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All in one theranostic nanoplatform enables efficient anti-tumor peptide I delivery for triple-modal imaging guided cancer therapy

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Nano Research 2019年第3期12卷 593-599页

作者： Xiaoyan Qu Zhengqing Liu Bohan Ma Na Li Hongyang Zhao Tian Yang Yumeng Xue Xiaozhi Zhang Yongping Shao Ying chang Jun Xu Bo Lei Yaping Du Frontier Institute of Science and Technology Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology B State Key Laboratory for Manufacturing Systems Engineering Instrument Analysis Center Xian Jiaotong University Xian 710000 China School of Materials Science and Engineering National Institute for Advanced Materials Center for Rare Earth and Inorganic Functional Materials Nankai I University Tianjin 300350 China Department of Radiation Oncology The First Affiliated Hospital of Xian Jiaotong University Xian 710000 China Center for Functional Nanomaterials Brookhaven National Laboratory Upton New York 11973 USA

Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(moo4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy.

关键词： rare earth nano particles multifu nctional property peptide delivery tumor imaging tumor therapy

Thermoplastic elastomer enhanced interface adhesion and bending durability for flexible organic solar cells

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npj Flexible Electronics 2022年第1期6卷 548-557页

作者： Zihan Xu Yunfei Han Yuanyuan Bai Xingze Chen Jingbo Guo Lianping Zhang Chao Gong Qun Luo Ting Zhang chang-Qi Ma School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefeiPR China Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouPR China i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouPR China

Stable interface adhesion and bending durability of flexible organic solar cells(FOSCs)is a basic requirement for its real application in wearable ***,the device performance always degraded during continuous ***,we revealed the weak interface adhesion force between moo_(3) hole transporting layer(HTL)and the organic photoactive layer was the main reason of poor bending *** insertion of an interface bonding layer with a thermoplastic elastomer,polystyrene-blockpoly(ethylene-ran-butylene)-block-polystyrene(SEBS)effectively improved the interface adhesion force of moo_(3) HTL and the active layer and decreased the modulus,which ensured higher than 90%of the initial efficiency remaining after 10000 ***,the FOSCs gave an efficiency of 14.18%and 16.15%for the PM6:Y6 and PM6:L8-BO devices,which was among the highest performance of *** results demonstrated the potential of improving the mechanical durability of FOSCs through thermoplastic elastomer interface modification.

关键词： elastomer interface durability

Destruction and removal efficiency of PICs by various iron ores during sintering-exploratory testing

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Baosteel Technical Research 2010年第S1期4卷 131-页

作者： Alfons Georges BUEKENS Joeri DENAYER Guy REGGERS Robert CARLEER Damien DEBECKER moo Been chang Zhejiang University Hangzhou China Vrije Universiteit Brussel VUB BrusselsBelgium Universiteit Hasselt Diepenbeek Belgium Universite catholique de Louvain UCL Louvain-la-Neuve Belgium NATIONAL CENTRAL UNIVERSITY C HUNGLITAIWAN

Worldwide,iron ore sintering is the largest industrial single source of dioxin emissions^(1-3).Conversely, some ores may help in reducing emissions,because of their aptitude of(a) adsorbing and(b) oxidising or decomposing TOC and dioxins^(4,5).Such dioxin abatement abilities were tested for five types of ores,representing major ore origins(Australia,Brazil,and South Africa ),minerals(magnetite,haematite,goethite,pisolite ),and properties,***,and Loss on Ignition(LOI) *** total,11 exploratory experimental runs were conducted on iron ores,to test the oxidation in air of four different organic trace test substances:acetone, chloroform,n-hexane,and toluene contained in a test gas were led simultaneously over the ore over a preestablished temperature *** test comprehends a first part with a programmed temperature rise,a brief soaking period at the temperature maximum(>400℃),and a ballistic cooling *** concentration of the four organics is continuously monitored by Mass Spectrometry(MS) operating in a full-scan mode(m/e < 100). Exploratory experiments allowed differentiating the ores tested according to the Destruction & Removal Efficiency(DRE) *** check the results the products of oxidation in the effluent were sampled on Tenax and ***,the dioxin load remaining on several test residues was examined and found to be quite limited (pg I-TEQ/g).

关键词： acetone catalytic oxidation chloroform dioxins goethite haematite iron ore magnetite mass spectrometry n-hexane,pisolite sintering,sorption Tenax,toluene

共面转换液晶显示器中获得对比度高于1:600的新技术

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现代显示 2004年第5期 31-33页

作者： Jae Hyun Kim Joun Ho Lee Ji Chul Lim chang Hoon Lee moo Hyoung Song Ju Yeon Yoon Hee Dong Choi Jeom Jae Kim chang Ho Oh Sang Deog Yeo 李路海 LG菲利普液晶显示电视开发部乐凯胶片厂

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树... 详细信息

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。

关键词：高对比度共面转换液晶显示器薄膜晶体管背光 TFT-LCD 滤色片光板偏振片紧凑

Mo-V-Nb-O-based catalysts for low-temperature selective oxidation of Cα-OH lignin model compounds

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Frontiers of Materials Science 2020年第1期14卷 52-61页

作者： Lu-Lu Zhang Kun Hao Rui-Kai Wang Xiu-Qiang Ma Tong Liu Liang Song Qing Yu Zhong-Wei Wang Jian-Min Zeng Rong-chang Zeng College of Materials Science and Engineering Shandong University of Science and Technology579 Qianwangang RoadQingdao266590China College of Materials Science and Engineering Qingdao University of Science and Technology53 Zhengzhou RoadQingdao266000China Ministry-Province Jointly-Constructed Cultivation Base for State Key Laboratory of Processing for Non-ferrous Metal and Featured Materials Guangxi University100 Daxue East RoadNanning530004China

Mo-V-Nb tri-component oxide catalysts were prepared and firstly used for the selective oxidation of Cα-OH lignin *** catalytic performance of the composite oxides was obviously enhanced due to the synergistic effects of Mo and V ***5-xVxO14 phase with a variable Mo/V ratio provided suitable active sites for the oxidative dehydrogenation(ODH)of Cα-OH lignin model *** optimized Mo-V-Nb molar composition was confirmed as Mo0.61V0.31Nb0.08Ox/TiO2,which exhibited the prominent catalytic activity with the turnover frequency of 1.04×10-3 mmol·g(cat)-1·*** at room temperature,the catalysts showed highly-efficient ODH reaction *** active phase for selective oxidation reaction and the inhibiting effect ofα-moo3 phase were also discussed in the study.

关键词： selective oxidation secondary alcohol lignin model compound room temperature

Hydrothermal Synthesis and Structure of a New Molybdenum Phosphate: (NH_3CH_2CH_2NH_3)_(2.5)[Mo_5O_(15)(PO_4) (HPO_4)]·7.5H_2O

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Chinese Journal of Structural Chemistry 2002年第1期21卷 42-45页

作者： LIN Zheng-Zhong ZHANG Han-Hui HUANG chang-Cang SUN Rui-Qing (Department of Chemistry, Fuzhou University, Fuzhou 350002, China ) ( State Key Laboratory of Structural Chemistry, Fuzhou 350002, China ) Department of Chemistry Fuzhou University Fuzhou 350002

The title compound (C5N5H41P2Mo5O30.5) was synthesized under hydrothermal condition and its crystal structure was determined by X-ray diffraction. It belongs to triclinic system, space group P , with a=9.9645(6), b=10.8666(7), c=15.814(1)? α=71.482(3), β=88.528(2), γ=78.448(2)°, V=1589.4(2)3, Dc=2.510g/cm3, Z=2,μ=2.138mm-1,λ(MoKα) = 0.71073 ? F(000)=1180. The final R and wR were 0.0396 and 0.1052 for 6626 observed reflections with I ≥2σ(I), respectively. The result of the structure analysis indicates that the [Mo5O15(PO4) (HPO4)]5- anion in the title compound consists of five edge-sharing or corner-sharing moo6 octahedra and two corner-sharing PO4 tetrahedra. Each moo6 octahedron adopts distorted octahedral geometry.

关键词： hydrothermal molybdenum phosphate crystal structure

Growth and Characteristics of Nd^(3+):GdAl_3(BO_3)_4 Crystal

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Chinese Journal of Structural Chemistry 2003年第2期22卷 169-173页

作者： TU Chao-Yang② ZHU Zhao-Jie LI Jian-Fu WU Bai-chang (Fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou, Fujian 350002, China) BRENIER Alain (Laboratoire de Physico-Chimie des Mat閞iaux Luminescents, Universit?Claude Bernard-Lyon1,UMR CNRS 5620, France) Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

Nd3+:GdAl3(BO3)4 (NGAB) crystal with the size of 30 mm was grown from the solvent system of K2O-Gd2O3-moo3-B2O3 by combining accelerated seed rotation technology with medium seeded solution growth (MSSG) method, and its crystal structure has been determined by X-ray powder diffraction. It crystallizes in the trigonal system, space group R32 with a = 9.2734(2), c = 7.2438(1) ? V = 538 ?, Z = 3 and Dc = 4.379 g/cm3. The absorption and emission spectra of NGAB in the function of s and polarizations at room temperature have been measured. UV generation tuneable in 378～382 nm, green (531 nm) generation and blue generation tuneable in 436～443 nm as well as red (669 nm) generation by self-frequency changing were obtained with the output of 105, 119.5, 445 and 19 mJ/pulse, respectively, when the crystal was pumped by a dye laser.

关键词： flux crystal growth Nd3+:GdAl3(BO3)4 crystal self-frequency changing laser

负载金属对moo_3-TiO_2光催化剂结构与催化性能的影响

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燃料化学学报 2005年第2期33卷 229-234页

作者：梅长松钟顺和天津大学化工学院天津300072

用溶胶-凝胶和浸渍-还原相结合的方法制得M/moo3 -TiO2 (M=Pd, Cu, Ni和Ag)光催化剂。利用X-射线衍射(XRD)、程序升温还原(TPR)、红外光谱(IR)、程序升温脱附(TPD)、紫外-可见漫反射光谱(UV-Vis DRS)和光反应等技术,研究了负载金属复合... 详细信息

用溶胶-凝胶和浸渍-还原相结合的方法制得M/moo3 -TiO2 (M=Pd, Cu, Ni和Ag)光催化剂。利用X-射线衍射(XRD)、程序升温还原(TPR)、红外光谱(IR)、程序升温脱附(TPD)、紫外-可见漫反射光谱(UV-Vis DRS)和光反应等技术,研究了负载金属复合半导体的物相结构、吸附性能、吸光性能和光催化反应性能。结果表明,金属M(M=Pd, Cu)负载在复合半导体上,延迟了TiO2 由锐钛矿向金红石相的转化,增强了Mo与载体TiO2 的相互作用,促进Mo物种由四面体配位向八面体配位转化,使TiO2 光吸收限发生蓝移,对可见光部分的吸收明显增加,拓宽了催化剂的光响应范围;固体材料吸光性能强弱顺序Pd/moo3 -TiO2 >Cu/moo3 -TiO2 >Ag/moo3 -TiO2>Ni/moo3 -TiO2;Pd对CO2 吸附能力过强,卧式吸附态脱附温度高,光催化效率不高;金属Cu对CO2 吸附能力适中,CO与CH脱附温度较接近,实现了光-表面-热的协同作用,光量子效率最高。

关键词：复合半导体光吸收性能二氧化碳丙烯甲基丙烯酸

重油加氢脱氮催化剂的研制──钼镍磷催化剂的表征

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燃料化学学报 2000年第2期28卷 105-110页

作者：朱华青高志贤程昌瑞谭长瑜中国科学院山西煤炭化学研究所煤转化国家重点实验室太原030001

用pH摆动法制备氧化铝为载体的重油加氢脱氮 (HDN)Mo -Ni-P催化剂及工业Mo -Ni -P催化剂进行了详细表征并与HDN活性关联。FTIR显示催化剂的B酸中心是Mo、Ni与载体相互作用所形成 ;NH3-TPD表明催化剂表面酸量增加。TEM照片显示自制氧化... 详细信息

用pH摆动法制备氧化铝为载体的重油加氢脱氮 (HDN)Mo -Ni-P催化剂及工业Mo -Ni -P催化剂进行了详细表征并与HDN活性关联。FTIR显示催化剂的B酸中心是Mo、Ni与载体相互作用所形成 ;NH3-TPD表明催化剂表面酸量增加。TEM照片显示自制氧化铝、催化剂属精细纤维结构。EPM分析活性组分在催化剂表面及表相和体相中的分布均匀 ;自制催化剂径向Mo的分布有空缺 ,但未影响其脱氮活性。根据UV -Vis漫反射结果推测催化剂HDN活性可能与Mo八面体和Mo四面体的比例有关。Mo、Ni的氨溶出率及催化剂的低温氧吸附 (LTOC)量与其HDN活性有良好相关性 ,氧吸附量在 0 0 7mmol/g以上的催化剂 ,脱氮反应后尾油中N小于 1 0 μg/g。

关键词：重油加氢脱氢钼镍磷催化剂