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Effects of Cordyceps militaris extract on angiogenesis and tumor growth

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Acta Pharmacologica Sinica 2004年第5期25卷 115-123页

作者： Hwa-seung yoo,Jang-woo SHIN,Jung-hyo CHO,chang-gue SON,Yeon-weol LEE,Sang-yong PARK,Chong-kwan CHO Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center R&D Lab of Bulrolife Co Ltd Daejeon Korea College of Oriental Medicine Daejeon University Daejeon 301-724 Institute ofTraditional Medicine and Bioscience Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine

AIM: To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS:Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angio-genic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumorgrowth in vivo were measured. RESULTS: CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22.9 % after 3-h and 14.9 % and32.8 % after 6-h treatment. CME did not affect MMP-9 gene expression in B16-F10 melanoma cells. CME 100 and200 mg/L also reduced bFGF gene expression in HUVECs by 22.2 % and 41.3 %. CME inhibited tube formation ofendothelial cells in vitro and in vivo. CME repressed the growth of B16-F10 melanoma cells in mice compared withcontrol group (P<0.05). CONCLUSION: CME has antiangiogenetic properties.

关键词： Cordyceps militaris angiogenesis human umbilical vein endothelial cells HT1080 cells B16-F10cells matrix metalloproteinases basic fibroblast growth factor

Machining characteristics of complex prism pattern on electroplated roll by copper

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中国有色金属学会会刊：英文版 2009年第B9期19卷 288-294页

作者： Tae-Jin JE Sang-Cheon PARK Kang-Won LEE Yeong-Eun yoo Doo-Sun CHOI Kyung-Hyun WHANG Myung-chang KANG Nano-Machining Laboratory Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Nano-Mechatronics Department University of Science and TechnologySinseongnoYouseong-GuDaejeonKorea National Core Research Center for Hybrid Materials Solution Pusan National University

The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

关键词：车床加工微棱镜铜电镀特征光学效率光学薄膜笔记本电脑金刚石工具

Retroperitoneal desmoplastic small round cell tumor:Pediatric patient treated with multimodal therapy

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World Journal of Gastroenterology 2009年第33期15卷 4212-4214页

作者： Yong Seok Kim Seong Jae Cha yoo Shin Choi Beom Gyu Kim Sung Jun Park In Taik chang Department of Surgery College of MedicineChung-Ang University

A desmoplastic small round cell tumor (DSRCT) is a rare, aggressive mesenchymal neoplasm. Although a DSRCT can develop at various sites, the intraabdominal site is the most common location. These tumors are found most commonly among young adolescents and the prognosis is extremely poor. Multimodal treatment with surgery, chemotherapy and radiotherapy is very important for these rare cases, and this treatment can improve patient survival. In this report, we describe the case of an 8-year-old boy diagnosed with DSRCT located in the retroperitoneal space. The patient has undergone surgical resection and adjuvant chemoradiation therapy, and is currently alive without disease recurrence.

关键词： Retroperitoneum Desmoplastic small round cell tumor Multimodal therapy

Orthotic approach to prevention and management of diabetic foot:A narrative review

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World Journal of Diabetes 2022年第11期13卷 912-920页

作者： Min Cheol chang yoo Jin Choo In Sik Park Myung Woo Park Du Hwan Kim Rehabilitation Medicine Yeungnam UniversityDaegu 42415South Korea Korean Podiatry and Pedorthics Institute Goyang 10442South Korea Physical Medicine and Rehabilitation Chung-Ang UniversitySeoul 06973South Korea

Diabetic foot is a common complication affecting more than one-fifth of patients with *** not treated in time,it may lead to diabetic foot ulcers or Charcot *** the management of diabetic foot,shoe modifications and orthoses can be used to reduce pressure on the affected foot or provide the foot with increased *** addition,the shoe modifications and orthotic devices can relieve patient discomfort during *** shoe modifications include changing the insole material,modifying the heel height,adding a steel shank or rocker sole,and using in-depth ***,a walking brace or ankle-foot orthosis can be used to reduce the pressure on the affected *** purpose of this narrative review was to provide a reference guide to support clinicians in prescribing shoe modifications and foot orthoses to treat diabetic foot ulcers and Charcot arthropathy.

关键词： Diabetic foot Foot ulcers Charcot arthropathy Shoes Foot orthosis

Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study

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International Journal of Oral Science 2014年第4期6卷 227-232页

作者： Jun Sang yoo Seok-Woo chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-Jee yoo Yeo-Rok Oh Sang-Bin Woo Seung-Hyun Han Qiang Zhu Kee-Yeon Kum Department of Dentistry U Dental Hospital Department of Conservative Dentistry School of Dentistry Kyung Hee University Department of Conservative Dentistry Dental Research Institute Seoul National University Dental Hospital Seoul National University School of Dentistry Division of Restorative Dentistry Schulich School of Medicine & Dentistry University of Western Ontario Department of Conservative Dentistry Jukjeon Dental Hospital College of Dentistry Dankook University Department of Oral Microbiology & Immunology Dental Research Institute and BK21 Program Seoul National University School of Dentistry Division of Endodontology Department of Oral Health and Diagnostic Sciences School of Dental Medicine University of Connecticut Health Center

The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate（MTA） was studied by scanning electron microscopy（SEM）. Single-rooted human premolars（n560） were instrumented to an apical size #50/0.06 using ProF ile and treated as follows： Group 1（n510） was filled with phosphate buffered saline（PBS）; Group 2（n510） was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3（n520） was obturated orthograde with a paste of OrthoM TA（BioM TA, Seoul, Korea） and PBS; and Group 4（n520） was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material（IRM）, and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots（Groups 3 and 4）. Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots（Group 4）. Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization.

关键词： bacterial entombment intratubular mineralization orthograde canal obturation scanning electron microscopy tag-like structure

Sexual function and psychological characteristics ofpenile paraffinoma

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Asian Journal of Andrology 2003年第3期5卷 191-194页

作者： Du Geon Moon Jeong Woo yoo Jae Hyun Bae chang Su Han Yong Ku Kim Je Jong Kim Department of Urology Korea University College of Medicine Seoul 136705 KoreaDepartment of Urology Korea University College of Medicine Seoul 136705 KoreaDepartment of Urology Korea University College of Medicine Seoul 136705 KoreaDepartment of Psychiatry Korea University College of Medicine Seoul 136705 KoreaDepartment of Psychiatry Korea University College of Medicine Seoul 136705 KoreaDepartment of Urology Korea University College of Medicine Seoul 136705 Korea

Aim: To identify the sexual, emotional and psychological status of men who augmented their penis with mineral oil injection for their small penis. Methods: Men who had penile paraffin were asked to answer the semi-structured questionnaire. The questionnaire was designed to assess the motivation, method of penile injection, changes in erectile function and satisfaction after penile injection. SCL (Symptom checklist)-90-R, STAI (State and Trait Anxiety Inventory) and Zung SDS (Self-rating depression scale) were also included in the questionnaire for psychological evaluation. Results: A total of 357 men completed the questionnaire. The first-ranked motivation of the injection was recommendation by their acquaintances (48.9 %). The majority of the respondents had the procedure by non-medical person (78.0 %). Before injection, 17.2 % had a sense of inferiority in their penis and 32 % worried about their weak erectile function. After injection, 33.0 % have found relief from their sense of inferiority and 17.8 % wish to feel improvement in their erectile function. Most of the respondents (91 %) were not satisfied with their penis and 74 % of them replied that they want to remove the injected material. Only 15.6 % did not experience side effects. Most of the subjects have suffered from various side effects such as inflammation, skin necrosis, pain, etc. No evidence of psychiatric pathology was found in psychological evaluation. Conclusion: The motivations of mineral oil injection were recommendation by their acquaintances or desire to be more mannish. Most of them had suffered from various side effects and only a small number of them felt improvement in their sense of inferiority, in their penis and erectile function. Increased public awareness is needed for the prevention of this physically and psychologically debilitating problem.

关键词： paraffinoma penis augmentation psychology

Materialization of strained CVD-graphene using thermal mismatch

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Nano Research 2015年第6期8卷 2082-2091页

作者： Seung-Mo Lee Sang-Min Kim Min Young Na Hye Jung chang Kwang-Seop Kim Hyunung Yu hak-Joo Lee Jae-Hyun Kim Nano-Convergence Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM) 156 Gajungbuk-ro Yuseong-gu Daejeon 305-343 Republic of Korea Nano Mechatronics University of Science and Technology (UST) 217 Gajeong-ro Yuseong-gu Daejeon 305-333 Republic of Korea Graduate School of Energy Environment Water and Sustainability Korea Advanced Institute of Science & Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Yonsei University SO Yonsei-ro Seodaemun-gu Seou1120-749 Republic of Korea Advanced Analysis Center Korea Institute of Science and Technology (KIST) Hwarang-ro 14-gil 5 Seongbuk-gu Seoul 130-791 Republic of Korea Korea Research Institute of Standards and Science (KRISS) 267 Gajeong-ro Yuseong-gu Daejeon 305-343 Republic of Korea

Theoretical physics foretells that ＂strain engineering＂ of graphene could hold the key to finding treasures still hidden in two-dimensional （2D） condensed matter physics and commercializing graphene-based devices. However, to produce strained graphene in large quantities is not an easy task by any means. Here, we demonstrate that thermal annealing of graphene placed on various substrates could be a surprisingly simple method for preparing strained graphene with a large area. We found that enhanced graphene-substrate interfacial adhesion plays a critical role in developing strained graphene. Creative device architectures that consider the thermal mismatch between graphene and the target substrate could enable the resulting strain to be intentionally tailored. We believe that our proposed method could suggest a shortcut to realization of graphene straintronics.

关键词： graphene strain engineering thermal mismatch strained graphene

Thermal performance analysis of borehole size effect on geothermal heat exchanger

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Journal of Central South University 2012年第12期19卷 3524-3529页

作者： CHOI Hoon-ki yoo Geun-jong LIM Kyung-bin LEE Sang-hoon LEE chang-hee Department of Mechanical Design and Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Design Engineering Hanbat National UniversityDaejon 305-719Korea Department of Energy Engineering Jeonju UniversityJeonju 560-759Korea STX Institute of Technology Changwon 642-845Korea

Thermal performance was the most important factor in the development of borehole heat exchanger utilizing geothermal energy. The thermal performance was affected by many different design parameters, such as configuration type and borehole size of geothermal heat exchanger. These eventually determined the operation and cost efficiency of the geothermal heat exchanger system. The main purpose of this work was to assess the thermal performance of geother^nal heat exchanger with variation of borehole sizes and numbers of U-tubes inside a borehole. For this, a thermal response test rig was established with line-source theory. The thermal response test was performed with in-line variable input heat source. Effective thermal conductivity and thermal resistance were obtained from the measured data. From the measurement, the effective thermal conductivity is found to have similar values for two- pair type （4 U-tubes） and three-pair type （6 U-tubes） borehole heat exchanger systems indicating similar heat transfer ability. Meanwhile, the thermal resistance shows lower value for the three-pair type compared to the two-pair type. Measured data based resistance have lower value compared to computed result from design programs. Overall comparison finds better thermal performance for the three-pair type, however, fluctuating temperature variation indicates complex flow behavior inside the borehole and requires further study on flow characteristics.

关键词： large size borehole heat exchanger thermal response test effective thermal conductivity thermal resistance borehole

Characteristic analysis of bleeding effect on standing column well (SCW) type geothermal heat exchanger

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Journal of Central South University 2012年第11期19卷 3202-3207页

作者： CHOI Hoon-ki yoo Geun-jong LIM Kyung-bin LEE Sang-hoon LEE chang-hee Department of Mechanical Design/Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Design Engineering Hanbat National UniversityDaejon 305-719Korea Department of Energy Engineering Jeonju UniversityJeonju 560-759Korea STX Institute of Technology Gyeongnam 642-845Korea

Thermal performance is the most important factor in the development of a borehole heat exchanger utilizing geothermal *** thermal performance is affected by many different design parameters and different operating conditions such as *** eventually determines the operation and cost efficiency of the borehole heat exchanger *** thermal performance of an open standing column well (SCW) type geothermal heat exchanger was assessed under the influence of *** this,a thermal response test rig was established with line-source *** test rig also had a bleeding function by releasing fluid while taking additional underground water through the heat *** thermal response test was performed with an additional constant input heat *** thermal conductivity and thermal resistance were obtained from the measured *** the measurement,the effective thermal conductivity is found to have 1.47 times higher value when bleeding is *** thermal resistance also increases by 1.58 times compared to a non-bleeding *** trend indicates enhanced heat transfer in the SCW type heat exchanger with a bleeding ***,therefore,could be an effective method of achieving a high heat transfer rate in the SCW type heat exchanger with sufficient underground water supply.

关键词： standing column well type thermal response test effective thermal conductivity thermal resistance bleeding effect