Sodium carboxymethylation-functionalized chitosan fibers for cutaneous wound healing application

作     者：Dong YAN Zhong-Zheng ZHOU Chang-Qing JIANG Xiao-Jie CHENG Ming KONG Ya LIU Chao FENG Xi-Guang CHEN 

作者机构：College of Marine Life Science Ocean University of China 5 Yushan Road Qingdao 266003 China 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2016年第10卷第4期

页      面：358-366页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 083202[工学-粮食、油脂及植物蛋白工程] 

基　　金：supported by the Foundation of NSFC & SD the China’s State Oceanic Administration Project 国家教育部高等学校博士学科点专项科研基金 the Taishan Scholar Program, China 

主　　题：sodium carboxymethylation-functionalized chitosan fiber water absorp-tion wound healing wound dressing 

摘      要：A water absorption biomaterial, sodium carboxymethylation-functiona- lized chitosan fibers （Na-NOCC fibers） were prepared, applied for cutaneous wound repair, and characterized by FTIR and NMR. The water absorption of Na-NOCC fibers increased significantly with substitution degree rising, from 3.2 to 6.8 g/g, and higher than that of chitosan fibers （2.2 g/g） confirmed by swelling behavior. In the antibacterial action, the high degree of substitution of Na-NOCC fibers exhibited stronger antibacterial activities against E. co//（from 66.54% up to 88.86%）. The inhibition of Na-NOCC fibers against S. aureus were above 90%, and more effective than E. coli. The cytotoxicity assay demonstrated that Na-NOCC2 fibers were no obvious cytotoxicity to mouse fibroblasts. Wound healing test and histological examination showed that significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with Na-NOCC fibers, as compared to those treated with gauze, which demonstrated that Na- NOCC fibers could promote skin repair and might have great application for wound healing.