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Ubiquitin proteasome system research in gastrointestinal cancer

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World Journal of Gastrointestinal Oncology 2016年第2期8卷 198-206页

作者： Jia-Ling Zhong chang-zhi huang Clinical Laboratory Department Sichuan Academy of Medical Science and Sichuan Provincial People’s HospitalChengdu 610072 Sichuan Province China Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021 China

The ubiquitin proteasome system(UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies,including esophageal,gastric and colorectal cancers. Here,we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer,highlighting its role in tumor occurrence and development,providing information for therapeutic targets research and antigastrointestinal tumor drug design.

关键词： Ubiquitin proteasome system Gastrointestinalcancer

PD-1 inhibitor in combination with fruquintinib therapy for initial unresectable colorectal cancer:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4669-4675页

作者： Hong-Qiang Zhang chang-zhi huang Jing-Yu Wu Zhen-Ling Wang Yu Shao Zan Fu Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND PD-1 inhibitors in combination with fruquintinib have not previously been reported as neoadjuvant therapy for patients with colorectal *** this case report,the combination of a PD-1 inhibitor and fruquintinib demonstrated good efficacy in patients with MSI-H colorectal *** SUMMARY The patient was a young man in his 30s who had MSI-H type colon *** patient underwent four cycles of neoadjuvant therapy with a PD-1 inhibitor combined with fruquintinib before surgery,resulting in regression of the mass and a successful *** Some patients with colorectal cancer have the MSI-H type,and the first-line chemotherapy regimen is not ***,PD-1 monoclonal antibody immunotherapy has a good therapeutic effect,which can be improved by combination therapy with *** recommend that patients with a history of colon or rectal cancer receive universal MSI testing;then,neoadjuvant therapy should be used.

关键词： Colorectal cancer Neoadjuvant PD-1 inhibitors Fruquintinib MSI-H Case report

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： zhi Li Yang Wei Kang Zhou Xin huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

非线性增益和波导结构对半导体激光器的谱线宽度的作用

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物理学报 1989年第5期38卷 699-705页

作者：郭长志黄永箴北京大学物理系

本文采用半经典理论研究了非线性增益和波导结构对量子相位噪声引起的模式谱线增宽过程的作用,得出谱线宽度不但与线性增益而且与三阶增益有关,并且都受到波导结构的制书。从而提出新的谱线增宽因子和与功率无关的线宽的新机制。

关键词：半导体激光器谱线波导宽度

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平行耦合腔波导对半导体激光器谱线宽度的控制作用

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物理学报 1989年第5期38卷 818-823页

作者：郭长志黄永箴北京大学物理系

本文详细分析了平行耦合腔波导对谱线增宽因子的作用,得出在弱耦合和两腔内涨落互不相关的条件下,可以调节波导参数使增宽因子趋于零,从而使谱线宽度降低一个数量级以上,并讨论了耦合腔波导结构的近场和远场分布以及同相和反相模式的选... 详细信息

本文详细分析了平行耦合腔波导对谱线增宽因子的作用,得出在弱耦合和两腔内涨落互不相关的条件下,可以调节波导参数使增宽因子趋于零,从而使谱线宽度降低一个数量级以上,并讨论了耦合腔波导结构的近场和远场分布以及同相和反相模式的选择过程.

关键词：耦合腔波导半导体激光器谱线

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近单模半导体激光器中模式间相互作用对光谱线宽的影响

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物理学报 1990年第7期39卷 1075-1081页

作者：郭长志黄永箴北京大学物理系北京100871

本文提出一种统计数值模拟法,从理论上较严格地研究自发辐射的量子涨落引起的半导体激光相位涨落积累量和模式线宽。结果在单模情况与小信号解析近似的结果一致;在近单模情况,边模使主模线宽略有增加;指出最近有人用Monte-Carlo法对此... 详细信息

本文提出一种统计数值模拟法,从理论上较严格地研究自发辐射的量子涨落引起的半导体激光相位涨落积累量和模式线宽。结果在单模情况与小信号解析近似的结果一致;在近单模情况,边模使主模线宽略有增加;指出最近有人用Monte-Carlo法对此得出过高估计的原因,并对小讯号解析近似已不适用的次模线宽得出其与功率无关的线宽分量约为100MHz,与实验一致。

关键词：半导体激光器模式位相光谱线宽

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen chang Cheng Yu-Han Wang Wen-Chao Cheng De-zhi Yuan Wen huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

Construction and mechanism study of hepatic tumour rat model induced by microcystin-LR

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Construction and mechanism study of hepatic tumour rat model...

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

2012全国发育生物学大会

作者： Han-yan Sun,Zi-han Wu,chang-zhi Xu,Bei huang School of Life Sciences,Anhui University,3 Feixi Road,Anhui Province,Hefei,230039

Microcystin-LR(MC-LR) is a cyclic heptapeptide toxin produced by cyanobacteria,it inhibits protein phosphatases PP1 and PP2A *** has been reported that MC-LR has a bimodal effect on *** is generally only reported at high doses of MC-LR both in vivo and in vitro,whereas potent tumour-promoting activity is observed at lower concentrations and the liver is the major target organ for microcystin-induced *** investigate the effect of microcystin-LR(MC-LR) on hepatic cell growth and hepatic tumorigenesis,the HL7702 and HepG2 cell lines were exposed to different doses of MC-LR,the proliferation and survival ratio of hepatic cells were promoted significantly by MC-LR in both a time- and dose-dependent manner by using MTT and colony formation assay,the highest cell viability at 48 h was observed when cells were treated with MC-LR at 6μg/L in *** vivo experiment,hepatocellular carcinomas models of rat were constructed by DEN plus MC-LR,then a series of changes in rat livers were observed with morphological and pathological *** results show that the process of hepatocarcinogenesis in rat included three stages:hepatic toxic lesion,hepatic proliferation/cirrhosis and hepatic ***,the effect of tumor promotion with DEN plus 10μg/kg MC-LR was better than others:the expression of GST-Pi in liver occurred earlier than in DEN alone treatment group and a large number of macroscopic nodules were observed。Meanwhile,the phosphorylation levels of AKT,mTOR and S6K in livers were significantly higher than those in the other treatment groups. Conclusions:Hepatic proliferation is significantly promoted by administration of MC-LR at lower concentrations and that the AKT/mTOR/S6K signalling pathway play an important role in cell proliferation and hepatic tumorigenesis which is induced by DEN as tumour initiator and MC-LR as promoter.

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang Dan-Dan Cui Kun-Rong Du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li zhi-Zhen Ren Liang Wang Wei-chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts