center of The Chinese People's Armed Police ForceTianjin 300162China Department of Respiratory Medicine Sir Run Run Shaw Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310016China Department of Pathology Medical SchoolDalian UniversityDalianLiaoning 116622China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Colorectal Surgery Tianjin Union Medical CenterNankai UniversityTianjin 300121China

The tumor heterogeneity results in different clinical characteristics of tumor patients,so precise therapy is a popular treatment strategy *** instability(MSI)is found in 10%-15%of colorectal cancer(CRC)patients and exhibits different clinical outcomes than microsatellite stable(MSS)***,MSI patients have a better prognosis than patients with stable *** patients exhibit clinical features that are not responsive to chemotherapy,however,Msl patients showed excellent responses to immunotherapy.'Although the subtype classification of MSI is beneficial to the clinical treatment of CRC patients,the mechanism of MSl remains unclear.

关键词： immunotherapy colorectal clinical

Interruption of bile acid enterohepatic circulation inhibits glycogen synthesis and promotes hepatocellular carcinoma progression

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Genes & Diseases 2023年第6期10卷 2218-2221页

作者： Jiyan Wang Xintong Dai Hongkai Chang Qingle Gao Jianshuang Guo Juze Yang Shuai Zhang changliang shan State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Department of Respiratory Medicine Sir Run Run Shaw Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310016China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

In recent years,increasing attention has been given to public *** and obesity are hot topics,in which glucose and lipid metabolism play an important *** synthase GYS2 has been found to regulate glycogen metabolism in hepatocellular carcinoma(HcC)and is a potential prognostic factor and therapeutic target.i Excessive bile acids induce intestinal injury and inflammatory bowel disease,and targeting bile acid receptors(FXRs)can regulate inflammation and repair damaged intestinal epithelial barriers.2 However,the research model of metabolic pathways focuses on the key enzymes,while ignoring the overall ***,we targeted the glycogen anabolism pathway and screened the upstream factor,bile acid transporter ***10A1 participates in the enterohepatic circulation of bile acids and regulates the transcriptional activity of the bile acid receptor ***,we found that diazinon could bind NTCP and inhibit glycogen synthesis by mimicking the disordered bile acid enterohepatic ***,enterohepatic circulation of bile acids coordinates lipid metabolism and glucose metabolism and draws the metabolic crosstalk network,which provides a new perspective for the clinical treatment of HCC.

关键词： metabolism bile hepatic

Angiotensin-converting enzyme 2:virus accomplice or host defender?

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Journal of Bio-X Research 2023年第3期6卷 93-103页

作者： Jiyan Wang Hongkai Chang Yaya Qiao Huanran Sun Xichuan Li Shuofeng Yuan Shuai Zhang changliang shan State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjin 300387China State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologyLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulam 999077Hong Kong Special Administrative RegionChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Objective:Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has led to social disruptions,mainly because we know too little about *** and Results:In this study,we integrated RNA sequencing results and found that SARS-CoV-2 infection alters aerobic glycolysis,the oxidative pentose phosphate pathway(oxiPPP),and DNA replication in lung tissues and ***,the direction of metabolic flux and DNA replication are dominated by angiotensin-converting enzyme 2(ACE2),a host cell-expressed viral receptor *** interestingly,although hosts with a high expression of ACE2 are more likely to be infected with SARS-CoV-2,the invading virus cannot perform nucleic acid replication well due to the restriction of glucose metabolism,eventually resulting in a prolonged infection cycle or infection ***:Our findings preliminarily explain the reasons for the emergence of asymptomatic infections at an early stage,which will provide assistance for the development of detection methods for diagnosing COVID-19.

关键词： ACE2 asymptomatic infection COVID-19 metabolism SARS-CoV-2

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

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Acta Pharmaceutica Sinica B 2023年第1期13卷 157-173页

作者： Mingming Sun Leilei Li Yujia Niu Yingzhi Wang Qi Yan Fei Xie Yaya Qiao Jiaqi Song Huanran Sun Zhen Li Sizhen Lai Hongkai Chang Han Zhang Jiyan Wang Chenxin Yang Huifang Zhao Junzhen Tan Yanping Li Shuangping Liu Bin Lu Min Liu Guangyao Kong Yujun Zhao Chunze Zhang Shu-Hai Lin Cheng Luo Shuai Zhang changliang shan State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen 361102China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pathology and Institute of Precision Medicine Jining Medical UniversityJining 272067China Department of Pathology Medical SchoolDalian UniversityDalian 116622China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesHengyang Medical SchoolUniversity of South ChinaHengyang 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China Institute of Biomedical Sciences Shandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Colorectal Surgery Tianjin Union Medical Center Nankai UniversityTianjin 300121China

Metabolic reprogramming is a hallmark of cancer,including lung ***,the exact underlying mechanism and therapeutic potential are largely *** we report that protein arginine methyltransferase 6(PRMT6)is highly expressed in lung cancer and is required for cell metabolism,tumorigenicity,and cisplatin response of lung ***6 regulated the oxidative pentose phosphate pathway(PPP)flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phosphogluconate dehydrogenase(6PGD)and a-enolase(ENO1).Furthermore,PRMT6 methylated R324 of 6PGD to enhancing its activity;while methylation at R9 and R372 of ENO1 promotes formation of active ENO1 dimers and 2-phosphoglycerate(2-PG)binding to ENO1,***,targeting PRMT6 blocked the oxidative PPP flux,glycolysis pathway,and tumor growth,as well as enhanced the antitumor effects of cisplatin in lung ***,this study demonstrates that PRMT6 acts as a posttranslational modification(PTM)regulator of glucose metabolism,which leads to the pathogenesis of lung *** was proven that the PRMT6-6PGD/ENO1 regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy.

关键词： Lung cancer Metabolic reprogramming Post-translational modification PRMT6 Pentose phosphate pathway flux Glycolysis 6-Phospho-gluconate dehydrogenase a-enolase ENO1

The m6A RNA Methylation Enhances 6-phosphogluconate dehydrogenase Expression to Promote Lung Cancer Growth

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The m6A RNA Methylation Enhances 6-phosphogluconate dehydrog...

靶向铜转运蛋白小分子抑制剂的发现与抗肿瘤活性研究

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Hao Sheng Yanke Guo Zhen Li Xiaoya Zhang Zhaoliang Lu Qi Feng Ronghui Liang Yanping Li Leilei Li Jing Li Dan Li Shuangping Liu Shuai Zhang changliang shan The First Affiliated Hospital Biomedical Translational Research InstituteGuangdong Province Key Laboratory of Molecular Immunology and Antibody EngineeringJinan University State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai University Division of Cellular & Molecular Research Humphrey Oei Institute of Cancer ResearchNational Cancer Centre Singapore Department of Pathology Medical SchoolDalian University Department of Medical Biochemistry and Molecular Biology School of MedicineJinan University

6-phosphogluconate dehydrogenase(6 PGD),the third enzyme in the oxidative pentose phosphate pathway(PPP) contributes to tumor *** previous study showed that lung cancer patients with higher 6 PGD levels had worse survival outcomes compared with patients with lower 6 PGD ***,how 6 PGD is upregulated in human lung cancers is *** this study,we demonstrate that 6 PGD is upregulated in lung cancer tissues and lung cancer cells relative to normal tissues and normal cells,***,we indentify methyltransferase-like 3(METTL3) as 6 PGD mRNA methyltransferase,and fat mass-and obesity-associated protein(FTO) as 6 PGD mRNA ***,we identify YTHDF2 regulates 6 PGD protein expression by facilitating its mRNA translation,which dependent on 6 PGD mRNA m6 A *** further find that YTHDF2,METTL3 and FTO would reprogram oxidative PPP as well as cancer cell proliferation and tumor growth via regulating 6 PGD *** together,our results demonstrate that m6 A modification regulates 6 PGD expression by promoting its mRNA translation and serves as a promising anticancer target.

关键词： 6-phosphogluconate dehydrogenase RNA m6A modification metabolism oxidative pentose phosphate pathway

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靶向铜转运蛋白小分子抑制剂的发现与抗肿瘤活性研究

基于热效应飞秒激光诱导LiNbO_3表面结构的研究

第八届全国化学生物学学术会议

作者：王晶卢俊彦 shan changliang Fan Jun 欧阳斯盛周宇柳红罗成 Chen Jing 蒋华良何川美国芝加哥大学中国科学院上海药物研究所新药研究国家重点实验室药物发现与设计中心美国Emory大学

铜是大多数有氧生物所必须的一种具有氧化还原活性的金属元素。其在众多生物过程中扮演重要作用,如能量产生,氧运输,细胞代谢以及血管生成等。在本研究中,我们运用计算机辅机药物设计手段,结合实验研究,首次发现了可以靶向两种铜转运蛋... 详细信息

铜是大多数有氧生物所必须的一种具有氧化还原活性的金属元素。其在众多生物过程中扮演重要作用,如能量产生,氧运输,细胞代谢以及血管生成等。在本研究中,我们运用计算机辅机药物设计手段,结合实验研究,首次发现了可以靶向两种铜转运蛋白Atoxl和hCCS的小分子抑制剂。这些小分子抑制剂通过结合于铜转运蛋白的铜转运界面,有效地干扰了了胞内铜离子的摄取与运输,进而

关键词：铜转运蛋白肿瘤活性氧族线粒体虚拟筛选

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激光技术 2015年第6期39卷 869-872页

作者：冯杰范宗学单常亮魏欣芮吴琴杨永佳周自刚西南科技大学理学院绵阳621010

为了研究飞秒激光与铌酸锂表面作用过程中热效应对其表面的影响,采用重复频率为25MHz、脉宽为100fs、平均输出功率为500m W的紧聚焦飞秒激光对铌酸锂表面进行刻蚀。通过建立热扩散理论模型,模拟重复频率25MHz的飞秒激光在刻蚀点的温度... 详细信息

为了研究飞秒激光与铌酸锂表面作用过程中热效应对其表面的影响,采用重复频率为25MHz、脉宽为100fs、平均输出功率为500m W的紧聚焦飞秒激光对铌酸锂表面进行刻蚀。通过建立热扩散理论模型,模拟重复频率25MHz的飞秒激光在刻蚀点的温度场分布,并通过电子显微镜对刻蚀点的形貌进行分析,发现刻蚀点从内至外形成了3种大小不同、排列疏密不同的颗粒状结构区域,且中心区域被高温烧蚀并伴有裂缝产生。通过能量色散谱仪对刻蚀点的3种不同结构区域中Nb和O元素的相对含量进行测量,结合刻蚀点的温度场分布、形貌和元素含量进行了分析。结果表明,Nb和O元素在温度场的驱动下向外扩散;两者的相对含量对刻蚀点的表面结构具有极大影响。这一结果对高重频飞秒激光刻蚀铌酸锂物理机制及应用的研究是有帮助的。

关键词：激光光学表面结构热效应铌酸锂飞秒激光温度场分布

铁水预脱磷温度对脱磷渣结构及行为的分析与探讨

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钢铁 2024年第8期59卷 27-39页

作者：周朝刚陈庆功闫占辉赵长亮刘道正王连全单庆林王书桓华北理工大学冶金与能源学院河北唐山063210 首钢京唐钢铁联合有限责任公司轧钢作业部河北唐山063200 首钢京唐钢铁联合有限责任公司炼钢部河北唐山063200 首钢股份公司迁安钢铁公司河北迁安064404 天津铁厂有限公司炼钢厂河北邯郸056400 唐山钢铁集团有限责任公司技术中心河北唐山063000

为探究不同铁水温度下脱磷熔渣结构演变对脱磷效果及磷迁移富集行为的影响,在铁水温度为1340~1420℃条件下进行了实验室试验,利用XRD、SEM-EDS、FTIR和Raman光谱对试验后脱磷终渣的结构进行了表征。热力学理论分析表明,随着温度的升高,... 详细信息

为探究不同铁水温度下脱磷熔渣结构演变对脱磷效果及磷迁移富集行为的影响,在铁水温度为1340~1420℃条件下进行了实验室试验,利用XRD、SEM-EDS、FTIR和Raman光谱对试验后脱磷终渣的结构进行了表征。热力学理论分析表明,随着温度的升高,磷的分配比逐渐降低。铁水脱磷试验表明,当铁水温度为1380℃时,铁水脱磷效率最高,温度过高或过低均不利于脱磷,且铁水硅质量分数随着温度的升高逐渐降低。XRD和SEM-EDS分析结果表明,磷主要富集在2CaO·SiO_(2)结晶区,富磷相由2CaO·SiO_(2)-3CaO·P_(2)O_(5)固溶体组成,温度的升高会降低富磷相的比例。拉曼和红外分析结果表明,Si—O—Si键受温度升高的影响较小。当温度较低时,炉渣中Q^(1)(Si)、Q^(2)(Si)和Q^(3)(Si)的含量增加。当温度升至1380℃时,Si—O—Si键断裂,Q^(0)(Si)增大。低聚合度的硅酸盐结构促进磷的迁移和聚集,以Q^(1)(P)形式存在的磷逐渐增加。当温度为1380~1420℃时,较高的铁水温度抑制了磷的迁移,进入渣中的硅往往以高聚合度的形式存在,随着脱硅反应的进行,渣的聚合度逐渐增加。此外,由于FeO_(6)八面体的显著增加和硅酸盐聚合度的提高,磷向硅氧网络结构中的迁移受到抑制,以Q^(0)(P)形式存在的磷逐渐增加,磷在炉渣中的扩散程度增加。可以为钢铁企业解决铁水磷质量分数超标问题和控制合理的预脱磷温度提供理论指导和参考。

关键词：预脱磷铁水温度氧化铁皮红外光谱拉曼光谱熔渣结构

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双电机刚性齿轮传动系统转矩均衡控制

电工技术学报 2017年第15期32卷 17-26页

作者：耿强单长帅刘涛夏长亮天津市电机系统先进设计与智能控制技术工程中心(天津工业大学) 天津300387

传统双电机刚性齿轮传动系统长时间运行后,齿轮的磨损和形变增大,导致两台电机间输出的电磁转矩差值随之增大,此时单台电机存在过载的风险。针对上述问题,提出一种基于交叉耦合控制算法的转矩均衡控制策略,通过设计转矩同步控制器,将两... 详细信息

传统双电机刚性齿轮传动系统长时间运行后,齿轮的磨损和形变增大,导致两台电机间输出的电磁转矩差值随之增大,此时单台电机存在过载的风险。针对上述问题,提出一种基于交叉耦合控制算法的转矩均衡控制策略,通过设计转矩同步控制器,将两台电机转矩控制作为一个整体来考虑,选取合适的耦合同步系数,通过交叉反馈对各台电机的转矩给定值分别进行补偿,最终实现输出转矩的均衡控制。仿真和实验结果验证了所提控制策略的正确性和有效性。

关键词：齿轮传动系统同步控制耦合同步系数转矩均衡控制

GATA3+Treg细胞在变应性鼻炎中的表达及意义

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南方医科大学学报 2023年第2期43卷 280-286页

作者：孙柳焦沃尔孔勇刚杨长亮续珊谯月龙陈始明中部战区总医院耳鼻咽喉头颈外科湖北武汉430070 武汉大学人民医院耳鼻咽喉头颈外科湖北武汉430060

目的研究GATA3+Treg细胞在变应性鼻炎(AR)患者和小鼠中的表达和意义。方法收集6例对照组患者(Control组)和6例变应性鼻炎患者(AR组)的鼻黏膜,检测其鼻黏膜炎症反应。同期收集12例Control组和12例AR组患者外周血单个核细胞(PBMC),检测... 详细信息

目的研究GATA3+Treg细胞在变应性鼻炎(AR)患者和小鼠中的表达和意义。方法收集6例对照组患者(Control组)和6例变应性鼻炎患者(AR组)的鼻黏膜,检测其鼻黏膜炎症反应。同期收集12例Control组和12例AR组患者外周血单个核细胞(PBMC),检测其Treg细胞和GATA3+Treg细胞比例。将C57BL/6小鼠分为正常对照组(Control组)和变应性鼻炎组(AR组)。比较两组小鼠AR症状学评分、外周血OVA-sIgE水平、鼻黏膜炎症反应。收集小鼠脾脏,检测两组小鼠体内Treg细胞和GATA3+Treg细胞比例以及Th2细胞因子表达。结果与Control组相比,AR组患者鼻黏膜中嗜酸性粒细胞浸润和杯状细胞增生明显增多(P<0.01),PBMC中Treg细胞和GATA3+Treg细胞表达下降(P<0.05)。动物实验发现:与Control组相比,AR组小鼠过敏症状评分、外周血OVA-sIgE水平、鼻黏膜嗜酸性粒细胞浸润和杯状细胞增生均明显增加(P<0.01)。与Control组相比,AR小鼠Treg细胞和GATA3+Treg细胞表达下调(P<0.01),并且Th2细胞因子IL-4、IL-6、IL-10表达上升(P<0.05)。结论GATA3+Treg细胞在AR患者和小鼠中表达下降,并可能与Th2细胞免疫应答相关,两者共同参与了AR的发生发展。GATA3+Treg细胞有望成为AR免疫调控的新靶点。

关键词：变应性鼻炎 Treg细胞 GATA3+Treg细胞免疫调控

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