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Cellular & Molecular Immunology 2014年第1期11卷 1-4页

作者： chang h kim Laboratory of Immunology and hematopoiesis Department of Comparative Pathobiology Weldon School of Biomedical Engineering Purdue Center for Cancer Research PurdueUniversity West Lafayette IN 47907 USA

Tcells are one of the most migratory cells in the body. The development and function of T cells depend on their interaction with other cells, which is, in turn, dependent on optimal cell migra- tion. T cells migrate largely in three dif- ferent ways： rapid distribution via blood vessels through hemodynamic move- ment, transendothelial migration and interstitial movement. Transendothelial migration involves sequential activation of selectins, chemokine receptors and integrin molecules expressed by migrat- ing T cells, leading to extravasation from blood vessel into local tissue environ- ments.

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Microbiota or short-chain fatty acids: which regulates diabetes?

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Cellular & Molecular Immunology 2018年第2期15卷 88-91页

作者： chang h kim Department of Comparative Pathobiology and Biological Sciences Laboratory of Immunology and HematopoiesisWeldon School of Biomedical EngineeringPurdue Institute of InflammationImmunology and Infectious DiseasesPurdue Center for Cancer ResearchPurdue UniversityWest Lafayette47907INUSA

Diabetes mellitus,with sustained high-sugar levels in the blood,has been steadily rising in prevalence *** 12–14%of the US population has been diagnosed with diabetes in recent years.1 One major reason for the rise of diabetes is dietary *** consumption of processed carbohydrates with inadequate consumption of dietary fiber(DF)has been recognized as a major risk factor for diabetes,as hypothesized several decades ago by Trowell.

关键词： diabetes sustained dietary

Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

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Cellular & Molecular Immunology 2023年第4期20卷 341-350页

作者： chang h.kim Department of Pathology University of Michigan School of MedicineAnn ArborMI48109USA Mary h.Weiser Food Allergy Center Center for Gastrointestinal Researchand Rogel Center for Can

Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at multiple levels during the development,activation and effector phases of T and B *** mechanisms are cell-intrinsically programmed and critical in preventing autoimmune *** have witnessed the existence of another type of immune tolerance mechanism that is shaped by lifestyle choices,such as diet,microbiome and microbial ***-chain fatty acids(SCFAs)are the most abundant microbial metabolites in the colonic lumen and are mainly produced by the microbial fermentation of prebiotics,such as dietary *** review focuses on the preventive and immunomodulatory effects of SCFAs on *** tissue-and disease-specific effects of dietary fiber,SCFAs and SCFA-producing microbes on major types of autoimmune diseases,including type I diabetes,multiple sclerosis,rheumatoid arthritis and lupus,are ***,their key regulatory mechanisms for lymphocyte development,tissue barrier function,host metabolism,immunity,autoantibody production,and inflammatory effector and regulatory lymphocytes are *** shared and differential effects of SCFAs on different types and stages of autoimmune diseases are discussed.

关键词： Short-chain fatty acids Immune tolerance Diabetes mellitus Rheumatoid arthritis Lupus Multiple sclerosis

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

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Cellular & Molecular Immunology 2021年第5期18卷 1161-1171页

作者： chang h.kim Department of Pathology and Mary h.Weiser Food Allergy Center University of Michigan School of MedicineAnn ArborMIUSA

A mounting body of evidence indicates that dietary fiber(DF)metabolites produced by commensal bacteria play essential roles in balancing the immune ***,considered nonessential nutrients in the past,is now considered to be necessary to maintain adequate levels of immunity and suppress inflammatory and allergic ***-chain fatty acids(SCFAs),such as acetate,propionate,and butyrate,are the major DF metabolites and mostly produced by specialized commensal bacteria that are capable of breaking down DF into simpler saccharides and further metabolizing the saccharides into *** act on many cell types to regulate a number of important biological processes,including host metabolism,intestinal functions,and immunity *** review specifically highlights the regulatory functions of DF and SCFAs in the immune system with a focus on major innate and adaptive *** information regarding how SCFAs regulate innate lymphoid cells,T helper cells,cytotoxic T cells,and B cells and how these functions impact immunity,inflammation,and allergic responses are discussed.

关键词： Microbiota Dietary fiber Short-chain fatty acids Innate lymphoid cells B cells Th1 Th17 Tregs CD8 Microbial metabolites

NANOSTRUCTURED MATERIALS FOR PhOTOELECROChEMICAL hYDROGEN PRODUCTION

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NANOSTRUCTURED MATERIALS FOR PHOTOELECROCHEMICAL HYDROGEN PR...

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

2007世界太阳能大会：太阳能与人类居住

作者： Peter h.Aurora chang h.kim Levi T.Thompson University of Michigan 2300 Hayward StreetMI 48109USA

highly ordered TiO nanotubes(TiNTs)were produced via an anodization *** gold nanoparticles were deposited onto the TiO surfaces using a deposition-precipitation *** addition of gold nanoparticles to the TiO nanotubes is expected to significantly improve the water oxidation *** addition to a modest improvement in the electrocatalytic properties,deposition of the Au nanoparticles caused a slight reduction in the TiO *** would allow the TiO to absorb more light in the visible portion of the *** performance of the TiNTs was compared to that for a commercial TiO powder(P25 from Degussa). The TiNT based electrodes achieved higher current densities than the powder based electrodes.

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑chang Sung Gwang‑hee Lee Byoungjoon hwang Sojung Seo Ji‑hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity hydrophobic chain

The efect of the couple stress parameter and Prandtl number on the transient natural convection flow over a vertical cylinder

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Acta Mechanica Sinica 2013年第5期29卷 649-656页

作者： h.P.Rani G.Janardhana Reddy chang Nyung kim Department of Mathematics National Institute of TechnologyWarangal-506004 AP India Department of Mechanical Engineering College of Advanced Technology (Industrial Liaison Research Institute)Kyung Hee UniversityGyeonggi-do 446-701 Korea

An analysis is performed to study transient free convective boundary layer flow of a couple stress fluid over a vertical cylinder, in the absence of body couples. The solution of the time-dependent non-linear and coupled governing equations is carried out with the aid of an unconditionally stable Crank-Nicolson type of numerical scheme. Numerical results for the steady-state velocity, temperature as well as the time histories of the skin-friction coefficient and Nus- selt number are presented graphically and discussed. It is seen that for all flow variables as the couple stress control parameter, Co, is amplified, the time required for reaching the temporal maximum increases but the steady-state decreases.

关键词： Couple stress fluid Natural convection Vertical cylinder Finite difference method

Optimal deployment schedule of an active twist rotor for performance enhancement and vibration reduction in high-speed flights

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Chinese Journal of Aeronautics 2017年第4期30卷 1427-1440页

作者： Young h.YOU Sung N.JUNG chang J.kim Department of Aerospace Information Engineering Konkuk University Seoul 05019 Republic of Korea

The best active twist schedules exploiting various waveform types are sought taking advantage of the global search algorithm for the reduction of hub vibration and/or power required of a rotor in high-speed conditions. The active twist schedules include two non-harmonic inputs formed based on segmented step functions as well as the simple harmonic waveform input. An advanced Particle Swarm assisted Genetic Algorithm（PSGA） is employed for the optimizer. A rotorcraft Computational Structural Dynamics（CSD） code CAMRAD II is used to perform the rotor aeromechanics analysis. A Computation Fluid Dynamics（CFD） code is coupled with CSD for verification and some physical insights. The PSGA optimization results are verified against the parameter sweep study performed using the harmonic actuation. The optimum twist schedules according to the performance and/or vibration reduction strategy are obtained and their optimization gains are compared between the actuation cases. A two-phase non-harmonic actuation schedule demonstrates the best outcome in decreasing the power required while a four-phase non-harmonic schedule results in the best vibration reduction as well as the simultaneous reductions in the power required and vibration. The mechanism of reduction to the performance gains is identified illustrating the section airloads, angle-of-attack distribution, and elastic twist deformation predicted by the present approaches.

关键词： Active twist high-speed flight hub vibration Non-harmonic Power required

Distribution of Ge Self-Assembled Quantum Dots on Six Ge1 - x Buffer Layers

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Journal of Rare Earths 2004年第Z2期22卷 133-135页

作者： Joonyeon chang hyungjun kim Nano Device Research Center Korea Institute of Science and TechnologySeoul 136-791Korea Department of Electrical EngireeringUniversity of California LosAngelesCA 90095-1595USA

The effect of buried misfit dislocation on the distribution of Ge self-assembled quantum dots (SAQDs) grown on a relaxed SiGe buffer layer was investigated. The strain field of arrays of buried dislocations in a relaxed SiGe buffer layer provided preferential nucleation sites for quantum dots. Burgers vector analysis using plan-view transmission electron microscopy (TEM) verified that the preferential nucleation sites of Ge SAQDs depended on the Burgers vector direction of corresponding dislocations. The measurement of the lateral distance between SAQDs and dislocations together with crosssection TEM observation clarified that the location of SAQDs was at the intersection of the dislocation slip plane and the top surface. The misfit strain should be an additional factor governing the uniformity in size, shape and distribution of Ge SAQDs.

关键词： misfit dislocation Ge self assembled quantum dots molecular beam epitaxy transmission electron microscopy

A NUMERICAL ANALYSIS OF ThE BLOOD FLOW AROUND ThE BILEAFLET MEChANICAL hEART VALVES WITh DIFFERENT ROTATIONAL IMPLANTATION ANGLES

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Journal of hydrodynamics 2011年第5期23卷 607-614页

作者： hONG Taehyup kim chang Nyung Department of Mechanical Engineering Graduate School Kyung Hee UniversityYongin Korea Department of Mechanical Engineering College of Engineering Kyung Hee University Yongin Korea

The effects of implantation angles of Bileaflet Mechanical heart Valves （BMhVs） on the blood flow and the leaflet motion are investigated in this paper. The physiological blood flow interacting with the moving leaflets of a BMhV is simulated with a strongly coupled implicit Fluid-Structure Interaction （FSI） method based on the Arbitrary-Lagrangian-Eulerian （ALE） approach and the dynamic mesh method （remeshing） in Fluent. BMhVs are widely used to be implanted to replace the diseased heart valves, but the patients would suffer from some complications such as hemolysis, platelet activation, tissue overgrowth and device failure. These complications are closely related to both the flow characteristics near the valves and the leaflet dynamics. The current numerical model is validated against a previous experimental study. The numerical results show that as the rotation angle of BMhV is increased the degree of asymmetry of the blood flow and the leaflet motion is increased, which may lead to an unbalanced force acting on the BMhVs. This study shows the applicability of the FSI model for the interaction between the blood flow and the leaflet motion in BMhVs.

关键词： mechanical heart valve rotational implantation blood flow leaflet motion fluid-structure interaction