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Identification and Determination of Phenolic Compounds in Rapeseed Meals (Brassica napus L.)

Journal of Agricultural Chemistry and Environment 2015年第1期4卷 14-23页

作者： Si-chang Yang Mariadhas Valan Arasu Jin-Hyuk Chun Young-Seok Jang Yong-Hwa Lee In Ho kim ki-Taek Lee Soon-Taek hong Sun-Ju kim Bio-Environmental and Chemistry Chungnam National University Daejeon Republic of Korea Department of Botany and Microbiology Addiriyah Chair for Environmental Studies College of Science King Saud University Riyadh Saudi Arabia Bio-Energy Crop Center National Institute of Food Science Rural Development Administration Muan-County Republic of Korea Department of Animal Resource & Science Dankook University Cheonan-Si Republic of Korea Food Science and Technology Chungnam National University Daejeon Republic of Korea

This study aimed in the identification and quantification of phenolic compounds in different four varieties of rapeseeds (Brassica napus L.) using LC-MS and HPLC. LC-MS analysis guided to identify 12 phenolic compounds including sinapine, sinapine(4-O-8')guaiacyl, feruloyl choline(4-O-8') guaiacyl, kaempferol-3-O-sinapoyl-sophoroside-7-O-glucoside, kaempferol-3-O-β-sophoroside, cyclic spermidine-alkaloid, feruloyl choline(5-8')guaiacyl, kaempferol-sinapoyl-trihexoside,1,2-di- O-sinapoyl-gentiobiose, 1,2-di-O-sinapoyl-glucose, feruloyl choline(4-O-8')guaiacyl-di-sinapoyl, and sinapine(4-O-8')guaiacyl-di-sinapoyl, respectively. Total phenolic compounds in rapeseed meals were ranged from 38.50 (2012 “Sunmang”) to 63.95 mg/g dry weight (DW) (2014 Jeju local cultivar). Main phenolic compositions were cyclic spermidine-alkaloid, kaempferol, feruloyl choline, and sinapine. Sinapine was predominant compound among all the samples ranged from 29.74 to 52.24 mg/g DW (mean 79% of total phenolic contents). This study provided the information for the variation of phenolic compounds between the varieties of rapeseeds and the cultivation periods. Furthermore, this information can be developed for bio-energy industry as a reducer of the cost of the bio-energy products.

关键词： LC-MS Analysis HPLC Analysis Rapeseed Meal Phenolic Compounds

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弥漫性半球胶质瘤临床病理特征及分子病理特征分析

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神经疾病与精神卫生 2024年第5期24卷 333-340页

作者：张立英常青杜江北京市神经外科研究所首都医科大学附属北京天坛医院神经病理中心100070 首都医科大学大兴教学医院病理科北京102600

目的探讨弥漫性半球胶质瘤(DHG)的临床病理特征及分子病理特征。方法选取2021年1月—2023年5月于首都医科大学附属北京天坛医院神经外科接受手术切除或立体定向活检的27例DHG患者为研究对象,收集患者临床资料并进行随访。采用苏木素-伊... 详细信息

目的探讨弥漫性半球胶质瘤(DHG)的临床病理特征及分子病理特征。方法选取2021年1月—2023年5月于首都医科大学附属北京天坛医院神经外科接受手术切除或立体定向活检的27例DHG患者为研究对象,收集患者临床资料并进行随访。采用苏木素-伊红染色及免疫组织化学染色检测肿瘤细胞特征性的蛋白表达;采用二代测序+焦磷酸测序的方法检测肿瘤分子病理学特征。结果27例DHG患者的中位发病年龄为22.5岁;男性占59.3%(16/27);24例肿瘤主要位于单侧额、顶、颞叶,仅3例位于双侧大脑半球。组织病理学结果显示,27例肿瘤形态学上5例呈星形细胞瘤形态,17例呈胶质母细胞瘤形态,1例呈胶质母细胞瘤伴节细胞样分化,4例呈原始神经外胚层肿瘤形态。免疫组化染色结果显示,27例肿瘤胶质纤维酸性蛋白染色均为弥漫阳性,少突胶质细胞转录因子2蛋白阴性表达,α-地中海贫血/精神发育迟滞综合征X染色体相关基因表达缺失,p53蛋白呈错义突变或无义突变表达,异柠檬酸脱氢酶1 R132H、异柠檬酸脱氢酶2 R172K、H3K27M、BRAF V600E蛋白均呈阴性表达,24例肿瘤细胞核不同程度地表达H3.3G34R蛋白,3例肿瘤弥漫性表达H3.3G34V蛋白。ki67增殖指数3%~80%不等。分子病理学检测结果显示,所有肿瘤均出现H3F3A基因H3.3 G34(35)突变,23例伴ATRX缺失,27例均伴TP53突变。随访2~24个月,其中5例在确诊10~24个月后死亡,中位无进展生存期为6.5个月,中位总生存时间为11个月,5例失访。结论DHG恶性程度高,尽管全切或近全切病变加放疗或化疗,患者仍很快复发进展或死亡。因此,对于DHG进行免疫组化及分子病理检测是必要的,更有利于对DHG患者的积极治疗和预后评估。

关键词：神经胶质瘤胶质母细胞瘤星形细胞瘤病理学弥漫性半球胶质瘤原始神经外胚层肿瘤

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Limited endoscopic sphincterotomy plus large balloon dilation for choledocholithiasis with periampullary diverticula

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World Journal of Gastroenterology 2010年第34期16卷 4335-4340页

作者： Hyung Wook kim Dae Hwan Kang Cheol Woong Choi Jong Hwan Park Jin Ho Lee Min Dae kim Il Doo kim ki Tae Yoon Mong Cho Ung Bae Jeon Suk kim chang Won kim Jun Woo Lee Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute Pusan National University Yangsan Hospital Department of Radiology Pusan National University School of Medicine and Medical Research Institute Pusan National University Hospital

AIM: To investigate the effectiveness and safety of limited endoscopic sphincterotomy (EST) plus large balloon dilation (LBD) for removing choledocholithiasis in patients with periampullary diverticula (PAD). METHODS: A total of 139 patients with common bile duct (CBD) stones were treated with LBD (10-20 mm balloon diameter) after limited EST. Of this total, 73 patients had PAD and 66 patients did not have PAD (controls). The results of stone removal and complications were retrospectively evaluated. RESULTS: There were no significant differences between the PAD and the control groups in overall successful stone removal (94.5% vs 93.9%), stone removal in first session (69.9% vs 81.8%), mechanical lithotripsy (12.3% vs 13.6%), and complications (11.0% vs 7.6%). Clinical outcomes were also similar between the types of PAD, but the rate of stone removal in first session and the number of sessions were significantly lower and more frequent, respectively, in type B PAD (papilla located near the diverticulum) than controls [23/38 (60.5%) vs 54/66 (81.8%), P = 0.021; and 1 (1-2) vs 1 (1-3), P = 0.037, respectively] and the frequency of pancreatitis was significantly higher in type A PAD (papilla located inside or in the margin of the diverticulum) than in controls (16.1% vs 3.0%, P = 0.047). CONCLUSION: Limited EST plus LBD was an effective and safe procedure for removing choledocholithiasis in patients with PAD. However, some types of PAD should be managed with caution.

关键词： Endoscopic sphincterotomy Large balloon dilation Choledocholithiasis Periampullary diverticula

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Behaviour of Concrete Filled Steel Square-Tube Stub Column with Steel-Fiber Reinforced High Strength Concrete

Behaviour of Concrete Filled Steel Square-Tube Stub Column w...

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2012 International Conference of Health,Structure,Material and Environment(HSME 2012)

作者： chang-Sik Choi Hyung-Suk Jung Hyun-ki Choi Department of architectural engineering Hanyang University Department of sustainable architectural engineering Hanyang University

The paper presents an experimental study on the behavior of axial loaded concrete-filled steel square-tube stub columns with high strength fiber reinforced concrete until *** specimens were tested to investigate the effect of high strength concrete on the load carrying capacity of the concrete-filled steel square-tube stub *** effect of the presence of steel fiber in high strength concrete which filled in the steel tube was also *** main parameters in the tests were:(1)the strength of concrete(30 Mpa and 100 Mpa),and(2)the use of reinforcing steel fiber in concrete(plain high strength concrete and steel fiber high strength concrete).The main purpose of these tests were three-step:(1)to describe a series of tests on composite stub columns,(2)to analyze the influence of several parameters,and(3)to compare the accuracy of the predictions by using the specifications in the code(ACI and EC4 etc.)for the design of high-strength composite *** results indicate that the high strength of concrete and use of steel-fiber in concrete had significant influence on both the axial compressive load capacity and the ductile of the steel square-tube stub columns.

关键词： Concrete-filled steel square-tubes High strength concrete Fiber reinforced concrete Composite structures

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胃神经内分泌瘤G2合并腺癌成分

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诊断病理学杂志 2024年第9期31卷 926-928页

作者：杜明占祁昌苏州大学附属第一医院病理科江苏苏州215006

目的探讨胃神经内分泌瘤(NET)G2伴腺癌成分病例的临床病理特征。方法收集苏州大学附属第一医院诊断的胃NET,G2伴腺癌成分1例,分析其临床特征、HE及免疫组化特点。结果患者51岁,男性。胃体大弯前壁见一个隆起型肿瘤,最大直径1.5 cm。行... 详细信息

目的探讨胃神经内分泌瘤(NET)G2伴腺癌成分病例的临床病理特征。方法收集苏州大学附属第一医院诊断的胃NET,G2伴腺癌成分1例,分析其临床特征、HE及免疫组化特点。结果患者51岁,男性。胃体大弯前壁见一个隆起型肿瘤,最大直径1.5 cm。行“部分胃切除术”。肿瘤边界较清楚,主要由两种成分组成,第一种成分瘤细胞呈片状、巢状分布,细胞染色质细腻,血窦丰富。第二种成分位于肿瘤深部,呈不规则腺样形态,可见腔内坏死。诊断为胃NET,G2(约占90%)伴中分化管状腺癌(约占10%)。周围黏膜未见明确神经内分泌细胞增生及萎缩改变。幽门螺旋杆菌阴性。p TNM:T2Nx Mx。免疫组织化学NET成分阳性表达Syn,Cg A,CD56,CK,SSTR2;ki-67热点区约10%;CK7表达减弱。腺癌成分阳性表达CK,CK7,CDX2;ki-67热点区约60%。两种成分p53均少量弱阳性,提示野生型。患者术后未进行放化疗,随访30个月,生存。结论胃NET伴有腺癌成分罕见,具有独特的组织学形态和免疫组化特点。

关键词：胃肿瘤神经内分泌瘤腺癌临床病理诊断鉴别

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Transarterial chemoembolization in Barcelona Clinic Liver Cancer Stage 0/A hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第3期20卷 745-754页

作者： Heung Cheol kim ki Tae Suk Dong Joon kim Jai Hoon Yoon Yeon Soo kim Gwang Ho Baik Jin Bong kim chang Hoon kim Hotaik Sung Jong Young Choi Kwang Hyub Han Seung Ha Park Department of Radiology Hallym University College of Medicine Department of Internal Medicine Hallym University College of Medicine College of Medicine Upstate Medical UniversityState University of New York Department of Biology Stanford University Department of Internal Medicine Catholic University College of Medicine Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Department of Internal Medicine Inje University College of Medicine

AIM: To evaluate the clinical characteristics of patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 and A hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).

关键词： Carcinoma Hepatocellular Chemoembolization Therapeutic Survival Stage Efficacy

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含BTK抑制剂的化疗方案治疗复发难治套细胞淋巴瘤的疗效及预后分析

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中国实验血液学杂志 2024年第1期32卷 125-131页

作者：陈欢柳喜洋常宇陈子琪李文琪张蕾郑州大学第一附属医院肿瘤内科河南郑州450000

目的:观察含BTK抑制剂的化疗方案治疗复发难治套细胞淋巴瘤(MCL)的疗效及预后。方法:回顾性分析134例复发难治MCL患者的临床资料,观察患者临床特征,以及化疗方案对疗效、总生存(OS)率及无进展生存(PFS)率的影响。结果:患者中位年龄58(56... 详细信息

目的:观察含BTK抑制剂的化疗方案治疗复发难治套细胞淋巴瘤(MCL)的疗效及预后。方法:回顾性分析134例复发难治MCL患者的临床资料,观察患者临床特征,以及化疗方案对疗效、总生存(OS)率及无进展生存(PFS)率的影响。结果:患者中位年龄58(56-61)岁,男女比例约为2.9∶1,Ann Arbor分期Ⅲ-Ⅳ期患者占77.6%,结外受累部位>2占43.3%,骨髓受累占60.4%,胃肠道受累占24.6%,肝脾肿大占38.1%。中位随访时间30(2-103)个月,总有效率41.8%,3年PFS未达到,3、5年OS率分别为62.7%、53.8%。含BTK抑制剂方案治疗组总有效率56.9%,优于不含BTK抑制剂方案治疗组的32.5%,比较差异有统计学意义(P=0.006),两组PFS率差异亦有统计学意义(P=0.002),而OS率差异无统计学意义(P>0.05)。经典型与特殊型之间PFS率差异无统计学意义(P>0.05),而OS率差异有统计学意义(Pki-67是复发难治MCL患者OS和PFS的影响因素。ki-67、B症状、套细胞淋巴瘤国际预后指数评分、Ann Arbor分期是影响患者OS的独立预后因素。二线治疗方案是影响患者PFS的独立预后因素。结论:含BTK抑制剂方案治疗复发难治MCL有效率高,且可明显延长PFS,ki-67、B症状、套细胞淋巴瘤国际预后指数评分、Ann Arbor分期为复发难治MCL的独立预后因素。

关键词： BTK抑制剂复发难治套细胞淋巴瘤生存预后

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Effect of curing time on the mesoscopic parameters of cemented paste backfill simulated using the particle flow code technique

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 590-602页

作者： Lang Liu Jie Xin Chao Huan Yu-jiao Zhao Xiang Fan Li-jie Guo ki-IL Song Energy School Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Western Mines and Hazards Prevention Ministry of Education of ChinaXi’an 710054China School of Highway Chang’an UniversityXi’an 710064China Beijing General Research Institute of Mining&Metallurgy Beijing 100160China Department of Civil Engineering Inha UniversityIncheon 402-751South Korea

Several special mechanical properties,such as dilatancy and compressibility,of cemented paste backfill(CPB)are controlled by its internal microstructure and *** mesoscopic structure changes of CPB during the development process were *** the basis of the scanning electron microscopy(SEM)and mechanical test results of CPB,the particle size information of CPB was extracted,and a two-dimensional particle flow code(PFC)model of CPB was established to analyze the evolution rule of mesoscopic parameters during CPB *** embedded FISH language in PFC was used to develop a program for establishing a PFC model on the basis of the SEM *** mesoscopic parameters of CPB samples at different curing times,such as coordination number(C_(n)),contact force chain,and rose diagram,were obtained by recording and loading and used to analyze the intrinsic relationship between mesoscopic parameter variations and macroscopic mechanical response during CPB *** is of considerable significance to establish the physical model of CPB using the PFC to reveal the mesoscopic structure of CPB.

关键词： cemented paste backfill particle flow code method mesoscopic parameters fabric

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51例淋巴浆细胞淋巴瘤累及骨髓的临床病理分析

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诊断病理学杂志 2024年第3期31卷 231-234,251页

作者：张益清张长淮北京海思特医学检验实验室病理科北京100176

目的探讨淋巴浆细胞淋巴瘤累及骨髓的临床病理特征、免疫表型、诊断及鉴别诊断。方法回顾性分析51例淋巴浆细胞淋巴瘤患者的骨髓活检、免疫组织化学、流式细胞学、免疫固定电泳及Ig基因重排检查结果并复习相关文献。结果男31例,女20例... 详细信息

目的探讨淋巴浆细胞淋巴瘤累及骨髓的临床病理特征、免疫表型、诊断及鉴别诊断。方法回顾性分析51例淋巴浆细胞淋巴瘤患者的骨髓活检、免疫组织化学、流式细胞学、免疫固定电泳及Ig基因重排检查结果并复习相关文献。结果男31例,女20例。淋巴浆细胞淋巴瘤累及骨髓的异常细胞比例在0.5%~95%不等,肿瘤性淋巴细胞增生模式以结节型为主,其周围及淋巴细胞间常见浆细胞少量增生,肥大细胞较常见,含铁血黄素颗粒多见。62.7%(32/51)为结节性骨髓浸润,29.4%(15/51)为弥漫性骨髓浸润,7.8%(4/51)为间质性骨髓浸润。51例行免疫组织化学,100%(51/51)均表达B细胞相关抗原(CD20、CD19、PAX-5),21%(11/51)表达CD23,浆细胞比例较低,0.5%~10%不等,限制性表达Ig轻链,70.6%(36/51)表达胞浆型单克隆Ig轻链Kappa;29.4%(15/51)表达胞浆型单克隆Ig轻链Lambda,ki-67增殖指数在5%~10%。51例行流式细胞学免疫分型,均可见单克隆小B淋巴细胞及少量单克隆浆细胞。其中23例做了免疫固定电泳,17例是IgM-KAP型M蛋白,6例是IgM-LAM型M蛋白。11例做了Ig基因重排,10例检测到IGHV、IGK基因克隆性重排,1例检测到IGK基因克隆性重排。结论淋巴浆细胞淋巴瘤累及骨髓以结节性浸润多见,浆细胞比例可以很低,诊断需结合临床表现、骨髓活检、免疫组化、流式细胞学、免疫固定电泳及Ig基因重排检测综合诊断。

关键词：淋巴浆细胞淋巴瘤免疫组化流式细胞学骨髓活检

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Amomum villosum induces longitudinal bone growth in adolescent female rats

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Journal of Traditional Chinese Medicine 2012年第3期32卷 453-458页

作者： Sun Haeng Lee Ji Young kim Hocheol kim Seul ki Park Cho Young kim Sun Yong Chung Gyu Tae chang Department of Pediatrics of Korean Medicine Kyung Hee University Hospital at Gang-dong892 Dongnam-roGangdong-guSeoul 134-727Republic of Korea Department of Herbal Pharmacology College of Korean MedicineKyung Hee University26 Kyungheedae-roDongdaemoon-guSeoul 130-701Republic of Korea Department of Neuropsychiatry of Korean Medicine Kyung Hee University Hospital at Gang-dong892 Dongnam-roGangdong-guSeoul 134727Republic of Korea

OBJECTIVE:This study was conducted to evaluate the effect of Amomum villosum on longitudinal bone ***:Adolescent female Sprague-Dawley rats were divided into 3 groups and treated for 4 days:control(distilled water,p.o.),recombinant human growth hormone(rhGH;100 μg/kg,s.c.),and ***(500 mg/kg,p.o.) *** day 3,tetracycline(20 g/kg,i.p.) was injected for growth plate *** days 2,3 and 4,5-bromo-2'-deoxyuridine(BrdU)(50 mg/kg,i.p.) was injected to label proliferating *** day 5,tibias were dissected and fixed in 4% paraformaldehyde,dehydrated,and sectioned for immunohistochemistry and ***:The rate of bone growth in the *** and rhGH groups increased to(410 ± 44) and(389 ± 46) μm/day(P<0.01),respectively,as compared with the control(330.7 ± 34.7) μm/*** thickness of the growth plates also increased to(591 ± 37) and(598 ± 32) μm,respectively,as compared with the control(524± 89) μm(P<0.001).The number of BrdU-positive cells in the chondrocytes of the *** and rhGH groups was also significantly higher(126±24) and(143±18) cells/mm 2,respectively) than in the control(109 ± 25) mm 2(P<0.05).Insulin-like growth factor-1 and bone morphogenetic protein-2 in the *** and rhGH groups were highly expressed in the growth plate as compared with the control samples,indicating increased bone ***:*** could be used to treat growth retardation during adolescence.

关键词： Amomum villosum Growth plate Bone Development Recombinant human growth hormone

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