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A new strengthening mechanism driven by disruptive shear and solute segregation during warm rolling in 1.4 GPa class 12.5 wt% Al added-FeMnC ultra-lightweight steel

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Journal of Materials Science & Technology 2023年第26期157卷 174-188页

作者： Chiwon Kim Hyun-Uk Hong Joonoh Moon Bong Ho lee Seong-Jun Park chang-hoon lee Department of Materials Convergence and System Engineering Changwon National University 20 Changwondaehak-roChangwonGyeongnam 51140Republic of Korea Advanced Analysis Team Daegu Gyeongbuk Institute of Science and Technology 333 Technojungang-daeroDaegu42988Republic of Korea Ferrous Alloy Department Korea Institute of Materials Science 797 ChangwondaeroChangwonGyeongnam 51508Republic of Korea

Novel strengthening of Fe-29.1Mn-12.5Al-1.35C-4.95Cr steel achieved by warm rolling was *** solution-treated steel consisted of aγ-matrix containing nano-sizedκ-carbide((Fe,Mn)_(3) AlC)and elongated prior ferrite,which was transformed into FeAl-type B2 and Fe_(3) Al-type D0_(3) *** solution-treated steel exhibited poor strain hardening owing to glide softening associated withκ-carbide shearing by ***,after warm rolling with a reduction ratio of 30%at 300℃,the yield and tensile strengths significantly increased from 917 to 1300 MPa and 1025 to 1419 MPa,*** tensile test conducted at 300℃to simulate warm rolling exhibited serrated flows,indicating dy-namic strain aging(DSA).Atom probe tomography exhibited that the C atoms inκ-carbide were swept away along the slip direction by disruptive shear during rolling at 300℃.The swept C atoms along the slip direction interacted strongly with dislocations at 300℃,with repeated pinning and breakaway of dislocations from the C *** contributed to significant strengthening owing to the formation of a solute-rich atmosphere after warm *** results of the tensile tests at 300℃indicated that the de-gree of strengthening was proportional to the pre-strain *** strength of 1.4 GPa can be achieved with good ductility(17%elongation)by warm *** novel warm-rolling strengthening method ex-pedites the potential application of Fe-29.1Mn-12.5Al-1.35C-4.95Cr as a 1.4 GPa class ultra-lightweight steel.

关键词： FeMnAlC Cr addition κ-carbide Dynamic strain aging Strengthening

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Repeatedly elevatedγ-glutamyltransferase levels are associated with an increased incidence of digestive cancers:A population-based cohort study

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World Journal of Gastroenterology 2021年第2期27卷 176-188页

作者： chang-hoon lee Kyungdo Han Da Hye Kim Min-Sun Kwak Department of Internal Medicine Seoul National University HospitalSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Department of Biostatistics College of MedicineCatholic University of KoreaSeoul 06591South Korea Department of Internal Medicine Healthcare Research InstituteHealthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea

BACKGROUND The association between elevatedγ-glutamyltransferase(GGT)at a certain point and incident cancer has been suggested;however,no study has evaluated the association between repeatedly elevated GGT and cancer *** To investigate the effects of repeatedly elevated GGT on the incidence of digestive *** Participants who had undergone health screening from 2009 to 2012 and 4 consecutive previous examinations were *** points were calculated as the number of times participants met the criteria of quartile 4 of GGT in four serial measurements(0-4 points).Multivariable Cox proportional hazard regression models were *** In total,3559109 participants were included;among them,43574 digestive cancers developed during a median of 6.8 years of *** incidence of total digestive cancers increased in a dose-response manner in men[adjusted hazard ratio(aHR)compared with those with 0 GGT points=1.28 and 95%confidence interval(CI)=1.24-1.33 in those with 1 point;aHR=1.40 and 95%CI=1.35-1.46 in those with 2 points;aHR=1.52 and 95%CI=1.46-1.58 in those with 3 points;aHR=1.88 and 95%CI=1.83-1.94 in those with 4 points;P for trend<0.001].This trend was more prominent in men than in women and those with healthy habits(no smoking,no alcohol consumption,and a low body mass index)than in those with unhealthy *** Repeatedly elevated GGT levels were associated with an increased risk of incident digestive cancer in a dose-responsive manner,particularly in men and those with healthy *** GGT measurements may be a good biomarker of incident digestive cancer and could help physicians identify high-risk populations.

关键词： Gamma-glutamyltransferase Cancer Digestive organ Serial exam Incident cancer Biomarker

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Disseminated soft tissue diffuse large B-cell lymphoma involving multiple abdominal wall muscles:A case report

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World Journal of Clinical Cases 2021年第28期9卷 8557-8562页

作者： chang-hoon lee So-Yeon Jeon Ho-Young Yhim Jae-Yong Kwak Department of Internal Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is the most common subtype of non�Hodgkin lymphoma,and patients with DLBCL typically present rapidly growing *** involving muscle is rare and accounts for only 5%;furthermore,multiple muscles and soft tissue involvement of DLBCL is *** to unusual clinical manifestation,accurate diagnosis could be *** SUMMARY A 61-year-old man complained of swelling,pain and erythematous changes in the lower ***,soft tissue infection was suspected,however,skin lesion did not respond to antibiotics.18Fluoro-2-deoxy-D-glucose(18F-FDG)positron emission tomography-computed tomography demonstrated FDG uptake not only in the skin and subcutaneous tissue of the abdomen but also in the abdominal wall muscles,peritoneum,perineum,penis and *** was confirmed by biopsy of the abdominal wall muscle and subcutaneous *** intensive treatment including chemotherapy with rituximab,cyclophosphamide,doxorubicin,vincristine and prednisolone,central nervous system prophylaxis(intrathecal injection of methotrexate,cytarabine and hydrocortisone)and orchiectomy,he underwent peripheral blood stem cell mobilization for an autologous hematopoietic stem cell *** intensive treatment,the disease progressed rapidly and the patient showed poor outcome(overall survival,9 mo;disease free survival,3 mo).CONCLUSION The first clinical manifestation of soft tissue DLBCL involving multiple muscles was similar to the infection of the soft tissue.

关键词： Primary extranodal diffuse large B-cell lymphoma Soft tissue lymphoma Disseminated muscles and soft tissue invasion Atypical presentation of diffuse large B�cell lymphoma Central nervous system relapse Case report

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Proportion and clinical features of never-smokers with non-small cell lung cancer

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Chinese Journal of Cancer 2017年第2期36卷 81-87页

作者： Jaeyoung Cho Sun Mi Choi Jinwoo lee chang-hoon lee Sang-Min lee Dong-Wan Kim Jae-Joon Yim Young Tae Kim Chul-Gyu Yoo Young Whan Kim Sung Koo Han Young Sik Park Department of Internal Medicine Seoul National University HospitalSeoul 110-744Republic of Korea Department of Thoracic and Cardiovascular Surgery Seoul National University HospitalSeoul 110-744Republic of Korea

Background: The proportion of never?smokers with non?small cell lung cancer(NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never?smokers with NSCLC in a large single ***: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December ***: Of the 1860 NSCLC patients, 707(38.0%) were never?smokers. The proportions of women(83.7% vs. 5.6%) and adenocarcinoma(89.8% vs. 44.9%) were higher among never?smokers than among ever?smokers. Significantly more never?smokers were diagnosed at a younger median age(65 vs. 68 years, P < 0.001) and earlier stage(stage I–II, 44.5% vs. 38.9%, P < 0.001) a= 0.015) compared with ever?smokers. Epidermal growth factor receptor mutations(57.8% vs. 24.4%, Pnd anaplastic lymphoma kinase rearrangements(7.8% vs. 2.8%, P < 0.001) were more common in never?smokers, whereas Kirsten rat sarcoma viral oncogene homolog mutations(5.8% vs. 9.6%, P ntly encountered in never?smokers than in ever?smokers. Never?smokers showed longer su= 0.021) were less frequervival after adjust?ing for the favorable effects of younger age, female sex, adenocarcinoma histology, better performance status, early stage disease, being asymptomatic at diagnosis, received antitumor treatment, and the presence of driver mutations(hazard ratio, 0.624; 95% confidence interval, 0.460–0.848; P = 0.003).Conclusions: More than one?third of the Korean patients with NSCLC were never?smokers. NSCLC in never?smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever?smokers.

关键词： Non-small cell lung carcinoma Never-smoker Epidermal growth factor receptor KRAS Prognosis

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Dwindling in the mountains: Description of a critically endangered and microendemic Onychodactylus species(Amphibia, Hynobiidae) from the Korean Peninsula

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Zoological Research 2022年第5期43卷 750-755页

作者： Amael Borzee Yucheol Shin Nikolay APoyarkov Jong Yoon Jeon Hae Jun Baek chang hoon lee Junghwa An Yoon Jee Hong Mi-Sook Min Laboratory of Animal Behaviour and Conservation College of Biology and the EnvironmentNanjing Forestry UniversityNanjingJiangsu 210037China Department of Biological Sciences School of Natural ScienceKangwon National UniversityChuncheon 24341Republic of Korea Department of Vertebrate Zoology Biological FacultyM.V.Lomonosov Moscow State UniversityMoscow 119234Russia Research Institute for Veterinary Science College of Veterinary MedicineSeoul National UniversitySeoul 08826Republic of Korea Animal Resources Division National Institute for Biological ResourcesIncheon 22689Republic of Korea

DEAR EDITOR,Species that are not formally described are generally not targets for conservation,regardless of their threatened *** habitat degradation has increased over the past several decades in the Republic of Kore... 详细信息

关键词： habitat endangered mountains

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Acute myelomonocytic leukemia and T-lymphoblastic lymphoma as simultaneous bilineage hematologic malignancy treated with decitabine:A case report

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World Journal of Clinical Cases 2023年第21期11卷 5129-5135页

作者： So-Yeon Jeon Na-Ri lee Seungah Cha Ho-Young Yhim Jae-Yong Kwak Kyu Yun Jang Namsu Kim Yong Gon Cho chang-hoon lee Department of Internal Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Pathology Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Laboratory Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Simultaneous bilineage hematologic malignancies are rare;however,several cases of acute myeloid leukemia(AML)and T-lymphoblastic lymphoma(T-LBL)cooccurrence have been reported.A standard treatment for simultaneous AML and T-LBL has not yet been established,and its prognosis is very *** studies to develop standard treatments are required to increase patient survival *** SUMMARY A 69-year-old man complaining of pleuritic chest pain visited the emergency *** tomography revealed multiple enlarged lymph nodes(LNs)in the neck and groin and pulmonary thromboembolism with pulmonary ***,a peripheral blood smear performed due to leukocytosis revealed circulating *** myelomonocytic leukemia(AMML)was diagnosed after bone marrow examination,and T-LBL positivity for terminal deoxynucleotidyl transferase,cluster of differentiation(CD)34,and CD4 was confirmed by cervical LN *** and dexamethasone were administered because he could not receive intensive chemotherapy due to poor performance *** remission of AMML and T-LBL was achieved after 4 cycles of decitabine plus *** We report the therapeutic effect of decitabine,a hypomethylating agent(HMA),in patients with concurrent bilineage hematologic malignancies and suggest that further studies are required to evaluate the therapeutic effect of HMAs on both lymphoid and bilineage hematologic malignancies.

关键词： Simultaneous bilineage hematologic malignancies Acute myelomonocytic leukemia T-lymphoblastic lymphoma Decitabine Pulmonary thromboembolism Case report

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Hemophagocytic lymphohistiocytosis triggered by relapsing polychondritis:A case report

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World Journal of Orthopedics 2024年第8期15卷 813-819页

作者： Mi-Ran Han Jeong-Hwan Hwang Seungah Cha So-Yeon Jeon Kyu Yun Jang Namsu Kim chang-hoon lee Department of Internal Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Pathology Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Laboratory Medicine Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare,life-threatening disorder caused by abnormal histiocytes and T cell *** adults,it is predominantly associated with infections,cancers,and autoimmune *** polychondritis(RP),another rare disease,is diagnosed based on symptoms without specific tests,featuring cartilage inflammation characterized by swelling,redness,and pain,rarely inducing *** SUMMARY A 74-year-old woman visited the emergency room with a fever of 38.6℃.Blood tests,cultures,and imaging were performed to evaluate *** showed increased fluorescent antinuclear antibody levels and mild cytopenia,with no other specific *** revealed lymph node enlargement was observed;however,biopsy results were *** re-evaluation of the physical exam,inflammatory signs suggestive of RP were observed in the ears and nose,prompting a tissue biopsy for ***,persistent fever accompanied by cytopenia prompted a bone marrow examination,revealing hemophagocytic *** finding no significant results in blood culture,viral markers,and tissue examination of enlarged lymph nodes,HLH was diagnosed by *** involved methylprednisolone followed by *** two months,bone marrow examination confirmed resolution of hemophagocytosis,with normalization of hyperferritinemia and *** Thorough physical examination enabled diagnosis and treatment of HLH trig gered by RP in patients presenting with fever of unknown origin.

关键词： Hemophagocytic lymphohistiocytosis Relapsing polychondritis Autoimmune disease Fever of unknown origin Steroid Case report

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Dynamic Modulation Scheme In Consideration of Cell Interference for LMDS

Dynamic Modulation Scheme In Consideration of Cell Interfere...

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1998 International Conference on Communication Technology

作者： chang-hoon lee Boo-Young Chung Su-Hee lee Korea Telecom Technology Evaluation CenterTechnology Standards Team 17 Woomyeon-dongSeocho-guSeoul 137-792Korea

＜正＞In this paper,dynamic modulation scheme for LMDS（Local Multipoint Distribution Service） will be *** budget at 26GHz will be ***,in a sectorized cellular system,considering inter-cellular interference in additi... 详细信息

ISBN: (纸本)7800908275

关键词： radio access networks radiofrequency interference modulation telecommunication network planning dynamic modulation scheme cell interference LMDS local multipoint distribution service link budget sectorized cellular system inter-cellular interference C/I contour curves 26 GHz

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非吸烟非小细胞肺癌患者的比例和临床特征研究

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癌症 2018年第1期37卷 26-32页

作者： Jaeyoung Cho Sun Mi Choi Jinwoo lee chang-hoon lee Sang-Min lee Dong-Wan Kim Jae-Joon Yim Young Tae Kim Chul-Gyu Yoo Young Whan Kim Sung Koo Han Young Sik Park Department of Internal Medicine Seoul National University Hospital Department of Thoracic and Cardiovascular Surgery Seoul National University Hospital

背景与目的非小细胞肺癌(non?small cell lung cancer, NSCLC)患者中非吸烟患者的比例正在增加,但在韩国,这个人数众多的群体并没有得到很好的治疗。本研究旨对NSCLC非吸烟患者的比例和临床特征进行一个单中心评估。方法我们分析了从201... 详细信息

背景与目的非小细胞肺癌(non?small cell lung cancer, NSCLC)患者中非吸烟患者的比例正在增加,但在韩国,这个人数众多的群体并没有得到很好的治疗。本研究旨对NSCLC非吸烟患者的比例和临床特征进行一个单中心评估。方法我们分析了从2011年6月到2014年12月所有新诊断为NSCLC的1860例患者的临床数据。结果在1860例NSCLC患者中,707例(38%)从不吸烟。非吸烟患者中女性(83.7%vs.5.6%)和腺癌(89.8%vs. 44.9%)的比例均高于吸烟患者。非吸烟患者与吸烟患者相比,中位年龄明显更低(65 vs. 68岁,P<0.001),早期肿瘤比例更高(I–II期,44.5%vs. 38.9%,P=0.015)。与吸烟患者相比,表皮生长因子受体突变(57.8%vs. 24.4%,P<0.001)和间变性淋巴瘤激酶重排(7.8%vs. 2.8%,P<0.001)在非吸烟患者中更常见,而Kirsten大鼠肉瘤病毒癌基因同源染色体的基因突变(5.8%vs. 9.6%,P=0.021)出现频率则较低。在对年龄低、女性、腺癌、体能更好、疾病早期、诊断时无症状、曾接受抗肿瘤治疗以及存在驱动基因突变等的有利影响进行校正后,非吸烟患者的生存期比吸烟患者更长(hazard ratio,0.624,95%CI:0.460–0.848; P=0.003)。结论韩国超过三分之一的NSCLC患者是非吸烟者。NSCLC非吸烟患者与吸烟患者相比,有着不同的临床特征和主要驱动基因突变,总生存期更长。

关键词：非小细胞肺癌非吸烟者表皮生长因子受体 KRAS 预后

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Dual Channel SIS Receiver of Trao Telescope

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天文研究与技术 1999年第S1期 82-85页

作者： Jong Ae Park 1,2 , Seog Tae Han 1, Tai Seong Kim 1, Kwang Dong Kim 1, Hyo Ryoung Kim 1, Hyun Soo Chung 1, Jae hoon Jung 1, chang hoon lee 1, Se Hyung Cho 1, Jongmann Yang 2 1. Taeduk Radio Astronomy Observatory (TRAO), Hwaam dong,

We have developed the dual channel receiver with 100GHz and 150GHz band, which is used to make the simultaneous observation with two bands. The SIS mixers are used in both bands. The constructed dewar for receiver has the performance with the vacuum of 10 -8 Torr and the temperature of 4 2K. The receiver noise temperature is 50K (DSB) for 100GHz band and 80K (DSB) for 150GHz band ,respectively. In order to achieve the simultaneous observations, the quasioptical system is precisely designed, and also evaluated by the measurement in the laboratory. We have observed the various sources using this receiver since October 1998. The relative pointing offset between two bands is 3″.

关键词： SIS Dual Channel SIS Receiver of Trao Telescope

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