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针灸对颈动脉粥样硬化早期患者血管弹性的影响

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针刺研究 2024年第6期49卷 611-617页

作者：黄熙畅赵琳张建兴叶思婷孟令萃周俊合周婷戚芷琪周鹏符文彬广州中医药大学第二临床医学院广州510000 广州中医药大学第二附属医院超声科广州510000 广州中医药大学第二附属医院针灸科广州510000 深圳市宝安区妇幼保健院康复科广东深圳518000 深圳市宝安区中医院广东深圳518000 符文彬广东省名中医传承工作室广州510000

目的:观察针灸对颈动脉粥样硬化早期患者动脉弹性的影响。方法:将62例颈动脉粥样硬化早期患者随机分为空白组(12例,脱落1例)、假针灸组(25例,脱落5例)和针灸组(25例,脱落3例)。针灸组予针灸治疗,包括①针刺:百会、印堂、人迎、内关、阳... 详细信息

目的:观察针灸对颈动脉粥样硬化早期患者动脉弹性的影响。方法:将62例颈动脉粥样硬化早期患者随机分为空白组(12例,脱落1例)、假针灸组(25例,脱落5例)和针灸组(25例,脱落3例)。针灸组予针灸治疗,包括①针刺:百会、印堂、人迎、内关、阳陵泉;②精灸:引气归元(中脘、下脘、气海、关元)、四花(膈俞、胆俞);③皮内针:心俞、胆俞。假针灸组予安慰针刺、艾灸和皮内针治疗,穴位同针灸组。以上两组每周治疗2次,共治疗12周。空白组不进行干预。3组均予饮食及生活方式宣教。观察3组患者治疗前及治疗1、2、3个月后极速脉搏波速度,包括收缩初期脉搏波速度(BS)和收缩末期脉搏波速度(ES),以及各时点血脂水平和血小板计数(PLT),并进行安全性评价。结果:与治疗前比较,针灸组治疗2个月和3个月后双侧BS值、ES值均下降(P<0.05);与空白组比较,针灸组治疗2个月后双侧ES均下降(P<0.05),治疗3个月后双侧BS与ES均下降(P<0.05);与假针灸组比较,针灸组治疗3个月后左侧BS与左侧ES均下降(P<0.05),针灸组左侧整体下降幅度优于右侧。各组患者治疗前后和组间血脂水平、PLT比较,差异均无统计学意义。治疗期间3组均无严重不良事件发生。结论:针灸疗法具有改善颈动脉粥样硬化早期患者动脉弹性的作用,且安全有效。

关键词：颈动脉粥样硬化血管弹性针灸极速脉搏波技术

Evaluation of multidimensional simulations of summer air temperature in China from CMIP5 to CMIP6 by the BCC models: From trends to modes

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Advances in Climate change Research 2022年第1期13卷 28-41页

作者： Yun-Wen LIU Liang zhao Gui-Rong TAN Xin-Yong SHEN Su-Ping NIE qing-Quan LI Li ZHANG Key Lciboratoiy of Meteorological Disaster Ministry of EducationJoint International Research Laboratory'of Climate and Environment ChangeCollaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Numerical Modeling for Atmosphere Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing 100081China

To determine whether the capability of the CMIP6 version of Beijing Climate Center(BCC)models(BCC-ESMI and BCC-CSM2-MR)in simulating China summer surface air temperature(SAT)has improved,we presented a multidimensional evaluation of the summer SAT in China including the trends,modes,and influencing *** comparisons are also made with the results of CMIP5(BCC-CSM1.1 and ***).In general,the CMIP6,especially BCC-CSM2-MR,has smaller deviations in the trends,the means,the mutations,the maximum centers,the variances,and the spatial patterns of the dominant modes from observatio relative to those of ***,the BCC CMIP6 models still underestimate the SAT variation in the qinghai-Tibetan Plateau and the northeastern regions of China,and the performance is unsatisfactory with respect to the physical drivers of the dominant ***,all the BCC models can capture the spatio-temporal characteristics of the first mode well and can,in general,characterize the spatial pattern of the second mode,but none of the models perform well in the principal component of the second mode(PC2)due to the low performance with respect to the interannual variation of ***,the factors influencing the leading two modes are *** two CMIP6 can simulate better the Northern Hemisphere subtropical high northern boundary affecting the first *** factor,the Asia polar vortex area,can only be simulated better by two low-resolution models(BCC-CSM1.1 and BCC-ESM I).For the second mode,all four models simulate the influence of Asian zonal circulation well,but poorly simulate that of the southern Indian Ocean dipole due to a large deviation in the Indian Ocean surface temperature.

关键词： Summer mean temperature China Dominant mode CMIP6 BCC

The Target of Benzimidazole Carbamate Against Cysticerci cellulosae

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Agricultural Sciences in China 2007年第8期6卷 1009-1017页

作者： LI qing-zhang HAO Yan-hong GAO Xue-jun GAO Wen-xue zhao Bing College of Biological Science Northeast Agricultural University Harbin 150030 P.R.China

To study the target of benzimidazole carbamate drugs against Cysticerci cellulosae and give a theoretical basis for type evolution and new drug design, the changes of key enzyme activities and metabolite contents in the pathway of energy metabolism in C. cellulosae in vitro and in vivo were tested with albendazole and oxfendazole, respectively. Both albendazole and oxfendazole inhibited the pathways of anaerobic glycolysis, partial inversed tricarboxylic acid cycle of Taenia Solium oncosphere, immature and mature Cysticerci in vitro, and immature and mature Cysticerci in vivo to a certain degree, and enhanced fat decomposing, amino acid decomposing, xanthine decomposing metabolism, and on the other hand, the absorption of glucose was hindered; furthermore, both albendazole and oxfendazole inhibited the activities of the fumaric reductase （FR） complex noncompetently in vitro. Benzimidazole carbamate drugs could inhibit the activities of FR complex noncompetently and hinder the absorption of glucose.

关键词： albendazole oxfendazole Cysticerci cellulosae target energy metabolism

Breast Cancer Subtypes and Survival in Chinese Women with Operable Primary Breast Cancer

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Chinese Journal of Cancer Research 2011年第2期23卷 134-139页

作者： zhao-sheng Li Lu Yao Yi-qiang Liu Tao Ouyang Jin-feng Li Tian-feng Wang zhao-qing Fan Tie Fan Ben-yao Lin Yun-tao Xie Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Breast Center Department of Pathology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To investigate the associations between the different breast cancer subtypes and survival in Chinese women with operable primary breast cancer. Methods： A total of 1538 Chinese women with operable primary breast cancer were analyzed in this study, the median follow-up was 77 months. Estrogen receptor （ER）, progesterone receptor （PR）, and HER2 status were available for these patients. Results： Luminal A （ER＋ and/or PR＋, HER2-） had a favorable disease-free survival （DFS） and overall survival （OS） compared with other subtypes in the entire cohort. Using the luminal A as a reference, among the patients with lymph node positive disease, HER2＋（ER-, PR-, HER2＋） had the worst DFS （hazard ratio, HR=1.80, 95% CI 1.11 to 2.91, P=0.017） and luminal B （ER＋ and/or PR＋, HER2＋） had the worst OS （HR=2.27, 95% CI 1.50 to 3.45, P0.001）; among the patients with lymph node negative disease, triple-negative （ER-, PR-, HER2-） had the worst DFS （HR=2.21, 95% CI 1.43 to 3.41, P0.001）, whereas no significant difference in DFS between HER2＋ and luminal B or luminal A was observed. Conclusion： As compared with luminal A, luminal B and HER2＋ have the worst survival in patients with lymph node positive disease, but this is not the case in patients with lymph node negative disease; triple-negative subtype has a worse survival in both lymph node positive and lymph node negative patients.

关键词： Breast cancer Subtypes Disease-free survival Overall survival

青稞种质资源抗条纹病鉴定及抗病基因分子检测

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四川农业大学学报 2024年第2期42卷 296-305页

作者：龙有赵珂侯璐青海大学农林科学院/青海省农林科学院/青海省农业有害生物综合治理重点实验室/青藏高原生物技术教育部重点实验室西宁810016

【目的】为发掘更多的抗条纹病青稞种质资源,明确抗条纹病基因在青稞种质资源中分布状况。【方法】选用127份青稞种质资源,利用2个菌株室内人工接种方法进行抗病性鉴定和评价,并利用3个已知抗条纹病基因的SSR分子标记引物进行检测。【... 详细信息

【目的】为发掘更多的抗条纹病青稞种质资源,明确抗条纹病基因在青稞种质资源中分布状况。【方法】选用127份青稞种质资源,利用2个菌株室内人工接种方法进行抗病性鉴定和评价,并利用3个已知抗条纹病基因的SSR分子标记引物进行检测。【结果】127份资源中综合抗病表现免疫、高抗、中抗、高感和中感的分别有13、26、19、52和17份,分别占鉴定材料总数10.24%、20.47%、14.96%、40.94%和13.39%。Rdg基因分子标记检测结果表明,可能携带Rdg1a、Rdg2a和Rdg3的青稞种质资源数分别有3、40和11份,分别占供试材料的2.36%、31.50%和8.66%。【结论】‘青0027’可能同时含有Rdg2a和Rdg3这2个抗性基因。

关键词：青稞条纹病抗病性鉴定分子检测

Identification of functionally active aerobic methanotrophs and their methane oxidation potential in sediments from the Shenhu Area,South China Sea

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China Geology 2022年第2期5卷 285-292页

作者： Jing Li chang-ling Liu Neng-you Wu Xiao-qing Xu Gao-wei Hu Yan-long Li qing-guo Meng Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266071China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Marine Life Science Ocean University of ChinaQingdao 266100China

Large amounts of gas hydrate are distributed in the northern slope of the South China Sea,which is a potential threat of methane *** methane oxidation by methanotrophs,significant methane biotransformation that occurs in sediment surface and water column,can effectively reduce atmospheric emission of hydrate-decomposed *** identify active aerobic methanotrophs and their methane oxidation potential in sediments from the Shenhu Area in the South China Sea,multi-day enrichment incubations were conducted in this *** results show that the methane oxidation rates in the studied sediments were 2.03‒2.36μmol/gdw/d,which were higher than those obtained by sediment incubations from other areas in marine *** the authors suspect that the methane oxidation potential of methanotrophs was relatively higher in sediments from the Shenhu *** the incubations family Methylococcaea(type I methanotrophs)mainly consisted of genus Methylobacter and Methylococcaea_Other were predominant with an increased proportion of 70.3%,whereas Methylocaldum decreased simultaneously in the incubated ***,this study may help to gain a better understanding of the methane biotransformation in the Shenhu Area.

关键词： Active methanotrophs Aerobic methane oxidation Marine sediments Natural gas hydrates NGHs exploration trial engineering Oil and gas exploration engineering Shenhu Area South China Sea

Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis

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World Journal of Gastroenterology 2006年第39期12卷 6376-6381页

作者： Xiao-Lan Zhang Jin-Ming Liu chang-Chun Yang Yi-Lin Zheng Li Liu Zhan-Kui Wang Hui-qing Jiang Department of Gastroenterology the Second Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China

AIM： To investigate whether extracellular signal-regulated kinase 1 （ERK1） is activated and associated with hepatic stellate cell （HSC） proliferation in fibrotic rat liver tissue.METHODS： Rat hepatic fibrosis was induced by bile duct ligation （BDL）. Histopathological changes were evalo uated by hernatoxylin and eosin staining, and Masson＇ s trichrorne method. ERK1 mRNA in rat liver tissue was determined by reverse transcription-polyrnerase chain reaction, while the distribution of ERK1 was assessed by irnrnunohistochernistry. ERK1 protein was detected by Western blotting analysis. The number of activated HSCs was quantified after alpha smooth muscle actin （α-MA） staining.RESULTS： With the development of hepatic fibrosis, the positive staining cells of α-SMA increased obviously, and mainly resided in the portal ducts. Fiber sepia and perisinuses were accompanied with proliferating bile ducts. The positive staining areas of the rat livers in model groups 1-4 wk after ligation of common bile duct （12.88% ± 2.63%, 22.65% ± 2.16%, 27.45% ± 1.86%, 35.25% ± 2.34%, respectively） were significantly larger than those in the control group （5.88% ± 1.46%, P 〈 0.01）. With the development of hepatic fibrosis, the positive cells of ERK1 increased a lot, and were mainly distributed in portal ducts, fiber sepia around the bile ducts, vascular endothelial cells and perisinusoidal cells. Western blotting analysis displayed that the expression of ERK1 and ERK1 protein was up-regulated during the model course, and its level was the highest 4 wk after operation, being 3.9-fold and 7.2-fold higher in fibrotic rat liver than in controls. ERK1 mRNA was expressed in normal rat livers as well, which was up-regulated two days after BDL and reached the highest 4 wk after BDL. The expression of ERK1 was positively correlated with α-MA expression （r = 0.958, P 〈 0.05）.CONCLUSION： The expression of ERK1 protein and mRNA is greatly increased in fibrotic rat liver tissues, which may play a key r

关键词： Extracellular signal-regulated kinase Hepatic fibrosis Hepatic stellate cells Proliferation

Expression and Antigenic Characterization of the Epitope-G_1 of the Bovine Ephemeral Fever Virus Glycoprotein in Pichia pastoris

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中国病毒学 2007年第5期22卷 347-352页

作者： Fu-ying ZHENG Guo-zhen LIN chang-qing QIU Kui-zhang YUAN Jun-ying SONG Key Laboratory of Animal Virology of Ministry of Agriculture State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046China Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001 China

The epitope-G1 gene of Bovine ephemeral fever virus(BEFV) glycoprotein was synthesised by PCR and cloned into expression vector pPIC9K to construct recombinant plasmid *** the pPIC9K-G1 was linearized and transformed into Pichia pastoris *** recombinant *** strains were selected by a G418 transformation screen and confirmed by *** being induced with methanol,an expressed protein with 26 kDa molecular weight was obtained,which was much bigger than the predicted size(15.54 kDa).Deglycosylation analysis indicated the recombinant G1 was *** blot and ELISA tests,as well as rabbit immunization and specificity experiments indicated that the target protein had both higher reaction activity and higher immunocompetence and *** recombinant G1 protein could be used as a coating antigen to develop an ELISA kit for bovine ephemeral fever diagnosis.

关键词：基因表达转基因抗原-G1 牛流行热病毒甲醇酵母

Energetics of protein backbone hydrogen bonds and their local electrostatic environment

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Science China Chemistry 2014年第12期57卷 1708-1715页

作者： DUAN Li L GAO Ya JI chang G MEI Ye ZHANG qing G TANG Bo ZHANG John Z.H College of Physics and Electronics Shandong Normal University College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University State Key Laboratory of Precision Spectroscopy Department of Physics Institute of Theoretical and Computational Science East China Normal University NYU-ECNU Center for Computational Chemistry at NYU Shanghai

MD simulation study of several peptides including a polyalanine,a helix(pdb:2I9M),and a leucine zipper were carried out to investigate hydrogen bond energetics using dynamic polarized protein-specific charge(DPPC)to account for the polarization effect in protein *** show that the backbone hydrogen-bond strength is generally correlated with its specific local electrostatic environment,measured by the number of water molecules near the hydrogen bond in the first solvation *** correlation coefficient is found to be 0.89,0.78,and 0.80,respectively,for polyalanine,2I9M protein,and leucine *** the polyalanine,the energies of the backbone hydrogen bonds are very similar to each other due to their similar local electrostatic *** current study helps demonstrate and support the understanding that hydrogen bonds are stronger in a hydrophobic surrounding than in a hydrophilic *** comparison,the result from simulation using standard force field shows a much weaker correlation between hydrogen bond energy and local electrostatic environment due to the lack of polarization effect in the force field.

关键词： dynamic polarized protein-specific charge hydrogen bond polarization hydrophobic hydrophilic lucine zipper MD simulation